Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Wang, He ^a   Guan, Wenjie ^b   Yang, Wanzhi ^c   Wang, Qi ^a   Zhao, Han ^a   Yang, Feng ^a   Lv, Xiongwen ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b The 105th Hospital of PLA   (China)

^c First Hospital of Anqing   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ACETALDEHYDE; ADENOSINE A2A RECEPTOR; CAFFEINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; PROCOLLAGEN TYPE 1; PROCOLLAGEN TYPE 3; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CYCLIC AMP;

ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; IN VITRO STUDY; LIVER FIBROSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STELLATE CELL; CELL CULTURE; DRUG EFFECTS; HUMAN; METABOLISM; ONCOGENE SRC;

ACETALDEHYDE; CAFFEINE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENES, SRC; HEPATIC STELLATE CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, ADENOSINE A2A; SIGNAL TRANSDUCTION;

EID: 84899788654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092482     Document Type: Article

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