Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: A prospective observational pilot study

Critical Care

Volumn 16, Issue 3, 2012, Pages

  Vermeulen Windsant, Iris C ^a,b   de Wit, Norbert C J ^a   Sertorio, Jonas T C ^c   Beckers, Erik A M ^a   Tanus Santos, Jose E ^c   Jacobs, Michael J ^a,d,e   Buurman, Wim A ^a,b  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; HEMOGLOBIN; NITRIC OXIDE;

ADULT; ARTICLE; BLOOD SAMPLING; CHI SQUARE TEST; CLINICAL ARTICLE; ERYTHROCYTE TRANSFUSION; FEMALE; FISHER EXACT TEST; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; OBSERVATIONAL STUDY; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANK SUM TEST; AGED; BLOOD; BLOOD TRANSFUSION; METABOLISM; MIDDLE AGED; PLASMA; RANDOMIZATION; TRENDS; YOUNG ADULT;

ADULT; AGED; BLOOD TRANSFUSION; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; PILOT PROJECTS; PLASMA; PROSPECTIVE STUDIES; RANDOM ALLOCATION; YOUNG ADULT;

EID: 84861414390     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11359     Document Type: Article

References (37)

1. Shaz BH, Hillyer CD. Is there transfusion-related acute renal injury?. Anesthesiology 2010, 113:1012-1013. 10.1097/ALN.0b013e3181f710b8, 20881590.
2. Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA. Clinical practice guideline: red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009, 37:3124-3157. 10.1097/CCM.0b013e3181b39f1b, 19773646.
3. Bennett-Guerrero E, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, Mulherin MA, Zhu H, Buck RD, Califf RM, McMahon TJ. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci USA 2007, 104:17063-17068. 10.1073/pnas.0708160104, 2040393, 17940021.
4. Wolfe LC. Oxidative injuries to the red cell membrane during conventional blood preservation. Semin Hematol 1989, 26:307-312.
5. Ho J, Sibbald WJ, Chin-Yee IH. Effects of storage on efficacy of red cell transfusion: when is it not safe?. Crit Care Med 2003, 31:S687-S697. 10.1097/01.CCM.0000099349.17094.A3, 14724467.
6. Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 2011, 26:465-476.
7. Zubair AC. Clinical impact of blood storage lesions. Am J Hematol 2010, 85:117-122.
8. Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol 2009, 16:515-523. 10.1097/MOH.0b013e32833157f4, 19701085.
9. Hod EA, Spitalnik SL. Harmful effects of transfusion of older stored red blood cells: iron and inflammation. Transfusion 2011, 51:881-885. 10.1111/j.1537-2995.2011.03096.x, 21496050.
10. Lee JS, Gladwin MT. Bad blood: the risks of red cell storage. Nat Med 2010, 16:381-382. 10.1038/nm0410-381, 20376046.
11. Adamson JW. New blood, old blood, or no blood?. N Engl J Med 2008, 358:1295-1296. 10.1056/NEJMe0800520, 18354108.
12. Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008, 358:1229-1239. 10.1056/NEJMoa070403, 18354101.
13. Marik PE, Sibbald WJ. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993, 269:3024-3029. 10.1001/jama.1993.03500230106037, 8501845.
14. Edgren G, Kamper-Jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullum H, Murphy EL, Busch MP, Reilly M, Melbye M, Hjalgrim H, Nyren O. Duration of red blood cell storage and survival of transfused patients. Transfusion 2010, 50:1185-1195. 10.1111/j.1537-2995.2010.02583.x, 3201703, 20158690.
15. Walsh TS, McArdle F, McLellan SA, Maciver C, Maginnis M, Prescott RJ, McClelland DB. Does the storage time of transfused red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients?. Crit Care Med 2004, 32:364-371. 10.1097/01.CCM.0000108878.23703.E0, 14758149.
16. Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO, Schechter AN, Gladwin MT. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002, 8:1383-1389. 10.1038/nm1202-799, 12426562.
17. Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest 2005, 115:3409-3417. 10.1172/JCI25040, 1283939, 16294219.
