메뉴 건너뛰기




Volumn 16, Issue 2, 2012, Pages 172-184

Strategies for assessing and managing the adverse events of sorafenib and other targeted therapies in the treatment of renal cell and hepatocellular carcinoma: Recommendations from a European nursing task group

Author keywords

Adverse event; Altered taste; Diarrhoea; Fatigue; Hand foot skin reaction; Management; Mucositis; Nexavar; Sorafenib; Targeted therapy

Indexed keywords


EID: 84857651429     PISSN: 14623889     EISSN: 15322122     Source Type: Journal    
DOI: 10.1016/j.ejon.2011.05.001     Document Type: Review
Times cited : (34)

References (99)
  • 1
    • 64049100782 scopus 로고    scopus 로고
    • Search for evidence-based approaches for the prevention and palliation of hand-foot skin reaction (HFSR) caused by multikinase inhibitors (MKIs)
    • Anderson R., Jatoi A., Robert C., Wood L.S., Keating K., Lacouture M.E. Search for evidence-based approaches for the prevention and palliation of hand-foot skin reaction (HFSR) caused by multikinase inhibitors (MKIs). Oncologist 2009, 14:291-302.
    • (2009) Oncologist , vol.14 , pp. 291-302
    • Anderson, R.1    Jatoi, A.2    Robert, C.3    Wood, L.S.4    Keating, K.5    Lacouture, M.E.6
  • 2
    • 34548706022 scopus 로고    scopus 로고
    • A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue
    • Armes J., Chalder T., ddington-Hall J., Richardson A., Hotopf M. A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue. Cancer 2007, 110:1385-1395.
    • (2007) Cancer , vol.110 , pp. 1385-1395
    • Armes, J.1    Chalder, T.2    ddington-Hall, J.3    Richardson, A.4    Hotopf, M.5
  • 4
    • 47849105015 scopus 로고    scopus 로고
    • Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor
    • Autier J., Escudier B., Wechsler J., Spatz A., Robert C. Prospective study of the cutaneous adverse effects of sorafenib, a novel multikinase inhibitor. Archives of Dermatololgy 2008, 144:886-892.
    • (2008) Archives of Dermatololgy , vol.144 , pp. 886-892
    • Autier, J.1    Escudier, B.2    Wechsler, J.3    Spatz, A.4    Robert, C.5
  • 5
    • 34249891080 scopus 로고    scopus 로고
    • Renal cell cancer and sorafenib: skin toxicity and treatment outcome
    • Bajetta E., Procopio G., Verzoni E., Catena L., De D.S., Platania M., et al. Renal cell cancer and sorafenib: skin toxicity and treatment outcome. Tumori 2007, 93:201-203.
    • (2007) Tumori , vol.93 , pp. 201-203
    • Bajetta, E.1    Procopio, G.2    Verzoni, E.3    Catena, L.4    De, D.S.5    Platania, M.6
  • 7
    • 84857659229 scopus 로고    scopus 로고
    • Bayer Healthcare Pharmaceuticals, Available at:
    • Nexavar Approved for Liver Cancer in China 2008, Bayer Healthcare Pharmaceuticals, Available at:. http://pharma.bayer.com/scripts/pages/en/news_room/news_room/news_room64.php.
    • (2008) Nexavar Approved for Liver Cancer in China
  • 8
    • 38549180269 scopus 로고    scopus 로고
    • The Oncologist's View: targeted therapies in advanced renal cell carcinoma
    • Bellmunt J. The Oncologist's View: targeted therapies in advanced renal cell carcinoma. European Urology Supplements 2008, 7:55-62.
    • (2008) European Urology Supplements , vol.7 , pp. 55-62
    • Bellmunt, J.1
  • 10
    • 41149108218 scopus 로고    scopus 로고
    • Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma
    • Bhojani N., Jeldres C., Patard J.J., Perrotte P., Suardi N., Hutterer G., et al. Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma. European Urology 2008, 53:917-930.
    • (2008) European Urology , vol.53 , pp. 917-930
    • Bhojani, N.1    Jeldres, C.2    Patard, J.J.3    Perrotte, P.4    Suardi, N.5    Hutterer, G.6
  • 12
    • 0027479124 scopus 로고
    • Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial
    • Cascinu S., Fedeli A., Fedeli S.L., Catalano G. Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial. Journal of Clinical Oncology 1993, 11:148-151.
