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Volumn 7, Issue , 2017, Pages

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

(19)  Navarro, Judith a   Gozalbo López, Beatriz b   Méndez, Andrea C b   Dantzer, Françoise c   Schreiber, Valérie c   Martínez, Carlos c,d   Arana, David M b   Farrés, Jordi a   Revilla Nuin, Beatriz d,e   Bueno, María F b   Ampurdanés, Coral a   Galindo Campos, Miguel A a   Knobel, Philip A f   Segura Bayona, Sandra f   Martin Caballero, Juan g   Stracker, Travis H g   Aparicio, Pedro h   Del Val, Margarita b   Yélamos, José a,e  


Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PARP1 PROTEIN, MOUSE; PARP2 PROTEIN, MOUSE;

EID: 85012005621     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep41962     Document Type: Article
Times cited : (53)

References (62)
  • 1
    • 17444396980 scopus 로고    scopus 로고
    • Molecular genetics of T cell development
    • Rothenberg, E. V. & Taghon, T. Molecular genetics of T cell development. Annu. Rev. Immunol. 23, 601-649 (2005).
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 601-649
    • Rothenberg, E.V.1    Taghon, T.2
  • 2
    • 84927652023 scopus 로고    scopus 로고
    • Dynamic tuning of lymphocytes: Physiological basis, mechanisms, and function
    • Grossman, Z. & Paul, W. E. Dynamic tuning of lymphocytes: physiological basis, mechanisms, and function. Annu. Rev. Immunol. 33, 677-713 (2015).
    • (2015) Annu. Rev. Immunol. , vol.33 , pp. 677-713
    • Grossman, Z.1    Paul, W.E.2
  • 3
    • 57449097558 scopus 로고    scopus 로고
    • Homeostasis of naive and memory T cells
    • Surh, C. D. & Sprent, J. Homeostasis of naive and memory T cells. Immunity. 29, 848-862 (2008).
    • (2008) Immunity , vol.29 , pp. 848-862
    • Surh, C.D.1    Sprent, J.2
  • 4
    • 0038003943 scopus 로고    scopus 로고
    • P53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest
    • Baek, K. H. et al. p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J. Leukoc. Biol. 73, 850-861 (2003).
    • (2003) J. Leukoc. Biol , vol.73 , pp. 850-861
    • Baek, K.H.1
  • 5
    • 84949257819 scopus 로고    scopus 로고
    • DNA repair cofactors ATMIN and NBS1 are required to suppress t cell activation
    • Prochazkova, J. et al. DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation. PLoS. Genet. 11, e1005645 (2015).
    • (2015) PLoS. Genet. , vol.11 , pp. e1005645
    • Prochazkova, J.1
  • 7
    • 84937604540 scopus 로고    scopus 로고
    • The promise of proteomics for the study of adp-ribosylation
    • Daniels, C. M., Ong, S. E. & Leung, A. K. The Promise of Proteomics for the Study of ADP-Ribosylation. Mol. Cell 58, 911-924 (2015).
    • (2015) Mol. Cell , vol.58 , pp. 911-924
    • Daniels, C.M.1    Ong, S.E.2    Leung, A.K.3
  • 8
    • 84937555760 scopus 로고    scopus 로고
    • Biology of poly(adp-ribose) polymerases: The factotums of cell maintenance
    • Bai, P. Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance. Mol. Cell 58, 947-958 (2015).
    • (2015) Mol. Cell , vol.58 , pp. 947-958
    • Bai, P.1
  • 9
  • 10
    • 84947751230 scopus 로고    scopus 로고
    • Targeting the DNA damage response in cancer
    • O'Connor, M. J. Targeting the DNA Damage Response in Cancer. Mol. Cell 60, 547-560 (2015).
    • (2015) Mol. Cell , vol.60 , pp. 547-560
    • O'Connor, M.J.1
  • 11
    • 77950669700 scopus 로고    scopus 로고
    • Investigation of PARP-1, PARP-2, and parg interactomes by affinity-purification mass spectrometry
    • Isabelle, M. et al. Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry. Proteome. Sci. 8, 22 (2010).
