메뉴 건너뛰기




Volumn 9, Issue 1, 2017, Pages

Molecular bases underlying the hepatoprotective effects of coffee

Author keywords

Caffeine; Chlorogenic acid; Liver cancer; Liver fibrosis; Liver steatosis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; CHLOROGENIC ACID; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMAD2 PROTEIN; SMAD3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; COFFEE; PLANT EXTRACT;

EID: 85011692250     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9010085     Document Type: Review
Times cited : (82)

References (54)
  • 1
    • 84861018546 scopus 로고    scopus 로고
    • Association of coffee drinking with total and cause-specific mortality
    • Freedman, N.D., Park, Y., Abnet, C.C., Hollenbeck, A.R., Sinha, R. Association of coffee drinking with total and cause-specific mortality. N. Engl. J. Med. 2012, 366,1891-190-4.
    • (2012) N. Engl. J. Med , vol.366 , pp. 1891-2190
    • Freedman, N.D.1    Park, Y.2    Abnet, C.C.3    Hollenbeck, A.R.4    Sinha, R.5
  • 4
    • 84895794335 scopus 로고    scopus 로고
    • Impact o. Coffee on liver diseases: A systematic review
    • C014
    • Saab, S., Mallam, D., Cox, G.A., 2nd, Tong, M.J. Impact o. coffee on liver diseases: A systematic review. Liver Int. C014, 34, 495-504.
    • Liver Int , vol.34 , pp. 495-504
    • Saab, S.1    Mallam, D.2    Cox, G.A.3    Tong, M.J.4
  • 5
    • 84922879137 scopus 로고    scopus 로고
    • Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the us multiethnic cohort
    • Setiawan, V.W., Wilkens, L.R., Lu, S.C., Hernandez, B.Y., Le Marchand, L., Henderson, B.E. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the us multiethnic cohort. Gastroenterology 2015,148,118-125.
    • (2015) Gastroenterology , vol.148 , pp. 118-125
    • Setiawan, V.W.1    Wilkens, L.R.2    Lu, S.C.3    Hernandez, B.Y.4    Le Marchand, L.5    Henderson, B.E.6
  • 6
    • 84893039492 scopus 로고    scopus 로고
    • Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: A systematic review and a dose-response meta-analysis
    • Ding, M., Bhupathiraju, S.N., Chen, M., van Dam, R.M., Hu, F.B. Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: A systematic review and a dose-response meta-analysis. Diabetes Care 2014, 37, 569-586.
    • (2014) Diabetes Care , vol.37 , pp. 569-586
    • Ding, M.1    Bhupathiraju, S.N.2    Chen, M.3    Van Dam, R.M.4    Hu, F.B.5
  • 7
    • 84962339204 scopus 로고    scopus 로고
    • Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies
    • Marventano, S., Salomone, F., Godos, J., Pluchinotta, F., Del Rio, D., Mistretta, A., Grosso, G. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin. Nutr. 2016.
    • (2016) Clin. Nutr
    • Marventano, S.1    Salomone, F.2    Godos, J.3    Pluchinotta, F.4    Del Rio, D.5    Mistretta, A.6    Grosso, G.7
  • 9
    • 84925519779 scopus 로고    scopus 로고
    • Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice
    • Ma, Y., Gao, M., Liu, D. Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm. Res. 2015, 32,1200-1209.
    • (2015) Pharm. Res , vol.32 , pp. 1200-1209
    • Ma, Y.1    Gao, M.2    Liu, D.3
  • 12
    • 84875703218 scopus 로고    scopus 로고
    • Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation
    • Ong, K.W., Hsu, A., Tan, B.K. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem. Pharmacol. 2013, 85,1341-1351.
    • (2013) Biochem. Pharmacol , vol.85 , pp. 1341-1351
    • Ong, K.W.1    Hsu, A.2    Tan, B.K.3
  • 13
    • 84861219859 scopus 로고    scopus 로고
    • Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats
    • Panchal, S.K., Poudyal, H., Waanders, J., Brown, L. Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats. J. Nutr. 2012,142, 690-697.
    • (2012) J. Nutr , vol.142 , pp. 690-697
    • Panchal, S.K.1    Poudyal, H.2    Waanders, J.3    Brown, L.4
  • 14
    • 78650762536 scopus 로고    scopus 로고
    • Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1C and related molecules in C57BL/6J mice
    • Murase, T., Misawa, K., Minegishi, Y., Aoki, M., Ominami, H., Suzuki, Y., Shibuya, Y., Hase, T. Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1C and related molecules in C57BL/6J mice. Am. J. Physiol. Endocrinol. Metab. 2011, 300, E122-E133.