    • (1993) Journal of Clinical Oncology , vol.11 , pp. 148-151
    • Cascinu, S.1    Fedeli, A.2    Fedeli, S.L.3    Catalano, G.4
  • 13
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng A.L., Kang Y.K., Chen Z., Tsao C.J., Qin S., Kim J.S., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncology 2009, 10:25-34.
    • (2009) Lancet Oncology , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 14
    • 52049119905 scopus 로고    scopus 로고
    • Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review
    • Cherny N.I. Evaluation and management of treatment-related diarrhea in patients with advanced cancer: a review. Journal of Pain and Symptom Management 2008, 36:413-423.
    • (2008) Journal of Pain and Symptom Management , vol.36 , pp. 413-423
    • Cherny, N.I.1
  • 15
    • 38349102230 scopus 로고    scopus 로고
    • Risk of hand-foot skin reaction with sorafenib: a systematic review and meta-analysis
    • Chu D., Lacouture M.E., Fillos T., Wu S. Risk of hand-foot skin reaction with sorafenib: a systematic review and meta-analysis. Acta Oncologica 2008, 47:176-186.
    • (2008) Acta Oncologica , vol.47 , pp. 176-186
    • Chu, D.1    Lacouture, M.E.2    Fillos, T.3    Wu, S.4
  • 16
    • 65249140606 scopus 로고    scopus 로고
    • Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a meta-analysis
    • Chu D., Lacouture M.E., Weiner E., Wu S. Risk of hand-foot skin reaction with the multitargeted kinase inhibitor sunitinib in patients with renal cell and non-renal cell carcinoma: a meta-analysis. Clinical Genitourinary Cancer 2009, 7:11-19.
    • (2009) Clinical Genitourinary Cancer , vol.7 , pp. 11-19
    • Chu, D.1    Lacouture, M.E.2    Weiner, E.3    Wu, S.4
  • 17
    • 49849105731 scopus 로고    scopus 로고
    • Reader seeks clarification on hand-foot skin reaction
    • Clark M. Reader seeks clarification on hand-foot skin reaction. Clinical Journal of Oncology Nursing 2008, 12:395.
    • (2008) Clinical Journal of Oncology Nursing , vol.12 , pp. 395
    • Clark, M.1
  • 19
    • 0035165032 scopus 로고    scopus 로고
    • Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge
    • Comeau T.B., Epstein J.B., Migas C. Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Supportive Care in Cancer 2001, 9:575-580.
    • (2001) Supportive Care in Cancer , vol.9 , pp. 575-580
    • Comeau, T.B.1    Epstein, J.B.2    Migas, C.3
  • 21
    • 43249131404 scopus 로고    scopus 로고
    • Nursing intervention for fatigue during the treatment for cancer
    • de Nijs E.J., Ros W., Grijpdonck M.H. Nursing intervention for fatigue during the treatment for cancer. Cancer Nursing 2008, 31:191-206.
    • (2008) Cancer Nursing , vol.31 , pp. 191-206
    • de Nijs, E.J.1    Ros, W.2    Grijpdonck, M.H.3
  • 23
  • 26
    • 84857640589 scopus 로고    scopus 로고
    • Nexavar 200 mg film-coated tablets
    • Electronic Medicines Compendium, Available at:
    • Nexavar 200 mg film-coated tablets. Summary of Product Characteristics 2009, Electronic Medicines Compendium, Available at:. http://emc.medicines.org.uk/emc/industry/default.asp?page=displaydoc.asp%26documentid=7577.
    • (2009) Summary of Product Characteristics
  • 27
    • 84857651933 scopus 로고    scopus 로고
    • EONS guidelines implementation toolkit 1-20
    • EONS, Available at:
    • EONS guidelines implementation toolkit 1-20. Oral Mucositis Guidelines 2005, EONS, Available at:. http://www.cancernurse.eu/documents/EONSClinicalGuidelinesSection4-en.pdf.
