Kimchi and Its Health Benefits

Fermented Foods in Health and Disease Prevention

Volumn , Issue , 2017, Pages 477-502

  Park, K Y ^a   Kim, H Y ^a   Jeong, J K ^a  

^a Pusan National University   (South Korea)

Author keywords

Fermentation; Health benefits; Kimchi; Lactic acid bacteria; Probiotics

Indexed keywords

EID: 85011056266     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-802309-9.00020-0     Document Type: Chapter

References (108)

1. Ahn S.J. The Effect of Kimchi Powder Supplement on the Body Weight Reduction of Obese Adult Women 2007, (MS thesis), Pusan National University, Busan, Korea.
2. Baek Y.H., Kwak J.R., Kim S.J., Han S.S., Song Y.O. Effects of kimchi supplementation and/or exercise training on body composition and plasma lipids in obese middle school girls. Journal of the Korean Society of Food Science and Nutrition 2001, 30:906-912.
3. Bengmark S. Use of prebiotics, probiotic and synbiotics in clinical immunonutrition. Proceedings of International Symposium on Food, Nutrition and Health for 21st Century. Seoul 2001, 187-213.
4. Bong Y.J., Jeong J.K., Park K.Y. Fermentation properties and increased health functionality of kimchi by kimchi lactic acid bacteria starters. Journal of the Korean Society of Food Science and Nutrition 2013, 42:1717-1726.
5. Chae O.W., Shin K.S., Chung H., Choe T.B. Immunostimulation effects of mice fed with cell lysate of Lactobacillus plantarum isolated from kimchi. Korean Journal of Biotechnology and Bioengineering 1998, 13:424-430.
6. Chang J.Y., Chang H.C. Improvements in the quality and shelf life of kimchi by fermentation with the induced bacteriocin-producing strain, Leuconostoc citreum GJ7 as a starter. Journal of Food Science 2010, 75:M103-M110.
7. Chang J.H., Shim Y.Y., Cha S.K., Chee K.M. Probiotic characteristics of lactic acid bacteria isolated from kimchi. Journal of Applied Microbiology 2010, 109:220-230.
8. Chang J.Y., Kim I.C., Chang H.C. Effect of solar salt on kimchi fermentation during long-term storage. Korean Journal of Food Science and Technology 2014, 46:456-464.
9. Chang J.H. Studies on the origin of Korean vegetable pickles. Thesis collection. Sungsin Womens College 1975, 6:149-154.
10. Cheigh H.S., Park K.Y. Biochemical, microbiological and nutritional aspect of kimchi. Critical Reviews in Food Science and Nutrition 1994, 43:175-203.
11. Cho J.H., Lee D.Y., Yang C.N., Jeon J.I., Kim J.H., Han H.U. Microbial population dynamics of kimchi, a fermented cabbage product. FEMS Microbiology Letters 2006, 257:262-267.
12. Cho Y.R., Chang J.Y., Chang H.C. Production of δ-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. Journal of Microbiology and Biotechnology 2007, 17:104-109.
13. Cho E.J. Standardization and cancer Chemopreventive Activities of Chinese Cabbage Kimchi 1999, (Ph.D. thesis), Pusan National University, Busan, Korea.
14. Choi S.M., Park K.Y. Effects of different kinds of salt on kimchi fermentation and chemopreventive functionality. Journal of Korean Association of Cancer Prevention 2002, 7:192-199.
15. Choi M.W., Kim K.H., Kim S.H., Park K.Y. Inhibitory effects of kimchi extracts on carcinogen-induced cytotoxicity and transformation in C3H10T1/2 cells. Journal of Food Science and Nutrition 1997, 2:241-245.
16. Choi S.M., Jeon Y.S., Rhee S.H., Park K.Y. Red pepper powder and kimchi reduce body weight and blood and tissue lipids in rats fed a high fat diet. Nutraceuticals and Food 2002, 7:162-167.
17. Choi J.M., Lee S.H., Park K.Y., Kang S.A., Cho E.J. Protective effect of kimchi against A25-35-induced impairment of cognition and memory. Journal of the Korean Society of Food Science and Nutrition 2014, 43:360-366.