    • (2011) Am. J. Physiol. Endocrinol. Metab , vol.300 , pp. E122-E133
    • Murase, T.1    Misawa, K.2    Minegishi, Y.3    Aoki, M.4    Ominami, H.5    Suzuki, Y.6    Shibuya, Y.7    Hase, T.8
  • 15
    • 78049516031 scopus 로고    scopus 로고
    • Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins
    • Vitaglione, P., Morisco, F., Mazzone, G., Amoruso, D.C., Ribecco, M.T., Romano, A., Fogliano, V., Caporaso, N., D'Argenio, G. Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010, 52,1652-1661.
    • (2010) Hepatology , vol.52 , pp. 1652-1661
    • Vitaglione, P.1    Morisco, F.2    Mazzone, G.3    Amoruso, D.C.4    Ribecco, M.T.5    Romano, A.6    Fogliano, V.7    Caporaso, N.8    D'argenio, G.9
  • 16
    • 0036903553 scopus 로고    scopus 로고
    • Chlorogenic acid modifies plasma and liver concentrations of: Cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats
    • Rodriguez de Sotillo, D.V., Hadley, M. Chlorogenic acid modifies plasma and liver concentrations of: Cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats. J. Nutr. Biochem. 2002,13, 717-726.
    • (2002) J. Nutr. Biochem , vol.13 , pp. 717-726
    • Rodriguez De Sotillo, D.V.1    Hadley, M.2
  • 17
    • 33746451661 scopus 로고    scopus 로고
    • Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice
    • Shimoda, H., Seki, E., Aitani, M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement. Altern. Med. 2006, 6, 9.
    • (2006) BMC Complement. Altern. Med , vol.6 , pp. 9
    • Shimoda, H.1    Seki, E.2    Aitani, M.3
  • 18
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw, S., Nihal, M., Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659-661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 19
    • 84918817256 scopus 로고    scopus 로고
    • Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways
    • Garcia-Ruiz, C., Mato, J.M., Vance, D., Kaplowitz, N., Fernandez-Checa, J.C. Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways. J. Hepatol. 2015, 62, 219-233.
    • (2015) J. Hepatol , vol.62 , pp. 219-233
    • Garcia-Ruiz, C.1    Mato, J.M.2    Vance, D.3    Kaplowitz, N.4    Fernandez-Checa, J.C.5
  • 22
    • 84855393810 scopus 로고    scopus 로고
    • Espresso coffees, caffeine and chlorogenic acid intake: Potential health implications
    • Crozier, T.W., Stalmach, A., Lean, M.E., Crozier, A. Espresso coffees, caffeine and chlorogenic acid intake: Potential health implications. Food Funct. 2012, 3, 30-33.
    • (2012) Food Funct , vol.3 , pp. 30-33
    • Crozier, T.W.1    Stalmach, A.2    Lean, M.E.3    Crozier, A.4
  • 25
    • 53249092406 scopus 로고    scopus 로고
    • Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor expression in hepatocytes via PPARy and SMAD2/3-dependent pathways
    • Gressner, O.A., Lahme, B., Rehbein, K., Siluschek, M., Weiskirchen, R., Gressner, A.M. Pharmacological application of caffeine inhibits TGF-β-stimulated connective tissue growth factor expression in hepatocytes via PPARy and SMAD2/3-dependent pathways. J. Hepatol. 2008, 49, 758-767.
    • (2008) J. Hepatol , vol.49 , pp. 758-767
    • Gressner, O.A.1    Lahme, B.2    Rehbein, K.3    Siluschek, M.4    Weiskirchen, R.5    Gressner, A.M.6
  • 26
    • 67049136624 scopus 로고    scopus 로고
    • Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells
    • Gressner, O.A., Lahme, B., Siluschek, M., Gressner, A.M. Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells. Liver Int. 2009, 29, 886-897.
    • (2009) Liver Int , vol.29 , pp. 886-897
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Gressner, A.M.4
  • 27
    • 84861179585 scopus 로고    scopus 로고
    • Oral application of 1,7-dimethylxanthine (Paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis
    • Klemmer, I., Yagi, S., Gressner, O.A. Oral application of 1,7-dimethylxanthine (paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis. Hepatol. Res. 2011, 41,1094-1109.