    • (2005) Oral Mucositis Guidelines
  • 29
    • 35549006672 scopus 로고    scopus 로고
    • A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α vs. placebo/interferon-α as first-line therapy in metastatic renal cell carcinoma
    • ASCO meeting proceedings 25, abstract 3
    • Escudier B., Koralewski P., Pluzanska A., Ravaud A., Bracarda S., Szczylik C., et al. A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α vs. placebo/interferon-α as first-line therapy in metastatic renal cell carcinoma. Journal of Clinical Oncology 2007, ASCO meeting proceedings 25, abstract 3.
    • (2007) Journal of Clinical Oncology
    • Escudier, B.1    Koralewski, P.2    Pluzanska, A.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6
  • 30
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B., Pluzanska A., Koralewski P., Ravaud A., Bracarda S., Szczylik C., et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007, 370:2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6
  • 31
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Staehler M., et al. Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. Journal of Clinical Oncology 2009, 27:3312-3318.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 32
    • 38449111072 scopus 로고    scopus 로고
    • What kind of rash is it?: deciphering the dermatologic toxicities of biologic and targeted therapies
    • Esper P., Gale D., Muehlbauer P. What kind of rash is it?: deciphering the dermatologic toxicities of biologic and targeted therapies. Clinical Journal of Oncology Nursing 2007, 11:659-666.
    • (2007) Clinical Journal of Oncology Nursing , vol.11 , pp. 659-666
    • Esper, P.1    Gale, D.2    Muehlbauer, P.3
  • 35
    • 84856265295 scopus 로고    scopus 로고
    • Oral mucositis a side effect in tyrosin-kinase inhibitor therapy (sunitinib): the role of assessment of symptoms in evaluation of toxicity
    • Ferrari V., Sgotti D., Amoroso V., Valcamonico F., Grisanti S., Consoli F., et al. Oral mucositis a side effect in tyrosin-kinase inhibitor therapy (sunitinib): the role of assessment of symptoms in evaluation of toxicity. European Journal of Cancer 2009, 195(Suppl. 7).
    • (2009) European Journal of Cancer , vol.195 , Issue.SUPPL. 7
    • Ferrari, V.1    Sgotti, D.2    Amoroso, V.3    Valcamonico, F.4    Grisanti, S.5    Consoli, F.6
  • 37
    • 0027216417 scopus 로고
    • Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy
    • Gebbia V., Carreca I., Testa A., Valenza R., Curto G., Cannata G., et al. Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy. Anticancer Drugs 1993, 4:443-445.
    • (1993) Anticancer Drugs , vol.4 , pp. 443-445
    • Gebbia, V.1    Carreca, I.2    Testa, A.3    Valenza, R.4    Curto, G.5    Cannata, G.6
  • 38
    • 0028856952 scopus 로고
    • Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients
    • Geller R.B., Gilmore C.E., Dix S.P., Lin L.S., Topping D.L., Davidson T.G., et al. Randomized trial of loperamide versus dose escalation of octreotide acetate for chemotherapy-induced diarrhea in bone marrow transplant and leukemia patients. American Journal of Hematology 1995, 50:167-172.
    • (1995) American Journal of Hematology , vol.50 , pp. 167-172
    • Geller, R.B.1    Gilmore, C.E.2    Dix, S.P.3    Lin, L.S.4    Topping, D.L.5    Davidson, T.G.6
  • 39
    • 45949090411 scopus 로고    scopus 로고
    • Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial
    • Giralt J., Regadera J.P., Verges R., Romero J., de la Fuente I., Biete A., et al. Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial. International Journal of Radiation Oncology, Biology, Physics 2008, 71(4):1213-1219.
    • (2008) International Journal of Radiation Oncology, Biology, Physics , vol.71 , Issue.4 , pp. 1213-1219
    • Giralt, J.1    Regadera, J.P.2    Verges, R.3    Romero, J.4    de la Fuente, I.5    Biete, A.6
  • 40
    • 84857657273 scopus 로고    scopus 로고
    • Incidence and nursing management of hand foot skin reaction in patients treated with oral tyrosine kinase inhibitors for metastatic renal cell carcinoma
    • abstract
    • Graham S. Incidence and nursing management of hand foot skin reaction in patients treated with oral tyrosine kinase inhibitors for metastatic renal cell carcinoma. Oncology Nursing Forum 2007, 34:2165. abstract.