18. Choi S.M. Antiobesity and Anticancer Effects of Red Pepper Powder and Kimchi 2001, (Ph.D. thesis), Pusan National University, Busan, Korea.
19. Chung H.K. The physiological characteristics and immunological functions of lactic acid bacteria from kimchi. Kimchi Science and Industry 1993, 2:23-28.
20. Collins M.D., Samelis J., Metaxopoulos J., Wallbanks S. Taxonomic studies on some leuconostoc-like organisms from fermented sausages: description of a new genus Weissella for the Leuconostoc paramesenteroides group of species. Journal of Applied Bacteriology 1993, 75:595-603.
21. Cui M., Kim H.Y., Lee K.H., Jeong J.K., Hwang J.H., Yeo K.Y., Ryu B.H., Choi J.H., Park K.Y. Antiobesity effects of kimchi in diet-induced obese mice. Journal of Ethnic Foods 2015, 2:137-144.
22. D'Elia L., Rossi G., Ippolito R., Cappuccio F.P., Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clinical Nutrition 2012, 31:489-498.
23. Goldin B.R., Gorbach S.L. The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. Journal of the National Cancer Institute 1976, 57:371-375.
24. Ha J.O., Park K.Y. Comparison of auto-oxidation rate and comutagenic effect of different kinds of salt. Journal of Korean Association of Cancer Prevention 1999, 4:44-51.
25. Han G.J., Son A.R., Lee S.M., Jung J.K., Kim S.H., Park K.Y. Improved quality and increased in vitro anticancer effects of kimchi by using natural sea salt without bittern and baked (Guwun) salt. Journal of Korean Society of Food Science and Nutrition 2009, 38:996-1002.
26. Han W., Hu W., Lee Y.M. Anticancer activity of human colon cancer (HT-29) cell line from different fraction of Zanthoxylum schnifolium fruits. Korean Journal of Pharmacology 2011, 42:282-287.
27. Higuchi T., Hayashi H., Abe K. Exchange of glutamate and δ-aminobutyrate in a Lactobacillus strain. Journal of Bacteriology 1997, 179:3362-3364.
28. Hur Y.M., Kim S.H., Park K.Y. Inhibitory effects of kimchi extracts on the growth and DNA synthesis of human cancer cells. Journal of Food Science and Nutrition 1999, 4:107-112.
29. Hur Y.M., Kim S.H., Choi Y.W., Park K.Y. Inhibition of tumor formation and changes in hepatic enzyme activities by kimchi extracts in sarcoma-180 cell transplanted mice. Journal of Food Science and Nutrition 2000, 5:48-53.
30. Hwang J.W., Song Y.O. The effects of solvent fractions of kimchi on plasma lipid concentration of rabbit-fed high-cholesterol diet. Journal of the Korean Society of Food Science and Nutrition 2000, 19:204-210.
31. 1. Environmental Mutagens and Carcinogens 1997, 17:133-137.
32. Islam M.S., Choi H. Antidiabetic effect of Korean traditional baechu (Chinese cabbage) kimchi in a type 2 diabetes model of rats. Journal of Medicinal Food 2009, 12:292-297.
33. Jakobs C., Jaeken J., Gibson K.M. Inherited disorders of GABA metabolism. Journal of Inherited Metabolic Disease 1993, 16:704-715.
34. Jang S.E., Joh E.H., Lee H.Y., Ahn Y.T., Lee J.H., Huh C.S., Han M.J., Kim D.H. Lactobacillus plantarum HY7712 ameliorates cyclophosphamide-induced immunosuppression in mice. Journal of Microbiology and Biotechnology 2013, 23:414-421.
35. Jeun J., Kim S., Cho S.Y., Jun H.J., Park H.J., Seo J.G., Chung M.J., Lee S.J. Hypocholesterolemic effects of Lactobacillus plantarum KCTC 3928 by increased bile acid excretion in C57BL/6 mice. Nurition 2010, 26:321-330.
36. Joossens J.V., Hill M.J., Elliott P., Stamler R., Stamler J., Lesaffre E., Dyer A., Nichols R., Kesteloot H. Dietary salt, nitrate and stomach cancer mortality in 24 countries. International Journal of Epidemiology 1996, 25:494-502.