18. Vermeulen Windsant IC, Snoeijs MG, Hanssen SJ, Altintas S, Heijmans JH, Koeppel TA, Schurink GW, Buurman WA, Jacobs MJ. Hemolysis is associated with acute kidney injury during major aortic surgery. Kidney Int 2010, 77:913-920. 10.1038/ki.2010.24, 20182411.
19. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999, 130:461-470.
20. Cruz-Landeira A, Bal MJ, Lopez-Rivadulla M. Determination of methemoglobin and total hemoglobin in toxicological studies by derivative spectrophotometry. J Anal Toxicol 2002, 26:67-72.
21. Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT. Biological activity of nitric oxide in the plasmatic compartment. Proc Natl Acad Sci USA 2004, 101:11477-11482. 10.1073/pnas.0402201101, 509225, 15258287.
22. Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999, 178:570-572. 10.1016/S0002-9610(99)00239-1, 10670874.
23. Purdy FR, Tweeddale MG, Merrick PM. Association of mortality with age of blood transfused in septic ICU patients. Can J Anaesth 1997, 44:1256-1261. 10.1007/BF03012772, 9429042.
24. Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC. Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 2002, 137:711-717. 10.1001/archsurg.137.6.711, 12049543.
25. Ranucci M, Carlucci C, Isgro G, Boncilli A, De Benedetti D, De la Torre T, Brozzi S, Frigiola A. Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood. Crit Care 2009, 13:R207. 10.1186/cc8217, 2811896, 20025760.
26. van de Watering L, Lorinser J, Versteegh M, Westendord R, Brand A. Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006, 46:1712-1718. 10.1111/j.1537-2995.2006.00958.x, 17002627.
27. Vamvakas EC, Carven JH. Length of storage of transfused red cells and postoperative morbidity in patients undergoing coronary artery bypass graft surgery. Transfusion 2000, 40:101-109. 10.1046/j.1537-2995.2000.40010101.x, 10644819.
28. Salzer U, Zhu R, Luten M, Isobe H, Pastushenko V, Perkmann T, Hinterdorfer P, Bosman GJ. Vesicles generated during storage of red cells are rich in the lipid raft marker stomatin. Transfusion 2008, 48:451-462. 10.1111/j.1537-2995.2007.01549.x, 18067507.
29. Nielsen MJ, Moestrup SK. Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging. Blood 2009, 114:764-771. 10.1182/blood-2009-01-198309, 19380867.
30. Oliviero S, Cortese R. The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J 1989, 8:1145-1151. 400927, 2787245.
31. Tanaka K, Kanamori Y, Sato T, Kondo C, Katayama Y, Yada I, Yuasa H, Kusagawa M. Administration of haptoglobin during cardiopulmonary bypass surgery. ASAIO Trans 1991, 37:M482-M483.
32. Hanssen SJ, Derikx JP, Vermeulen Windsant IC, Heijmans JH, Koeppel TA, Schurink GW, Buurman WA, Jacobs MJ. Visceral injury and systemic inflammation in patients undergoing extracorporeal circulation during aortic surgery. Ann Surg 2008, 248:117-125. 10.1097/SLA.0b013e3181784cc5, 18580215.
33. Habib RH, Zacharias A, Schwann TA, Riordan CJ, Engoren M, Durham SJ, Shah A. Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: implications on operative outcome. Crit Care Med 2005, 33:1749-1756. 10.1097/01.CCM.0000171531.06133.B0, 16096452.
34. Huybregts RA, de Vroege R, Jansen EK, van Schijndel AW, Christiaans HM, van Oeveren W. The association of hemodilution and transfusion of red blood cells with biochemical markers of splanchnic and renal injury during cardiopulmonary bypass. Anesth Analg 2009, 109:331-339. 10.1213/ane.0b013e3181ac52b2, 19608799.
35. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, MacIntyre NR, Shabot MM, Duh MS, Shapiro MJ. The CRIT Study: anemia and blood transfusion in the critically ill - current clinical practice in the United States. Crit Care Med 2004, 32:39-52. 10.1097/01.CCM.0000104112.34142.79, 14707558.
36. Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 2011, 124:465-476. 10.1161/CIRCULATIONAHA.110.008698, 21747051.
37. Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL. Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency. Am J Hematol 2008, 83:15-18. 10.1002/ajh.21016, 17696198.