메뉴 건너뛰기




Volumn 25, Issue 5, 2017, Pages 1713-1739

Oral mucosal changes induced by anticancer targeted therapies and immune checkpoint inhibitors

Author keywords

Angiogenesis inhibitors; Anti PD 1; BCR ABL inhibitor; Benign migratory glossitis; BRAF inhibitors; Cancer; Dysgeusia; EGFR inhibitors; Hyperkeratotic lesion; Hyperpigmentation; Immune checkpoint inhibitors; Immunotherapy; Lichenoid reaction; mIAS; mTOR inhibitors; Mucosal changes; Mucosal sensitivity; Mucositis; Oral adverse events; Oral cavity; Oral squamous cell carcinoma; Osteonecrosis of jaw; Stomatitis; Targeted therapies; Telangiectasias; Xerostomia

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE INHIBITOR; ANGIOGENESIS INHIBITOR; ANTIBODY DRUG CONJUGATE; ANTINEOPLASTIC AGENT; B RAF KINASE INHIBITOR; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EVEROLIMUS; HEDGEHOG PATHWAY INHIBITOR; IMATINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PANITUMUMAB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; TEMSIROLIMUS; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

EID: 85013389036     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-017-3629-4     Document Type: Review
Times cited : (131)

References (184)
  • 1
    • 84944238588 scopus 로고    scopus 로고
    • Current treatment options for recurrent or metastatic head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC28Xms1amurw%3D, PID: 26351341
    • Sacco AG, Cohen EE (2015) Current treatment options for recurrent or metastatic head and neck squamous cell carcinoma. J Clin Oncol 33:3305–3313
    • (2015) J Clin Oncol , vol.33 , pp. 3305-3313
    • Sacco, A.G.1    Cohen, E.E.2
  • 2
    • 84877037038 scopus 로고    scopus 로고
    • Antiangiogenic therapies for advanced hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3sXptFeltrw%3D, PID: 23576483
    • Sampat KR, O’Neil B (2013) Antiangiogenic therapies for advanced hepatocellular carcinoma. Oncologist 18:430–438
    • (2013) Oncologist , vol.18 , pp. 430-438
    • Sampat, K.R.1    O’Neil, B.2
  • 3
    • 84863587948 scopus 로고    scopus 로고
    • Targeted therapy in head and neck cancer
    • COI: 1:CAS:528:DC%2BC38XmsF2nu7s%3D, PID: 22373581
    • Kundu SK, Nestor M (2012) Targeted therapy in head and neck cancer. Tumour Biol 33:707–721
    • (2012) Tumour Biol , vol.33 , pp. 707-721
    • Kundu, S.K.1    Nestor, M.2
  • 4
    • 84975221154 scopus 로고    scopus 로고
    • Emerging targeted therapies for melanoma
    • COI: 1:CAS:528:DC%2BC28Xot1ymtLc%3D, PID: 27148822
    • Johnson DB, Pollack MH, Sosman JA (2016) Emerging targeted therapies for melanoma. Expert Opin Emerg Drugs 21:195–207
    • (2016) Expert Opin Emerg Drugs , vol.21 , pp. 195-207
    • Johnson, D.B.1    Pollack, M.H.2    Sosman, J.A.3
  • 6
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
    • COI: 1:CAS:528:DC%2BC2MXjtFShs7s%3D, PID: 25704439
    • Rizvi NA, Mazières J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ et al (2015) Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 16:257–265
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6
  • 7
    • 84955253186 scopus 로고    scopus 로고
    • Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial
    • COI: 1:CAS:528:DC%2BC2MXhs1yks7zF, PID: 26482279
    • Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T et al (2015) Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial. Lancet Oncol 16:1473–1482
    • (2015) Lancet Oncol , vol.16 , pp. 1473-1482
    • Motzer, R.J.1    Hutson, T.E.2    Glen, H.3    Michaelson, M.D.4    Molina, A.5    Eisen, T.6
  • 8
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC2MXhtFyrsbrF, PID: 25891173
    • Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L et al (2015) Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372:2521–2532
    • (2015) N Engl J Med , vol.372 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3    Arance, A.4    Grob, J.J.5    Mortier, L.6
  • 9
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552
    • Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L et al (2015) Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372:320–330
    • (2015) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3    Dutriaux, C.4    Maio, M.5    Mortier, L.6
  • 10
    • 84936871442 scopus 로고    scopus 로고
    • The evolving role of immune checkpoint inhibitors in cancer treatment
    • COI: 1:CAS:528:DC%2BC2MXhs12iu7bK, PID: 26069281
    • Pennock GK, Chow LQ (2015) The evolving role of immune checkpoint inhibitors in cancer treatment. Oncologist 20:812–822
    • (2015) Oncologist , vol.20 , pp. 812-822
    • Pennock, G.K.1    Chow, L.Q.2
  • 11
    • 84937112293 scopus 로고    scopus 로고
    • Immune therapy in GI malignancies: a review
    • COI: 1:CAS:528:DC%2BC2MXht1eisb3E, PID: 25918295
    • Wang J, Reiss KA, Khatri R, Jaffee E, Laheru D (2015) Immune therapy in GI malignancies: a review. J Clin Oncol 33:1745–1753
    • (2015) J Clin Oncol , vol.33 , pp. 1745-1753
    • Wang, J.1    Reiss, K.A.2    Khatri, R.3    Jaffee, E.4    Laheru, D.5
  • 12
    • 84922516101 scopus 로고    scopus 로고
    • Cutaneous adverse effects of targeted therapies: part I: inhibitors of the cellular membrane
    • COI: 1:CAS:528:DC%2BC2MXhtFGrsbY%3D, PID: 25592338
    • Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A (2015) Cutaneous adverse effects of targeted therapies: part I: inhibitors of the cellular membrane. J Am Acad Dermatol 72:203–218
    • (2015) J Am Acad Dermatol , vol.72 , pp. 203-218
    • Macdonald, J.B.1    Macdonald, B.2    Golitz, L.E.3    LoRusso, P.4    Sekulic, A.5
  • 13
    • 84922569171 scopus 로고    scopus 로고
    • Cutaneous adverse effects of targeted therapies: part II: inhibitors of intracellular molecular signaling pathways
    • COI: 1:CAS:528:DC%2BC2MXhtFKls78%3D, PID: 25592339
    • Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A (2015) Cutaneous adverse effects of targeted therapies: part II: inhibitors of intracellular molecular signaling pathways. J Am Acad Dermatol 72:221–236
    • (2015) J Am Acad Dermatol , vol.72 , pp. 221-236
    • Macdonald, J.B.1    Macdonald, B.2    Golitz, L.E.3    LoRusso, P.4    Sekulic, A.5
  • 14
    • 84859387313 scopus 로고    scopus 로고
    • Advances in the management of cutaneous toxicities of targeted therapies
    • COI: 1:CAS:528:DC%2BC38Xltlagtbc%3D, PID: 22484194
    • Robert C, Sibaud V, Mateus C, Cherpelis BS (2012) Advances in the management of cutaneous toxicities of targeted therapies. Semin Oncol 39:227–240
    • (2012) Semin Oncol , vol.39 , pp. 227-240
    • Robert, C.1    Sibaud, V.2    Mateus, C.3    Cherpelis, B.S.4
  • 15
    • 58149345018 scopus 로고    scopus 로고
    • Dermatologic symptoms associated with the multikinase inhibitor sorafenib
    • PID: 19028406
    • Robert C, Mateus C, Spatz A, Wechsler J, Escudier B (2009) Dermatologic symptoms associated with the multikinase inhibitor sorafenib. J Am Acad Dermatol 60:299–305
    • (2009) J Am Acad Dermatol , vol.60 , pp. 299-305
    • Robert, C.1    Mateus, C.2    Spatz, A.3    Wechsler, J.4    Escudier, B.5
  • 16
    • 79952927826 scopus 로고    scopus 로고
    • Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer
    • PID: 20680104
    • Fakih M, Vincent M (2010) Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer. Curr Oncol 17(Suppl 1):S18–S30
    • (2010) Curr Oncol , vol.17 , pp. S18-S30
    • Fakih, M.1    Vincent, M.2
  • 17
    • 21344462378 scopus 로고    scopus 로고
    • Cutaneous side-effects of kinase inhibitors and blocking antibodies
    • COI: 1:CAS:528:DC%2BD2MXlvVWktLw%3D, PID: 15992698
    • Robert C, Soria JC, Spatz A, Le Cesne A, Malka D, Pautier P et al (2005) Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol 6:491–500
    • (2005) Lancet Oncol , vol.6 , pp. 491-500
    • Robert, C.1    Soria, J.C.2    Spatz, A.3    Le Cesne, A.4    Malka, D.5    Pautier, P.6
  • 18
    • 85044292244 scopus 로고    scopus 로고
    • Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II. Targeted therapy
    • COI: 1:CAS:528:DC%2BC2cXhtFGqu7fN
    • Reyes-Habito CM, Roh EK (2014) Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II. Targeted therapy. J Am Acad Dermatol 71:217.e1–217.e11
    • (2014) J Am Acad Dermatol , vol.71 , pp. 217.e1-217.e11
    • Reyes-Habito, C.M.1    Roh, E.K.2
  • 19
    • 84949988089 scopus 로고    scopus 로고
    • Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
    • COI: 1:STN:280:DC%2BC283it1Khtw%3D%3D, PID: 26371282
    • Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME et al (2015) Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 26:2375–2391
    • (2015) Ann Oncol , vol.26 , pp. 2375-2391
    • Naidoo, J.1    Page, D.B.2    Li, B.T.3    Connell, L.C.4    Schindler, K.5    Lacouture, M.E.6
  • 20
    • 84964777630 scopus 로고    scopus 로고
    • Dermatologic complications of anti-PD-1/PD-L-1 immune checkpoint antibodies
    • COI: 1:CAS:528:DC%2BC28XptFGlu7o%3D
    • Sibaud V, Meyer N, Lamant L, Vigarios E, Mazieres J, Delord JP (2016) Dermatologic complications of anti-PD-1/PD-L-1 immune checkpoint antibodies. Curr Opinion Oncol 28:254–263
    • (2016) Curr Opinion Oncol , vol.28 , pp. 254-263
    • Sibaud, V.1    Meyer, N.2    Lamant, L.3    Vigarios, E.4    Mazieres, J.5    Delord, J.P.6
  • 21
    • 84901242074 scopus 로고    scopus 로고
    • Oral toxicity of targeted anticancer therapies
    • COI: 1:STN:280:DC%2BC2cfksF2isQ%3D%3D, PID: 24835648, [Article in French]
    • Sibaud V, Boralevi F, Vigarios E, Fricain JC (2014) Oral toxicity of targeted anticancer therapies. Ann Dermatol Venereol 141:354–363 [Article in French]
    • (2014) Ann Dermatol Venereol , vol.141 , pp. 354-363
    • Sibaud, V.1    Boralevi, F.2    Vigarios, E.3    Fricain, J.C.4
  • 22
    • 84875257898 scopus 로고    scopus 로고
    • A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients
    • COI: 1:CAS:528:DC%2BC3sXnt1WgtQ%3D%3D, PID: 23312237
    • Martins F, de Oliveira MA, Wang Q, Sonis S, Gallottini M, George S et al (2013) A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients. Oral Oncol 49:293–298
    • (2013) Oral Oncol , vol.49 , pp. 293-298
    • Martins, F.1    de Oliveira, M.A.2    Wang, Q.3    Sonis, S.4    Gallottini, M.5    George, S.6
  • 23
    • 79958038490 scopus 로고    scopus 로고
    • Oral complications of targeted cancer therapies: a narrative literature review
    • COI: 1:CAS:528:DC%2BC3MXnt1Krt7g%3D, PID: 21514211
    • Watters AL, Epstein JB, Agulnik M (2011) Oral complications of targeted cancer therapies: a narrative literature review. Oral Oncol 47:441–448
    • (2011) Oral Oncol , vol.47 , pp. 441-448
    • Watters, A.L.1    Epstein, J.B.2    Agulnik, M.3
  • 24
    • 84892854570 scopus 로고    scopus 로고
    • Oral mucosal injury caused by cancer therapies: current management and new frontiers in research
    • PID: 24261541
    • Jensen SB, Peterson DE (2014) Oral mucosal injury caused by cancer therapies: current management and new frontiers in research. J Oral Pathol Med 43:81–90
    • (2014) J Oral Pathol Med , vol.43 , pp. 81-90
    • Jensen, S.B.1    Peterson, D.E.2
  • 25
    • 84944722816 scopus 로고    scopus 로고
    • Oral adverse events in cancer patients treated with VEGFR-directed multitargeted tyrosine kinase inhibitors
    • COI: 1:CAS:528:DC%2BC2MXhsV2lt7jF, PID: 26403941
    • Yuan A, Kurtz SL, Barysauskas CM, Pilotte AP, Wagner AJ, Treister NS (2015) Oral adverse events in cancer patients treated with VEGFR-directed multitargeted tyrosine kinase inhibitors. Oral Oncol 51:1026–1033
    • (2015) Oral Oncol , vol.51 , pp. 1026-1033
    • Yuan, A.1    Kurtz, S.L.2    Barysauskas, C.M.3    Pilotte, A.P.4    Wagner, A.J.5    Treister, N.S.6
  • 27
    • 74549192779 scopus 로고    scopus 로고
    • Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    • COI: 1:CAS:528:DC%2BC3cXitFGiurw%3D, PID: 19862817
    • Sonis S, Treister N, Chawla S, Demetri G, Haluska F (2010) Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients. Cancer 116:210–215
    • (2010) Cancer , vol.116 , pp. 210-215
    • Sonis, S.1    Treister, N.2    Chawla, S.3    Demetri, G.4    Haluska, F.5
  • 28
    • 84856267919 scopus 로고    scopus 로고
    • Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review
    • COI: 1:CAS:528:DC%2BC38XjslGqsLY%3D, PID: 22207567
    • Boers-Doets CB, Epstein JB, Raber-Durlacher JE, Ouwerkerk J, Logan RM, Brakenhoff JA et al (2012) Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review. Oncologist 17:135–144
    • (2012) Oncologist , vol.17 , pp. 135-144
    • Boers-Doets, C.B.1    Epstein, J.B.2    Raber-Durlacher, J.E.3    Ouwerkerk, J.4    Logan, R.M.5    Brakenhoff, J.A.6
  • 29
    • 84856212971 scopus 로고    scopus 로고
    • The risk of skin rash and stomatitis with the mammalian target of rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis
    • COI: 1:CAS:528:DC%2BC38XhsVOls74%3D, PID: 22206873
    • Gomez-Fernandez C, Garden BC, Wu S, Feldman DR, Lacouture ME (2012) The risk of skin rash and stomatitis with the mammalian target of rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis. Eur J Cancer 48:340–346
    • (2012) Eur J Cancer , vol.48 , pp. 340-346
    • Gomez-Fernandez, C.1    Garden, B.C.2    Wu, S.3    Feldman, D.R.4    Lacouture, M.E.5
  • 30
    • 84885575248 scopus 로고    scopus 로고
    • Risk of oral and gastrointestinal mucosal injury among patients receiving selected targeted agents: a meta-analysis
    • PID: 23636648
    • Elting LS, Chang YC, Parelkar P, Boers-Doets CB, Michelet M, Hita G et al (2013) Risk of oral and gastrointestinal mucosal injury among patients receiving selected targeted agents: a meta-analysis. Support Care Cancer 21:3243–3254
    • (2013) Support Care Cancer , vol.21 , pp. 3243-3254
    • Elting, L.S.1    Chang, Y.C.2    Parelkar, P.3    Boers-Doets, C.B.4    Michelet, M.5    Hita, G.6
  • 31
    • 84930380186 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma and hyperkeratotic lesions with BRAF inhibitors
    • COI: 1:CAS:528:DC%2BC2MXps12nsro%3D, PID: 25495246
    • Vigarios E, Lamant L, Delord JP, Fricain JC, Chevreau C, Barrés B et al (2015) Oral squamous cell carcinoma and hyperkeratotic lesions with BRAF inhibitors. Br J Dermatol 172:1680–1682
    • (2015) Br J Dermatol , vol.172 , pp. 1680-1682
    • Vigarios, E.1    Lamant, L.2    Delord, J.P.3    Fricain, J.C.4    Chevreau, C.5    Barrés, B.6
  • 32
    • 80053959068 scopus 로고    scopus 로고
    • Clinical presentation and management of mTOR inhibitor-associated stomatitis
    • PID: 21890398
    • De Oliveira MA, Martins E, Martins F, Wang Q, Sonis S, Demetri G et al (2011) Clinical presentation and management of mTOR inhibitor-associated stomatitis. Oral Oncol 47:998–1003
    • (2011) Oral Oncol , vol.47 , pp. 998-1003
    • De Oliveira, M.A.1    Martins, E.2    Martins, F.3    Wang, Q.4    Sonis, S.5    Demetri, G.6
  • 33
    • 84941645551 scopus 로고    scopus 로고
    • Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up
    • PID: 26142468
    • Peterson DE, Boers-Doets CB, Bensadoun RJ, Herrstedt J, Guidelines Committee ESMO (2015) Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up. Ann Oncol 26:v139–v151
    • (2015) Ann Oncol , vol.26 , pp. v139-v151
    • Peterson, D.E.1    Boers-Doets, C.B.2    Bensadoun, R.J.3    Herrstedt, J.4    Guidelines Committee, E.S.M.O.5
  • 34
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • COI: 1:CAS:528:DC%2BC2cXpsVSku74%3D, PID: 24590637
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH et al (2014) Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 32:1020–1030
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 35
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced non squamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE et al (2015) Nivolumab versus docetaxel in advanced non squamous non-small-cell lung cancer. N Engl J Med 373:1627–1639
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 36
    • 84962497081 scopus 로고    scopus 로고
    • Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study
    • COI: 1:CAS:528:DC%2BC2sXhslOhtQ%3D%3D, PID: 26755520
    • McDermott DF, Sosman JA, Sznol M, Massard C, Gordon MS, Hamid O et al (2016) Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study. J Clin Oncol 34:833–842
    • (2016) J Clin Oncol , vol.34 , pp. 833-842
    • McDermott, D.F.1    Sosman, J.A.2    Sznol, M.3    Massard, C.4    Gordon, M.S.5    Hamid, O.6
  • 38
    • 84999085042 scopus 로고    scopus 로고
    • Clinical and histologic features of lichenoid mucocutaneous eruptions due to anti-programmed cell death 1 and anti-programmed cell death ligand 1 immunotherapy
    • PID: 27411054
    • Shi VJ, Rodic N, Gettinger S, Leventhal JS, Neckman JP, Girardi M et al (2016) Clinical and histologic features of lichenoid mucocutaneous eruptions due to anti-programmed cell death 1 and anti-programmed cell death ligand 1 immunotherapy. JAMA Dermatol 152:1128–1136
    • (2016) JAMA Dermatol , vol.152 , pp. 1128-1136
    • Shi, V.J.1    Rodic, N.2    Gettinger, S.3    Leventhal, J.S.4    Neckman, J.P.5    Girardi, M.6
  • 39
    • 84923206499 scopus 로고    scopus 로고
    • Incidence and risk of high-grade stomatitis with mTOR inhibitors in cancer patients
    • COI: 1:CAS:528:DC%2BC2MXivFWisbg%3D
    • Shameem R, Lacouture M, Wu S (2015) Incidence and risk of high-grade stomatitis with mTOR inhibitors in cancer patients. Cancer Investig 33:70–77
    • (2015) Cancer Investig , vol.33 , pp. 70-77
    • Shameem, R.1    Lacouture, M.2    Wu, S.3
  • 41
    • 84957594926 scopus 로고    scopus 로고
    • Occurrence and characterization of everolimus adverse events during first and subsequent cycles in the treatment of metastatic breast cancer
    • PID: 26847349
    • Vargo CA, Berger MJ, Phillips G, Mrozek E (2016) Occurrence and characterization of everolimus adverse events during first and subsequent cycles in the treatment of metastatic breast cancer. Support Care Cancer 24:2913–2918
    • (2016) Support Care Cancer , vol.24 , pp. 2913-2918
    • Vargo, C.A.1    Berger, M.J.2    Phillips, G.3    Mrozek, E.4
  • 42
    • 84959903467 scopus 로고    scopus 로고
    • Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy
    • COI: 1:STN:280:DC%2BC28rps1Clug%3D%3D, PID: 26759276
    • Rugo HS, Hortobagyi GN, Yao J, Pavel M, Ravaud A, Franz D et al (2016) Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy. Ann Oncol 27:519–525
    • (2016) Ann Oncol , vol.27 , pp. 519-525
    • Rugo, H.S.1    Hortobagyi, G.N.2    Yao, J.3    Pavel, M.4    Ravaud, A.5    Franz, D.6
  • 43
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BC3MXhvVyiu7s%3D, PID: 21306238
    • Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E et al (2011) Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364:514–523
    • (2011) N Engl J Med , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3    Bohas, C.L.4    Wolin, E.M.5    Van Cutsem, E.6
  • 44
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • COI: 1:CAS:528:DC%2BC38XisVKqsrs%3D, PID: 22149876
    • Baselga J, Campone M, Piccart M, Burris HA, Rugo HS, Sahmoud T et al (2012) Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366:520–529
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3    Burris, H.A.4    Rugo, H.S.5    Sahmoud, T.6
  • 45
    • 84960494358 scopus 로고    scopus 로고
    • Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial
    • COI: 1:CAS:528:DC%2BC28XnvFSjsQ%3D%3D, PID: 26794930
    • Armstrong AJ, Halabi S, Eisen T, Broderick S, Stadler WM, Jones RJ et al (2016) Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial. Lancet Oncol 17:378–388
    • (2016) Lancet Oncol , vol.17 , pp. 378-388
