Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells

Liver International

Volumn 29, Issue 6, 2009, Pages 886-897

  Gressner, Olav A ^a   Lahme, Birgit ^a   Siluschek, Monika ^a   Gressner, Axel M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Caffeine; Connective tissue growth factor; CTGF; Liver fibrosis; Paraxanthine; TGF ; Theobromine; Theophylline

Indexed keywords

ADENOSINE 3',5' PHOSPHOROTHIOATE; CONNECTIVE TISSUE GROWTH FACTOR; PARAXANTHINE; THEOBROMINE; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; LIVER CELL; LIVER PARENCHYMA; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; STELLATE CELL;

ANIMALS; BLOTTING, WESTERN; CAFFEINE; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION; HEPATOCYTES; INHIBITORY CONCENTRATION 50; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THEOBROMINE; THEOPHYLLINE;

EID: 67049136624     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.01987.x     Document Type: Article

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