-
2
-
-
84879884454
-
Clinical perspective of afatinib in non-small cell lung cancer
-
Chen X, ZhuQ, Zhu L et al. Clinical perspective of afatinib in non-small cell lung cancer. Lung Cancer 2013; 81: 155-161.
-
(2013)
Lung Cancer
, vol.81
, pp. 155-161
-
-
Chen, X.1
Zhu, Q.2
Zhu, L.3
-
3
-
-
81055157135
-
Non-small-cell lung cancer
-
Goldstraw P, Ball D, Jett JR et al. Non-small-cell lung cancer. Lancet 2011; 378: 1727-1740.
-
(2011)
Lancet
, vol.378
, pp. 1727-1740
-
-
Goldstraw, P.1
Ball, D.2
Jett, J.R.3
-
4
-
-
84874575400
-
From targets to targeted therapies and molecular profiling in non-small cell lung carcinoma
-
Thomas A, Rajan A, Lopez-Chavez A et al. From targets to targeted therapies and molecular profiling in non-small cell lung carcinoma. Ann Oncol 2013; 24: 577-585.
-
(2013)
Ann Oncol
, vol.24
, pp. 577-585
-
-
Thomas, A.1
Rajan, A.2
Lopez-Chavez, A.3
-
5
-
-
84875937242
-
Genotyping and genomic profiling of non-small-cell lung cancer: Implications for current and future therapies
-
Li T, Kung HJ, Mack PC et al. Genotyping and genomic profiling of non-small-cell lung cancer: Implications for current and future therapies. J Clin Oncol 2013; 31: 1039-1049.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1039-1049
-
-
Li, T.1
Kung, H.J.2
Mack, P.C.3
-
6
-
-
33645302908
-
A review of the benefit-risk profile of gefitinib in Asian patients with advanced non-small-cell lung cancer
-
Park K, Goto K. A review of the benefit-risk profile of gefitinib in Asian patients with advanced non-small-cell lung cancer. CurrMedRes Opin 2006; 22: 561-573.
-
(2006)
CurrMedRes Opin
, vol.22
, pp. 561-573
-
-
Park, K.1
Goto, K.2
-
7
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361: 947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
8
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-smallcell lung cancer
-
Kwak EL, Bang YJ, Camidge DR et al. Anaplastic lymphoma kinase inhibition in non-smallcell lung cancer. N Engl J Med 2010; 363: 1693-1703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
9
-
-
84896957081
-
Ceritinib in ALKrearranged non-small-cell lung cancer
-
ShawAT, KimDW, MehraRet al. Ceritinib in ALKrearranged non-small-cell lung cancer. N Engl JMed 2014; 370: 1189-1197.
-
(2014)
N Engl JMed
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
-
10
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013; 368: 2385-2394.
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
11
-
-
12144287534
-
United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets
-
Cohen MH, Williams GA, Sridhara R et al. United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res 2004; 10: 1212-1218.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1212-1218
-
-
Cohen, M.H.1
Williams, G.A.2
Sridhara, R.3
-
12
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005; 366: 1527-1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
14
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
-
Kim ES, Hirsh V, Mok T et al. Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial. Lancet 2008; 372: 1809-1818.
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
-
16
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl JMed 2005; 353: 123-132.
-
(2005)
N Engl JMed
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
17
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010; 11: 521-529.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
18
-
-
84927645414
-
-
Accessed January 18
-
FDA approval for erlotinib hydrochloride. Available at http://www. cancer. gov/cancertopics/druginfo/fda-erlotinib-hydrochloride. Accessed January 18, 2015.
-
(2015)
FDA approval for erlotinib hydrochloride
-
-
-
19
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
-
20
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
21
-
-
0012381722
-
Multiinstitutional randomized phase II trial of gefitinib for previously treated patients with advanced nonsmall-cell lung cancer (the IDEAL 1 trial)
-
Fukuoka M, Yano S, Giaccone G et al. Multiinstitutional randomized phase II trial of gefitinib for previously treated patients with advanced nonsmall-cell lung cancer (the IDEAL 1 trial). J Clin Oncol 2003; 21: 2237-2246.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
22
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
-
GiacconeG, HerbstRS, ManegoldCetal. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1. J Clin Oncol 2004; 22: 777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
23
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl JMed 2010; 362: 2380-2388.