    • Armstrong, A.J.1    Halabi, S.2    Eisen, T.3    Broderick, S.4    Stadler, W.M.5    Jones, R.J.6
  • 46
    • 84899992665 scopus 로고    scopus 로고
    • Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial
    • PID: 24742739
    • André F, O’Regan R, Ozguroglu M, Toi M, Xu B, Jerusalem G et al (2014) Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 15:580–591
    • (2014) Lancet Oncol , vol.15 , pp. 580-591
    • André, F.1    O’Regan, R.2    Ozguroglu, M.3    Toi, M.4    Xu, B.5    Jerusalem, G.6
  • 48
    • 84946552683 scopus 로고    scopus 로고
    • Cabozantinib versus everolimus in advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC28XnvFCktLY%3D, PID: 26406150
    • Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F et al (2015) Cabozantinib versus everolimus in advanced renal-cell carcinoma. N Engl J Med 373:1814–1823
    • (2015) N Engl J Med , vol.373 , pp. 1814-1823
    • Choueiri, T.K.1    Escudier, B.2    Powles, T.3    Mainwaring, P.N.4    Rini, B.I.5    Donskov, F.6
  • 49
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXmtVKkurs%3D, PID: 17538086
    • Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A et al (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356:2271–2281
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3    Dutcher, J.4    Figlin, R.5    Kapoor, A.6
  • 50
    • 84872518645 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer
    • COI: 1:CAS:528:DC%2BC3sXhvV2gsrY%3D, PID: 23233719
    • Wolff AC, Lazar AA, Bondarenko I, Garin AM, Brincat S, Chow L et al (2013) Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol 31:195–202
    • (2013) J Clin Oncol , vol.31 , pp. 195-202
    • Wolff, A.C.1    Lazar, A.A.2    Bondarenko, I.3    Garin, A.M.4    Brincat, S.5    Chow, L.6
  • 51
    • 84899679988 scopus 로고    scopus 로고
    • Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC2cXnsl2iur8%3D, PID: 24297950
    • Hutson TE, Escudier B, Esteban E, Bjarnason GA, Lim HY, Pittman KB et al (2014) Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 32:760–767
    • (2014) J Clin Oncol , vol.32 , pp. 760-767
    • Hutson, T.E.1    Escudier, B.2    Esteban, E.3    Bjarnason, G.A.4    Lim, H.Y.5    Pittman, K.B.6
  • 52
    • 84899630091 scopus 로고    scopus 로고
    • Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial
    • COI: 1:CAS:528:DC%2BC2cXnsl2iur4%3D, PID: 24297945
    • Rini BI, Bellmunt J, Clancy J, Wang K, Niethammer AG, Hariharan S et al (2014) Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol 32:752–759
    • (2014) J Clin Oncol , vol.32 , pp. 752-759
    • Rini, B.I.1    Bellmunt, J.2    Clancy, J.3    Wang, K.4    Niethammer, A.G.5    Hariharan, S.6
  • 53
    • 79953182631 scopus 로고    scopus 로고
    • Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study
    • COI: 1:CAS:528:DC%2BC3MXkt1GqsrY%3D, PID: 21440503
    • Ansell SM, Tang H, Kurtin PJ, Koenig PA, Inwards DJ, Shah K et al (2011) Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study. Lancet Oncol 12:361–368
    • (2011) Lancet Oncol , vol.12 , pp. 361-368
    • Ansell, S.M.1    Tang, H.2    Kurtin, P.J.3    Koenig, P.A.4    Inwards, D.J.5    Shah, K.6
  • 54
    • 84964389363 scopus 로고    scopus 로고
    • Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial
    • COI: 1:CAS:528:DC%2BC28XmtFaqtbY%3D, PID: 27083334
    • Park K, Tan EH, O’Byrne K, Zhang L, Boyer M, Mok T et al (2016) Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial. Lancet Oncol 17:577–589
    • (2016) Lancet Oncol , vol.17 , pp. 577-589
    • Park, K.1    Tan, E.H.2    O’Byrne, K.3    Zhang, L.4    Boyer, M.5    Mok, T.6
  • 55
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
    • COI: 1:CAS:528:DC%2BC38Xmslyhsbg%3D, PID: 22452896
    • Miller VA, Hirsh V, Cadranel J, Chen YM, Park K, Kim SW et al (2012) Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 13:528–538
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3    Chen, Y.M.4    Park, K.5    Kim, S.W.6
  • 56
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhtF2gu78%3D, PID: 24439929
    • Wu YL, Zhou C, Hu CP, Feng J, Lu S, Huang Y et al (2014) Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol 15:213–222
    • (2014) Lancet Oncol , vol.15 , pp. 213-222
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3    Feng, J.4    Lu, S.5    Huang, Y.6
  • 57
    • 84933678811 scopus 로고    scopus 로고
    • Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXms1ynurg%3D, PID: 25892145
    • Machiels JP, Haddad RI, Fayette J, Licitra LF, Tahara M, Vermorken JB et al (2015) Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial. Lancet Oncol 16:583–594
    • (2015) Lancet Oncol , vol.16 , pp. 583-594
    • Machiels, J.P.1    Haddad, R.I.2    Fayette, J.3    Licitra, L.F.4    Tahara, M.5    Vermorken, J.B.6
  • 58
    • 84938210278 scopus 로고    scopus 로고
    • Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXhtFehsbvO, PID: 26156651
    • Soria JC, Felip E, Cobo M, Lu S, Syrigos K, Lee KH et al (2015) Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial. Lancet Oncol 16:897–907
    • (2015) Lancet Oncol , vol.16 , pp. 897-907
    • Soria, J.C.1    Felip, E.2    Cobo, M.3    Lu, S.4    Syrigos, K.5    Lee, K.H.6
  • 59
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • COI: 1:CAS:528:DC%2BC3sXhs1KrsrzP, PID: 23816960
    • Sequist LV, Yang JC, Yamamoto N, O’Byrne K, Hirsh V, Mok T et al (2013) Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 31:3327–3334
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3    O’Byrne, K.4    Hirsh, V.5    Mok, T.6
  • 60
    • 84960496215 scopus 로고    scopus 로고
    • Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial
    • COI: 1:CAS:528:DC%2BC28XhsV2nsLk%3D, PID: 26822398
    • Harbeck N, Huang CS, Hurvitz S, Yeh DC, Shao Z, Im SA et al (2016) Afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one previous trastuzumab treatment (LUX-Breast 1): an open-label, randomised, phase 3 trial. Lancet Oncol 17:357–366
    • (2016) Lancet Oncol , vol.17 , pp. 357-366
    • Harbeck, N.1    Huang, C.S.2    Hurvitz, S.3    Yeh, D.C.4    Shao, Z.5    Im, S.A.6
  • 61
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • COI: 1:CAS:528:DC%2BD2sXhslSqsA%3D%3D, PID: 17192538
    • Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T et al (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355:2733–2743
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3    Chan, S.4    Romieu, C.G.5    Pienkowski, T.6
  • 62
    • 84871712684 scopus 로고    scopus 로고
    • Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial
    • COI: 1:CAS:528:DC%2BC3sXhsV2ltw%3D%3D, PID: 23234763
    • Goss PE, Smith IE, O’Shaughnessy J, Ejlertsen B, Kaufmann M, Boyle F et al (2013) Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol 14:88–96
    • (2013) Lancet Oncol , vol.14 , pp. 88-96
    • Goss, P.E.1    Smith, I.E.2    O’Shaughnessy, J.3    Ejlertsen, B.4    Kaufmann, M.5    Boyle, F.6
  • 63
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • COI: 1:CAS:528:DC%2BD1MXhtVygsbfK, PID: 19692680
    • Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N et al (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947–957
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3    Yang, C.H.4    Chu, D.T.5    Saijo, N.6
  • 64
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC3cXhtlGgtbo%3D, PID: 20022809
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J et al (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11:121–128
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 65
    • 84908616654 scopus 로고    scopus 로고
    • Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhslKjtrbK, PID: 25439691
    • Ramalingam SS, Jänne PA, Mok T, O’Byrne K, Boyer MJ, Von Pawel J et al (2014) Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial. Lancet Oncol 15:1369–1378
    • (2014) Lancet Oncol , vol.15 , pp. 1369-1378
    • Ramalingam, S.S.1    Jänne, P.A.2    Mok, T.3    O’Byrne, K.4    Boyer, M.J.5    Von Pawel, J.6
  • 66
    • 84857501696 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study
    • COI: 1:CAS:528:DC%2BC38XjsVCgtrw%3D, PID: 22277837
    • Ciuleanu T, Stelmakh L, Cicenas S, Miliauskas S, Grigorescu AC, Hillenbach C et al (2012) Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study. Lancet Oncol 13:300–308
    • (2012) Lancet Oncol , vol.13 , pp. 300-308
    • Ciuleanu, T.1    Stelmakh, L.2    Cicenas, S.3    Miliauskas, S.4    Grigorescu, A.C.5    Hillenbach, C.6
  • 67
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • COI: 1:CAS:528:DC%2BC3MXpslKhsbY%3D, PID: 21783417
    • Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C et al (2011) Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12:735–742
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6
  • 69
    • 84908614640 scopus 로고    scopus 로고
    • Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhslKjtrbI, PID: 25439692
    • Ellis PM, Shepherd FA, Millward M, Perrone F, Seymour L, Liu G et al (2014) Dacomitinib compared with placebo in pretreated patients with advanced or metastatic non-small-cell lung cancer (NCIC CTG BR.26): a double-blind, randomised, phase 3 trial. Lancet Oncol 15:1379–1388
    • (2014) Lancet Oncol , vol.15 , pp. 1379-1388
    • Ellis, P.M.1    Shepherd, F.A.2    Millward, M.3    Perrone, F.4    Seymour, L.5    Liu, G.6
  • 70
    • 84925230574 scopus 로고    scopus 로고
    • Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial
    • PID: 25456362
    • Jänne PA, Ou SH, Kim DW, Oxnard GR, Martins R, Kris MG et al (2014) Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial. Lancet Oncol 15:1433–1441
    • (2014) Lancet Oncol , vol.15 , pp. 1433-1441
    • Jänne, P.A.1    Ou, S.H.2    Kim, D.W.3    Oxnard, G.R.4    Martins, R.5    Kris, M.G.6
  • 71
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BD2cXlvFGitbk%3D, PID: 15269313