    • (2010) Proteome. Sci. , vol.8 , pp. 22
    • Isabelle, M.1
  • 12
    • 80052961045 scopus 로고    scopus 로고
    • Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays
    • Troiani, S. et al. Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays. FEBS J. 278, 3676-3687 (2011).
    • (2011) FEBS J. , vol.278 , pp. 3676-3687
    • Troiani, S.1
  • 13
    • 84960493553 scopus 로고    scopus 로고
    • PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
    • Riccio, A. A., Cingolani, G. & Pascal, J. M. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res. (2015).
    • (2015) Nucleic Acids Res
    • Riccio, A.A.1    Cingolani, G.2    Pascal, J.M.3
  • 14
    • 84974575150 scopus 로고    scopus 로고
    • Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
    • Gibson, B. A. et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 353, 45-50 (2016).
    • (2016) Science , vol.353 , pp. 45-50
    • Gibson, B.A.1
  • 15
    • 33749530027 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis i and spermiogenesis
    • Dantzer, F. et al. Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc. Natl. Acad. Sci. USA 103, 14854-14859 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14854-14859
    • Dantzer, F.1
  • 16
    • 84883750410 scopus 로고    scopus 로고
    • Parp-2 is required to maintain hematopoiesis following sublethal gamma-irradiation in mice
    • Farres, J. et al. Parp-2 is required to maintain hematopoiesis following sublethal gamma-irradiation in mice. Blood 122, 44-54 (2013).
    • (2013) Blood , vol.122 , pp. 44-54
    • Farres, J.1
  • 17
    • 84930764291 scopus 로고    scopus 로고
    • PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors
    • Farres, J. et al. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death. Differ. 22, 1144-1157 (2015).
    • (2015) Cell Death. Differ. , vol.22 , pp. 1144-1157
    • Farres, J.1
  • 18
    • 66049143898 scopus 로고    scopus 로고
    • Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
    • Robert, I., Dantzer, F. & Reina-San-Martin, B. Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination. J. Exp. Med. 206, 1047-1056 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 1047-1056
    • Robert, I.1    Dantzer, F.2    Reina-San-Martin, B.3
  • 19
    • 33748929288 scopus 로고    scopus 로고
    • PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes
    • Yelamos, J. et al. PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes. EMBO J. 25, 4350-4360 (2006).
    • (2006) EMBO J. , vol.25 , pp. 4350-4360
    • Yelamos, J.1
  • 20
    • 77952426818 scopus 로고    scopus 로고
    • Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice
    • Nicolas, L. et al. Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice. Oncogene 29, 2877-2883 (2010).
    • (2010) Oncogene , vol.29 , pp. 2877-2883
    • Nicolas, L.1
  • 21
    • 84873410910 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease
    • Mehrotra, P. et al. Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates T(H)2 differentiation and allergic airway disease. J. Allergy Clin. Immunol. 131, 521-531 (2013).
    • (2013) J. Allergy Clin. Immunol. , vol.131 , pp. 521-531
    • Mehrotra, P.1
  • 22
    • 39149088997 scopus 로고    scopus 로고
    • Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells
    • Valdor, R. et al. Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells. Mol. Immunol. 45, 1863-1871 (2008).
    • (2008) Mol. Immunol. , vol.45 , pp. 1863-1871
    • Valdor, R.1
  • 23
    • 84887365846 scopus 로고    scopus 로고
    • PARP-1 regulates expression of TGF-beta receptors in T cells
    • Zhang, P. et al. PARP-1 regulates expression of TGF-beta receptors in T cells. Blood 122, 2224-2232 (2013).
    • (2013) Blood , vol.122 , pp. 2224-2232
    • Zhang, P.1
  • 24
    • 84948467935 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells
    • Luo, X. et al. Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. J. Biol. Chem. 290, 28675-28682 (2015).
    • (2015) J. Biol. Chem. , vol.290 , pp. 28675-28682
    • Luo, X.1
  • 25
    • 43449100054 scopus 로고    scopus 로고
    • Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation
    • Saenz, L. et al. Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation. BMC. Genomics 9, 171 (2008).