    • (2007) Oncology Nursing Forum , vol.34 , pp. 2165
    • Graham, S.1
  • 41
    • 34648813908 scopus 로고    scopus 로고
    • Managing side effects of angiogenesis inhibitors in renal cell carcinoma
    • Grunwald V., Heinzer H., Fiedler W. Managing side effects of angiogenesis inhibitors in renal cell carcinoma. Onkologie 2007, 30:519-524.
    • (2007) Onkologie , vol.30 , pp. 519-524
    • Grunwald, V.1    Heinzer, H.2    Fiedler, W.3
  • 44
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies
    • Hutson T.E., Figlin R.A., Kuhn J.G., Motzer R.J. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 2008, 13:1084-1096.
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3    Motzer, R.J.4
  • 45
    • 77955917461 scopus 로고    scopus 로고
    • Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase III TARGET
    • Hutson T.E., Bellmunt J., Porta C., Szczylik C., Staehler M., Nadel A., et al. Long-term safety of sorafenib in advanced renal cell carcinoma: Follow-up of patients from phase III TARGET. European Journal of Cancer 2010, 46:2432-2440.
    • (2010) European Journal of Cancer , vol.46 , pp. 2432-2440
    • Hutson, T.E.1    Bellmunt, J.2    Porta, C.3    Szczylik, C.4    Staehler, M.5    Nadel, A.6
  • 48
    • 0017364576 scopus 로고
    • Symposium on diarrhea. 1. Definition and mechanisms of diarrhea
    • Jeejeebhoy K.N. Symposium on diarrhea. 1. Definition and mechanisms of diarrhea. Canadian Medical Association Journal 1977, 116:737-739.
    • (1977) Canadian Medical Association Journal , vol.116 , pp. 737-739
    • Jeejeebhoy, K.N.1
  • 49
    • 78649888468 scopus 로고    scopus 로고
    • Practical management of tyrosine kinase inhibitor-associated side effects in GIST
    • Joensuu H., Trent J.C., Reichardt P. Practical management of tyrosine kinase inhibitor-associated side effects in GIST. Cancer Treatment Reviews 2011, 37:75-88.
    • (2011) Cancer Treatment Reviews , vol.37 , pp. 75-88
    • Joensuu, H.1    Trent, J.C.2    Reichardt, P.3
  • 52
    • 33749076303 scopus 로고    scopus 로고
    • Multitargeted agents for therapeutically challenging tumor: an introduction for oncology nurses
    • King C.R. Multitargeted agents for therapeutically challenging tumor: an introduction for oncology nurses. Oncology Nursing Society News 2006, 21(8 Suppl):57-58.
    • (2006) Oncology Nursing Society News , vol.21 , Issue.8 SUPPL , pp. 57-58
    • King, C.R.1
  • 54
    • 52949138886 scopus 로고    scopus 로고
    • Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib
    • Lacouture M.E., Reilly L.M., Gerami P., Guitart J. Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib. Annals of Oncology 2008, 19:1955-1961.
    • (2008) Annals of Oncology , vol.19 , pp. 1955-1961
    • Lacouture, M.E.1    Reilly, L.M.2    Gerami, P.3    Guitart, J.4
  • 55
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture M.E., Wu S., Robert C., Atkins M.B., Kong H.H., Guitart J., et al. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 2008, 13:1001-1011.
    • (2008) Oncologist , vol.13 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3    Atkins, M.B.4    Kong, H.H.5    Guitart, J.6
  • 56
    • 38649140477 scopus 로고    scopus 로고
    • FDA approves sorafenib for patients with inoperable liver cancer
    • Lang L. FDA approves sorafenib for patients with inoperable liver cancer. Gastroenterology 2008, 134:379.
    • (2008) Gastroenterology , vol.134 , pp. 379
    • Lang, L.1
  • 57
    • 71949112710 scopus 로고    scopus 로고
    • Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lee W.J., Lee J.L., Chang S.E., Lee M.W., Kang Y.K., Choi J.H., et al. Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib. British Journal of Dermatology 2009, 161:1045-1051.