-
(2010)
N Engl JMed
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
24
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with nonsmall-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y et al. Gefitinib versus cisplatin plus docetaxel in patients with nonsmall-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol 2010; 11: 121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
25
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): Amulticentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): Amulticentre, open-label, randomised phase 3 trial. Lancet Oncol 2012; 13: 239-246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
26
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-smallcell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011; 12: 735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
27
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC, YamamotoNet al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013; 31: 3327-3334.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
28
-
-
84860461938
-
A new generation of EGFR tyrosine-kinase inhibitors in NSCLC
-
Hirsch FR, Bunn PA Jr. A new generation of EGFR tyrosine-kinase inhibitors in NSCLC. Lancet Oncol 2012; 13: 442-443.
-
(2012)
Lancet Oncol
, vol.13
, pp. 442-443
-
-
Hirsch, F.R.1
Bunn, P.A.2
-
29
-
-
84877291745
-
Impact of EGFR inhibitor in non-small cell lung cancer on progressionfree and overall survival: Ameta-analysis
-
Lee CK, Brown C, Gralla RJ et al. Impact of EGFR inhibitor in non-small cell lung cancer on progressionfree and overall survival: Ameta-analysis. JNatl Cancer Inst 2013; 105: 595-605.
-
(2013)
JNatl Cancer Inst
, vol.105
, pp. 595-605
-
-
Lee, C.K.1
Brown, C.2
Gralla, R.J.3
-
30
-
-
84875298116
-
Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: A systematic review
-
Chen X, Liu Y, RøeODet al. Gefitinib or erlotinib as maintenance therapy in patients with advanced stage non-small cell lung cancer: A systematic review. PLoS One 2013; 8: e59314.
-
(2013)
PLoS One
, vol.8
-
-
Chen, X.1
Liu, Y.2
Røe, O.D.3
-
31
-
-
78651075835
-
Different efficacies of erlotinib and gefitinib in taiwanese patients with advanced non-small cell lung cancer: A retrospective multicenter study
-
Fan WC, Yu CJ, Tsai CM et al. Different efficacies of erlotinib and gefitinib in taiwanese patients with advanced non-small cell lung cancer: A retrospective multicenter study. J Thorac Oncol 2011; 6: 148-155.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 148-155
-
-
Fan, W.C.1
Yu, C.J.2
Tsai, C.M.3
-
32
-
-
79958227079
-
Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review
-
Murphy M, Stordal B. Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review. Drug Resist Updat 2011; 14: 177-190.
-
(2011)
Drug Resist Updat
, vol.14
, pp. 177-190
-
-
Murphy, M.1
Stordal, B.2
-
33
-
-
77951951659
-
Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: Pooled analysis
-
Paz-Ares L, Soulières D, Melezínek I et al. Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: Pooled analysis. J Cell Mol Med 2010; 14: 51-69.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 51-69
-
-
Paz-Ares, L.1
Soulières, D.2
Melezínek, I.3
-
34
-
-
84857414572
-
Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: Ameta-analysis of 13 randomized trials
-
Petrelli F, Borgonovo K, Cabiddu M et al. Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: Ameta-analysis of 13 randomized trials. Clin Lung Cancer 2012; 13: 107-114.
-
(2012)
Clin Lung Cancer
, vol.13
, pp. 107-114
-
-
Petrelli, F.1
Borgonovo, K.2
Cabiddu, M.3
-
35
-
-
84871464846
-
Comparison of gefitiniband erlotinib efficacies as third-line therapy for advanced non-small-cell lung cancer
-
Shao YY, Shau WY, Lin ZZ et al. Comparison of gefitiniband erlotinib efficacies as third-line therapy for advanced non-small-cell lung cancer. Eur J Cancer 2013; 49: 106-114.