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A et al (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337–345
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 72
    • 84899981129 scopus 로고    scopus 로고
    • Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study
    • COI: 1:CAS:528:DC%2BC2cXmtlWhtLw%3D, PID: 24739896
    • Price TJ, Peeters M, Kim TW, Li J, Cascinu S, Ruff P et al (2014) Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study. Lancet Oncol 15:569–579
    • (2014) Lancet Oncol , vol.15 , pp. 569-579
    • Price, T.J.1    Peeters, M.2    Kim, T.W.3    Li, J.4    Cascinu, S.5    Ruff, P.6
  • 73
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    • COI: 1:CAS:528:DC%2BC3cXjslKktA%3D%3D, PID: 19897418
    • Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK et al (2010) Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 11:21–28
    • (2010) Lancet Oncol , vol.11 , pp. 21-28
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Cohen, R.B.4    Jones, C.U.5    Sur, R.K.6
  • 74
    • 84958780848 scopus 로고    scopus 로고
    • Cetuximab and radiotherapy versus cisplatin and radiotherapy for locally advanced head and neck cancer: a randomized phase II trial
    • COI: 1:CAS:528:DC%2BC28XhtFemu7nF, PID: 26644536
    • Magrini SM, Buglione M, Corvò R, Pirtoli L, Paiar F, Ponticelli P et al (2016) Cetuximab and radiotherapy versus cisplatin and radiotherapy for locally advanced head and neck cancer: a randomized phase II trial. J Clin Oncol 34:427–435
    • (2016) J Clin Oncol , vol.34 , pp. 427-435
    • Magrini, S.M.1    Buglione, M.2    Corvò, R.3    Pirtoli, L.4    Paiar, F.5    Ponticelli, P.6
  • 75
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • COI: 1:CAS:528:DC%2BD28Xhtleksbs%3D, PID: 16467544
    • Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB et al (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567–578
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Azarnia, N.4    Shin, D.M.5    Cohen, R.B.6
  • 76
    • 84907200175 scopus 로고    scopus 로고
    • Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522
    • COI: 1:CAS:528:DC%2BC2cXitVClt7%2FP, PID: 25154822
    • Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman EJ, Weber RS et al (2014) Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol 32:2940–2950
    • (2014) J Clin Oncol , vol.32 , pp. 2940-2950
    • Ang, K.K.1    Zhang, Q.2    Rosenthal, D.I.3    Nguyen-Tan, P.F.4    Sherman, E.J.5    Weber, R.S.6
  • 77
    • 84876951761 scopus 로고    scopus 로고
    • Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial
    • COI: 1:CAS:528:DC%2BC3sXmt1OntLw%3D, PID: 23594786
    • Lordick F, Kang YK, Chung HC, Salman P, Oh SC, Bodoky G et al (2013) Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol 14:490–499
    • (2013) Lancet Oncol , vol.14 , pp. 490-499
    • Lordick, F.1    Kang, Y.K.2    Chung, H.C.3    Salman, P.4    Oh, S.C.5    Bodoky, G.6
  • 78
    • 84888129994 scopus 로고    scopus 로고
    • Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: a phase 3, open-label, randomised trial
    • COI: 1:CAS:528:DC%2BC3sXhslOjs7%2FP, PID: 24231627
    • Kim ES, Neubauer M, Cohn A, Schwartzberg L, Garbo L, Caton J et al (2013) Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: a phase 3, open-label, randomised trial. Lancet Oncol 14:1326–1336
    • (2013) Lancet Oncol , vol.14 , pp. 1326-1336
    • Kim, E.S.1    Neubauer, M.2    Cohn, A.3    Schwartzberg, L.4    Garbo, L.5    Caton, J.6
  • 79
    • 84899900161 scopus 로고    scopus 로고
    • Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2cXlvVSnu70%3D, PID: 24717919
    • Primrose J, Falk S, Finch-Jones M, Valle J, O’Reilly D, Siriwardena A et al (2014) Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. Lancet Oncol 15:601–611
    • (2014) Lancet Oncol , vol.15 , pp. 601-611
    • Primrose, J.1    Falk, S.2    Finch-Jones, M.3    Valle, J.4    O’Reilly, D.5    Siriwardena, A.6
  • 80
    • 84879785532 scopus 로고    scopus 로고
    • Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial
    • COI: 1:CAS:528:DC%2BC3sXptFGjtrk%3D, PID: 23746666
    • Vermorken JB, Stöhlmacher-Williams J, Davidenko I, Licitra L, Winquist E, Villanueva C et al (2013) Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol 14:697–710
    • (2013) Lancet Oncol , vol.14 , pp. 697-710
    • Vermorken, J.B.1    Stöhlmacher-Williams, J.2    Davidenko, I.3    Licitra, L.4    Winquist, E.5    Villanueva, C.6
  • 81
    • 84959159986 scopus 로고    scopus 로고
    • Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: a randomized phase 2 trial (Vecti-BIL study)
    • COI: 1:CAS:528:DC%2BC28XitF2kurs%3D, PID: 26540314
    • Leone F, Marino D, Cereda S, Filippi R, Belli C, Spadi R et al (2016) Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: a randomized phase 2 trial (Vecti-BIL study). Cancer 122:574–581
    • (2016) Cancer , vol.122 , pp. 574-581
    • Leone, F.1    Marino, D.2    Cereda, S.3    Filippi, R.4    Belli, C.5    Spadi, R.6
  • 82
    • 84876992498 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial
    • COI: 1:CAS:528:DC%2BC3sXmt1Oksb0%3D, PID: 23594787
    • Waddell T, Chau I, Cunningham D, Gonzalez D, Okines AF, Okines C et al (2013) Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. Lancet Oncol 14:481–489
    • (2013) Lancet Oncol , vol.14 , pp. 481-489
    • Waddell, T.1    Chau, I.2    Cunningham, D.3    Gonzalez, D.4    Okines, A.F.5    Okines, C.6
  • 83
    • 84896713052 scopus 로고    scopus 로고
    • Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXis1Cks7c%3D, PID: 24556040
    • Motzer RJ, Porta C, Vogelzang NJ, Sternberg CN, Szczylik C, Zolnierek J et al (2014) Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial. Lancet Oncol 15:286–296
    • (2014) Lancet Oncol , vol.15 , pp. 286-296
    • Motzer, R.J.1    Porta, C.2    Vogelzang, N.J.3    Sternberg, C.N.4    Szczylik, C.5    Zolnierek, J.6
  • 84
    • 84876974877 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC3sXmt1Ontbw%3D, PID: 23598172
    • Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S et al (2013) Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 14:552–562
    • (2013) Lancet Oncol , vol.14 , pp. 552-562
    • Motzer, R.J.1    Escudier, B.2    Tomczak, P.3    Hutson, T.E.4    Michaelson, M.D.5    Negrier, S.6
  • 85
    • 84891915708 scopus 로고    scopus 로고
    • Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial
    • COI: 1:CAS:528:DC%2BC3sXhvFSksrbL, PID: 24081937
    • Cheng AL, Kang YK, Lin DY, Park JW, Kudo M, Qin S et al (2013) Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial. J Clin Oncol 31:4067–4075
    • (2013) J Clin Oncol , vol.31 , pp. 4067-4075
    • Cheng, A.L.1    Kang, Y.K.2    Lin, D.Y.3    Park, J.W.4    Kudo, M.5    Qin, S.6
  • 86
    • 84882781441 scopus 로고    scopus 로고
    • Pazopanib versus sunitinib in metastatic renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXhtlCrsrbP, PID: 23964934
    • Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J et al (2013) Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722–731
    • (2013) N Engl J Med , vol.369 , pp. 722-731
    • Motzer, R.J.1    Hutson, T.E.2    Cella, D.3    Reeves, J.4    Hawkins, R.5    Guo, J.6
  • 87
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXksVGqsw%3D%3D, PID: 17215529
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115–124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Rixe, O.6
  • 88
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • COI: 1:CAS:528:DC%2BC3MXhvVyisrY%3D, PID: 21306237
    • Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C et al (2011) Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364:501–513
    • (2011) N Engl J Med , vol.364 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.L.3    Bang, Y.J.4    Borbath, I.5    Lombard-Bohas, C.6
  • 89
    • 67651201656 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial
    • COI: 1:CAS:528:DC%2BD1MXptlalsrc%3D, PID: 19615940
    • Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S et al (2009) Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 10:757–763
    • (2009) Lancet Oncol , vol.10 , pp. 757-763
    • Gore, M.E.1    Szczylik, C.2    Porta, C.3    Bracarda, S.4    Bjarnason, G.A.5    Oudard, S.6
  • 91
    • 84954029886 scopus 로고    scopus 로고
    • Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXhs1Kisb3I, PID: 26474518
    • Tournigand C, Chibaudel B, Samson B, Scheithauer W, Vernerey D, Mésange P et al (2015) Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial. Lancet Oncol 16:1493–1505
    • (2015) Lancet Oncol , vol.16 , pp. 1493-1505
    • Tournigand, C.1    Chibaudel, B.2    Samson, B.3    Scheithauer, W.4    Vernerey, D.5    Mésange, P.6
  • 92
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • PID: 12637609
    • O’Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F et al (2003) Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348:994–1004
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O’Brien, S.G.1    Guilhot, F.2    Larson, R.A.3    Gathmann, I.4    Baccarani, M.5    Cervantes, F.6
  • 93
  • 94
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
    • COI: 1:CAS:528:DC%2BD1cXht1KqtLfL, PID: 18824712
    • Raymond E, Brandes AA, Dittrich C, Fumoleau P, Coudert B, Clement PM et al (2008) Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. J Clin Oncol 26:4659–4665
    • (2008) J Clin Oncol , vol.26 , pp. 4659-4665
    • Raymond, E.1    Brandes, A.A.2    Dittrich, C.3    Fumoleau, P.4    Coudert, B.5    Clement, P.M.6
  • 95
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • COI: 1:CAS:528:DC%2BC3sXhtVSnu7%2FM, PID: 23724913
    • Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ et al (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368:2385–2394
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3    Seto, T.4    Crinó, L.5    Ahn, M.J.6