37. Joosten H.M.L.J., Nunez M. Prevention of histamine formation in cheese by bacteriocin-producing lactic acid bacteria. Applied and Environmental Microbiology 1996, 62:1178-1181.
38. Jung J.Y., Lee S.H., Kim J.M., Park M.S., Bae J.W., Hahn Y., Madsen E.L., Jeon C.O. Metagenomic analysis of kimchi, a traditional Korean fermented food. Applied and Environmental Microbiology 2011, 77:2264-2274.
39. Jung J.Y., Lee S.H., Lee H.J., Seo H.Y., Park W.S., Jeon C.O. Effect of Leuconostoc mesenteroides starter cultures on microbial communities and metabolites during kimchi fermentation. International Journal of Food Microbiology 2012, 153:378-387.
40. Kalac P., Krausova P. A review of dietary polyamines: formation, implication for growth and health and occurrence in foods. Food Chemistry 2005, 77:349-351.
41. Kil J.H. Studies on Development of Cancer Preventive and Anticancer Kimchi and Its Anticancer Mechanism 2004, (Ph.D. thesis), Pusan National University, Busan, Korea.
42. Kim M.J., Chun J.S. Bacterial community structure in kimchi, a Korean fermented vegetable food, as revealed by 16S rRNA gene analysis. International Journal of Food Microbiology 2005, 103:91-96.
43. Kim J.Y., Lee Y.S. The effects of kimchi intake on lipid contents of body and mitogen response of spleen lymphocytes in rats. Journal of the Korean Society of Food Science and Nutrition 1997, 26:1200-1207.
44. Kim S.H., Lee E.H., Kawabata T., Ishbashi T., Endo T., Matsui M. Possibility of N-nitrosamine formation during fermentation of kimchi. Journal of the Korean Society of Food Science and Nutrition 1984, 13:291-306.
45. Kim H.Y., Bae H.S., Baek Y.J. In vivo antitumor effects of lactic acid bacteria on Sarcoma 180 and mouse Lewis lung carcinoma. Journal of the Korean Cancer Association 1991, 23:188-196.
46. Kim S.H., Park K.Y., Suh M.J. Comutagenic effect of sodium chloride in the Salmonella/mammalian microsome assay. Food Science and Biotechnology 1995, 4:264-267.
47. Kim B.J., Chun J., Han H.U. Leuconostoc kimchii sp. nov., a new species from kimchi. International Journal of Systematic and Evolutionary Microbiology 2000, 50:1915-1919.
48. Kim J.H., Ryu J.D., Lee H.G., Park J.H. The effect of kimchi on production of free radicals and antioxidative enzyme activities in the brain of SAM. Journal of the Korean Society of Food Science and Nutrition 2002, 31:117-123.
49. Kim H.J., Lee J.S., Chung H.Y., Song S.H., Suh H.S., Noh J.S., Song Y.O. 3-(4-hydroxyl-3,5-dimethoxylphenyl) propionic acid, an active principle of kimchi, inhibits development of atherosclerosis in rabbits. Journal of Agricultural and Food Chemistry 2007, 55:10486-10492.
50. Kim Y.T., Kim B.K., Park K.Y. Antimutagenic and anticancer effects of leaf mustard and leaf mustard kimchi. Journal of Food Science and Nutrition 2007, 12:84-88.
51. Kim B.K., Park K.Y., Kim H.Y., Ahn S.C., Cho E.J. Antiaging effects and mechanisms of kimchi during fermentation under stress-induced premature senescence cellular system. Food Science and Biotechnology 2011, 20:643-649.
52. Kim E.K., An S.Y., Lee M.S., Kim T.H., Lee H.K., Hwang W.S., Choe S.J., Kim T.Y., Han S.J., Kim H.J., Kim D.J., Lee K.W. Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients. Nutrition Research 2011, 31:436-443.
53. Kim H.Y., Song J.L., Chang H.K., Kang S.A., Park K.Y. Kimchi protects against azoxymethane/dextran sulfate sodium-induced colorectal carcinogenesis in mice. Journal of Medicinal Food 2014, 17:833-841.
54. Kim K.M. Increases in Swimming Endurance Capacity of Mice by Capsaicin 1998, (Ph.D. thesis), Kyoto University, Kyoto, Japan.
