Basic oral care for hematology–oncology patients and hematopoietic stem cell transplantation recipients: a position paper from the joint task force of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)

Supportive Care in Cancer

Volumn 23, Issue 1, 2015, Pages 223-236

  Elad, Sharon ^a,b   Raber Durlacher, Judith E ^c,d   Brennan, Michael T ^e   Saunders, Deborah P ^f   Mank, Arno P ^g   Zadik, Yehuda ^h,i   Quinn, Barry ^j,k   Epstein, Joel B ^l,m   Blijlevens, Nicole M A ⁿ   Waltimo, Tuomas ^o   Passweg, Jakob R ^p   Correa, M Elvira P ^q   Dahllöf, Göran ^r   Garming Legert, Karin U E ^r   Logan, Richard M ^s   Potting, Carin M J ⁿ   Shapira, Michael Y ^t   Soga, Yoshihiko ^u   Stringer, Jacqui ^v   Stokman, Monique A ^w   Vokurka, Samuel ^x   Wallhult, Elisabeth ^y   Yarom, Noam ^z,aa   Jensen, Siri Beier ^ab   more..

^a UNIVERSITY OF ROCHESTER   (United States)

^b STRONG MEMORIAL HOSPITAL   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e CAROLINAS MEDICAL CENTER   (United States)

^f Tel Hashomer ^*  (Canada)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

^h MEDICAL CORPS   (Israel)

ⁱ HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^j CHELSEA AND WESTMINSTER HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^k UNIVERSITY OF SURREY   (United Kingdom)

^l CEDARS SINAI MEDICAL CENTER   (United States)

^m CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

ⁿ RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^o UNIVERSITY OF BASEL   (Switzerland)

^p UNIVERSITY HOSPITAL BASEL   (Switzerland)

^q UNIVERSITY OF CAMPINAS   (Brazil)

^r KAROLINSKA INSTITUTE   (Sweden)

^s UNIVERSITY OF ADELAIDE   (Australia)

^t HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^u OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^v CHRISTIE HOSPITAL   (United Kingdom)

^w UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^x CHARLES UNIVERSITY   (Czech Republic)

^y SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^z SHEBA MEDICAL CENTER   (Israel)

^aa TEL AVIV UNIVERSITY   (Israel)

^ab UNIVERSITY OF COPENHAGEN   (Denmark)

more..

Author keywords

Cancer; Dental; Hematology; Hematopoietic stem cell transplantation; Hygiene; Oral

Indexed keywords

ANALGESIA; CANCER CHEMOTHERAPY; CANCER PATIENT; CLINICAL PROTOCOL; GRAFT RECIPIENT; HEALTH CARE PERSONNEL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUTH; MOUTH HYGIENE; MOUTH INFECTION; ORAL FUNCTION; QUALITY OF LIFE; REVIEW; ADVERSE EFFECTS; BONE MARROW; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CYTOLOGY; DENTAL PROCEDURE; FEMALE; HEALTH; HEMATOLOGIC NEOPLASMS; HUMAN; MALE;

BONE MARROW; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CLINICAL PROTOCOLS; DENTAL CARE; FEMALE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; ORAL HEALTH; ORAL HYGIENE; PAIN MANAGEMENT; QUALITY OF LIFE;

EID: 84918821352     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-014-2378-x     Document Type: Review

References (86)