    • (2008) BMC. Genomics , vol.9 , pp. 171
    • Saenz, L.1
  • 26
    • 0038219534 scopus 로고    scopus 로고
    • Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
    • Menissier de, M. J. et al. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J. 22, 2255-2263 (2003).
    • (2003) EMBO J. , vol.22 , pp. 2255-2263
    • De Menissier, M.J.1
  • 27
    • 0041381363 scopus 로고    scopus 로고
    • Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
    • Seder, R. A. & Ahmed, R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 4, 835-842 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 835-842
    • Seder, R.A.1    Ahmed, R.2
  • 28
    • 77951634464 scopus 로고    scopus 로고
    • Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency
    • Nasta, F., Laudisi, F., Sambucci, M., Rosado, M. M. & Pioli, C. Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency. J. Immunol. 184, 3470-3477 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3470-3477
    • Nasta, F.1    Laudisi, F.2    Sambucci, M.3    Rosado, M.M.4    Pioli, C.5
  • 29
    • 77049119468 scopus 로고    scopus 로고
    • Auto-reconstitution of the T-cell compartment by radioresistant hematopoietic cells following lethal irradiation and bone marrow transplantation
    • Bosco, N., Swee, L. K., Benard, A., Ceredig, R. & Rolink, A. Auto-reconstitution of the T-cell compartment by radioresistant hematopoietic cells following lethal irradiation and bone marrow transplantation. Exp. Hematol. 38, 222-232 (2010).
    • (2010) Exp. Hematol. , vol.38 , pp. 222-232
    • Bosco, N.1    Swee, L.K.2    Benard, A.3    Ceredig, R.4    Rolink, A.5
  • 30
    • 4444354779 scopus 로고    scopus 로고
    • Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease
    • Anderson, B. E. et al. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104, 1565-1573 (2004).
    • (2004) Blood , vol.104 , pp. 1565-1573
    • Anderson, B.E.1
  • 31
    • 0037124329 scopus 로고    scopus 로고
    • Multiple choices: Regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15
    • Prlic, M., Lefrancois, L. & Jameson, S. C. Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J. Exp. Med. 195, F49-F52 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. F49-F52
    • Prlic, M.1    Lefrancois, L.2    Jameson, S.C.3
  • 32
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S. M. et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4, 1191-1198 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 1191-1198
    • Kaech, S.M.1
  • 33
    • 79958290116 scopus 로고    scopus 로고
    • NKAP is required for T cell maturation and acquisition of functional competency
    • Hsu, F. C., Pajerowski, A. G., Nelson-Holte, M., Sundsbak, R. & Shapiro, V. S. NKAP is required for T cell maturation and acquisition of functional competency. J. Exp. Med. 208, 1291-1304 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1291-1304
    • Hsu, F.C.1    Pajerowski, A.G.2    Nelson-Holte, M.3    Sundsbak, R.4    Shapiro, V.S.5
  • 34
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 1955-1960
    • Peschon, J.J.1
  • 35
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptordeficient mice
    • Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. & Weissman, I. L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptordeficient mice. Cell 89, 1033-1041 (1997).
    • (1997) Cell , vol.89 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 36
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty, S. T follicular helper cell differentiation, function, and roles in disease. Immunity. 41, 529-542 (2014).
    • (2014) Immunity. , vol.41 , pp. 529-542
    • Crotty, S.1
  • 37
    • 77956806285 scopus 로고    scopus 로고
    • Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response
    • Yuen, T. J. et al. Analysis of A47, an immunoprevalent protein of vaccinia virus, leads to a reevaluation of the total antiviral CD8+ T cell response. J. Virol. 84, 10220-10229 (2010).
    • (2010) J. Virol. , vol.84 , pp. 10220-10229
    • Yuen, T.J.1
  • 38
    • 84880691370 scopus 로고    scopus 로고
    • N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation
    • Iborra, S. et al. N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation. J. Exp. Med. 210, 1463-1479 (2013).