55. Kim B.K. Antiaging Effects and Anticancer Mechanisms of Kimchi During Fermentation 2009, (Ph.D. thesis), Pusan National University, Busan, Korea.
56. Kwon E.A., Kim M.H. Microbial evaluation of commercially packed kimchi products. Food Science and Biotechnology 2007, 16:615-620.
57. Kwon M.J., Song Y.O., Song Y.S. Effect of kimchi on tissue and fecal lipid composition and apoprotein and thyroxine levels in rats. Journal of Korean Society of Food Science and Nutrition 1997, 26:507-513.
58. Kwon M.J., Chun J.H., Song Y.S., Song Y.O. Daily kimchi consumption and its hypolipidemic effect in middle-aged men. Journal of the Korean Society of Food Science and Nutrition 1999, 28:1144-1150.
59. Kwon J.Y., Cheigh H.S., Song Y.O. Weight reduction and lipid lowering effects of kimchi lactic acid powder in rats fed high fat diets. Korean Journal of Food Science and Technology 2004, 36:1014-1019.
60. Lee S.W., Woo S.J. Effect of some materials on the contents of nitrate, nitrite and vitamin C in kimchi during fermentation. Korean Journal of Dietary Culture 1989, 4:161-166.
61. Lee C.W., Ko C.Y., Ha D.M. Microfloral changes of the lactic acid bacteria during kimchi fermentation and identification of the isolates. Korean Journal of Applied Microbiology and Biotechnology 1992, 20:102-109.
62. Lee J.S., Jung M.C., Kim W.S., Kim H.J., Park C.S., Joo Y.J., Lee H.J., Ahn J.S., Park W., Park Y.H., Mheen T.I. Identification of lactic acid bacteria from kimchi by cellular FAMEs analysis. Korean Journal of Microbiology and Biotechnology 1996, 24:234-241.
63. Lee J.S., Chun C.O., Jung M.C., Kim W.S., Kim H.J., Hector M., Kim S.B., Park C.S., Ahn J.S., Park Y.H., Mheen T.I. Classification of isolates originating from kimchi using carbon-source utilization patterns. Journal of Microbiology and Biotechnology 1997, 7:68-74.
64. Lee J., Hwang K.T., Heo M.S., Lee J.H., Park K.Y. Resistance of Lactobacillus plantarum KCTC 3099 from kimchi to oxidative stress. Journal of Medicinal Food 2005, 8:299-304.
65. Lee J.S., Heo G.Y., Lee J.W., Oh Y.J., Park J.A., Park Y.H., Pyun Y.R., Ahn J.S. Analysis of kimchi microflora using denaturing gradient gel electrophoresis. International Journal of Food Microbiology 2005, 102:143-150.
66. Lee J.H., Kweon D.H., Lee S.C. Isolation and characterization of an immunopotentiating factor from Lactobacillus plantarum in kimchi: assessment of immunostimulatory activities. Food Science and Biotechnology 2006, 15:877-883.
67. Lee D.Y., Kim S.J., Cho J.H., Kim J.H. Microbial population dynamics and temperature changes during fermentation of kimjang kimchi. Journal of Microbiology 2008, 46:590-593.
68. Lee G.I., Lee H.M., Lee C.H. Food safety issues in industrialization of traditional Korean foods. Food Control 2012, 24:1-5.
69. Lee S.Y., Song Y.O., Han E.S., Han J.S. Comparative study on dietary habits, food intakes, and serum lipid levels according to kimchi consumption in college students. Journal of the Korean Society of Food Science and Nutrition 2012, 41:351-361.
70. Lee S.W. Studies on the movements and inter-changes of vegetable pickles in China, Korea and Japan. Journal of the Korean Society of Food Science and Nutrition 1975, 4:71-76.
71. Lim C.R., Park H.K., Han H.U. Reevaluation of isolation and identification of gram positive bacteria in kimchi. The Korean Journal of Microbiology 1989, 27:404-414.
72. Mah J.H., Kim Y.J., No H.K., Hwang H.J. Determination of biogenic amines in kimchi, Korean traditional fermented vegetable products. Food Science and Biotechnology 2004, 13:826-829.