-
(2013)
Eur J Cancer
, vol.49
, pp. 106-114
-
-
Shao, Y.Y.1
Shau, W.Y.2
Lin, Z.Z.3
-
36
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial. Lancet Oncol 2012; 13: 528-538.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
37
-
-
84892997539
-
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial
-
Wu YL, Zhou C, Hu CP et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial. Lancet Oncol 2014; 15: 213-222.
-
(2014)
Lancet Oncol
, vol.15
, pp. 213-222
-
-
Wu, Y.L.1
Zhou, C.2
Hu, C.P.3
-
38
-
-
84927632288
-
-
Accessed March 6, R package version 2. 5-1. 2013. Available at
-
Schwarzer G. Meta-analysis with R. R package version 2. 5-1. 2013. Available at http://cran. r-project. org/web/packages/meta/index. html. Accessed March 6, 2015.
-
(2015)
Meta-analysis with R
-
-
Schwarzer, G.1
-
39
-
-
77958110812
-
Conducting meta-analyses in R with themetafor package
-
Viechtbauer W. Conducting meta-analyses in R with themetafor package. J Stat Softw 2010; 36: 1-48.
-
(2010)
J Stat Softw
, vol.36
, pp. 1-48
-
-
Viechtbauer, W.1
-
40
-
-
84870688172
-
Gefitinib versus pemetrexed as second-line treatment in patients with nonsmall cell lung cancer previously treated with platinum-based chemotherapy (KCSG-LU08-01): An open-label, phase 3 trial
-
Sun JM, Lee KH, Kim SW et al. Gefitinib versus pemetrexed as second-line treatment in patients with nonsmall cell lung cancer previously treated with platinum-based chemotherapy (KCSG-LU08-01): An open-label, phase 3 trial. Cancer 2012; 118: 6234-6242.
-
(2012)
Cancer
, vol.118
, pp. 6234-6242
-
-
Sun, J.M.1
Lee, K.H.2
Kim, S.W.3
-
41
-
-
33646867322
-
Phase II, open-label, randomizedstudy (SIGN) of single-agent gefitinib (IRESSA) or docetaxel as second-line therapy in patients with advanced (stage IIIb or IV) non-small-cell lung cancer
-
Cufer T, Vrdoljak E, Gaafar R et al. Phase II, open-label, randomizedstudy (SIGN) of single-agent gefitinib (IRESSA) or docetaxel as second-line therapy in patients with advanced (stage IIIb or IV) non-small-cell lung cancer. Anticancer Drugs 2006; 17: 401-409.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 401-409
-
-
Cufer, T.1
Vrdoljak, E.2
Gaafar, R.3
-
42
-
-
76749154617
-
Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy
-
Lee DH, Park K, Kim JH et al. Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy. Clin Cancer Res 2010; 16: 1307-1314.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1307-1314
-
-
Lee, D.H.1
Park, K.2
Kim, J.H.3
-
43
-
-
65549154268
-
Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced nonsmall-cell lung cancer and poor performance status
-
Goss G, Ferry D, Wierzbicki Ret al. Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced nonsmall-cell lung cancer and poor performance status. J Clin Oncol 2009; 27: 2253-2260.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2253-2260
-
-
Goss, G.1
Ferry, D.2
Wierzbicki, R.3
-
44
-
-
77956805350
-
Randomizedphase II trialofgefitinib or gemcitabineordocetaxel chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2 or 3 (IFCT-0301 study)
-
Morère JF, Bréchot JM, Westeel V et al. Randomizedphase II trialofgefitinib or gemcitabineordocetaxel chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2 or 3 (IFCT-0301 study). Lung Cancer 2010; 70: 301-307.