  • 97
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • COI: 1:CAS:528:DC%2BC38XhsVCjsb3E, PID: 22954507
    • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB et al (2012) Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 13:1011–1019
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3    Iafrate, A.J.4    Varella-Garcia, M.5    Fox, S.B.6
  • 98
    • 84918804764 scopus 로고    scopus 로고
    • First-line crizotinib versus chemotherapy in ALK-positive lung cancer
    • PID: 25470694
    • Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T et al (2014) First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 371:2167–2177
    • (2014) N Engl J Med , vol.371 , pp. 2167-2177
    • Solomon, B.J.1    Mok, T.2    Kim, D.W.3    Wu, Y.L.4    Nakagawa, K.5    Mekhail, T.6
  • 99
    • 84861856844 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib in advanced basal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC38XovVehsb8%3D, PID: 22670903
    • Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD et al (2012) Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 366:2171–2179
    • (2012) N Engl J Med , vol.366 , pp. 2171-2179
    • Sekulic, A.1    Migden, M.R.2    Oro, A.E.3    Dirix, L.4    Lewis, K.D.5    Hainsworth, J.D.6
  • 100
    • 84930274867 scopus 로고    scopus 로고
    • Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial
    • COI: 1:CAS:528:DC%2BC2MXosVCmtLc%3D, PID: 25981813
    • Basset-Seguin N, Hauschild A, Grob JJ, Kunstfeld R, Dréno B, Mortier L et al (2015) Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial. Lancet Oncol 16:729–736
    • (2015) Lancet Oncol , vol.16 , pp. 729-736
    • Basset-Seguin, N.1    Hauschild, A.2    Grob, J.J.3    Kunstfeld, R.4    Dréno, B.5    Mortier, L.6
  • 101
    • 84952870525 scopus 로고    scopus 로고
    • Dosing and safety implications for oncologists when administering everolimus to patients with hormone receptor-positive breast cancer
    • COI: 1:CAS:528:DC%2BC2MXhsF2gtrnI, PID: 26507507
    • Rugo HS (2016) Dosing and safety implications for oncologists when administering everolimus to patients with hormone receptor-positive breast cancer. Clin Breast Cancer 16:18–22
    • (2016) Clin Breast Cancer , vol.16 , pp. 18-22
    • Rugo, H.S.1
  • 102
    • 84897102034 scopus 로고    scopus 로고
    • Incidence and time course of everolimus-related adverse events in postmenopausal women with hormone receptor-positive advanced breast cancer: insights from BOLERO-2
    • COI: 1:STN:280:DC%2BC2crisFymsg%3D%3D, PID: 24615500
    • Rugo HS, Pritchard KI, Gnant M, Noguchi S, Piccart M, Hortobagyi G et al (2014) Incidence and time course of everolimus-related adverse events in postmenopausal women with hormone receptor-positive advanced breast cancer: insights from BOLERO-2. Ann Oncol 25:808–815
    • (2014) Ann Oncol , vol.25 , pp. 808-815
    • Rugo, H.S.1    Pritchard, K.I.2    Gnant, M.3    Noguchi, S.4    Piccart, M.5    Hortobagyi, G.6
  • 103
    • 70449525211 scopus 로고    scopus 로고
    • Mucositis: the impact, biology and therapeutic opportunities of oral mucositis
    • COI: 1:CAS:528:DC%2BD1MXhsVGltbbF, PID: 19828360
    • Sonis ST (2009) Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 45:1015–1020
    • (2009) Oral Oncol , vol.45 , pp. 1015-1020
    • Sonis, S.T.1
  • 104
    • 1942469964 scopus 로고    scopus 로고
    • The pathobiology of mucositis
    • COI: 1:CAS:528:DC%2BD2cXis1Gmt78%3D, PID: 15057287
    • Sonis ST (2004) The pathobiology of mucositis. Nat Rev Cancer 4:277–284
    • (2004) Nat Rev Cancer , vol.4 , pp. 277-284
    • Sonis, S.T.1
  • 105
    • 84865195671 scopus 로고    scopus 로고
    • Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas
    • PID: 22116139
    • Nishimura N, Nakano K, Ueda K, Kodaira M, Yamada S, Mishima Y et al (2012) Prospective evaluation of incidence and severity of oral mucositis induced by conventional chemotherapy in solid tumors and malignant lymphomas. Support Care Cancer 20:2053–2059
    • (2012) Support Care Cancer , vol.20 , pp. 2053-2059
    • Nishimura, N.1    Nakano, K.2    Ueda, K.3    Kodaira, M.4    Yamada, S.5    Mishima, Y.6
  • 106
    • 84918821352 scopus 로고    scopus 로고
    • Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)
    • PID: 25189149
    • Elad S, Raber-Durlacher JE, Brennan MT, Saunders DP, Mank AP, Zadik Y et al (2015) Basic oral care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT). Support Care Cancer 23:223–236
    • (2015) Support Care Cancer , vol.23 , pp. 223-236
    • Elad, S.1    Raber-Durlacher, J.E.2    Brennan, M.T.3    Saunders, D.P.4    Mank, A.P.5    Zadik, Y.6
  • 107
    • 84899950755 scopus 로고    scopus 로고
    • MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
    • PID: 24615748
    • Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM et al (2014) MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453–1461
    • (2014) Cancer , vol.120 , pp. 1453-1461
    • Lalla, R.V.1    Bowen, J.2    Barasch, A.3    Elting, L.4    Epstein, J.5    Keefe, D.M.6
  • 108
    • 84879899632 scopus 로고    scopus 로고
    • Management of adverse events in patients with hormone receptor-positive breast cancer treated with everolimus: observations from a phase III clinical trial
    • PID: 23686401
    • Peterson ME (2013) Management of adverse events in patients with hormone receptor-positive breast cancer treated with everolimus: observations from a phase III clinical trial. Support Care Cancer 21:2341–2349
    • (2013) Support Care Cancer , vol.21 , pp. 2341-2349
    • Peterson, M.E.1
  • 109
    • 84885678657 scopus 로고    scopus 로고
    • Systematic review of basic oral care for the management of oral mucositis in cancer patients
    • PID: 24018908
    • McGuire DB, Fulton JS, Park J, Brown CG, Correa ME, Eilers J et al (2013) Systematic review of basic oral care for the management of oral mucositis in cancer patients. Support Care Cancer 21:3165–3177
    • (2013) Support Care Cancer , vol.21 , pp. 3165-3177
    • McGuire, D.B.1    Fulton, J.S.2    Park, J.3    Brown, C.G.4    Correa, M.E.5    Eilers, J.6
  • 110
    • 85000692373 scopus 로고    scopus 로고
    • Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice
    • COI: 1:CAS:528:DC%2BC28Xht1KrsLrM, PID: 27334013
    • Peterson DE, O’Shaughnessy JA, Rugo HS, Elad S, Schubert MM, Viet CT et al (2016) Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice. Cancer Med 5:1897–1907
    • (2016) Cancer Med , vol.5 , pp. 1897-1907
    • Peterson, D.E.1    O’Shaughnessy, J.A.2    Rugo, H.S.3    Elad, S.4    Schubert, M.M.5    Viet, C.T.6
  • 112
    • 79957566962 scopus 로고    scopus 로고
    • Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXmvVejs70%3D, PID: 21481584
    • Porta C, Osanto S, Ravaud A, Climent MA, Vaishampayan U, White DA et al (2011) Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma. Eur J Cancer 47:1287–1298
    • (2011) Eur J Cancer , vol.47 , pp. 1287-1298
    • Porta, C.1    Osanto, S.2    Ravaud, A.3    Climent, M.A.4    Vaishampayan, U.5    White, D.A.6
  • 113
    • 84961217958 scopus 로고    scopus 로고
    • Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols
    • PID: 26984249
    • Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR et al (2016) Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols. Support Care Cancer 24:2793–2805
    • (2016) Support Care Cancer , vol.24 , pp. 2793-2805
    • Zecha, J.A.1    Raber-Durlacher, J.E.2    Nair, R.G.3    Epstein, J.B.4    Elad, S.5    Hamblin, M.R.6
  • 114
    • 84898703037 scopus 로고    scopus 로고
    • Everolimus: side effect profile and management of toxicities in breast cancer
    • COI: 1:CAS:528:DC%2BC3sXht1Wrsr7N, PID: 23907751
    • Paplomata E, Zelnak A, O’Regan R (2013) Everolimus: side effect profile and management of toxicities in breast cancer. Breast Cancer Res Treat 140:453–462
    • (2013) Breast Cancer Res Treat , vol.140 , pp. 453-462
    • Paplomata, E.1    Zelnak, A.2    O’Regan, R.3
  • 115
    • 79953075835 scopus 로고    scopus 로고
    • Safety and treatment patterns of multikinase inhibitors in patients with metastatic renal cell carcinoma at a tertiary oncology center in Italy
    • COI: 1:CAS:528:DC%2BC3MXksVOqt7g%3D, PID: 21435216
    • Porta C, Paglino C, Imariso I, Canipari C, Chen K, Neary M et al (2011) Safety and treatment patterns of multikinase inhibitors in patients with metastatic renal cell carcinoma at a tertiary oncology center in Italy. BMC Cancer 11:105–113
    • (2011) BMC Cancer , vol.11 , pp. 105-113
    • Porta, C.1    Paglino, C.2    Imariso, I.3    Canipari, C.4    Chen, K.5    Neary, M.6
  • 117
    • 80052323870 scopus 로고    scopus 로고
    • Drug-induced taste and smell alterations: a case/non-case evaluation of an italian database of spontaneous adverse drug reaction reporting
    • COI: 1:CAS:528:DC%2BC3MXhtlOnsbnP, PID: 21879779
    • Tuccori M, Lapi F, Testi A, Ruggiero E, Moretti U, Vannacci A et al (2011) Drug-induced taste and smell alterations: a case/non-case evaluation of an italian database of spontaneous adverse drug reaction reporting. Drug Saf 34:849–859
    • (2011) Drug Saf , vol.34 , pp. 849-859
    • Tuccori, M.1    Lapi, F.2    Testi, A.3    Ruggiero, E.4    Moretti, U.5    Vannacci, A.6
  • 118
    • 79960700200 scopus 로고    scopus 로고
    • Oral complications in the treatment of cancer patients
    • COI: 1:STN:280:DC%2BC3Mjgt1Kktg%3D%3D, PID: 21306481
    • Mosel DD, Bauer RL, Lynch DP, Hwang ST (2011) Oral complications in the treatment of cancer patients. Oral Dis 17:550–559
    • (2011) Oral Dis , vol.17 , pp. 550-559
    • Mosel, D.D.1    Bauer, R.L.2    Lynch, D.P.3    Hwang, S.T.4
  • 119
    • 77956834590 scopus 로고    scopus 로고
    • Taste alterations in cancer patients receiving chemotherapy: a neglected side effect?