1. Bradley LL, Chambers M, Conklin CE, Fox PC, Garden AS, Haveman CW, Jackson SR, Lowenstein NL, Peterson DE, Schubert MM, Sonis ST (2003) Oral health in cancer therapy. A guide for health care professionals. In: Rankin KV, Jones DL, Redding SW (eds) Oral health in cancer therapy. Dallas, Texas
2. Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, Popplewell L, Maghami E (2012) Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin 62(6):400–422. doi:10.3322/caac.21157
3. Epstein JB, Raber-Durlacher JE, Wilkins A, Chavarria MG, Myint H (2009) Advances in hematologic stem cell transplant: an update for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(3):301–312. doi:10.1016/j.tripleo.2008.12.006
4. Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®) http://www.cancer.gov/cancertopics/pdq/supportivecare/oralcomplications/HealthProfessional/page1, National Cancer Institute. Accessed on Aug. 2014
5. Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB (2003) The burdens of cancer therapy Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 98(7):1531–1539. doi:10.1002/cncr.11671
6. Bellm LA, Epstein JB, Rose-Ped A, Martin P, Fuchs HJ (2000) Patient reports of complications of bone marrow transplantation. Support Care Cancer 8(1):33–39
7. Epstein J, Haveman C, Huber M, Peterson D, Plemons J, Sanfilippo N, Schubert M, Sonis S (2008) Oral health in cancer therapy. A guide for the health care professionals. In: Rankin K, Jones D, Redding S (eds) Oral health in cancer therapy. San Antonio, Texas
8. Meier JK, Wolff D, Pavletic S, Greinix H, Gosau M, Bertz H, Lee SJ, Lawitschka A, Elad S (2011) Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD. Clin Oral Investig 15(2):127–139. doi:10.1007/s00784-010-0450-6
9. Guideline on dental management of pediatric patients receiving chemotherapy, hematopoietic cell transplantation, and/or radiation (2008). Pediatr Dent 30 (7 Suppl):219–225
10. Quinn B, Potting CM, Stone R, Blijlevens NM, Fliedner M, Margulies A, Sharp L (2008) Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients. Eur J Cancer 44(1):61–72. doi:10.1016/j.ejca.2007.09.014
11. Bystricka E, Ghelase R, Gorican IK, Mazur E, Vokurka S (2012) Oral cavity care in patients after high-dose chemotherapy and stem cell transplantation: the East Forum EBMT Nurses Group standard of care. Bone Marrow Transplant 47(1):149–150. doi:10.1038/bmt.2011.19
12. McGuire DB, Correa ME, Johnson J, Wienandts P (2006) The role of basic oral care and good clinical practice principles in the management of oral mucositis. Support Care Cancer 14(6):541–547. doi:10.1007/s00520-006-0051-8
13. Rankin KV, Epstein J, Huber MA, Peterson DE, Plemons JM, Redding SS, Sanfillippo NJ, Schubert MM, Sonis ST (2009) Oral health in cancer therapy. Tex Dent J 126(5):389–397, 406–319, 422–337
14. UK Oral Mucositis in Cancer. www.ukomic.co.uk. Accessed on Jul. 2014
15. Epstein JB, Parker IR, Epstein MS, Gupta A, Kutis S, Witkowski DM (2007) A survey of National Cancer Institute-designated comprehensive cancer centers’ oral health supportive care practices and resources in the USA. Support Care Cancer 15(4):357–362. doi:10.1007/s00520-006-0160-4
16. Migliorati CA, Woo SB, Hewson I, Barasch A, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of bisphosphonate osteonecrosis (BON) in cancer. Support Care Cancer 18(8):1099–1106. doi:10.1007/s00520-010-0882-1
17. Hovan AJ, Williams PM, Stevenson-Moore P, Wahlin YB, Ohrn KE, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer 18(8):1081–1087. doi:10.1007/s00520-010-0902-1