    • (2009) British Journal of Dermatology , vol.161 , pp. 1045-1051
    • Lee, W.J.1    Lee, J.L.2    Chang, S.E.3    Lee, M.W.4    Kang, Y.K.5    Choi, J.H.6
  • 60
    • 70350539495 scopus 로고    scopus 로고
    • Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial
    • Lower E.E., Fleishman S., Cooper A., Zeldis J., Faleck H., Yu Z., et al. Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: a randomized clinical trial. Journal of Pain and Symptom Management 2009, 38:650-662.
    • (2009) Journal of Pain and Symptom Management , vol.38 , pp. 650-662
    • Lower, E.E.1    Fleishman, S.2    Cooper, A.3    Zeldis, J.4    Faleck, H.5    Yu, Z.6
  • 61
    • 58949096799 scopus 로고    scopus 로고
    • A systematic review of the scales used for the measurement of cancer-related fatigue (CRF)
    • Minton O., Stone P. A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Annals of Oncology 2008, 20:17-25.
    • (2008) Annals of Oncology , vol.20 , pp. 17-25
    • Minton, O.1    Stone, P.2
  • 65
    • 33846998406 scopus 로고    scopus 로고
    • The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial
    • Molassiotis A., Sylt P., Diggins H. The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial. Complementary Therapies in Medicine 2007, 15:228-237.
    • (2007) Complementary Therapies in Medicine , vol.15 , pp. 228-237
    • Molassiotis, A.1    Sylt, P.2    Diggins, H.3
  • 66
    • 84857656880 scopus 로고    scopus 로고
    • Managing side effects of targeted therapy and ensuring access to treatment
    • Available at:
    • Moore S.H. Managing side effects of targeted therapy and ensuring access to treatment. Oncology Nurses 30th Annual Congress 2006, Available at:. http://www.meniscus.com/rcc-targeted-tx/rcc-targeted-tx.pdf.
    • (2006) Oncology Nurses 30th Annual Congress
    • Moore, S.H.1
  • 67
    • 0031924595 scopus 로고    scopus 로고
    • Phase I trial of subcutaneous recombinant human interleukin-12 in patients with advanced renal cell carcinoma
    • Motzer R.J., Rakhit A., Schwartz L.H., Olencki T., Malone T.M., Sandstrom K., et al. Phase I trial of subcutaneous recombinant human interleukin-12 in patients with advanced renal cell carcinoma. Clinical Cancer Research 1998, 4:1183-1191.
    • (1998) Clinical Cancer Research , vol.4 , pp. 1183-1191
    • Motzer, R.J.1    Rakhit, A.2    Schwartz, L.H.3    Olencki, T.4    Malone, T.M.5    Sandstrom, K.6
  • 68
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Oudard S., et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 2009, 27:3584-3590.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 70
    • 33745538721 scopus 로고    scopus 로고
    • Octreotide long-acting formulation (LAR) in chronic loperamide-refractory diarrhea not related to cancer treatment
    • Mystakidou K., Katsouda E., Tsilika E., Smyrniotis V., Vassiliou I., Tsiatas M., et al. Octreotide long-acting formulation (LAR) in chronic loperamide-refractory diarrhea not related to cancer treatment. Anticancer Research 2006, 26(3B):2325-2328.
    • (2006) Anticancer Research , vol.26 , Issue.3 B , pp. 2325-2328
    • Mystakidou, K.1    Katsouda, E.2    Tsilika, E.3    Smyrniotis, V.4    Vassiliou, I.5    Tsiatas, M.6
  • 71
    • 70350238222 scopus 로고    scopus 로고
    • National Cancer Institute, Available at:
    • Common Terminology Criteria for Adverse Events v4.0 (CTCAE) 2009, National Cancer Institute, Available at:. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm.
    • (2009) Common Terminology Criteria for Adverse Events v4.0 (CTCAE)
  • 72
    • 84857655054 scopus 로고    scopus 로고
    • National Cancer Institute, Available at:
    • Fatigue 2010, National Cancer Institute, Available at:. http://www.nccn.org/professionals/physician_gls/PDF/fatigue.pdf.
    • (2010) Fatigue
  • 73
    • 21344435247 scopus 로고    scopus 로고
    • The assessment and management of cancer treatment-related diarrhea
    • O'Brien B.E., Kaklamani V.G., Benson A.B. The assessment and management of cancer treatment-related diarrhea. Clinical Colorectal Cancer 2005, 4(6):375-381.