    • COI: 1:CAS:528:DC%2BC3cXht1SqtbnL, PID: 20667968
    • Zabernigg A, Gamper EM, Giesinger JM, Rumpold G, Kemmler G, Gattringer K et al (2010) Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 15:913–920
    • (2010) Oncologist , vol.15 , pp. 913-920
    • Zabernigg, A.1    Gamper, E.M.2    Giesinger, J.M.3    Rumpold, G.4    Kemmler, G.5    Gattringer, K.6
  • 120
    • 84886381476 scopus 로고    scopus 로고
    • Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer
    • PID: 24165041
    • Imai H, Soeda H, Komine K, Otsuka K, Shibata H (2013) Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer. BMC Palliat Care 12:38
    • (2013) BMC Palliat Care , vol.12 , pp. 38
    • Imai, H.1    Soeda, H.2    Komine, K.3    Otsuka, K.4    Shibata, H.5
  • 121
    • 74649083950 scopus 로고    scopus 로고
    • Taste disorders in cancer patients: pathogenesis, and approach to assessment and management
    • PID: 20036797
    • Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46:77–81
    • (2010) Oral Oncol , vol.46 , pp. 77-81
    • Epstein, J.B.1    Barasch, A.2
  • 123
    • 84889883869 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw related to everolimus: a case report
    • PID: 24094895
    • Kim DW, Jung YS, Park HS, Jung HD (2013) Osteonecrosis of the jaw related to everolimus: a case report. Br J Oral Maxillofac Surg 51:e302–e304
    • (2013) Br J Oral Maxillofac Surg , vol.51 , pp. e302-e304
    • Kim, D.W.1    Jung, Y.S.2    Park, H.S.3    Jung, H.D.4
  • 124
    • 84937512136 scopus 로고    scopus 로고
    • Drug induced osteonecrosis of the jaw
    • COI: 1:CAS:528:DC%2BC2MXmvFamuro%3D, PID: 25913713
    • Hamadeh IS, Ngwa BA, Gong Y (2015) Drug induced osteonecrosis of the jaw. Cancer Treat Rev 41:455–464
    • (2015) Cancer Treat Rev , vol.41 , pp. 455-464
    • Hamadeh, I.S.1    Ngwa, B.A.2    Gong, Y.3
  • 125
    • 84984568870 scopus 로고    scopus 로고
    • Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities
    • PID: 21630130
    • Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB et al (2011) Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer 19:1079–1095
    • (2011) Support Care Cancer , vol.19 , pp. 1079-1095
    • Lacouture, M.E.1    Anadkat, M.J.2    Bensadoun, R.J.3    Bryce, J.4    Chan, A.5    Epstein, J.B.6
  • 126
    • 33748466742 scopus 로고    scopus 로고
    • The PRIDE (papulopustules and/or paronychia, regulatory abnormalities of hair growth, itching, and dryness due to epidermal growth factor receptor inhibitors) syndrome
    • COI: 1:STN:280:DC%2BD28rktVGlsg%3D%3D, PID: 16965448
    • Lacouture ME, Lai SE (2006) The PRIDE (papulopustules and/or paronychia, regulatory abnormalities of hair growth, itching, and dryness due to epidermal growth factor receptor inhibitors) syndrome. Br J Dermatol 155:852–854
    • (2006) Br J Dermatol , vol.155 , pp. 852-854
    • Lacouture, M.E.1    Lai, S.E.2
  • 127
    • 79954435125 scopus 로고    scopus 로고
    • EGFR-targeted therapies combined with chemotherapy for treating advanced non-small-cell lung cancer: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3MXitlaqtLw%3D, PID: 21207017
    • Chen P, Wang L, Liu B, Zhang HZ, Liu HC, Zou Z (2011) EGFR-targeted therapies combined with chemotherapy for treating advanced non-small-cell lung cancer: a meta-analysis. Eur J Clin Pharmacol 67:235–243
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 235-243
    • Chen, P.1    Wang, L.2    Liu, B.3    Zhang, H.Z.4    Liu, H.C.5    Zou, Z.6
  • 128
    • 84927660507 scopus 로고    scopus 로고
    • Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials
    • COI: 1:CAS:528:DC%2BC2MXns1Sktb0%3D, PID: 25795635
    • Burotto M, Manasanch EE, Wilkerson J, Fojo T (2015) Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials. Oncologist 20:400–410
    • (2015) Oncologist , vol.20 , pp. 400-410
    • Burotto, M.1    Manasanch, E.E.2    Wilkerson, J.3    Fojo, T.4
  • 129
    • 84906538860 scopus 로고    scopus 로고
    • Management of common toxicities in metastatic NSCLC related to anti-lung cancer therapies with EGFR-TKIs
    • PID: 25279350
    • Melosky B, Hirsh V (2014) Management of common toxicities in metastatic NSCLC related to anti-lung cancer therapies with EGFR-TKIs. Front Oncol 4:238
    • (2014) Front Oncol , vol.4 , pp. 238
    • Melosky, B.1    Hirsh, V.2
  • 130
    • 84955170594 scopus 로고    scopus 로고
    • Risk of grade 3–4 diarrhea and mucositis in colorectal cancer patients receiving anti-EGFR monoclonal antibodies regimens: a meta-analysis of 18 randomized controlled clinical trials
    • PID: 26160607
    • Miroddi M, Sterrantino C, Simonelli I, Ciminata G, Phillips RS, Calapai G (2015) Risk of grade 3–4 diarrhea and mucositis in colorectal cancer patients receiving anti-EGFR monoclonal antibodies regimens: a meta-analysis of 18 randomized controlled clinical trials. Crit Rev Oncol Hematol 96:355–371
    • (2015) Crit Rev Oncol Hematol , vol.96 , pp. 355-371
    • Miroddi, M.1    Sterrantino, C.2    Simonelli, I.3    Ciminata, G.4    Phillips, R.S.5    Calapai, G.6
  • 131
    • 84925287083 scopus 로고    scopus 로고
    • Efficacy and toxicity of adding cetuximab to chemotherapy in the treatment of metastatic colorectal cancer: a meta-analysis from 12 randomized controlled trials
    • COI: 1:CAS:528:DC%2BC2cXitVSgtrnI, PID: 25417200
    • Lv ZC, Ning JY, Chen HB (2014) Efficacy and toxicity of adding cetuximab to chemotherapy in the treatment of metastatic colorectal cancer: a meta-analysis from 12 randomized controlled trials. Tumour Biol 35:11741–11750
    • (2014) Tumour Biol , vol.35 , pp. 11741-11750
    • Lv, Z.C.1    Ning, J.Y.2    Chen, H.B.3
  • 132
    • 84975078550 scopus 로고    scopus 로고
    • Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: assessment from a phase 3 registration trial
    • COI: 1:CAS:528:DC%2BC28XpvVWrurs%3D, PID: 27323346
    • Bonner JA, Giralt J, Harari PM, Baselga J, Spencer S, Bell D et al (2016) Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: assessment from a phase 3 registration trial. Eur J Cancer 64:1–11
    • (2016) Eur J Cancer , vol.64 , pp. 1-11
    • Bonner, J.A.1    Giralt, J.2    Harari, P.M.3    Baselga, J.4    Spencer, S.5    Bell, D.6
  • 133
    • 63449110924 scopus 로고    scopus 로고
    • Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy
    • COI: 1:CAS:528:DC%2BD1MXktlKnsLw%3D, PID: 19170238
    • Tejwani A, Wu S, Jia Y, Agulnik M, Millender L, Lacouture ME (2009) Increased risk of high-grade dermatologic toxicities with radiation plus epidermal growth factor receptor inhibitor therapy. Cancer 115:1286–1299
    • (2009) Cancer , vol.115 , pp. 1286-1299
    • Tejwani, A.1    Wu, S.2    Jia, Y.3    Agulnik, M.4    Millender, L.5    Lacouture, M.E.6
  • 134
    • 77952514740 scopus 로고    scopus 로고
    • A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group
    • PID: 20145956
    • Lacouture ME, Maitland ML, Segaert S, Setser A, Baran R, Fox LP et al (2010) A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group. Support Care Cancer 18:509–522
    • (2010) Support Care Cancer , vol.18 , pp. 509-522
    • Lacouture, M.E.1    Maitland, M.L.2    Segaert, S.3    Setser, A.4    Baran, R.5    Fox, L.P.6
  • 135
    • 80053969554 scopus 로고    scopus 로고
    • Distinct patterns of stomatitis with concurrent cetuximab and radiotherapy for head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXht1ylsbvJ, PID: 21852185
    • Pryor DI, Burmeister E, Burmeister BH, Poulsen MG, Porceddu SV (2011) Distinct patterns of stomatitis with concurrent cetuximab and radiotherapy for head and neck squamous cell carcinoma. Oral Oncol 47:984–987
    • (2011) Oral Oncol , vol.47 , pp. 984-987
    • Pryor, D.I.1    Burmeister, E.2    Burmeister, B.H.3    Poulsen, M.G.4    Porceddu, S.V.5
  • 136
    • 84955248709 scopus 로고    scopus 로고
    • Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma
    • PID: 26817597
    • Zhu G, Lin JC, Kim SB, Bernier J, Agarwal JP, Vermorken JB et al (2016) Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma. BMC Cancer 16:42
    • (2016) BMC Cancer , vol.16 , pp. 42
    • Zhu, G.1    Lin, J.C.2    Kim, S.B.3    Bernier, J.4    Agarwal, J.P.5    Vermorken, J.B.6
  • 137
    • 79956269985 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma: recommendations for management of non-cardiovascular toxicities
    • COI: 1:CAS:528:DC%2BC3MXht12itr3I, PID: 21490127
    • Kollmannsberger C, Bjarnason G, Burnett P, Creel P, Davis M, Dawson N et al (2011) Sunitinib in metastatic renal cell carcinoma: recommendations for management of non-cardiovascular toxicities. Oncologist 16:543–553
    • (2011) Oncologist , vol.16 , pp. 543-553
    • Kollmannsberger, C.1    Bjarnason, G.2    Burnett, P.3    Creel, P.4    Davis, M.5    Dawson, N.6
  • 139
    • 84891486967 scopus 로고    scopus 로고
    • Sunitinib adverse events in metastatic renal cell carcinoma: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhvFymsL%2FM, PID: 23179639