18. Lalla RV, Latortue MC, Hong CH, Ariyawardana A, D’Amato-Palumbo S, Fischer DJ, Martof A, Nicolatou-Galitis O, Patton LL, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer 18(8):985–992. doi:10.1007/s00520-010-0892-z
19. Elad S, Zadik Y, Hewson I, Hovan A, Correa ME, Logan R, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea. Support Care Cancer 18(8):993–1006. doi:10.1007/s00520-010-0900-3
20. Hong CH, Napenas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer 18(8):1007–1021. doi:10.1007/s00520-010-0873-2
21. Peterson DE, Doerr W, Hovan A, Pinto A, Saunders D, Elting LS, Spijkervet FK, Brennan MT (2010) Osteoradionecrosis in cancer patients: the evidence base for treatment-dependent frequency, current management strategies, and future studies. Support Care Cancer 18(8):1089–1098. doi:10.1007/s00520-010-0898-6
22. Bensadoun RJ, Riesenbeck D, Lockhart PB, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer 18(8):1033–1038. doi:10.1007/s00520-010-0847-4
23. Epstein JB, Hong C, Logan RM, Barasch A, Gordon SM, Oberle-Edwards L, McGuire D, Napenas JJ, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of orofacial pain in patients receiving cancer therapy. Support Care Cancer 18(8):1023–1031. doi:10.1007/s00520-010-0897-7
24. Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer 18(8):1061–1079. doi:10.1007/s00520-010-0837-6
25. Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Napenas JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von Bultzingslowen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer 18(8):1039–1060. doi:10.1007/s00520-010-0827-8
26. Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias VE, Niscola P, Riesenbeck D, Stokman M, Tissing W, Yeoh E, Elad S, Lalla RV (2013) Systematic review of amifostine for the management of oral mucositis in cancer patients. Support Care Cancer 21(1):357–364. doi:10.1007/s00520-012-1613-6
27. Migliorati C, Hewson I, Lalla RV, Antunes HS, Estilo CL, Hodgson B, Lopes NN, Schubert MM, Bowen J, Elad S (2013) Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients. Support Care Cancer 21(1):333–341. doi:10.1007/s00520-012-1605-6
28. Peterson DE, Ohrn K, Bowen J, Fliedner M, Lees J, Loprinzi C, Mori T, Osaguona A, Weikel DS, Elad S, Lalla RV (2013) Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer 21(1):327–332. doi:10.1007/s00520-012-1562-0
29. Raber-Durlacher JE, von Bultzingslowen I, Logan RM, Bowen J, Al-Azri AR, Everaus H, Gerber E, Gomez JG, Pettersson BG, Soga Y, Spijkervet FK, Tissing WJ, Epstein JB, Elad S, Lalla RV (2013) Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients. Support Care Cancer 21(1):343–355. doi:10.1007/s00520-012-1594-5
30. Jensen SB, Jarvis V, Zadik Y, Barasch A, Ariyawardana A, Hovan A, Yarom N, Lalla RV, Bowen J, Elad S (2013) Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients. Support Care Cancer 21(11):3223–3232. doi:10.1007/s00520-013-1884-6
31. Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, van de Wetering MD, Rao NG, Potting C, Cheng KK, Freidank A, Brennan MT, Bowen J, Dennis K, Lalla RV (2013) Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer 21(11):3191–3207. doi:10.1007/s00520-013-1871-y
32. Yarom N, Ariyawardana A, Hovan A, Barasch A, Jarvis V, Jensen SB, Zadik Y, Elad S, Bowen J, Lalla RV (2013) Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer 21(11):3209–3221. doi:10.1007/s00520-013-1869-5
33. McGuire DB, Fulton JS, Park J, Brown CG, Correa ME, Eilers J, Elad S, Gibson F, Oberle-Edwards LK, Bowen J, Lalla RV (2013) Systematic review of basic oral care for the management of oral mucositis in cancer patients. Support Care Cancer 21(11):3165–3177. doi:10.1007/s00520-013-1942-0
34. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, Sonis ST, Elad S (2014) MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120(10):1453–1461. doi:10.1002/cncr.28592
35. Elad S, Thierer T, Bitan M, Shapira MY, Meyerowitz C (2008) A decision analysis: the dental management of patients prior to hematology cytotoxic therapy or hematopoietic stem cell transplantation. Oral Oncol 44(1):37–42. doi:10.1016/j.oraloncology.2006.12.006
36. Elad S, Garfunkel AA, Or R, Michaeli E, Shapira MY, Galili D (2003) Time limitations and the challenge of providing infection-preventing dental care to hematopoietic stem-cell transplantation patients. Support Care Cancer 11(10):674–677. doi:10.1007/s00520-003-0499-8
37. Durey K, Patterson H, Gordon K (2009) Dental assessment prior to stem cell transplant: treatment need and barriers to care. Br Dent J 206(9):E19. doi:10.1038/sj.bdj.2009.304, discussion 478–479
38. Zadik Y, Yarom N, Elad S (2012) Orofacial Neuropathy and Pain in Cancer Patients. In: Raffa R, Langford R, JV. PJ, Porreca F, Tallarida R (eds) Chemotherapy Induced Neuropathic Pain CRC press, pp 95–108
39. Elad S, Raber-Durlacher J, Shapira MY (2010) Oral complications of hematopoietic stem cell transplantation. In: Epstein J (ed) Davies A. Oral complications of cancer and its management Oxford University Press, New York, pp 129–140
40. Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y, Inoue N (2012) Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer 20(2):367–373. doi:10.1007/s00520-011-1116-x
41. Yamagata K, Arai C, Sasaki H, Takeuchi Y, Onizawa K, Yanagawa T, Ishibashi N, Karube R, Shinozuka K, Hasegawa Y, Chiba S, Bukawa H (2012) The effect of oral management on the severity of oral mucositis during hematopoietic SCT. Bone Marrow Transplant 47(5):725–730. doi:10.1038/bmt.2011.171
42. Peterson DE, Overholser CD (1981) Increased morbidity associated with oral infection in patients with acute nonlymphocytic leukemia. Oral Surg Oral Med Oral Pathol 51(4):390–393
43. Greenberg MS, Cohen SG, McKitrick JC, Cassileth PA (1982) The oral flor as a source of septicemia in patients with acute leukemia. Oral Surg Oral Med Oral Pathol 53(1):32–36
44. Raber-Durlacher JE, Laheij AM, Epstein JB, Epstein M, Geerligs GM, Wolffe GN, Blijlevens NM, Donnelly JP (2013) Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study. Support Care Cancer 21(6):1621–1627. doi:10.1007/s00520-012-1706-2
45. Ruescher TJ, Sodeifi A, Scrivani SJ, Kaban LB, Sonis ST (1998) The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies. Cancer 82(11):2275–2281. doi:10.1002/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q
46. Qutob AF, Allen G, Gue S, Revesz T, Logan RM, Keefe D (2013) Implementation of a hospital oral care protocol and recording of oral mucositis in children receiving cancer treatment: a retrospective and a prospective study. Support Care Cancer 21(4):1113–1120. doi:10.1007/s00520-012-1633-2
47. Newbrun E (2001) Topical fluorides in caries prevention and management: a North American perspective. J Dent Educ 65(10):1078–1083
48. Ransier A, Epstein JB, Lunn R, Spinelli J (1995) A combined analysis of a toothbrush, foam brush, and a chlorhexidine-soaked foam brush in maintaining oral hygiene. Cancer Nurs 18(5):393–396
49. Sambunjak D, Nickerson JW, Poklepovic T, Johnson TM, Imai P, Tugwell P, Worthington HV (2011) Flossing for the management of periodontal diseases and dental caries in adults. Cochrane Database Syst Rev 12, CD008829. doi:10.1002/14651858.CD008829.pub2
50. http://www.gsk-dentalprofessionals.co.uk/product.aspx?parent=corsodyl_treatment&id=cor_original_mouthwash. Accessed on Dec. 2012