    • (2011) Hepatol. Res , vol.41 , pp. 1094-1109
    • Klemmer, I.1    Yagi, S.2    Gressner, O.A.3
  • 29
    • 84923651526 scopus 로고    scopus 로고
    • Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells
    • Wang, Q., Dai, X., Yang, W., Wang, H., Zhao, H., Yang, F., Yang, Y., Li, J., Lv, X. Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells. Int. Immunopharmacol. 2015,25, 340-352.
    • (2015) Int. Immunopharmacol , vol.25 , pp. 340-352
    • Wang, Q.1    Dai, X.2    Yang, W.3    Wang, H.4    Zhao, H.5    Yang, F.6    Yang, Y.7    Li, J.8    Lv, X.9
  • 30
    • 84899788654 scopus 로고    scopus 로고
    • Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 mapk signal pathway
    • Wang, H., Guan, W., Yang, W., Wang, Q., Zhao, H., Yang, F., Lv, X., Li, J. Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 mapk signal pathway. PLoS ONE 2014, 9, e92482.
    • (2014) Plos ONE , vol.9
    • Wang, H.1    Guan, W.2    Yang, W.3    Wang, Q.4    Zhao, H.5    Yang, F.6    Lv, X.7    Li, J.8
  • 33
    • 84870689066 scopus 로고    scopus 로고
    • Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway
    • Shi, H., Dong, L., Jiang, J., Zhao, J., Zhao, G., Dang, X., Lu, X., Jia, M. Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway. Toxicology 2013, 303, 107-114.
    • (2013) Toxicology , vol.303 , pp. 107-114
    • Shi, H.1    Dong, L.2    Jiang, J.3    Zhao, J.4    Zhao, G.5    Dang, X.6    Lu, X.7    Jia, M.8
  • 34
    • 84878223917 scopus 로고    scopus 로고
    • Effect of chlorogenic acid on lps-induced proinflammatory signaling in hepatic stellate cells. Inflamm
    • Shi, H., Dong, L., Dang, X., Liu, Y., Jiang, J., Wang, Y., Lu, X., Guo, X. Effect of chlorogenic acid on lps-induced proinflammatory signaling in hepatic stellate cells. Inflamm. Res. 2013, 62, 581-587.
    • (2013) Res , vol.62 , pp. 581-587
    • Shi, H.1    Dong, L.2    Dang, X.3    Liu, Y.4    Jiang, J.5    Wang, Y.6    Lu, X.7    Guo, X.8
  • 36
    • 84880699422 scopus 로고    scopus 로고
    • Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage
    • Arauz, J., Moreno, M.G., Cortes-Reynosa, P., Salazar, E.P., Muriel, P. Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage. J. Appl. Toxicol. 2013, 33, 970-979.
    • (2013) J. Appl. Toxicol. , vol.33 , pp. 970-979
    • Arauz, J.1    Moreno, M.G.2    Cortes-Reynosa, P.3    Salazar, E.P.4    Muriel, P.5
  • 37
    • 70350185396 scopus 로고    scopus 로고
    • Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats
    • Shi, H., Dong, L., Bai, Y., Zhao, J., Zhang, Y., Zhang, L. Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats. Eur. J. Pharmacol. 2009, 623,119-124.
    • (2009) Eur. J. Pharmacol , vol.623 , pp. 119-124
    • Shi, H.1    Dong, L.2    Bai, Y.3    Zhao, J.4    Zhang, Y.5    Zhang, L.6
  • 39
    • 1642421843 scopus 로고    scopus 로고
    • Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatoma-bearing rats
    • Miura, Y., Ono, K., Okauchi, R., Yagasaki, K. Inhibitory effect of coffee on hepatoma proliferation and invasion in culture and on tumor growth, metastasis and abnormal lipoprotein profiles in hepatoma-bearing rats. J. Nutr. Sci. Vitaminol. (Tokyo) 2004, 50, 38-44.
    • (2004) J. Nutr. Sci. Vitaminol. (Tokyo) , vol.50 , pp. 38-44
    • Miura, Y.1    Ono, K.2    Okauchi, R.3    Yagasaki, K.4
  • 40
    • 0031426211 scopus 로고    scopus 로고
    • Inhibitory effect of serum from rats administered with coffee on the proliferation and invasion of rat ascites hepatoma cells
    • Miura, Y., Furuse, T., Yagasaki, K. Inhibitory effect of serum from rats administered with coffee on the proliferation and invasion of rat ascites hepatoma cells. Cytotechnology 1997, 25, 221-225.
