TOP BP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Journal of Cell Biology

Volumn 212, Issue 3, 2016, Pages 281-288

  Moudry, Pavel ^a,b   Watanabe, Kenji ^a   Wolanin, Kamila M ^a   Bartkova, Jirina ^a,g   Wassing, Isabel E ^c   Watanabe, Sugiko ^a,h   Strauss, Robert ^a   Pedersen, Rune Troelsgaard ^d   Oestergaard, Vibe H ^d   Lisby, Michael ^d   Andújar Sánchez, Miguel ^f   Maya Mendoza, Apolinar ^a   Esashi, Fumiko ^c   Lukas, Jiri ^a,e   Bartek, Jiri ^a,b,g  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e University of Copenhagen   (Denmark)

^f University Hospital   (Spain)

^g KAROLINSKA INSTITUTE   (Sweden)

^h KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; BINDING PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLAPARIB; POLO LIKE KINASE 1; RAD51 PROTEIN; REPLICATION FACTOR A; REPLICATION PROTEIN A 32; SERINE DERIVATIVE; SMALL INTERFERING RNA; THREONINE; TOPOISOMERASE II BETA BINDING PROTEIN 1; UNCLASSIFIED DRUG; CARRIER PROTEIN; CELL CYCLE PROTEIN; CHROMATIN; DNA BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NUCLEAR PROTEIN; ONCOPROTEIN; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; POLO-LIKE KINASE 1; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RAD51 PROTEIN, HUMAN; TOPBP1 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CELL FRACTIONATION; CHROMATIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INACTIVATION; FEMALE; GENE MUTATION; GENE SILENCING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; OVARIAN CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RNA ANALYSIS; U2OS CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; OVARIAN NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; PROTEIN DOMAIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEK293 CELLS; HELA CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; PHOSPHORYLATION; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RAD51 RECOMBINASE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84959469777     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201507042     Document Type: Article

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