51. Hoffmann T, Bruhn G, Richter S, Netuschil L, Brecx M (2001) Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene. Clin Oral Investig 5(2):89–95
52. Axelsson P, Lindhe J (1987) Efficacy of mouthrinses in inhibiting dental plaque and gingivitis in man. J Clin Periodontol 14(4):205–212
53. Van Strydonck DA, Timmerman MF, van der Velden U, van der Weijden GA (2005) Plaque inhibition of two commercially available chlorhexidine mouthrinses. J Clin Periodontol 32(3):305–309. doi:10.1111/j.1600-051X.2005.00681.x
54. Van Strydonck DA, Slot DE, Van der Velden U, Van der Weijden F (2012) Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol 39(11):1042–1055. doi:10.1111/j.1600-051X.2012.01883.x
55. Addy M (2008) Oral hygiene products: potential for harm to oral and systemic health? Periodontol 2000(48):54–65. doi:10.1111/j.1600-0757.2008.00253.x
56. de Souza RF, de Freitas Oliveira Paranhos H, Lovato da Silva CH, Abu-Naba’a L, Fedorowicz Z, Gurgan CA (2009) Interventions for cleaning dentures in adults. Cochrane Database Syst Rev 4, CD007395. doi:10.1002/14651858.CD007395.pub2
57. Elad S, Wexler A, Garfunkel AA, Shapira MY, Bitan M, Or R (2006) Oral candidiasis prevention in transplantation patients: a comparative study. Clin Transplant 20(3):318–324. doi:10.1111/j.1399-0012.2005.00484.x
58. Raber-Durlacher JE, Elad S, Barasch A (2010) Oral mucositis. Oral Oncol 46(6):452–456. doi:10.1016/j.oraloncology.2010.03.012
59. Sonis ST (2007) Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol 5(9 Suppl 4):3–11
60. Sonis ST (2011) Oral mucositis. Anticancer Drugs 22(7):607–612. doi:10.1097/CAD.0b013e3283462086
61. Benoliel R, Epstein J, Eliav E, Jurevic R, Elad S (2007) Orofacial pain in cancer: part I–mechanisms. J Dent Res 86(6):491–505
62. Epstein JB, Elad S, Eliav E, Jurevic R, Benoliel R (2007) Orofacial pain in cancer: part II–clinical perspectives and management. J Dent Res 86(6):506–518
63. Parulekar W, Mackenzie R, Bjarnason G, Jordan RC (1998) Scoring oral mucositis. Oral Oncol 34(1):63–71
64. Barasch A, Elad S, Altman A, Damato K, Epstein J (2006) Antimicrobials, mucosal coating agents, anesthetics, analgesics, and nutritional supplements for alimentary tract mucositis. Support Care Cancer 14(6):528–532. doi:10.1007/s00520-006-0066-1
65. Boer CC, Correa ME, Miranda EC, de Souza CA (2010) Taste disorders and oral evaluation in patients undergoing allogeneic hematopoietic SCT. Bone Marrow Transplant 45(4):705–711. doi:10.1038/bmt.2009.237
66. Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46(2):77–81. doi:10.1016/j.oraloncology.2009.11.008
67. Stiff P (2001) Mucositis associated with stem cell transplantation: current status and innovative approaches to management. Bone Marrow Transplant 27(Suppl 2):S3–S11. doi:10.1038/sj.bmt.1702863
68. Mohty M, Apperley JF (2010) Long-term physiological side effects after allogeneic bone marrow transplantation. Hematology Am Soc Hematol Educ Program 2010:229–236. doi:10.1182/asheducation-2010.1.229
69. Schubert MM, Correa ME (2008) Oral graft-versus-host disease. Dent Clin North Am 52(1):79–109. doi:10.1016/j.cden.2007.10.004, viii-ix
70. Strietzel FP, Lafaurie GI, Mendoza GR, Alajbeg I, Pejda S, Vuletic L, Mantilla R, Falcao DP, Leal SC, Bezerra AC, Tran SD, Menard HA, Kimoto S, Pan S, Martin-Granizo RA, Lozano ML, Zunt SL, Krushinski CA, Melilli D, Campisi G, Paderni C, Dolce S, Yepes JF, Lindh L, Koray M, Mumcu G, Elad S, Zeevi I, Barrios BC, Lopez Sanchez RM, Beiski BZ, Wolff A, Konttinen YT (2011) Efficacy and safety of an intraoral electrostimulation device for xerostomia relief: a multicenter, randomized trial. Arthritis Rheum 63(1):180–190. doi:10.1002/art.27766