73. Martineau B., Laflamme D.P. Effect of diet on markers of intestinal health in dogs. Research in Veterinary Science 2002, 72:223-227.
74. Moon Y.J., Soh J.R., Yu J.J., Sohn H.S., Cha Y.S., Oh S.H. Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from kimchi on differentiating adipocyte. Journal of Applied Microbiology 2012, 113:652-658.
75. O'Donnell M., Mente A. Urinary sodium and potassium excretion, mortality, and cardiovascular events. New England Journal of Medicine 2014, 371:612-623.
76. Oh Y.J., Hwang I.J., Leitzmann C. Regular intake of kimchi prevents colon cancer. Kimchi Science and Industry 1993, 2:9-22.
77. Oh C.K., Oh M.C., Hyon J.S., Choi W.J., Lee S.H., Kim S.H. Depletion of nitrite by lactic acid bacteria from kimchi (II). Journal of Korean Society of Food Science and Nutrition 1997, 26:556-562.
78. Oh C.K., Oh M.C., Kim S.H. The depletion of sodium nitrite by lactic acid bacteria isolated from kimchi. Journal of Medicinal Food 2004, 7:38-44.
79. Park K.Y., Cheigh H.S. Kimchi and nitrosamines. Journal of Korean Society of Food Science and Nutrition 1992, 21:109-116.
80. Park K.Y., Cheigh H.S. Kimchi. Handbook of Food Science and Beverage Fermentation Technology 2004, 621-655. Marcel Dekker, New York. Y.H. Hui, L. Meunier-Goddik, A.S. Hansen, J. Josephsen, W.K. Nip, P.S. Stanfield, F. Toldra (Eds.).
81. Park K.Y., Kim B.K. Lactic acid bacteria in vegetable fermentation. Lactic Acid Bacteria 2012, 187-211. CRC Press, Boca Raton, FL, USA. S. Lahtnen, A.C. Ouwehand, S. Salminen, A. von Wright (Eds.).
82. Park K.Y., Rhee S.H. Functional foods from fermented vegetable products: kimchi (Korean fermented vegetables) and functionality. Asian Functional Foods 2005, 341-380. CRC Press Inc., Boca Raton, FL. J. Shi, C.T. Ho, F. Shahidi (Eds.).
83. Park K.Y., Kim S.H., Suh M.J. Comutagenicity of high-salted kimchi in the Salmonella assay system. Journal of the College of Home Economics, Pusan National University 1990, 16:45-50.
84. Park K.Y., Baek K.A., Rhee S.H., Cheigh H.S. Antimutagenic effect of kimchi. Foods and Biotechnology 1995, 4:141-145.
85. Park J.S., Park K.Y., Yu R. Inhibition of in vitro nitrosation by capsaicin and its metabolites. Journal of Korean Society of Food Science and Nutrition 1998, 27:1015-1018.
86. v12-induced DNA synthesis. Journal of Medicinal Food 2003, 6:151-156.
87. Park J.M., Shin J.H., Lee D.W., Song J.C., Suh H.J., Chang U.J., Kim J.M. Identification of the lactic acid acteria in kimchi according to initial and over-ripened fermentation using PCR and 16S rRNA gene sequence analysis. Food Science and Biotechnology 2010, 19:541-546.
88. Park E.J., Chun J.S., Cha C.J., Park W.S., Jeon C.O., Bae J.W. Bacterial community analysis during fermentation of ten representative kinds of kimchi with barcoded pyrosequencing. Food Microbiology 2012, 30:197-204.
89. Park J.A., Pichiah P.B.T., Yu J.J., Oh S.H., Daily J.W., Cha Y.S. Anti-obesity effect of kimchi fermented with Weissella koreensis OK1-6 as starter in high-fat diet-induced obese C57BL/6J mice. Journal of Applied Microbiology 2012, 113:1507-1516.
90. Park K.Y. The nutritional evaluation, and antimutagenic and anticancer effects of kimchi. Journal of the Korean Society of Food Science and Nutrition 1995, 24:169-182.