    • Ibrahim EM, Kazkaz GA, Abouelkhair KM, Bayer AM, Elmasri OA (2013) Sunitinib adverse events in metastatic renal cell carcinoma: a meta-analysis. Int J Clin Oncol 18:1060–1069
    • (2013) Int J Clin Oncol , vol.18 , pp. 1060-1069
    • Ibrahim, E.M.1    Kazkaz, G.A.2    Abouelkhair, K.M.3    Bayer, A.M.4    Elmasri, O.A.5
  • 140
    • 84857651429 scopus 로고    scopus 로고
    • Strategies for assessing and managing the adverse events of sorafenib and other targeted therapies in the treatment of renal cell and hepatocellular carcinoma: recommendations from a European nursing task group
    • PID: 21641280
    • Edmonds K, Hull D, Spencer-Shaw A, Koldenhof J, Chrysou M, Boers-Doets C et al (2012) Strategies for assessing and managing the adverse events of sorafenib and other targeted therapies in the treatment of renal cell and hepatocellular carcinoma: recommendations from a European nursing task group. Eur J Oncol Nurs 16:172–184
    • (2012) Eur J Oncol Nurs , vol.16 , pp. 172-184
    • Edmonds, K.1    Hull, D.2    Spencer-Shaw, A.3    Koldenhof, J.4    Chrysou, M.5    Boers-Doets, C.6
  • 141
    • 84857417613 scopus 로고    scopus 로고
    • Characteristics of oral mucosal events related to bevacizumab treatment
    • COI: 1:CAS:528:DC%2BC38XlsV2ltr0%3D, PID: 22282905
    • Gavrilovic IT, Balagula Y, Rosen AC, Ramaswamy V, Dickler MN, Dunkel IJ et al (2012) Characteristics of oral mucosal events related to bevacizumab treatment. Oncologist 17:274–278
    • (2012) Oncologist , vol.17 , pp. 274-278
    • Gavrilovic, I.T.1    Balagula, Y.2    Rosen, A.C.3    Ramaswamy, V.4    Dickler, M.N.5    Dunkel, I.J.6
  • 144
    • 84896483861 scopus 로고    scopus 로고
    • Sorafenib in metastatic thyroid cancer: a systematic review
    • COI: 1:CAS:528:DC%2BC2cXosFCktL4%3D, PID: 24563075
    • Thomas L, Lai SY, Dong W, Feng L, Dadu R, Regone RM et al (2014) Sorafenib in metastatic thyroid cancer: a systematic review. Oncologist 19:251–258
    • (2014) Oncologist , vol.19 , pp. 251-258
    • Thomas, L.1    Lai, S.Y.2    Dong, W.3    Feng, L.4    Dadu, R.5    Regone, R.M.6
  • 145
    • 59749100961 scopus 로고    scopus 로고
    • Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone
    • COI: 1:CAS:528:DC%2BD1MXis12gsb4%3D, PID: 19212145
    • Christodoulou C, Pervena A, Klouvas G, Galani E, Falagas ME, Tsakalos G et al (2009) Combination of bisphosphonates and antiangiogenic factors induces osteonecrosis of the jaw more frequently than bisphosphonates alone. Oncology 76:209–211
    • (2009) Oncology , vol.76 , pp. 209-211
    • Christodoulou, C.1    Pervena, A.2    Klouvas, G.3    Galani, E.4    Falagas, M.E.5    Tsakalos, G.6
  • 146
    • 84995459577 scopus 로고    scopus 로고
    • Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district
    • Ponzetti A, Pinta F, Spadi R, Mecca C, Fanchini L, Zanini M et al. (2016) Jaw osteonecrosis associated with aflibercept, irinotecan and fluorouracil: attention to oral district. Tumori 102(Suppl. 2)
    • (2016) Tumori , vol.102
    • Ponzetti, A.1    Pinta, F.2    Spadi, R.3    Mecca, C.4    Fanchini, L.5    Zanini, M.6
  • 147
    • 84965053887 scopus 로고    scopus 로고
    • Osteonecrosis of jaw beyond antiresorptive (bone-targeted) agents: new horizons in oncology
    • COI: 1:CAS:528:DC%2BC28XnslWnurk%3D, PID: 27074901
    • Fusco V, Santini D, Armento G, Tonini G, Campisi G (2016) Osteonecrosis of jaw beyond antiresorptive (bone-targeted) agents: new horizons in oncology. Expert Opin Drug Saf 15:925–935
    • (2016) Expert Opin Drug Saf , vol.15 , pp. 925-935
    • Fusco, V.1    Santini, D.2    Armento, G.3    Tonini, G.4    Campisi, G.5
  • 148
    • 84909619222 scopus 로고    scopus 로고
    • American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update
    • PID: 25234529
    • Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B et al (2014) American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg 72:1938–1956
    • (2014) J Oral Maxillofac Surg , vol.72 , pp. 1938-1956
    • Ruggiero, S.L.1    Dodson, T.B.2    Fantasia, J.3    Goodday, R.4    Aghaloo, T.5    Mehrotra, B.6
  • 149
    • 84959565058 scopus 로고    scopus 로고
    • Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis
    • PID: 26362756
    • Gaudin E, Seidel L, Bacevic M, Rompen E, Lambert F (2015) Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis. J Clin Periodontol 42:922–932
    • (2015) J Clin Periodontol , vol.42 , pp. 922-932
    • Gaudin, E.1    Seidel, L.2    Bacevic, M.3    Rompen, E.4    Lambert, F.5
  • 150
    • 84919934170 scopus 로고    scopus 로고
    • Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus
    • PID: 25414052
    • Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F et al (2015) Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res 30:3–23
    • (2015) J Bone Miner Res , vol.30 , pp. 3-23
    • Khan, A.A.1    Morrison, A.2    Hanley, D.A.3    Felsenberg, D.4    McCauley, L.K.5    O’Ryan, F.6
  • 151
    • 84946483209 scopus 로고    scopus 로고
    • Preventive strategies for patients at risk of medication-related osteonecrosis of the jaw
    • PID: 26293331
    • Goodday RH (2015) Preventive strategies for patients at risk of medication-related osteonecrosis of the jaw. Oral Maxillofac Surg Clin North Am 27:527–536
    • (2015) Oral Maxillofac Surg Clin North Am , vol.27 , pp. 527-536
    • Goodday, R.H.1
  • 152
    • 44449171930 scopus 로고    scopus 로고
    • Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib
    • COI: 1:STN:280:DC%2BD1czjs1OlsA%3D%3D, PID: 18274784
    • Rosenbaum SE, Wu S, Newman MA, West DP, Kuzel T, Lacouture ME (2008) Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib. Support Care Cancer 16:557–566
    • (2008) Support Care Cancer , vol.16 , pp. 557-566
    • Rosenbaum, S.E.1    Wu, S.2    Newman, M.A.3    West, D.P.4    Kuzel, T.5    Lacouture, M.E.6
  • 154
    • 80052719361 scopus 로고    scopus 로고
    • Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate, nilotinib, and dasatinib
    • PID: 21910796
    • Amitay-Laish I, Stemmer SM, Lacouture ME (2011) Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate, nilotinib, and dasatinib. Dermatol Ther 24:386–395
    • (2011) Dermatol Ther , vol.24 , pp. 386-395
    • Amitay-Laish, I.1    Stemmer, S.M.2    Lacouture, M.E.3
  • 155
    • 84925586741 scopus 로고    scopus 로고
    • Oral and cutaneous lichenoid eruption with nail changes due to imatinib treatment in a chinese patient with chronic myeloid leukemia
    • PID: 25834373
    • Zhang JA, Yu JB, Li XH, Zhao L (2015) Oral and cutaneous lichenoid eruption with nail changes due to imatinib treatment in a chinese patient with chronic myeloid leukemia. Ann Dermatol 27:228–229
    • (2015) Ann Dermatol , vol.27 , pp. 228-229
    • Zhang, J.A.1    Yu, J.B.2    Li, X.H.3    Zhao, L.4
  • 156
    • 58149240783 scopus 로고    scopus 로고
    • Oral and cutaneous lichenoid reaction with nail changes secondary to imatinib: report of a case and literature review
    • COI: 1:STN:280:DC%2BD1M7ovFequw%3D%3D, PID: 19265627
    • Wahiduzzaman M, Pubalan M (2008) Oral and cutaneous lichenoid reaction with nail changes secondary to imatinib: report of a case and literature review. Dermatol Online J 14:14
    • (2008) Dermatol Online J , vol.14 , pp. 14
    • Wahiduzzaman, M.1    Pubalan, M.2
  • 157
    • 33845295787 scopus 로고    scopus 로고
    • Oral and cutaneous lichenoid reaction secondary to imatinib: report of two cases
    • PID: 17184272
    • Pascual JC, Matarredona J, Miralles J, Conesa V, Borras-Blasco J (2006) Oral and cutaneous lichenoid reaction secondary to imatinib: report of two cases. Int J Dermatol 45:1471–1473
    • (2006) Int J Dermatol , vol.45 , pp. 1471-1473
    • Pascual, J.C.1    Matarredona, J.2    Miralles, J.3    Conesa, V.4    Borras-Blasco, J.5
  • 158
    • 3543016166 scopus 로고    scopus 로고
    • Oral lichenoid eruption secondary to imatinib (Glivec)
    • COI: 1:STN:280:DC%2BD2M7jtlSgtQ%3D%3D, PID: 15764042
    • Ena P, Chiarolini F, Siddi GM, Cossu A (2004) Oral lichenoid eruption secondary to imatinib (Glivec). J Dermatolog Treat 15:253–255
    • (2004) J Dermatolog Treat , vol.15 , pp. 253-255
    • Ena, P.1    Chiarolini, F.2    Siddi, G.M.3    Cossu, A.4
  • 160
    • 84902160440 scopus 로고    scopus 로고
    • The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review
    • PID: 24379329
    • Fitzpatrick SG, Hirsch SA, Gordon SC (2014) The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc 145:45–56
    • (2014) J Am Dent Assoc , vol.145 , pp. 45-56
    • Fitzpatrick, S.G.1    Hirsch, S.A.2    Gordon, S.C.3
  • 161
    • 79960704589 scopus 로고    scopus 로고
    • Oral melanosis after tyrosine kinase inhibition with imatinib for chronic myelogenous leukemia: report of a case and review of the literature
    • PID: 21635826
    • Wong M, Sade S, Gilbert M, Klieb HB (2011) Oral melanosis after tyrosine kinase inhibition with imatinib for chronic myelogenous leukemia: report of a case and review of the literature. Dermatol Online J 17:4