71. Castellarin P, Stevenson K, Biasotto M, Yuan A, Woo SB, Treister NS (2012) Extensive dental caries in patients with oral chronic graft-versus-host disease. Biol Blood Marrow Transplant 18(10):1573–1579. doi:10.1016/j.bbmt.2012.04.009
72. Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR (2007) Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil 34(10):724–732. doi:10.1111/j.1365-2842.2006.01718.x
73. Shen P, Manton DJ, Cochrane NJ, Walker GD, Yuan Y, Reynolds C, Reynolds EC (2011) Effect of added calcium phosphate on enamel remineralization by fluoride in a randomized controlled in situ trial. J Dent 39(7):518–525. doi:10.1016/j.jdent.2011.05.002
74. Greinix HT, Volc-Platzer B, Rabitsch W, Gmeinhart B, Guevara-Pineda C, Kalhs P, Krutmann J, Honigsmann H, Ciovica M, Knobler RM (1998) Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 92(9):3098–3104
75. Treister N, Duncan C, Cutler C, Lehmann L (2012) How we treat oral chronic graft-versus-host disease. Blood 120(17):3407–3418. doi:10.1182/blood-2012-05-393389
76. Mawardi H, Elad S, Correa ME, Stevenson K, Woo SB, Almazrooa S, Haddad R, Antin JH, Soiffer R, Treister N (2011) Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes. Bone Marrow Transplant 46(6):884–891. doi:10.1038/bmt.2011.77
77. Sivolella S, Lumachi F, Stellini E, Favero L (2013) Denosumab and anti-angiogenetic drug-related osteonecrosis of the jaw: an uncommon but potentially severe disease. Anticancer Res 33(5):1793–1797
78. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F (2014) American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update. J Oral Maxillofac Surg. doi:10.1016/j.joms.2014.04.031
79. Chaushu G, Bercovici M, Dori S, Waller A, Taicher S, Kronenberg J, Talmi YP (2000) Salivary flow and its relation with oral symptoms in terminally ill patients. Cancer 88 (5):984–987. doi:10.1002/(SICI)1097-0142(20000301)88:5<984::AID-CNCR6>3.0.CO;2–0 [pii]
80. Chaushu G, Itzkovitz-Chaushu S, Yefenof E, Slavin S, Or R, Garfunkel AA (1995) A longitudinal follow-up of salivary secretion in bone marrow transplant patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(2):164–169
81. Laaksonen M, Ramseier AM, Rovo A, Jensen SB, Raber-Durlacher JE, Zitzmann NU, Waltimo T (2011) Longitudinal assessment of hematopoietic stem cell transplantation and hyposalivation. J Dent Res 90(10):1177–1182. doi:10.1177/0022034511414156
82. Glenny AM, Gibson F, Auld E, Coulson S, Clarkson JE, Craig JV, Eden OB, Khalid T, Worthington HV, Pizer B (2010) The development of evidence-based guidelines on mouth care for children, teenagers and young adults treated for cancer. Eur J Cancer 46(8):1399–1412. doi:10.1016/j.ejca.2010.01.023
83. Council on Clinical Affairs (2013) Guideline on dental management of pediatric patients receiving chemotherapy, hematopoietic cell transplantation, and/or radiation. Pediatr Dent 35(5):E185–193
84. US Food and Drug Administration (2014) FDA Drug Safety Communication: FDA recommends not using lidocaine to treat teething pain and requires new Boxed Warning. http://www.fda.gov/Drugs/DrugSafety/ucm402240.htm Accessed Jul. 2014
85. Bagesund M, Richter S, Agren B, Ringden O, Dahllof G (2000) Scintigraphic study of the major salivary glands in pediatric bone marrow transplant recipients. Bone Marrow Transplant 26(7):775–779. doi:10.1038/sj.bmt.1702556
86. American Academy of Pediatric Dentistry Clinical Affairs Committee, American Academy of Pediatric Dentistry Council on Clinical Affairs, (2005) Guideline on dental management of pediatric patients receiving chemotherapy, hematopoietic cell transplantation, and/or radiation. Pediatr Dent 27(7 Suppl):170–175