TGF-β1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity

Journal of Immunology

Volumn 172, Issue 11, 2004, Pages 7015-7023

  Kim, Won Ki ^a,b   Hwang, So Young ^c   Oh, Eok Soo ^b   Piao, Hua Zi ^a,b   Kim, Ki Wan ^c   Han, Inn Oc ^c  

^a Ewha Womans University School of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYTOKINE; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 6; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; CHROMONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MORPHOLINE DERIVATIVE; NEUROPROTECTIVE AGENT; NITRIC OXIDE; TGFB1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; BRAIN DISEASE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; IMMUNOBLOTTING; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CHROMONES; CYTOKINES; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MORPHOLINES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2442716392     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.7015     Document Type: Article

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