Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Neuron

Volumn 84, Issue 1, 2014, Pages 63-77

  Liu, Chia Chen ^a,d   Tsai, Chih Wei ^a   Deak, Ferenc ^a,f   Rogers, Justin ^a   Penuliar, Michael ^a   Sung, You Me ^e   Maher, James N ^e   Fu, Yuan ^a   Li, Xia ^a   Xu, Huaxi ^d   Estus, Steven ^b   Hoe, Hyang Sook ^e,g   Fryer, John D ^a,c   Kanekiyo, Takahisa ^a   Bu, Guojun ^a,c,d  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c MAYO CLINIC   (United States)

^d XIAMEN UNIVERSITY   (China)

^e GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^g Korea Brain Research Institute (KBRI)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LRP6 PROTEIN, HUMAN;

AGED; ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; HUMAN TISSUE; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; RECEPTOR DOWN REGULATION; RESPONSE TIME; STIMULUS RESPONSE; SYNAPTIC TRANSMISSION; TASK PERFORMANCE; TRANSNEURONAL DEGENERATION; WNT SIGNALING PATHWAY; ANIMAL; DEFICIENCY; FEMALE; HEK293 CELL LINE; HIPPOCAMPUS; KNOCKOUT MOUSE; MALE; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY; SYNAPSE; TRANSGENIC MOUSE; TUMOR CELL LINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE, TUMOR; FEMALE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; SYNAPSES; WNT SIGNALING PATHWAY;

EID: 84907985969     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.08.048     Document Type: Article

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