Human BLCAP transcript: New editing events in normal and cancerous tissues

International Journal of Cancer

Volumn 127, Issue 1, 2010, Pages 127-137

  Galeano, Federica ^a   Leroy, Anne ^b   Rossetti, Claudia ^a   Gromova, Irina ^c   Gautier, Philippe ^b   Keegan, Liam P ^b   Massimi, Luca ^d   Di Rocco, Concezio ^d   O'Connell, Mary A ^b   Gallo, Angela ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

ADARs; BLCAP; Cancer; dsRNA structure; RNA editing

Indexed keywords

ADAR1; ADAR2; AMINO ACID; BLADDER CANCER ASSOCIATED PROTEIN; ENZYME; PROTEIN; UNCLASSIFIED DRUG; BLCAP PROTEIN, HUMAN; MESSENGER RNA; PRIMER DNA; TUMOR PROTEIN; UNTRANSLATED RNA;

ARTICLE; ASTROCYTOMA; BLADDER CANCER; CANCER CELL CULTURE; CANCER TISSUE; CELL STRAIN HEK293; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; GENETIC CODE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; PRIORITY JOURNAL; PROGNOSIS; AMINO ACID SEQUENCE; CASE CONTROL STUDY; CHEMISTRY; GENETIC EPIGENESIS; GENETICS; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL LINE, TUMOR; DNA PRIMERS; EPIGENESIS, GENETIC; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA EDITING; RNA, MESSENGER; RNA, UNTRANSLATED; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 77953412786     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25022     Document Type: Article

References (51)