    • (1997) Cytotechnology , vol.25 , pp. 221-225
    • Miura, Y.1    Furuse, T.2    Yagasaki, K.3
  • 41
    • 0025078051 scopus 로고
    • Inhibitory effects of chlorogenic acid, reserpine, polyprenoic acid (E-5166), or coffee on hepatocarcinogenesis in rats and hamsters
    • Tanaka, T., Nishikawa, A., Shima, H., Sugie, S., Shinoda, T., Yoshimi, N., Iwata, H., Mori, H. Inhibitory effects of chlorogenic acid, reserpine, polyprenoic acid (E-5166), or coffee on hepatocarcinogenesis in rats and hamsters. Basic Life Sci. 1990, 52, 429-440.
    • (1990) Basic Life Sci , vol.52 , pp. 429-440
    • Tanaka, T.1    Nishikawa, A.2    Shima, H.3    Sugie, S.4    Shinoda, T.5    Yoshimi, N.6    Iwata, H.7    Mori, H.8
  • 45
    • 0022631931 scopus 로고
    • Inhibitory effect of chlorogenic acid on methylazoxymethanol acetate-induced carcinogenesis in large intestine and liver of hamsters
    • Mori, H., Tanaka, T., Shima, H., Kuniyasu, T., Takahashi, M. Inhibitory effect of chlorogenic acid on methylazoxymethanol acetate-induced carcinogenesis in large intestine and liver of hamsters. Cancer Lett. 1986, 30,49-54.
    • (1986) Cancer Lett , vol.30 , pp. 49-54
    • Mori, H.1    Tanaka, T.2    Shima, H.3    Kuniyasu, T.4    Takahashi, M.5
  • 47
    • 38649113944 scopus 로고    scopus 로고
    • Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
    • Higgins, L.G., Cavin, C., Itoh, K., Yamamoto, M., Hayes, J.D. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol. Appl. Pharmacol. 2008, 226, 328-337.
    • (2008) Toxicol. Appl. Pharmacol , vol.226 , pp. 328-337
    • Higgins, L.G.1    Cavin, C.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 48
    • 77958093867 scopus 로고    scopus 로고
    • Coffee induces expression of glucuronosyltransferases by the Aryl hydrocarbon receptor and Nrf2 in liver and stomach
    • Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M.P., Strassburg, C.P. Coffee induces expression of glucuronosyltransferases by the Aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology 2010,139,1699-1710.
    • (2010) Gastroenterology , vol.139 , pp. 1699-1710
    • Kalthoff, S.1    Ehmer, U.2    Freiberg, N.3    Manns, M.P.4    Strassburg, C.P.5
  • 49
    • 84892172397 scopus 로고    scopus 로고
    • Coffee modulates transcription factor Nrf2 and highly increases the activity of antioxidant enzymes in rats
    • Vicente, S.J., Ishimoto, E.Y., Torres, E.A. Coffee modulates transcription factor Nrf2 and highly increases the activity of antioxidant enzymes in rats. J. Agric. Food Chem. 2014, 62,116-122.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 116-122
    • Vicente, S.J.1    Ishimoto, E.Y.2    Torres, E.A.3
  • 51
    • 0037174397 scopus 로고    scopus 로고
    • Absorption of phenolic acids in humans after coffee consumption
    • Nardini, M., Cirillo, E., Natella, F., Scaccini, C. Absorption of phenolic acids in humans after coffee consumption. J. Agric. Food Chem. 2002,50,5735-5741.
    • (2002) J. Agric. Food Chem , vol.50 , pp. 5735-5741
    • Nardini, M.1    Cirillo, E.2    Natella, F.3    Scaccini, C.4
  • 53
    • 34948827593 scopus 로고    scopus 로고
    • Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans
    • Monteiro, M., Farah, A., Perrone, D., Trugo, L.C., Donangelo, C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J. Nutr. 2007,137,2196-2201.
    • (2007) J. Nutr , vol.137 , pp. 2196-2201
    • Monteiro, M.1    Farah, A.2    Perrone, D.3    Trugo, L.C.4    Donangelo, C.5
  • 54
    • 77950633375 scopus 로고    scopus 로고
    • Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy
    • Stalmach, A., Steiling, H., Williamson, G., Crozier, A. Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Arch. Biochem. Biophys. 2010, 501, 98-105.
    • (2010) Arch. Biochem. Biophys , vol.501 , pp. 98-105
    • Stalmach, A.1    Steiling, H.2    Williamson, G.3    Crozier, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.