    • (2013) J. Exp. Med , vol.210 , pp. 1463-1479
    • Iborra, S.1
  • 39
    • 2442624472 scopus 로고    scopus 로고
    • Cellular and humoral immunity against vaccinia virus infection of mice
    • Xu, R., Johnson, A. J., Liggitt, D. & Bevan, M. J. Cellular and humoral immunity against vaccinia virus infection of mice. J. Immunol. 172, 6265-6271 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 6265-6271
    • Xu, R.1    Johnson, A.J.2    Liggitt, D.3    Bevan, M.J.4
  • 40
    • 84919459597 scopus 로고    scopus 로고
    • CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization
    • Fang, M., Remakus, S., Roscoe, F., Ma, X. & Sigal, L. J. CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization. J. Virol. 89, 776-783 (2015).
    • (2015) J. Virol. , vol.89 , pp. 776-783
    • Fang, M.1    Remakus, S.2    Roscoe, F.3    Ma, X.4    Sigal, L.J.5
  • 41
    • 0036672918 scopus 로고    scopus 로고
    • Maintaining the norm: T-cell homeostasis
    • Jameson, S. C. Maintaining the norm: T-cell homeostasis. Nat. Rev. Immunol. 2, 547-556 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 547-556
    • Jameson, S.C.1
  • 42
    • 0030667434 scopus 로고    scopus 로고
    • Integrating genetic approaches into the discovery of anticancer drugs
    • Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating genetic approaches into the discovery of anticancer drugs. Science 278, 1064-1068 (1997).
    • (1997) Science , vol.278 , pp. 1064-1068
    • Hartwell, L.H.1    Szankasi, P.2    Roberts, C.J.3    Murray, A.W.4    Friend, S.H.5
  • 43
    • 84881096188 scopus 로고    scopus 로고
    • Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system
    • Sinclair, C., Bains, I., Yates, A. J. & Seddon, B. Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc. Natl. Acad. Sci. USA 110, E2905-E2914 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E2905-E2914
    • Sinclair, C.1    Bains, I.2    Yates, A.J.3    Seddon, B.4
  • 44
    • 0033180491 scopus 로고    scopus 로고
    • The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
    • Ernst, B., Lee, D. S., Chang, J. M., Sprent, J. & Surh, C. D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity. 11, 173-181 (1999).
    • (1999) Immunity , vol.11 , pp. 173-181
    • Ernst, B.1    Lee, D.S.2    Chang, J.M.3    Sprent, J.4    Surh, C.D.5
  • 45
    • 84898665746 scopus 로고    scopus 로고
    • Differential kinetics of antigen dependency of CD4+ and CD8+ T cells
    • Rabenstein, H. et al. Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. J. Immunol. 192, 3507-3517 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 3507-3517
    • Rabenstein, H.1
  • 46
    • 0034698828 scopus 로고    scopus 로고
    • Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells
    • Cho, B. K., Rao, V. P., Ge, Q., Eisen, H. N. & Chen, J. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J. Exp. Med. 192, 549-556 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 549-556
    • Cho, B.K.1    Rao, V.P.2    Ge, Q.3    Eisen, H.N.4    Chen, J.5
  • 47
    • 84937044948 scopus 로고    scopus 로고
    • PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function
    • Ghonim, M. A. et al. PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function. J. Transl. Med. 13, 225 (2015).
    • (2015) J. Transl. Med. , vol.13 , pp. 225
    • Ghonim, M.A.1
  • 48
    • 84888881969 scopus 로고    scopus 로고
    • Effects of PARP-1 deficiency on Th1 and Th2 cell differentiation
    • Sambucci, M. et al. Effects of PARP-1 deficiency on Th1 and Th2 cell differentiation. ScientificWorldJournal. 2013, 375024 (2013).
