Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization

Journal of Neurochemistry

Volumn 140, Issue 6, 2017, Pages 955-962

  Higashide, Hidekazu ^a   Ishihara, Seiko ^a   Nobuhara, Mika ^a   Ihara, Yasuo ^a   Funamoto, Satoru ^a  

^a DOSHISHA UNIVERSITY   (Japan)

Author keywords

Alzheimer disease; amyloid ; dimerization; enzyme processing; gamma secretase; transmembrane domain

Indexed keywords

ALANINE; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; POLYACRYLAMIDE GEL; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR C-TERMINAL FRAGMENT BETA, HUMAN; PEPTIDE FRAGMENT; SECRETASE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ELECTROPHORESIS; HAMSTER; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN MOTIF; TANDEM REPEAT; AMINO ACID SEQUENCE; ANIMAL; CHO CELL LINE; CRICETULUS; GENETICS; HUMAN; INSECT; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ALANINE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; INSECTS; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION;

EID: 85011268731     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13942     Document Type: Article

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