-
(2010)
Lung Cancer
, vol.70
, pp. 301-307
-
-
Morère, J.F.1
Bréchot, J.M.2
Westeel, V.3
-
45
-
-
45149102984
-
Phase III trial ofmaintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stageIIInon-small-cell lungcancer: SWOG S0023
-
Kelly K, Chansky K, Gaspar LE et al. Phase III trial ofmaintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stageIIInon-small-cell lungcancer: SWOG S0023. J Clin Oncol 2008; 26: 2450-2456.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2450-2456
-
-
Kelly, K.1
Chansky, K.2
Gaspar, L.E.3
-
46
-
-
80053365381
-
A double-blind, randomised, placebo-controlled phase III intergroup study of gefitinib in patients with advanced NSCLC, non-progressing after first line platinum-based chemotherapy (EORTC 08021/ILCP 01/03)
-
Gaafar RM, Surmont VF, Scagliotti GV et al. A double-blind, randomised, placebo-controlled phase III intergroup study of gefitinib in patients with advanced NSCLC, non-progressing after first line platinum-based chemotherapy (EORTC 08021/ILCP 01/03). Eur J Cancer 2011; 47: 2331-2340.
-
(2011)
Eur J Cancer
, vol.47
, pp. 2331-2340
-
-
Gaafar, R.M.1
Surmont, V.F.2
Scagliotti, G.V.3
-
47
-
-
84860479704
-
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): A multicentre, double-blind randomised phase 3 trial
-
Zhang L, Ma S, Song X et al. Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): A multicentre, double-blind randomised phase 3 trial. Lancet Oncol 2012; 13: 466-475.
-
(2012)
Lancet Oncol
, vol.13
, pp. 466-475
-
-
Zhang, L.1
Ma, S.2
Song, X.3
-
48
-
-
77649203360
-
Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: Results of awest Japan thoracic oncology group trial (WJTOG0203)
-
Takeda K, Hida T, Sato T et al. Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: Results of awest Japan thoracic oncology group trial (WJTOG0203). J Clin Oncol 2010; 28: 753-760.
-
(2010)
J Clin Oncol
, vol.28
, pp. 753-760
-
-
Takeda, K.1
Hida, T.2
Sato, T.3
-
49
-
-
84863783193
-
Randomized phase II trial of first-line treatmentwith pemetrexedcisplatin, followed sequentially by gefitinib or pemetrexed, in East Asian, never-smoker patients with advanced non-small cell lung cancer
-
Ahn MJ, Yang JC, Liang J et al. Randomized phase II trial of first-line treatmentwith pemetrexedcisplatin, followed sequentially by gefitinib or pemetrexed, in East Asian, never-smoker patients with advanced non-small cell lung cancer. Lung Cancer 2012; 77: 346-352.
-
(2012)
Lung Cancer
, vol.77
, pp. 346-352
-
-
Ahn, M.J.1
Yang, J.C.2
Liang, J.3
-
50
-
-
52049096854
-
Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): A randomized, phase II study
-
Crinò L, Cappuzzo F, Zatloukal P et al. Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): A randomized, phase II study. J Clin Oncol 2008; 26: 4253-4260.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4253-4260
-
-
Crinò, L.1
Cappuzzo, F.2
Zatloukal, P.3
-
51
-
-
84857501696
-
Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
-
Ciuleanu T, Stelmakh L, Cicenas S et al. Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study. Lancet Oncol 2012; 13: 300-308.
