-
1
-
-
84951568684
-
Applications of CRISPR-Cas systems in neuroscience
-
Heidenreich, M. & Zhang, F. Applications of CRISPR-Cas systems in neuroscience. Nat Rev Neurosci 17, 36-44 (2016).
-
(2016)
Nat Rev Neurosci
, vol.17
, pp. 36-44
-
-
Heidenreich, M.1
Zhang, F.2
-
2
-
-
0030032063
-
Hybrid restriction enzymes: Zinc finger fusions to Fok i cleavage domain
-
Kim, Y. G., Cha, J. & Chandrasegaran, S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci USA 93, 1156-1160 (1996).
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1156-1160
-
-
Kim, Y.G.1
Cha, J.2
Chandrasegaran, S.3
-
3
-
-
23444441147
-
Gene targeting using zinc finger nucleases
-
Porteus, M. H. & Carroll, D. Gene targeting using zinc finger nucleases. Nat Biotechnol 23, 967-973 (2005).
-
(2005)
Nat Biotechnol
, vol.23
, pp. 967-973
-
-
Porteus, M.H.1
Carroll, D.2
-
4
-
-
79751487297
-
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
-
Zhang, F. et al. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol 29, 149-153 (2011).
-
(2011)
Nat Biotechnol
, vol.29
, pp. 149-153
-
-
Zhang, F.1
-
5
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
6
-
-
84960374079
-
Providing appropriate risk information on genome editing for patients
-
Araki, M. & Ishii, T. Providing Appropriate Risk Information on Genome Editing for Patients. Trends Biotechnol 34, 86-90 (2016).
-
(2016)
Trends Biotechnol
, vol.34
, pp. 86-90
-
-
Araki, M.1
Ishii, T.2
-
7
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
8
-
-
4644309196
-
The functions of animal microRNAs
-
Ambros, V. The functions of animal microRNAs. Nature 431, 350-355 (2004).
-
(2004)
Nature
, vol.431
, pp. 350-355
-
-
Ambros, V.1
-
9
-
-
60149088848
-
Origins and Mechanisms of miRNAs and siRNAs
-
Carthew, R. W. & Sontheimer, E. J. Origins and Mechanisms of miRNAs and siRNAs. Cell 136, 642-655 (2009).
-
(2009)
Cell
, vol.136
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
10
-
-
84954441161
-
Sirna versus mirna as therapeutics for gene silencing
-
Lam, J. K., Chow, M. Y., Zhang, Y. & Leung, S. W. siRNA Versus miRNA as Therapeutics for Gene Silencing. Mol Ther Nucleic Acids 4, e252 (2015).
-
(2015)
Mol Ther Nucleic Acids
, vol.4
, pp. e252
-
-
Lam, J.K.1
Chow, M.Y.2
Zhang, Y.3
Leung, S.W.4
-
11
-
-
0035997389
-
RNA editing by adenosine deaminases that act on RNA
-
Bass, B. L. RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 71, 817-846 (2002).
-
(2002)
Annu Rev Biochem
, vol.71
, pp. 817-846
-
-
Bass, B.L.1
-
12
-
-
77952293063
-
Functions and regulation of RNA editing by ADAR deaminases
-
Nishikura, K. Functions and regulation of RNA editing by ADAR deaminases. Annu Rev Biochem 79, 321-349 (2010).
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 321-349
-
-
Nishikura, K.1
-
13
-
-
81855192230
-
Substitutional A-To-I RNA editing
-
Wulff, B. E. & Nishikura, K. Substitutional A-To-I RNA editing. WIREs RNA 1, 90-101 (2010).
-
(2010)
WIREs RNA
, vol.1
, pp. 90-101
-
-
Wulff, B.E.1
Nishikura, K.2
-
14
-
-
0030711050
-
Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs
-
Ganot, P., Bortolin, M. L. & Kiss, T. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell 89, 799-809 (1997).
-
(1997)
Cell
, vol.89
, pp. 799-809
-
-
Ganot, P.1
Bortolin, M.L.2
Kiss, T.3
-
15
-
-
0032052773
-
SnoRNA-guided ribose methylation of rRNA: Structural features of the guide RNA duplex influencing the extent of the reaction
-
Cavaille, J. & Bachellerie, J. P. SnoRNA-guided ribose methylation of rRNA: structural features of the guide RNA duplex influencing the extent of the reaction. Nucleic Acids Res 26, 1576-1587 (1998).
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 1576-1587
-
-
Cavaille, J.1
Bachellerie, J.P.2
-
16
-
-
0033153297
-
Guided tours: From precursor snoRNA to functional snoRNP
-
Weinstein, L. B. & Steitz, J. A. Guided tours: from precursor snoRNA to functional snoRNP. Curr Opin Cell Biol 11, 378-384 (1999).
