Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

Nature Communications

Volumn 8, Issue , 2017, Pages

  Sagie, Shira ^a   Toubiana, Shir ^a   Hartono, Stella R ^b   Katzir, Hagar ^a   Tzur Gilat, Aya ^a   Havazelet, Shany ^a   Francastel, Claire ^c   Velasco, Guillaume ^c   Chédin, Frédéric ^b   Selig, Sara ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEASE H; DNA; LONG UNTRANSLATED RNA; RIBONUCLEASE HI;

CELLS AND CELL COMPONENTS; CHROMOSOME; DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; HYBRID; INJURY; RNA; VULNERABILITY;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL CYCLE S PHASE; CELL FUNCTION; CONTROLLED STUDY; CPG ISLAND; DNA BASE COMPOSITION; DNA DAMAGE; DNA RNA HYBRIDIZATION; DNA SEQUENCE; FIBROBLAST; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; ICF SYNDROME; LENTIVIRUS INFECTION; TELOMERE; TELOMERE LENGTH; TRANSCRIPTION INITIATION SITE; ABNORMALITIES; BLOOD; CELL LINE; CHROMOSOMAL INSTABILITY; FACE; GENETICS; IMMUNE DEFICIENCY; LYMPHOCYTE; METABOLISM; NUCLEOTIDE REPEAT; PRIMARY CELL CULTURE; TELOMERE SHORTENING;

CELL LINE; CHROMOSOMAL INSTABILITY; DNA; DNA DAMAGE; FACE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; LYMPHOCYTES; PRIMARY CELL CULTURE; REPETITIVE SEQUENCES, NUCLEIC ACID; RIBONUCLEASE H; RNA, LONG NONCODING; TELOMERE; TELOMERE SHORTENING;

EID: 85010904123     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14015     Document Type: Article

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