    • (2005) Clinical Colorectal Cancer , vol.4 , Issue.6 , pp. 375-381
    • O'Brien, B.E.1    Kaklamani, V.G.2    Benson, A.B.3
  • 74
    • 35348904439 scopus 로고    scopus 로고
    • Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study
    • Osterlund P., Ruotsalainen T., Korpela R., Saxelin M., Ollus A., Valta P., et al. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study. British Journal Cancer 2007, 97:1028-1034.
    • (2007) British Journal Cancer , vol.97 , pp. 1028-1034
    • Osterlund, P.1    Ruotsalainen, T.2    Korpela, R.3    Saxelin, M.4    Ollus, A.5    Valta, P.6
  • 75
    • 0026094482 scopus 로고
    • Validation of an index of the quality of review articles
    • Oxman A., Guyatt G. Validation of an index of the quality of review articles. Journal of Clinical Epidemiology 1991, 44:1271-1278.
    • (1991) Journal of Clinical Epidemiology , vol.44 , pp. 1271-1278
    • Oxman, A.1    Guyatt, G.2
  • 77
    • 38349030422 scopus 로고    scopus 로고
    • Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib
    • Porta C., Paglino C., Imarisio I., Bonomi L. Uncovering Pandora's vase: the growing problem of new toxicities from novel anticancer agents. The case of sorafenib and sunitinib. Clinical and Experimental Medicine 2007, 7:127-134.
    • (2007) Clinical and Experimental Medicine , vol.7 , pp. 127-134
    • Porta, C.1    Paglino, C.2    Imarisio, I.3    Bonomi, L.4
  • 78
    • 64549104195 scopus 로고    scopus 로고
    • Tolerability of first-line therapy for metastatic renal cell carcinoma
    • Porta C., Szczylik C. Tolerability of first-line therapy for metastatic renal cell carcinoma. Cancer Treatment Reviews 2009, 35:297-307.
    • (2009) Cancer Treatment Reviews , vol.35 , pp. 297-307
    • Porta, C.1    Szczylik, C.2
  • 79
    • 0033024796 scopus 로고    scopus 로고
    • Cancer-related fatigue: guidelines for evaluation and management
    • Portenoy R.K., Itri L.M. Cancer-related fatigue: guidelines for evaluation and management. Oncologist 1999, 4:1-10.
    • (1999) Oncologist , vol.4 , pp. 1-10
    • Portenoy, R.K.1    Itri, L.M.2
  • 80
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain M.J., Eisen T., Stadler W.M., Flaherty K.T., Kaye S.B., Rosner G.L., et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 2006, 24:2505-2512.
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3    Flaherty, K.T.4    Kaye, S.B.5    Rosner, G.L.6
  • 82
    • 67650327598 scopus 로고    scopus 로고
    • Metastatic renal cell carcinoma: many treatment options, one patient
    • Rini B.I. Metastatic renal cell carcinoma: many treatment options, one patient. Journal of Clinical Oncology 2009, 27:3225-3234.
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 3225-3234
    • Rini, B.I.1
  • 85
    • 68849124283 scopus 로고    scopus 로고
    • Toxicity associated with the long-term use of targeted therapies in patients with advanced renal cell carcinoma
    • Shepard D.R., Garcia J.A. Toxicity associated with the long-term use of targeted therapies in patients with advanced renal cell carcinoma. Expert Reviews in Anticancer Therapy 2009, 9:795-805.
    • (2009) Expert Reviews in Anticancer Therapy , vol.9 , pp. 795-805
    • Shepard, D.R.1    Garcia, J.A.2
  • 86
    • 6944250200 scopus 로고    scopus 로고
    • Fatigue in cancer patients receiving chemotherapy: an analysis of published studies
    • Spazzapan S., Bearz A., Tirelli U. Fatigue in cancer patients receiving chemotherapy: an analysis of published studies. Annals of Oncology 2004, 15:1576.