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 378-384
-
-
Weinstein, L.B.1
Steitz, J.A.2
-
17
-
-
0029808113
-
Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides
-
Cavaille, J., Nicoloso, M. & Bachellerie, J. P. Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides. Nature 383, 732-735 (1996).
-
(1996)
Nature
, vol.383
, pp. 732-735
-
-
Cavaille, J.1
Nicoloso, M.2
Bachellerie, J.P.3
-
18
-
-
37749034810
-
Targeted pre-mRNA modification for gene silencing and regulation
-
Zhao, X. & Yu, Y. T. Targeted pre-mRNA modification for gene silencing and regulation. Nat Methods 5, 95-100 (2008).
-
(2008)
Nat Methods
, vol.5
, pp. 95-100
-
-
Zhao, X.1
Yu, Y.T.2
-
19
-
-
79959284255
-
Converting nonsense codons into sense codons by targeted pseudouridylation
-
Karijolich, J. & Yu, Y. T. Converting nonsense codons into sense codons by targeted pseudouridylation. Nature 474, 395-398 (2011).
-
(2011)
Nature
, vol.474
, pp. 395-398
-
-
Karijolich, J.1
Yu, Y.T.2
-
20
-
-
85027937587
-
Site-directed RNA editing with antagomir deaminases-A tool to study protein and RNA function
-
Vogel, P. & Stafforst, T. Site-directed RNA editing with antagomir deaminases-A tool to study protein and RNA function. ChemMedChem 9, 2021-2025 (2014).
-
(2014)
ChemMedChem
, vol.9
, pp. 2021-2025
-
-
Vogel, P.1
Stafforst, T.2
-
21
-
-
84943621334
-
Profiling RNA editing in human tissues: Towards the inosinome Atlas
-
Picardi, E. et al. Profiling RNA editing in human tissues: Towards the inosinome Atlas. Sci Rep 5, 14941 (2015).
-
(2015)
Sci Rep
, vol.5
, pp. 14941
-
-
Picardi, E.1
-
22
-
-
84867835332
-
An RNA-deaminase conjugate selectively repairs point mutations
-
Stafforst, T. & Schneider, M. F. An RNA-deaminase conjugate selectively repairs point mutations. Angew Chem Int Ed Engl 51, 11166-11169 (2012).
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 11166-11169
-
-
Stafforst, T.1
Schneider, M.F.2
-
23
-
-
84903209128
-
Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
-
Schneider, M. F., Wettengel, J., Hoffmann, P. C. & Stafforst, T. Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans. Nucleic Acids Res 42, e87 (2014).
-
(2014)
Nucleic Acids Res
, vol.42
, pp. e87
-
-
Schneider, M.F.1
Wettengel, J.2
Hoffmann, P.C.3
Stafforst, T.4
-
24
-
-
84902201236
-
Improving site-directed RNA editing in vitro and in cell culture by chemical modification of the guideRNA
-
Vogel, P., Schneider, M. F., Wettengel, J. & Stafforst, T. Improving site-directed RNA editing in vitro and in cell culture by chemical modification of the guideRNA. Angew Chem Int Ed Engl 53, 6267-6271 (2014).
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 6267-6271
-
-
Vogel, P.1
Schneider, M.F.2
Wettengel, J.3
Stafforst, T.4
-
25
-
-
85016148680
-
An efficient system for selectively altering genetic information within mRNAs
-
Montiel-Gonzalez, M. F., Vallecillo-Viejo, I. C. & Rosenthal, J. J. An efficient system for selectively altering genetic information within mRNAs. Nucleic Acids Res 44, e157 (2016).
-
(2016)
Nucleic Acids Res
, vol.44
, pp. e157
-
-
Montiel-Gonzalez, M.F.1
Vallecillo-Viejo, I.C.2
Rosenthal, J.J.3
-
26
-
-
84887300101
-
Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing
-
Montiel-Gonzalez, M. F., Vallecillo-Viejo, I., Yudowski, G. A. & Rosenthal, J. J. Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing. Proc Natl Acad Sci USA 110, 18285-18290 (2013).
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 18285-18290
-
-
Montiel-Gonzalez, M.F.1
Vallecillo-Viejo, I.2
Yudowski, G.A.3
Rosenthal, J.J.4
-
27
-
-
85018319578
-
Harnessing human ADAR2 for RNA repair-Recoding a PINK1 mutation rescues mitophagy
-
Wettengel, J., Reautschnig, P., Geisler, S., Kahle, P. J. & Stafforst, T. Harnessing human ADAR2 for RNA repair-Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res 10.1093/nar/gkw911 (2016).
