-
1
-
-
77954732543
-
Neuropathological asymmetry in argyrophilic grain disease
-
Adachi T, Saito Y, Hatsuta H, Funabe S, Tokumaru AM, Ishii K, Arai T, Sawabe M, Kanemaru K, Miyashita A, et al (2010) Neuropathological asymmetry in argyrophilic grain disease. J Neuropathol Exp Neurol 69: 737-744.
-
(2010)
J Neuropathol Exp Neurol
, vol.69
, pp. 737-744
-
-
Adachi, T.1
Saito, Y.2
Hatsuta, H.3
Funabe, S.4
Tokumaru, A.M.5
Ishii, K.6
Arai, T.7
Sawabe, M.8
Kanemaru, K.9
Miyashita, A.10
-
2
-
-
80155148102
-
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation
-
Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ (2011) Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. J Neurosci 31: 15861-15869.
-
(2011)
J Neurosci
, vol.31
, pp. 15861-15869
-
-
Hong, S.1
Quintero-Monzon, O.2
Ostaszewski, B.L.3
Podlisny, D.R.4
Cavanaugh, W.T.5
Yang, T.6
Holtzman, D.M.7
Cirrito, J.R.8
Selkoe, D.J.9
-
3
-
-
40349102241
-
Active gamma-secretase is localized to detergent-resistant membranes in human brain
-
Hur JY, Welander H, Behbahani H, Aoki M, Frånberg J, Winblad B, Frykman S, Tjernberg LO (2008) Active gamma-secretase is localized to detergent-resistant membranes in human brain. FEBS J 275: 1174-1187.
-
(2008)
FEBS J
, vol.275
, pp. 1174-1187
-
-
Hur, J.Y.1
Welander, H.2
Behbahani, H.3
Aoki, M.4
Frånberg, J.5
Winblad, B.6
Frykman, S.7
Tjernberg, L.O.8
-
4
-
-
44349146545
-
Guidelines for management of idiopathic normal pressure hydrocephalus
-
Ishikawa M, Hashimoto M, Kuwana N, Mori E, Miyake H, Wachi A, Takeuchi T, Kazui H, Koyama H (2008) Guidelines for management of idiopathic normal pressure hydrocephalus. Neurol Med Chir (Tokyo) 48: S1-S23.
-
(2008)
Neurol Med Chir (Tokyo)
, vol.48
-
-
Ishikawa, M.1
Hashimoto, M.2
Kuwana, N.3
Mori, E.4
Miyake, H.5
Wachi, A.6
Takeuchi, T.7
Kazui, H.8
Koyama, H.9
-
5
-
-
0028169925
-
Visualization of Aβ42(43) and Aβ40 in senile plaque with end-specific Aβ monoclonals: evidence that an initially deposited forms is Aβ42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of Aβ42(43) and Aβ40 in senile plaque with end-specific Aβ monoclonals: evidence that an initially deposited forms is Aβ42(43). Neuron 13: 45-53.
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
6
-
-
33744957163
-
Equimolar production of amyloid β-protein and amyloid precursor protein intracellular domain from β-carboxyl-terminal fragment by γ-secretase
-
Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y (2006) Equimolar production of amyloid β-protein and amyloid precursor protein intracellular domain from β-carboxyl-terminal fragment by γ-secretase. J Biol Chem 281: 14776-14786.
-
(2006)
J Biol Chem
, vol.281
, pp. 14776-14786
-
-
Kakuda, N.1
Funamoto, S.2
Yagishita, S.3
Takami, M.4
Osawa, S.5
Dohmae, N.6
Ihara, Y.7
-
7
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21: 372-381.
-
(2001)
J Neurosci
, vol.21
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.H.2
Saido, T.C.3
Shoji, M.4
Ashe, K.H.5
Younkin, S.G.6
-
8
-
-
0030897134
-
The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at Aβ42(43)
-
Kosaka T, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, Imai K, Iwatsubo T (1997) The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at Aβ42(43). Neurology 48: 741-745.
-
(1997)
Neurology
, vol.48
, pp. 741-745
-
-
Kosaka, T.1
Imagawa, M.2
Seki, K.3
Arai, H.4
Sasaki, H.5
Tsuji, S.6
Asami-Odaka, A.7
Fukushima, T.8
Imai, K.9
Iwatsubo, T.10
-
9
-
-
33745282142
-
Dynamin-binding protein gene on chromosome 10q is associated with late-onsheimer's disease
-
Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, et al (2006) Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet 15: 2170-2182.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 2170-2182
-
-
Kuwano, R.1
Miyashita, A.2
Arai, H.3
Asada, T.4
Imagawa, M.5
Shoji, M.6
Higuchi, S.7
Urakami, K.8
Kakita, A.9
Takahashi, H.10
-
10
-
-
0030925314
-
The validity of the family history method for identifying Alzheimer disease
-
Li G, Aryan M, Silverman JM, Haroutunian V, Perl DP, Birstein S, Lantz M, Marin DB, Mohs RC, Davis KL (1997) The validity of the family history method for identifying Alzheimer disease. Arch Neurol 54: 634-640.
