Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Nature Communications

Volumn 8, Issue , 2017, Pages

  Liu, Chun Hua ^a,b   Gong, Zheng ^a   Liang, Zong Lai ^a   Liu, Zhi Xin ^a   Yang, Fan ^a   Sun, Yu Jing ^a   Ma, Ming Liang ^a   Wang, Yi Jing ^a   Ji, Chao Ran ^a   Wang, Yu Hong ^a   Wang, Mei Jie ^a   Cui, Fu Ai ^a   Lin, Amy ^a   Zheng, Wen Shuai ^a   He, Dong Fang ^a   Qu, Chang Xiu ^a   Xiao, Peng ^a   Liu, Chuan Yong ^a   Thomsen, Alex R B ^c   Cahill, Thomas Joseph ^c   Kahsai, Alem W ^c   Yi, Fan ^a   Xiao, Kun Hong ^c,d   Xue, Tian ^e   Zhou, Zhuan ^f   Yu, Xiao ^a   Sun, Jin Peng ^a   more..

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TAISHAN MEDICAL UNIVERSITY   (China)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^f PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; ANGIOTENSIN 2 RECEPTOR; BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; CALCIUM; CALCIUM CHANNEL L TYPE; CATECHOLAMINE; EPINEPHRINE; G PROTEIN COUPLED RECEPTOR; GLUTATHIONE TRANSFERASE; HORMONE RECEPTOR STIMULATING AGENT; NORADRENALIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; RUTHENIUM RED; SNX 482; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; TRV 120027; UNCLASSIFIED DRUG; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ANGIOTENSIN 1 RECEPTOR; ESTRANE DERIVATIVE; LIGAND; OLIGOPEPTIDE; PHOSPHOLIPASE C GAMMA; SARCOSINE-ARGINYL-VALYL-TYROSYL-ISOLEUCYL-HISTIDYL-PROLYL-ALANINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

CATION; PHYSIOLOGICAL RESPONSE; PLASMA; PROTEIN; SECRETION;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CATECHOLAMINE RELEASE; CHROMAFFIN CELL; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; HORMONE RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR POTENTIAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CHEMISTRY; DRUG EFFECT; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; SECRETION (PROCESS);

ANIMALS; BETA-ARRESTIN 1; BETA-ARRESTIN 2; CALCIUM; CATECHOLAMINES; ESTRENES; HEK293 CELLS; HUMANS; LIGANDS; MICE, KNOCKOUT; OLIGOPEPTIDES; PHOSPHOLIPASE C GAMMA; PYRROLIDINONES; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION; TRPC CATION CHANNELS;

EID: 85012050956     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14335     Document Type: Article

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