    • (2011) Dermatol Online J , vol.17 , pp. 4
    • Wong, M.1    Sade, S.2    Gilbert, M.3    Klieb, H.B.4
  • 162
    • 84870862813 scopus 로고    scopus 로고
    • Hyperpigmentation of the hard palate associated with imatinib therapy for chronic myeloid leukemia with a genetic variation in the proto-oncogene c-KIT
    • COI: 1:CAS:528:DC%2BC38XhvVWjsL7F, PID: 22712835
    • Khoo TL, Catalano A, Supple S, Chong L, Yeoh SC, Yeung S et al (2013) Hyperpigmentation of the hard palate associated with imatinib therapy for chronic myeloid leukemia with a genetic variation in the proto-oncogene c-KIT. Leuk Lymphoma 54:186–188
    • (2013) Leuk Lymphoma , vol.54 , pp. 186-188
    • Khoo, T.L.1    Catalano, A.2    Supple, S.3    Chong, L.4    Yeoh, S.C.5    Yeung, S.6
  • 163
    • 84866888873 scopus 로고    scopus 로고
    • Oral and maxillofacial pathology case of the month. Palatal melanosis associated with imatinib mesylate therapy
    • Yu YH, Shere Y, Vigneswaran N (2012) Oral and maxillofacial pathology case of the month. Palatal melanosis associated with imatinib mesylate therapy. Tex Dent J 129(764–5):786–788
    • (2012) Tex Dent J , vol.129 , Issue.764-5 , pp. 786-788
    • Yu, Y.H.1    Shere, Y.2    Vigneswaran, N.3
  • 168
    • 84965032301 scopus 로고    scopus 로고
    • Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination
    • COI: 1:CAS:528:DC%2BC28XnsF2qu7o%3D, PID: 27141885
    • Boutros C, Tarhini A, Routier E, Lambotte O, Ladurie FL, Carbonnel F et al (2016) Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination. Nat Rev Clin Oncol 13:473–486
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 473-486
    • Boutros, C.1    Tarhini, A.2    Routier, E.3    Lambotte, O.4    Ladurie, F.L.5    Carbonnel, F.6
  • 169
    • 84964290544 scopus 로고    scopus 로고
    • Nivolumab in resected and Unresectable metastatic melanoma: characteristics of immune-related adverse events and association with outcomes
    • COI: 1:CAS:528:DC%2BC28XivFGmtrc%3D, PID: 26446948
    • Freeman-Keller M, Kim Y, Cronin H, Richards A, Gibney G, Weber JS (2016) Nivolumab in resected and Unresectable metastatic melanoma: characteristics of immune-related adverse events and association with outcomes. Clin Cancer Res 22:886–894
    • (2016) Clin Cancer Res , vol.22 , pp. 886-894
    • Freeman-Keller, M.1    Kim, Y.2    Cronin, H.3    Richards, A.4    Gibney, G.5    Weber, J.S.6
  • 170
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2MXitVGrtLzI, PID: 26712084
    • Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY et al (2016) Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 387:1540–1550
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Pérez-Gracia, J.L.5    Han, J.Y.6
  • 171
    • 84964345287 scopus 로고    scopus 로고
    • Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy
    • COI: 1:CAS:528:DC%2BC28XltF2qsr0%3D, PID: 27085692
    • Hofmann L, Forschner A, Loquai C, Goldinger SM, Zimmer L, Ugurel S et al (2016) Cutaneous, gastrointestinal, hepatic, endocrine, and renal side-effects of anti-PD-1 therapy. Eur J Cancer 60:190–209
    • (2016) Eur J Cancer , vol.60 , pp. 190-209
    • Hofmann, L.1    Forschner, A.2    Loquai, C.3    Goldinger, S.M.4    Zimmer, L.5    Ugurel, S.6
  • 172
    • 84963723011 scopus 로고    scopus 로고
    • Immunohistochemical analysis of lichenoid reactions in patients treated with anti-PD-L1 and anti-PD-1 therapy
    • PID: 26762844
    • Schaberg KB, Novoa RA, Wakelee HA, Kim J, Cheung C, Srinivas S et al (2016) Immunohistochemical analysis of lichenoid reactions in patients treated with anti-PD-L1 and anti-PD-1 therapy. J Cutan Pathol 43:339–346
    • (2016) J Cutan Pathol , vol.43 , pp. 339-346
    • Schaberg, K.B.1    Novoa, R.A.2    Wakelee, H.A.3    Kim, J.4    Cheung, C.5    Srinivas, S.6
  • 173
    • 84875453915 scopus 로고    scopus 로고
    • Analysis of dermatologic events in vemurafenib-treated patients with melanoma
    • COI: 1:CAS:528:DC%2BC3sXotFSjsbc%3D, PID: 23457002
    • Lacouture ME, Duvic M, Hauschild A, Prieto VG, Robert C, Schadendorf D et al (2013) Analysis of dermatologic events in vemurafenib-treated patients with melanoma. Oncologist 18:314–322
    • (2013) Oncologist , vol.18 , pp. 314-322
    • Lacouture, M.E.1    Duvic, M.2    Hauschild, A.3    Prieto, V.G.4    Robert, C.5    Schadendorf, D.6
  • 174
    • 84878451069 scopus 로고    scopus 로고
    • Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients
    • COI: 1:STN:280:DC%2BC3szotVOktQ%3D%3D, PID: 23406731
    • Boussemart L, Routier E, Mateus C, Opletalova K, Sebille G, Kamsu-Kom N et al (2013) Prospective study of cutaneous side-effects associated with the BRAF inhibitor vemurafenib: a study of 42 patients. Ann Oncol 24:1691–1697
    • (2013) Ann Oncol , vol.24 , pp. 1691-1697
    • Boussemart, L.1    Routier, E.2    Mateus, C.3    Opletalova, K.4    Sebille, G.5    Kamsu-Kom, N.6
  • 175
    • 84962212020 scopus 로고    scopus 로고
    • Cutaneous side effects of BRAF inhibitors in advanced melanoma: review of the literature
    • PID: 27042173
    • Gençler B, Gönül M (2016) Cutaneous side effects of BRAF inhibitors in advanced melanoma: review of the literature. Dermatol Res Pract 2016:5361569
    • (2016) Dermatol Res Pract , vol.2016 , pp. 5361569
    • Gençler, B.1    Gönül, M.2
  • 176
    • 84862908526 scopus 로고    scopus 로고
    • RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors
    • COI: 1:CAS:528:DC%2BC38XjsFCitL4%3D, PID: 22067401
    • Oberholzer PA, Kee D, Dziunycz P, Sucker A, Kamsukom N, Jones R et al (2012) RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J Clin Oncol 30:316–321
    • (2012) J Clin Oncol , vol.30 , pp. 316-321
    • Oberholzer, P.A.1    Kee, D.2    Dziunycz, P.3    Sucker, A.4    Kamsukom, N.5    Jones, R.6
  • 177
    • 84869104359 scopus 로고    scopus 로고
    • Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study
    • COI: 1:CAS:528:DC%2BC38Xhs12gur3O, PID: 22609219
    • Chu EY, Wanat KA, Miller CJ, Amaravadi RK, Fecher LA, Brose MS et al (2012) Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study. J Am Acad Dermatol 67:1265–1272
    • (2012) J Am Acad Dermatol , vol.67 , pp. 1265-1272
    • Chu, E.Y.1    Wanat, K.A.2    Miller, C.J.3    Amaravadi, R.K.4    Fecher, L.A.5    Brose, M.S.6
  • 178
    • 84922480216 scopus 로고    scopus 로고
    • Vemurafenib-associated gingival hyperplasia in patient with metastatic melanoma
    • PID: 25437992
    • Mangold AR, Bryce A, Sekulic A (2014) Vemurafenib-associated gingival hyperplasia in patient with metastatic melanoma. J Am Acad Dermatol 71:e205–e206
    • (2014) J Am Acad Dermatol , vol.71 , pp. e205-e206
    • Mangold, A.R.1    Bryce, A.2    Sekulic, A.3
  • 180
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • COI: 1:CAS:528:DC%2BC38Xhs1eksLrJ, PID: 23020132
    • Flaherty KT, Infante JR, Daud A et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367:1694–1703
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 181
    • 84890796086 scopus 로고    scopus 로고
    • Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib
    • COI: 1:CAS:528:DC%2BC3sXhslaqsrvL, PID: 24189279
    • Chang AL, Solomon JA, Hainsworth JD, Goldberg L, McKenna E, Day BM et al (2014) Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. J Am Acad Dermatol 70:60–69
    • (2014) J Am Acad Dermatol , vol.70 , pp. 60-69
    • Chang, A.L.1    Solomon, J.A.2    Hainsworth, J.D.3    Goldberg, L.4    McKenna, E.5    Day, B.M.6
  • 182
    • 84959168826 scopus 로고    scopus 로고
    • Understanding the impact of taste changes in oncology care
    • PID: 26820877
    • Epstein JB, Smutzer G, Doty RL (2016) Understanding the impact of taste changes in oncology care. Support Care Cancer 24:1917–1931
    • (2016) Support Care Cancer , vol.24 , pp. 1917-1931
    • Epstein, J.B.1    Smutzer, G.2    Doty, R.L.3
  • 183
    • 84904102406 scopus 로고    scopus 로고
    • Ado-trastuzumab emtansine-associated telangiectasias in metastatic breast cancer: a case series
    • PID: 24929675
    • Sibaud V, Niec RE, Schindler K, Busam KJ, Roché H, Modi S et al (2014) Ado-trastuzumab emtansine-associated telangiectasias in metastatic breast cancer: a case series. Breast Cancer Res Treat 146:451–456
    • (2014) Breast Cancer Res Treat , vol.146 , pp. 451-456
    • Sibaud, V.1    Niec, R.E.2    Schindler, K.3    Busam, K.J.4    Roché, H.5    Modi, S.6
  • 184
    • 84925335065 scopus 로고    scopus 로고
    • T-DM1-related telangiectasias: a potential role in secondary bleeding events
    • COI: 1:STN:280:DC%2BC2M3ovVSitQ%3D%3D, PID: 25403586
    • Sibaud V, Vigarios E, Combemale P, Lamant L, Lacouture ME, Lacaze JL et al (2015) T-DM1-related telangiectasias: a potential role in secondary bleeding events. Ann Oncol 26:436–437
    • (2015) Ann Oncol , vol.26 , pp. 436-437
    • Sibaud, V.1    Vigarios, E.2    Combemale, P.3    Lamant, L.4    Lacouture, M.E.5    Lacaze, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.