-
(2016)
Nucleic Acids Res
-
-
Wettengel, J.1
Reautschnig, P.2
Geisler, S.3
Kahle, P.J.4
Stafforst, T.5
-
28
-
-
1542360534
-
RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients
-
Vollmar, W. et al. RNA editing (R/G site) and flip-flop splicing of the AMPA receptor subunit GluR2 in nervous tissue of epilepsy patients. Neurobiol Dis 15, 371-379 (2004).
-
(2004)
Neurobiol Dis
, vol.15
, pp. 371-379
-
-
Vollmar, W.1
-
29
-
-
0037492813
-
Fluorescent dye terminator sequencing methods for quantitative determination of replication fitness of human immunodeficiency virus type 1 containing the codon 74 and 184 mutations in reverse transcriptase
-
Nurpeisov, V., Hurwitz, S. J. & Sharma, P. L. Fluorescent dye terminator sequencing methods for quantitative determination of replication fitness of human immunodeficiency virus type 1 containing the codon 74 and 184 mutations in reverse transcriptase. J Clin Microbiol 41, 3306-3311 (2003).
-
(2003)
J Clin Microbiol
, vol.41
, pp. 3306-3311
-
-
Nurpeisov, V.1
Hurwitz, S.J.2
Sharma, P.L.3
-
30
-
-
33947510692
-
High-Throughput screening for functional adenosine to inosine RNA editing systems
-
Pokharel, S. & Beal, P. A. High-Throughput screening for functional adenosine to inosine RNA editing systems. ACS Chem Biol 1, 761-765 (2006).
-
(2006)
ACS Chem Biol
, vol.1
, pp. 761-765
-
-
Pokharel, S.1
Beal, P.A.2
-
31
-
-
77049099984
-
A mammalian reporter system for fast and quantitative detection of intracellular A-To-I RNA editing levels
-
Gommans, W. M., McCane, J., Nacarelli, G. S. & Maas, S. A mammalian reporter system for fast and quantitative detection of intracellular A-To-I RNA editing levels. Anal Biochem 399, 230-236 (2010).
-
(2010)
Anal Biochem
, vol.399
, pp. 230-236
-
-
Gommans, W.M.1
McCane, J.2
Nacarelli, G.S.3
Maas, S.4
-
32
-
-
84952837160
-
Site-directed RNA Editing in Vivo can be triggered by the light-driven assembly of an artificial riboprotein
-
Hanswillemenke, A., Kuzdere, T., Vogel, P., Jekely, G. & Stafforst, T. Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein. J Am Chem Soc 137, 15875-15881 (2015).
-
(2015)
J Am Chem Soc
, vol.137
, pp. 15875-15881
-
-
Hanswillemenke, A.1
Kuzdere, T.2
Vogel, P.3
Jekely, G.4
Stafforst, T.5
-
33
-
-
84894285881
-
Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-To-inosine RNA editing
-
Fukuda, M., Kurihara, K., Yamaguchi, S., Oyama, Y. & Deshimaru, M. Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-To-inosine RNA editing. RNA 20, 392-405 (2014).
-
(2014)
RNA
, vol.20
, pp. 392-405
-
-
Fukuda, M.1
Kurihara, K.2
Yamaguchi, S.3
Oyama, Y.4
Deshimaru, M.5
-
34
-
-
14844348294
-
Evolutionarily conserved human targets of adenosine to inosine RNA editing
-
Levanon, E. Y. et al. Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res 33, 1162-1168 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 1162-1168
-
-
Levanon, E.Y.1
-
35
-
-
77953412786
-
Human BLCAP transcript: New editing events in normal and cancerous tissues
-
Galeano, F. et al. Human BLCAP transcript: new editing events in normal and cancerous tissues. Int J Cancer 127, 127-137 (2010).
-
(2010)
Int J Cancer
, vol.127
, pp. 127-137
-
-
Galeano, F.1
-
36
-
-
77957822421
-
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove
-
Stefl, R. et al. The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove. Cell 143, 225-237 (2010).
-
(2010)
Cell
, vol.143
, pp. 225-237
-
-
Stefl, R.1
-
37
-
-
79956271523
-
Predicting sites of ADAR editing in double-stranded RNA
-
Eggington, J. M., Greene, T. & Bass, B. L. Predicting sites of ADAR editing in double-stranded RNA. Nat Commun 2, 319 (2011).