1. Bass BL. RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem 2002;71:817-46.
2. Keegan LP, Gallo A, O'Connell MA. The many roles of an RNA editor. Nat Rev 2001;2:869-78.
3. Basilio C, Wahba AJ, Lengyel P, Speyer JF, Ochoa S. Synthetic polynucleotides and the amino acid code. V. Proc Natl Acad Sci USA 1962;48:613-6.
4. Rueter SM, Dawson TR, Emeson RB. Regulation of alternative splicing by RNA editing. Nature 1999;399:75-80. (Pubitemid 129524289)
5. Nishikura K. Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol 2006;7: 919-31.
6. Seeburg PH. A-to-I editing: new and old sites, functions and speculations. Neuron 2002;35:17-20.
7. Chen CX, Cho DS, Wang Q, Lai F, Carter KC, Nishikura K. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA (New York, NY) 2000;6:755-67.
8. Melcher T, Maas S, Herb A, Sprengel R, Higuchi M, Seeburg PH. RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem 1996;271:31795-8.
9. Morse DP, Bass BL. Detection of inosine in messenger RNA by inosine-specific cleavage. Biochemistry 1997;36:8429-34.
10. Levanon EY, Eisenberg E, Yelin R, Nemzer S, Hallegger M, Shemesh R, Fligelman ZY, Shoshan A, Pollock SR, Sztybel D, Olshansky M, Rechavi G, et al. Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol 2004;22:1001-5.
11. Morse DP, Bass BL. Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci USA 1999;96:6048-53.
12. Athanasiadis A, Rich A, Maas S. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol 2004;2:e391. (Pubitemid 40284134)
13. Brusa R, Zimmermann F, Koh DS, Feldmeyer D, Gass P, Seeburg PH, Sprengel R. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science (New York, NY) 1995;270:1677-80.
14. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron 2002;34:349-56.
15. Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S. Glutamate receptors: RNA editing and death of motor neurons. Nature 2004;427:801.
16. Maas S, Kim YG, Rich A. Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases. Mamm Genome 2001;12: 387-93.
17. Paz N, Levanon EY, Amariglio N, Heimberger AB, Ram Z, Constantini S, Barbash ZS, Adamsky K, Safran M, Hirschberg A, Krupsky M, Ben-Dov I, et al. Altered adenosine-to-inosine RNA editing in human cancer. Genome Res 2007;17:1586-95.
18. Cenci C, Barzotti R, Galeano F, Corbelli S, Rota R, Massimi L, Di Rocco C, O'Connell MA, Gallo A. Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. J Biol Chem 2008;283: 7251-60.
19. Gallo A, Galardi S. A-to-I RNA editing and cancer: from pathology to basic science. RNA Biol 2008;5.
20. Maas S, Patt S, Schrey M, Rich A. Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci USA 2001;98:14687-92.
21. Paschen W, Dux E, Djuricic B. Developmental changes in the extent of RNA editing of glutamate receptor subunit GluR5 in rat brain. Neurosci Lett 1994;174: 109-12.
22. Paupard MC, O'Connell MA, Gerber AP, Zukin RS. Patterns of developmental expression of the RNA editing enzyme rADAR2. Neuroscience 2000;95:869-79.
23. Lai F, Chen CX, Lee VM, Nishikura K. Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons. J Neurochem 1997;69:43-52. (Pubitemid 27274154)
24. Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol 2009;10: 109-15.
25. Xia S, Yang J, Su Y, Qian J, Ma E, Haddad GG. Identification of new targets of Drosophila pre-mRNA adenosine deaminase. Physiol Genom 2005;20: 195-202. (Pubitemid 40388519)
26. A receptor subunit a3. RNA (New York, NY) 2007;13: 698-703.
27. Morse DP. Identification of substrates for adenosine deaminases that act on RNA. Methods Mol Biol 2004;265:199-218.
28. Gromova I, Gromov P, Celis JE. bc10: a novel human bladder cancer-associated protein with a conserved genomic structure downregulated in invasive cancer. Int J Cancer 2002;98:539-46.
29. Clutterbuck DR, Leroy A, O'Connell MA, Semple CA. A bioinformatic screen for novel A-I RNA editing sites reveals recoding editing in BC10. Bioinformatics 2005;21:2590-5.
30. Rae FK, Stephenson SA, Nicol DL, Clements JA. Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. Int J Cancer 2000;88:726-32.
31. Zuo Z, Zhao M, Liu J, Gao G, Wu X. Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma. Tumour Biol 2006;27:221-6.
32. Larder BA, Kohli A, Kellam P, Kemp SD, Kronick M, Henfrey RD. Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing. Nature 1993;365:671-3.
33. Herb A, Higuchi M, Sprengel R, Seeburg PH. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc Natl Acad Sci USA 1996;93:1875-80.
34. Higuchi M, Maas S, Single FN, Hartner J, Rozov A, Burnashev N, Feldmeyer D, Sprengel R, Seeburg PH. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 2000;406:78-81. (Pubitemid 30460214)
35. Higuchi M, Single FN, Kohler M, Sommer B, Sprengel R, Seeburg PH. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 1993;75: 1361-70.
36. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003;31:3406-15.
37. Walter AE, Turner DH, Kim J, Lyttle MH, Muller P, Mathews DH, Zuker M. Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding. Proc Natl Acad Sci USA 1994;91:9218-22.
38. Levanon EY, Hallegger M, Kinar Y, Shemesh R, Djinovic-Carugo K, Rechavi G, Jantsch MF, Eisenberg E. Evolutionarily conserved human targets of adenosine to inosine RNA editing. Nucleic Acids Res 2005;33:1162-8.
39. Gallo A, Galardi S. A-to-I RNA editing and cancer: from pathology to basic science. RNA Biol 2008;5:135-9.
40. Laurencikiene J, Kallman AM, Fong N, Bentley DL, Ohman M. RNA editing and alternative splicing: the importance of cotranscriptional coordination. EMBO Rep 2006;7:303-7.
41. A receptor function by RNA editing. J Neurosci 2008;28:6196-201.
42. Riedmann EM, Schopoff S, Hartner JC, Jantsch MF. Specificity of ADAR-mediated RNA editing in newly identified targets. RNA (New York, NY) 2008;14:1110-8.
43. Makalowski W, Boguski MS. Evolutionary parameters of the transcribed mammalian genome: an analysis of 2,820 orthologous rodent and human sequences. Proc Natl Acad Sci USA 1998;95:9407-12.
44. Holt MR, Koffer A. Cell motility: proline-rich proteins promote protrusions. Trends Cell Biol 2001;11:38-46. (Pubitemid 32056192)
45. Kay BK, Williamson MP, Sudol M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J 2000;14:231-41.
46. Nishimoto Y, Yamashita T, Hideyama T, Tsuji S, Suzuki N, Kwak S. Determination of editors at the novel A-to-I editing positions. Neurosci Res 2008;61:201-6.
47. Wahlstedt H, Daniel C, Enstero M, Ohman M. Large-scale mRNA sequencing determines global regulation of RNA editing during brain development. Genome Res 2009;19:978-86.
48. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol 2005;25: 6956-63.
49. Kwak S, Kawahara Y. Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis. J Mol Med 2005;83:110-20.
50. Peng PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu D, Lau L, Liu S, Liu F, Lu Y. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Neuron 2006;49:719-33.
51. Zilberman DE, Safran M, Paz N, Amariglio N, Simon A, Fridman E, Kleinmann N, Ramon J, Rechavi G. Does RNA editing play a role in the development of urinary bladder cancer? Urologic Oncol 2009;27 (PMID 19186082, In Press).