    • (2004) Annals of Oncology , vol.15 , pp. 1576
    • Spazzapan, S.1    Bearz, A.2    Tirelli, U.3
  • 87
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
    • Sternberg C.N., Davis I.D., Mardiak J., Szczylik C., Lee E., Wagstaff J., et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. Journal of Clinical Oncology 2010, 28:1061-1068.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 88
    • 0036512736 scopus 로고    scopus 로고
    • The measurement, causes and effective management of cancer-related fatigue
    • Stone P. The measurement, causes and effective management of cancer-related fatigue. International Journal of Palliative Nursing 2002, 8:120-128.
    • (2002) International Journal of Palliative Nursing , vol.8 , pp. 120-128
    • Stone, P.1
  • 90
    • 84984775323 scopus 로고    scopus 로고
    • Several therapies may prevent or reduce the severity of oral mucositis associated with cancer treatment
    • Sutherland S. Several therapies may prevent or reduce the severity of oral mucositis associated with cancer treatment. Evidence Based Dentistry 2006, 7:104-105.
    • (2006) Evidence Based Dentistry , vol.7 , pp. 104-105
    • Sutherland, S.1
  • 91
    • 35348870651 scopus 로고    scopus 로고
    • Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma
    • Topkan E., Karaoglu A. Octreotide in the management of chemoradiotherapy-induced diarrhea refractory to loperamide in patients with rectal carcinoma. Oncology 2006, 71:354-360.
    • (2006) Oncology , vol.71 , pp. 354-360
    • Topkan, E.1    Karaoglu, A.2
  • 92
    • 85047693931 scopus 로고    scopus 로고
    • Overview of chemotherapy-induced diarrhea
    • Viele C.S. Overview of chemotherapy-induced diarrhea. Seminars in Oncology Nursing 2003, 19(4 Suppl. 3):2-5.
    • (2003) Seminars in Oncology Nursing , vol.19 , Issue.4 SUPPL. 3 , pp. 2-5
    • Viele, C.S.1
  • 94
    • 84857645799 scopus 로고    scopus 로고
    • Experiences in the treatment of advanced hepatocellular carcinoma (HCC) with sorafenib beyond the SHARP trial - Management of side effects
    • Weinmann A., Schulze-Bergkamen H., Schuchmann M., Düber C., Otto G., Galle P., et al. Experiences in the treatment of advanced hepatocellular carcinoma (HCC) with sorafenib beyond the SHARP trial - Management of side effects. Zeitschrift für Gastroenterologie 2008, 10.1055/s-2008-1037650.
    • (2008) Zeitschrift für Gastroenterologie
    • Weinmann, A.1    Schulze-Bergkamen, H.2    Schuchmann, M.3    Düber, C.4    Otto, G.5    Galle, P.6
  • 95
    • 33751234523 scopus 로고    scopus 로고
    • Managing the side effects of sorafenib and sunitinib
    • Wood L. Managing the side effects of sorafenib and sunitinib. Community Oncology 2006, 3:558-562.
    • (2006) Community Oncology , vol.3 , pp. 558-562
    • Wood, L.1
  • 96
    • 84856154294 scopus 로고    scopus 로고
    • Targeted therapies for advanced renal cell carcinoma: part II - sorafenib
    • November/December
    • Wood L.S. Targeted therapies for advanced renal cell carcinoma: part II - sorafenib. Oncology Nursing News 2007, 37-38. November/December.
    • (2007) Oncology Nursing News , pp. 37-38
    • Wood, L.S.1
  • 97
    • 38449101219 scopus 로고    scopus 로고
    • Sorafenib: a promising new targeted therapy for renal cell carcinoma
    • Wood L.S., Manchen B. Sorafenib: a promising new targeted therapy for renal cell carcinoma. Clinical Journal of Oncology Nursing 2007, 11:649-656.
    • (2007) Clinical Journal of Oncology Nursing , vol.11 , pp. 649-656
    • Wood, L.S.1    Manchen, B.2
  • 98
    • 77649213517 scopus 로고    scopus 로고
    • Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors
    • Wood L.S., Lemont H., Jatoi A., Lacouture M.E., Robert C., Keating K., et al. Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors. Community Oncology 2010, 7:23-29.
    • (2010) Community Oncology , vol.7 , pp. 23-29
    • Wood, L.S.1    Lemont, H.2    Jatoi, A.3    Lacouture, M.E.4    Robert, C.5    Keating, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.