-
(2012)
Lancet Oncol
, vol.13
, pp. 300-308
-
-
Ciuleanu, T.1
Stelmakh, L.2
Cicenas, S.3
-
52
-
-
84861336479
-
Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinumbased therapy
-
Kelly K, Azzoli CG, ZatloukalPet al. Randomized phase 2b study of pralatrexate versus erlotinib in patients with stage IIIB/IV non-small-cell lung cancer (NSCLC) after failure of prior platinumbased therapy. J Thorac Oncol 2012; 7: 1041-1048.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1041-1048
-
-
Kelly, K.1
Azzoli, C.G.2
Zatloukal, P.3
-
53
-
-
84865154870
-
First-line erlotinib followedby second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial
-
Gridelli C, Ciardiello F, Gallo C et al. First-line erlotinib followedby second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: The TORCH randomized trial. J Clin Oncol 2012; 30: 3002-3011.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3002-3011
-
-
Gridelli, C.1
Ciardiello, F.2
Gallo, C.3
-
54
-
-
84867059528
-
Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy inadvanced non-small-cell lung cancer
-
Pérol M, Chouaid C, Pérol D et al. Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy inadvanced non-small-cell lung cancer. J Clin Oncol 2012; 30: 3516-3524.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3516-3524
-
-
Pérol, M.1
Chouaid, C.2
Pérol, D.3
-
55
-
-
84858339030
-
Phase II randomized trial of erlotinib or vinorelbine in chemonaive, advanced, non-small cell lung cancer patients aged 70 years or older
-
Chen YM, Tsai CM, Fan WC et al. Phase II randomized trial of erlotinib or vinorelbine in chemonaive, advanced, non-small cell lung cancer patients aged 70 years or older. J Thorac Oncol 2012; 7: 412-418.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 412-418
-
-
Chen, Y.M.1
Tsai, C.M.2
Fan, W.C.3
-
56
-
-
80052273497
-
A randomized phase II trial of first-line treatment with gemcitabine, erlotinib, or gemcitabine and erlotinib in elderly patients (age$70 years) with stage IIIB/IV non-small cell lung cancer
-
Stinchcombe TE, Peterman AH, Lee CB et al. A randomized phase II trial of first-line treatment with gemcitabine, erlotinib, or gemcitabine and erlotinib in elderly patients (age$70 years) with stage IIIB/IV non-small cell lung cancer. J Thorac Oncol 2011; 6: 1569-1577.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 1569-1577
-
-
Stinchcombe, T.E.1
Peterman, A.H.2
Lee, C.B.3
-
57
-
-
80053943975
-
Amulticentre phase II randomised trial of weekly docetaxel/gemcitabine followed byerlotinibonprogression, vs the reverse sequence, in elderly patients with advanced non small-cell lung cancer selected with a comprehensive geriatric assessment (the GFPC 0504 study)
-
LeCaer H, Barlesi F, Corre R et al. Amulticentre phase II randomised trial of weekly docetaxel/gemcitabine followed byerlotinibonprogression, vs the reverse sequence, in elderly patients with advanced non small-cell lung cancer selected with a comprehensive geriatric assessment (the GFPC 0504 study). Br J Cancer 2011; 105: 1123-1130.
-
(2011)
Br J Cancer
, vol.105
, pp. 1123-1130
-
-
LeCaer, H.1
Barlesi, F.2
Corre, R.3
-
58
-
-
84861742943
-
A multicenterphase IIrandomizedtrial ofgemcitabine followed by erlotinib at progression, versus the reverse sequence, in vulnerable elderly patients with advanced non small-cell lung cancer selected with a comprehensive geriatric assessment (the GFPC 0505 study)
-
LeCaer H, Greillier L, Corre R et al. A multicenterphase IIrandomizedtrial ofgemcitabine followed by erlotinib at progression, versus the reverse sequence, in vulnerable elderly patients with advanced non small-cell lung cancer selected with a comprehensive geriatric assessment (the GFPC 0505 study). Lung Cancer 2012; 77: 97-103.
-
(2012)
Lung Cancer
, vol.77
, pp. 97-103
-
-
LeCaer, H.1
Greillier, L.2
Corre, R.3
-
59
-
-
79952376771
-
Treatment of non-small-cell lung cancer with erlotinib or gefitinib
-
Cataldo VD, Gibbons DL, Pérez-Soler R et al. Treatment of non-small-cell lung cancer with erlotinib or gefitinib. N Engl JMed 2011; 364: 947-955.
-
(2011)
N Engl JMed
, vol.364
, pp. 947-955
-
-
Cataldo, V.D.1
Gibbons, D.L.2
Pérez-Soler, R.3
-
60
-
-
77649152379
-
Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer: The Okayama Lung Cancer Study Group experience
-
Hotta K, Kiura K, Takigawa N et al. Comparison of the incidence and pattern of interstitial lung disease during erlotinib and gefitinib treatment in Japanese Patients with non-small cell lung cancer: The Okayama Lung Cancer Study Group experience. J Thorac Oncol 2010; 5: 179-184.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 179-184
-
-
Hotta, K.1
Kiura, K.2
Takigawa, N.3
-
61
-
-
37849012740
-
Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals
-
Ling J, Fettner S, Lum BL et al. Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals. Anticancer Drugs 2008; 19: 209-216.