-
(1997)
Arch Neurol
, vol.54
, pp. 634-640
-
-
Li, G.1
Aryan, M.2
Silverman, J.M.3
Haroutunian, V.4
Perl, D.P.5
Birstein, S.6
Lantz, M.7
Marin, D.B.8
Mohs, R.C.9
Davis, K.L.10
-
11
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
12
-
-
21444450394
-
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid β-peptides
-
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, et al (2005) Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid β-peptides. J Biol Chem 280: 19070-19077.
-
(2005)
J Biol Chem
, vol.280
, pp. 19070-19077
-
-
Nakaya, Y.1
Yamane, T.2
Shiraishi, H.3
Wang, H.Q.4
Matsubara, E.5
Sato, T.6
Dolios, G.7
Wang, R.8
De Strooper, B.9
Shoji, M.10
-
13
-
-
0034975370
-
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain
-
Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y (2001) Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. Am J Pathol 158: 2209-2218.
-
(2001)
Am J Pathol
, vol.158
, pp. 2209-2218
-
-
Oshima, N.1
Morishima-Kawashima, M.2
Yamaguchi, H.3
Yoshimura, M.4
Sugihara, S.5
Khan, K.6
Games, D.7
Schenk, D.8
Ihara, Y.9
-
14
-
-
19944430034
-
Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase
-
Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saiso TC, Wang R, et al (2005) Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase. J Neurosci 25: 436-445.
-
(2005)
J Neurosci
, vol.25
, pp. 436-445
-
-
Qi-Takahara, Y.1
Morishima-Kawashima, M.2
Tanimura, Y.3
Dolios, G.4
Hirotani, N.5
Horikoshi, Y.6
Kametani, F.7
Maeda, M.8
Saiso, T.C.9
Wang, R.10
-
15
-
-
47549117283
-
Biochemical markers in persons with preclinical familial Alzheimer disease
-
Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, et al (2008) Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology 71: 85-92.
-
(2008)
Neurology
, vol.71
, pp. 85-92
-
-
Ringman, J.M.1
Younkin, S.G.2
Pratico, D.3
Seltzer, W.4
Cole, G.M.5
Geschwind, D.H.6
Rodriguez-Agudelo, Y.7
Schaffer, B.8
Fein, J.9
Sokolow, S.10
-
16
-
-
79960819248
-
Potent amyloidogenicity and pathogenicity of Aβ43
-
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, et al (2011) Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci 14: 1023-1032.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1023-1032
-
-
Saito, T.1
Suemoto, T.2
Brouwers, N.3
Sleegers, K.4
Funamoto, S.5
Mihira, N.6
Matsuba, Y.7
Yamada, K.8
Nilsson, P.9
Takano, J.10
-
17
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease in increase in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, et al (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease in increase in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
18
-
-
21844454462
-
Amyloid β 38, 40, and 42 species in cerebrospinal fluid: more of the same
-
Schoonenboom NS, Mulder C, Van Kamp GJ, Mehta SP, Scheltens P, Blankenstein MA, Mehta PD (2005) Amyloid β 38, 40, and 42 species in cerebrospinal fluid: more of the same. Ann Neurol 58: 139-142.
-
(2005)
Ann Neurol
, vol.58
, pp. 139-142
-
-
Schoonenboom, N.S.1
Mulder, C.2
Van Kamp, G.J.3
Mehta, S.P.4
Scheltens, P.5
Blankenstein, M.A.6
Mehta, P.D.7
-
19
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
20
-
-
65549140727
-
γ-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease
-
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horre K, Van Houtvin T, Esselmann H, Paul S, Schafer MK, Berezovska O, et al (2009) γ-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science 324: 639-642.
-
(2009)
Science
, vol.324
, pp. 639-642
-
-
Serneels, L.1
Van Biervliet, J.2
Craessaerts, K.3
Dejaegere, T.4
Horre, K.5
Van Houtvin, T.6
Esselmann, H.7
Paul, S.8
Schafer, M.K.9
Berezovska, O.10
-
21
-
-
0032581113
-
Combination assay of CSF tau, Aβ1-40 and Aβ 1-42(43) as a biochemical marker of Alzheimer's disease
-
Shoji M, Matsubara E, Kanai M, Watanabe M, Nakamura T, Tomidokoro Y, Shizuka M, Wakabayashi K, Igeta Y, Ikeda Y, et al (1998) Combination assay of CSF tau, Aβ1-40 and Aβ 1-42(43) as a biochemical marker of Alzheimer's disease. J Neurol Sci 158: 134-140.