-
(2011)
Nat Commun
, vol.2
, pp. 319
-
-
Eggington, J.M.1
Greene, T.2
Bass, B.L.3
-
38
-
-
0030067869
-
Editing of the GLuR-B ion channel RNA in vitro by recombinant double-stranded RNA adenosine deaminase
-
Dabiri, G. A., Lai, F., Drakas, R. A. & Nishikura, K. Editing of the GLuR-B ion channel RNA in vitro by recombinant double-stranded RNA adenosine deaminase. EMBO J 15, 34-45 (1996).
-
(1996)
EMBO J
, vol.15
, pp. 34-45
-
-
Dabiri, G.A.1
Lai, F.2
Drakas, R.A.3
Nishikura, K.4
-
39
-
-
78650542645
-
RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1
-
Yeo, J., Goodman, R. A., Schirle, N. T., David, S. S. & Beal, P. A. RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci USA 107, 20715-20719 (2010).
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20715-20719
-
-
Yeo, J.1
Goodman, R.A.2
Schirle, N.T.3
David, S.S.4
Beal, P.A.5
-
40
-
-
10744223020
-
Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes
-
Keegan, L. P., Leroy, A., Sproul, D. & O Connell, M. A. Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. Genome Biol 5, 209 (2004).
-
(2004)
Genome Biol
, vol.5
, pp. 209
-
-
Keegan, L.P.1
Leroy, A.2
Sproul, D.3
Oconnell, M.A.4
-
41
-
-
0345133268
-
Modulation of RNA editing by functional nucleolar sequestration of ADAR2
-
Sansam, C. L., Wells, K. S. & Emeson, R. B. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci USA 100, 14018-14023 (2003).
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14018-14023
-
-
Sansam, C.L.1
Wells, K.S.2
Emeson, R.B.3
-
42
-
-
33646759917
-
A-To-I RNA editing and human disease
-
Maas, S., Kawahara, Y., Tamburro, K. M. & Nishikura, K. A-To-I RNA editing and human disease. RNA Biol 3, 1-9 (2006).
-
(2006)
RNA Biol
, vol.3
, pp. 1-9
-
-
Maas, S.1
Kawahara, Y.2
Tamburro, K.M.3
Nishikura, K.4
-
43
-
-
84888866436
-
Adenosine-To-inosine RNA editing and human disease
-
Slotkin, W. & Nishikura, K. Adenosine-To-inosine RNA editing and human disease. Genome Med 5, 105 (2013).
-
(2013)
Genome Med
, vol.5
, pp. 105
-
-
Slotkin, W.1
Nishikura, K.2
-
44
-
-
84856580212
-
Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons
-
Hideyama, T. et al. Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons. Neurobiol Dis 45, 1121-1128 (2012).
-
(2012)
Neurobiol Dis
, vol.45
, pp. 1121-1128
-
-
Hideyama, T.1
-
45
-
-
81855226648
-
Editing of neurotransmitter receptor and ion channel RNAs in the nervous system
-
Hood, J. L. & Emeson, R. B. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol 353, 61-90 (2012).
-
(2012)
Curr Top Microbiol Immunol
, vol.353
, pp. 61-90
-
-
Hood, J.L.1
Emeson, R.B.2
-
46
-
-
84912098781
-
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA
-
Mannion, N. M. et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 9, 1482-1494 (2014).
-
(2014)
Cell Rep
, vol.9
, pp. 1482-1494
-
-
Mannion, N.M.1
-
47
-
-
84860356214
-
A-To-I RNA editing: The ADAR" side of human cancer
-
Galeano, F., Tomaselli, S., Locatelli, F. & Gallo, A. A-To-I RNA editing: The "ADAR" side of human cancer. Semin Cell Dev Biol 23, 244-250 (2012).
-
(2012)
Semin Cell Dev Biol
, vol.23
, pp. 244-250
-
-
Galeano, F.1
Tomaselli, S.2
Locatelli, F.3
Gallo, A.4
-
48
-
-
35948957777
-
Altered adenosine-To-inosine RNA editing in human cancer
-
Paz, N. et al. Altered adenosine-To-inosine RNA editing in human cancer. Genome Res 17, 1586-1595 (2007).
-
(2007)
Genome Res
, vol.17
, pp. 1586-1595
-
-
Paz, N.1
-
49
-
-
34447542355
-
RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions
-
Valente, L. & Nishikura, K. RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions. J Biol Chem 282, 16054-16061 (2007).
-
(2007)
J Biol Chem
, vol.282
, pp. 16054-16061
-
-
Valente, L.1
Nishikura, K.2
-
50
-
-
33745610720
-
Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain
-
Poulsen, H. et al. Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain. RNA 12, 1350-1360 (2006).
-
(2006)
RNA
, vol.12
, pp. 1350-1360
-
-
Poulsen, H.1
|