91. Ray B., Bhunia A. Fundamental Food Microbiology 2008, 165-168. CRC Press, Boca Raton, FL, USA. fourth ed.
92. Raznikoff C.A., Bertram J.S., Brankow D.W., Heidelberger C.L. Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to post confluence inhibition of cell division. Cancer Research 1973, 33:3239-3429.
93. Ryu J.C., Park K.Y. Anticlastogenic effect of Baechu (Chinese cabbage) kimchi and Buchu (leek) kimchi in mitomycin C-induced micronucleus formations by supravital staining of mouse peripheral reticulocytes. Environmental Mutagens and Carcinogens 2001, 21:51-56.
94. Ryu S.H., Jeon Y.S., Kwon M.J., Moon J.W., Lee Y.S., Moon G.S. Effect of kimchi extracts to reactive oxygen species in skin cell cytotoxicity. Journal of the Korean Society of Food Science and Nutrition 1997, 26:814-821.
95. Ryu B.M. Effect of Kimchi on Inhibition of Skin Aging of Hairless Mouse 2000, (Ph.D. thesis), Pusan National University, Busan, Korea.
96. Segawa S., Hayashi A., Nakakita Y., Kaneda H., Watari J., Yasui H. Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates the development of dermatitis and inhibits immunoglobulin E production in atopic dermatitis model NC/Nga mice. Biological and Pharmaceutical Bulletin 2008, 31:884-889.
97. Seok J.H., Park K.B., Kim Y.H., Bae M.O., Lee M.K., Oh S.H. Production and characterization of kimchi with enhanced levels of δ-aminobutyric acid. Food Science and Biotechnology 2008, 17:940-946.
98. Settanni L., Corsetti A. The use of multiplex PCR to detect and differentiate food- and beverage-associated microorganisms: a review. Journal of Microbiological Methods 2007, 69:1-22.
99. Shin K.S., Chae O.W., Park I.C., Hong S.K., Choe T.B. Antitumor effects of mice fed with cell lysate of Lactobacillus plantarum isolated from kimchi. Korean Journal of Biotechnology and Bioengineering 1998, 13:357-363.
100. Shruti S., Park H.K., Kim J.K., Kim M.H. Determination of biogenic amines in Korean traditional fermented soybean paste (Doenjang). Food Chemical Toxicology 2010, 48:1191-1195.
101. Sousa R., Halper J., Zhang J., Lewis S.J., Li W.I. Effect of Lactobacillus acidophilus supernatants on body weight and leptin expression in rats. BMC Complementary and Alternative Medicine 2008, 8:1-8.
102. Sunada Y., Nakamura S., Kamei C. Effect of Lactobacillus acidophilus strain L-55 on the development of atopic dermatitis-like skin lesions in NC/Nga mice. International Immunopharmacology 2008, 8:1761-1766.
103. Tobita K., Yanaka H., Otani H. Heat-treated Lactobacillus crispatus KT strains reduce allergic symptoms in mice. Journal of Agricultural and Food Chemistry 2009, 57:5586-5590.
104. Watanabe T., Hamada K., Tategaki A., Kishida H., Tanaka H., Kitano M., Miyamoto T. Oral administration of lactic acid bacteria isolated from traditional South Asian fermented milk 'dahi' inhibits the development of atopic dermatitis in NC/Nga mice. Journal of Nutritional Science and Vitaminology 2009, 55:271-278.
105. Won T.J., Kim B., Lim Y.T., Song D.S., Park S.Y., Park E.S., Lee D.I., Hwang K.W. Oral administration of Lactobacillus strains from kimchi inhibits atopic dermatitis in NC/Nga mice. Journal of Applied Microbiology 2011, 110:1195-1202.
106. Wong C.G.T., Bottiglieri T., Snead O.C. GABA, δ-hydroxybutyric acid, and neurological disease. Annals of Neurology 2003, 54:S3-S12.
107. Yoon H.H., Chang H.C. Growth inhibitory effect of kimchi prepared with four year-old solar salt and Topan solar salt on cancer cells. Journal of the Korean Society of Food Science and Nutrition 2011, 40:935-941.
108. Yoon J.Y., Jung K.O., Kim S.H., Park K.Y. Antiobesity effect of baek-kimchi (whitish baechu kimchi) in rats fed high fat diet. Journal of Food Science and Nutrition 2004, 9:259-264.