-
(1998)
J Neurol Sci
, vol.158
, pp. 134-140
-
-
Shoji, M.1
Matsubara, E.2
Kanai, M.3
Watanabe, M.4
Nakamura, T.5
Tomidokoro, Y.6
Shizuka, M.7
Wakabayashi, K.8
Igeta, Y.9
Ikeda, Y.10
-
22
-
-
0038038284
-
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis
-
Silverberg GD, Mayo M, Saul T, Rubenstein E, McGuire D (2003) Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol 2: 506-511.
-
(2003)
Lancet Neurol
, vol.2
, pp. 506-511
-
-
Silverberg, G.D.1
Mayo, M.2
Saul, T.3
Rubenstein, E.4
McGuire, D.5
-
23
-
-
33947703676
-
Amyloid β1-40 quantification in CSF: comparison between chromatographic and immunochemical methods
-
Simonsen AH, Hansson SF, Ruetschi U, McGuire J, Podust VN, Davies HA, Mehta P, Waldemar G, Zetterberg H, Andreasen N, et al (2007) Amyloid β1-40 quantification in CSF: comparison between chromatographic and immunochemical methods. Dement Geriatr Cogn Disord 23: 246-250.
-
(2007)
Dement Geriatr Cogn Disord
, vol.23
, pp. 246-250
-
-
Simonsen, A.H.1
Hansson, S.F.2
Ruetschi, U.3
McGuire, J.4
Podust, V.N.5
Davies, H.A.6
Mehta, P.7
Waldemar, G.8
Zetterberg, H.9
Andreasen, N.10
-
24
-
-
70350451482
-
γ-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of β-carboxyl terminal fragment
-
Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y (2009) γ-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of β-carboxyl terminal fragment. J Neurosci 29: 13042-13052.
-
(2009)
J Neurosci
, vol.29
, pp. 13042-13052
-
-
Takami, M.1
Nagashima, Y.2
Sano, Y.3
Ishihara, S.4
Morishima-Kawashima, M.5
Funamoto, S.6
Ihara, Y.7
-
25
-
-
0037468759
-
The role of presenilin cofactors in the γ-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T (2003) The role of presenilin cofactors in the γ-secretase complex. Nature 422: 438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
26
-
-
0345275891
-
Gamma-secretase activity is present in rafts but is not cholesterol-dependent
-
Wada S, Morishima-Kawashima M, Qi Y, Misonou H, Shimada Y, Ohno-Iwashita Y, Ihara Y (2003) Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry 47: 13977-13986.
-
(2003)
Biochemistry
, vol.47
, pp. 13977-13986
-
-
Wada, S.1
Morishima-Kawashima, M.2
Qi, Y.3
Misonou, H.4
Shimada, Y.5
Ohno-Iwashita, Y.6
Ihara, Y.7
-
27
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, et al (2001) A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature 414: 212-216.
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
-
28
-
-
4544350756
-
Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
-
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Backman L, Albert M, Almkvist O, et al (2004) Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256: 240-246.
-
(2004)
J Intern Med
, vol.256
, pp. 240-246
-
-
Winblad, B.1
Palmer, K.2
Kivipelto, M.3
Jelic, V.4
Fratiglioni, L.5
Wahlund, L.O.6
Nordberg, A.7
Backman, L.8
Albert, M.9
Almkvist, O.10
-
29
-
-
0037008723
-
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins
-
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arakawa S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, et al (2002) Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J Biol Chem 277: 28135-28142.
-
(2002)
J Biol Chem
, vol.277
, pp. 28135-28142
-
-
Yang, D.S.1
Tandon, A.2
Chen, F.3
Yu, G.4
Yu, H.5
Arakawa, S.6
Hasegawa, H.7
Duthie, M.8
Schmidt, S.D.9
Ramabhadran, T.V.10
-
30
-
-
34547871652
-
Angiotensin-converting enzyme converts amyloid β-protein 1-42 (Aβ(1-42)) to Aβ(1-40), and its inhibition enhances brain Aβ deposition
-
Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, et al (2007) Angiotensin-converting enzyme converts amyloid β-protein 1-42 (Aβ(1-42)) to Aβ(1-40), and its inhibition enhances brain Aβ deposition. J Neurosci 27: 8628-8635.
-
(2007)
J Neurosci
, vol.27
, pp. 8628-8635
-
-
Zou, K.1
Yamaguchi, H.2
Akatsu, H.3
Sakamoto, T.4
Ko, M.5
Mizoguchi, K.6
Gong, J.S.7
Yu, W.8
Yamamoto, T.9
Kosaka, K.10
|