Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock

Circulation Research

Volumn 100, Issue 1, 2007, Pages 130-139

  Ichinose, Fumito ^a   Buys, Emmanuel S ^a   Neilan, Tomas G ^a   Furutani, Elissa M ^a   Morgan, John G ^a   Jassal, Davinder S ^a   Graveline, Amanda R ^a   Searles, Robert J ^a   Lim, Chee C ^c   Kaneki, Masao ^a   Picard, Michael H ^a   Scherrer Crosbie, Marielle ^a   Janssens, Stefan ^d   Liao, Ronglih ^b   Bloch, Kenneth D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Calcium handling; Endotoxin; Myofilament; Nitric oxide; Reactive oxygen species

Indexed keywords

ALLOPURINOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEATH; ENDOTOXEMIA; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; MALE; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SEPTIC SHOCK; SURVIVAL; WILD TYPE;

ALLOPURINOL; ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CARDIOTONIC AGENTS; ENDOTOXEMIA; ENDOTOXINS; ENZYME INHIBITORS; HEART; HEART DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SARCOPLASMIC RETICULUM; SHOCK, SEPTIC; XANTHINE OXIDASE;

EID: 33846116583     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000253888.09574.7a     Document Type: Article

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