    • (2013) ScientificWorldJournal. , vol.2013 , pp. 375024
    • Sambucci, M.1
  • 49
    • 69249158350 scopus 로고    scopus 로고
    • Non-equilibrium and differential function between intraepithelial and lamina propria virus-specific TCRalphabeta(+) CD8alphabeta(+) T cells in the small intestinal mucosa
    • Isakov, D., Dzutsev, A., Belyakov, I. M. & Berzofsky, J. A. Non-equilibrium and differential function between intraepithelial and lamina propria virus-specific TCRalphabeta(+) CD8alphabeta(+) T cells in the small intestinal mucosa. Mucosal. Immunol. 2, 450-461 (2009).
    • (2009) Mucosal. Immunol. , vol.2 , pp. 450-461
    • Isakov, D.1    Dzutsev, A.2    Belyakov, I.M.3    Berzofsky, J.A.4
  • 50
    • 33645530402 scopus 로고    scopus 로고
    • HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death
    • Sibon, D. et al. HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J. Clin. Invest 116, 974-983 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 974-983
    • Sibon, D.1
  • 51
    • 84940585634 scopus 로고    scopus 로고
    • Genomic landscape of cutaneous T cell lymphoma
    • Choi, J. et al. Genomic landscape of cutaneous T cell lymphoma. Nat. Genet. 47, 1011-1019 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 1011-1019
    • Choi, J.1
  • 52
    • 84895829862 scopus 로고    scopus 로고
    • Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas
    • Palomero, T. et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat. Genet. 46, 166-170 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 166-170
    • Palomero, T.1
  • 53
    • 3543010169 scopus 로고    scopus 로고
    • Life, death, and tax: Role of HTLV-I oncoprotein in genetic instability and cellular transformation
    • Jeang, K. T., Giam, C. Z., Majone, F. & Aboud, M. Life, death, and tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation. J. Biol. Chem. 279, 31991-31994 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 31991-31994
    • Jeang, K.T.1    Giam, C.Z.2    Majone, F.3    Aboud, M.4
  • 54
    • 78649321855 scopus 로고    scopus 로고
    • The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
    • Weston, V. J. et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood 116, 4578-4587 (2010).
    • (2010) Blood , vol.116 , pp. 4578-4587
    • Weston, V.J.1
  • 55
    • 84903707964 scopus 로고    scopus 로고
    • Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines
    • Kubota, E. et al. Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Cell Cycle 13, 2129-2137 (2014).
    • (2014) Cell Cycle , vol.13 , pp. 2129-2137
    • Kubota, E.1
  • 56
    • 84861907790 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53
    • Williamson, C. T. et al. Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. EMBO Mol. Med. 4, 515-527 (2012).
    • (2012) EMBO Mol. Med. , vol.4 , pp. 515-527
    • Williamson, C.T.1
  • 57
    • 84959469777 scopus 로고    scopus 로고
    • TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
    • Moudry, P. et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J. Cell Biol. 212, 281-288 (2016).
    • (2016) J. Cell Biol. , vol.212 , pp. 281-288
    • Moudry, P.1
  • 58
    • 0040984333 scopus 로고    scopus 로고
    • Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
    • de Murcia, J. M. et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA 94, 7303-7307 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7303-7307
    • De Murcia, J.M.1
  • 59
    • 18244365863 scopus 로고    scopus 로고
    • A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
    • Lee, P. P. et al. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity. 15, 763-774 (2001).
    • (2001) Immunity , vol.15 , pp. 763-774
    • Lee, P.P.1
  • 60
    • 0031844311 scopus 로고    scopus 로고
    • XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    • Masson, M. et al. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell Biol. 18, 3563-3571 (1998).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3563-3571
    • Masson, M.1
  • 61
    • 33746132748 scopus 로고    scopus 로고
    • A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus
    • Moutaftsi, M. et al. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat. Biotechnol. 24, 817-819 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 817-819
    • Moutaftsi, M.1
  • 62
    • 70449713909 scopus 로고    scopus 로고
    • Furin-processed antigens targeted to the secretory route elicit functional TAP1/?CD8+ T lymphocytes in vivo
    • Medina, F. et al. Furin-processed antigens targeted to the secretory route elicit functional TAP1/?CD8+ T lymphocytes in vivo. J. Immunol. 183, 4639-4647 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 4639-4647
    • Medina, F.1


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