-
(2008)
Anticancer Drugs
, vol.19
, pp. 209-216
-
-
Ling, J.1
Fettner, S.2
Lum, B.L.3
-
62
-
-
10444231159
-
Relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: Results of a randomized, open-label, three-period crossover study in healthy volunteers
-
Cantarini MV, McFarquhar T, Smith RP et al. Relative bioavailability and safety profile of gefitinib administered as a tablet or as a dispersion preparation via drink or nasogastric tube: Results of a randomized, open-label, three-period crossover study in healthy volunteers. Clin Ther 2004; 26: 1630-1636.
-
(2004)
Clin Ther
, vol.26
, pp. 1630-1636
-
-
Cantarini, M.V.1
McFarquhar, T.2
Smith, R.P.3
-
63
-
-
34250694236
-
Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
-
Li J, ZhaoM, He P et al. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 2007; 13: 3731-3737.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3731-3737
-
-
Li, J.1
Zhao, M.2
He, P.3
-
64
-
-
84892551057
-
Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects
-
Bronte G, Rolfo C, Giovannetti E et al. Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects. Crit Rev Oncol Hematol 2013; 89: 300-313.
-
(2013)
Crit Rev Oncol Hematol
, vol.89
, pp. 300-313
-
-
Bronte, G.1
Rolfo, C.2
Giovannetti, E.3
-
65
-
-
33847406095
-
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
-
Yun CH, Boggon TJ, Li Y et al. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell 2007; 11: 217-227.
-
(2007)
Cancer Cell
, vol.11
, pp. 217-227
-
-
Yun, C.H.1
Boggon, T.J.2
Li, Y.3
-
66
-
-
84883055532
-
Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer andwild-typeEGFRtumours (TAILOR): Arandomised controlled trial
-
Garassino MC, Martelli O, Broggini M et al. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer andwild-typeEGFRtumours (TAILOR): Arandomised controlled trial. Lancet Oncol 2013; 14: 981-988.
-
(2013)
Lancet Oncol
, vol.14
, pp. 981-988
-
-
Garassino, M.C.1
Martelli, O.2
Broggini, M.3
-
67
-
-
84855554187
-
Targeted therapies development in thetreatment ofadvancednonsmallcell lung cancer
-
Gridelli C, Felip E. Targeted therapies development in thetreatment ofadvancednonsmallcell lung cancer. J Biomed Biotechnol 2011; 2011: 415641.
-
(2011)
J Biomed Biotechnol
, vol.2011
-
-
Gridelli, C.1
Felip, E.2
-
68
-
-
84893080787
-
Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: Is afatinib better or simply newer?
-
Langer CJ. Epidermal growth factor receptor inhibition in mutation-positive non-small-cell lung cancer: Is afatinib better or simply newer? J Clin Oncol 2013; 31: 3303-3306.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3303-3306
-
-
Langer, C.J.1
-
69
-
-
84927658952
-
-
Accessed January 18
-
Afatinib. Available at http://www. fda. gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm360574. htm. Accessed January 18, 2015.
-
(2015)
Afatinib
-
-
-
70
-
-
84884618137
-
LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both
-
KatakamiN, Atagi S, Goto K et al. LUX-Lung 4: A phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both. J Clin Oncol 2013; 31: 3335-3341.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3335-3341
-
-
Katakami, N.1
Atagi, S.2
Goto, K.3
-
71
-
-
84921892043
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUXLung 6): Analysis of overall survival data from two randomised, phase 3 trials
-
Yang JC, Wu YL, SchulerMet al. Afatinib versus cisplatin-based chemotherapy for EGFR mutationpositive lung adenocarcinoma (LUX-Lung 3 and LUXLung 6): Analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol 2015; 16: 141-151.
-
(2015)
Lancet Oncol
, vol.16
, pp. 141-151
-
-
Yang, J.C.1
Wu, Y.L.2
Schuler, M.3
|