More on the lack of correlation between TERRA expression and telomere length

Frontiers in Oncology

Volumn 3 SEP, Issue , 2013, Pages

  Vitelli, Valerio ^a   Falvo, Paolo ^a   Khoriauli, Lela ^a   Smirnova, Alexandra ^a   Gamba, Riccardo ^a   Santagostino, Marco ^a   Nergadze, Solomon George ^a   Giulotto, Elena ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Cancer cell lines; Northern blotting; qRT PCR; Telomere length; TERRA

Indexed keywords

RNA; TELOMERIC REPEAT CONTAINING RNA; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; MASS SPECTROMETRY; NORTHERN BLOTTING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TELOMERE HOMEOSTASIS; TRANSCRIPTION REGULATION;

EID: 84891135999     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00245     Document Type: Article

References (17)

1. Van Beneden A, Arnoult N, Decottignies A. Telomeric RNA expression: length matters. Front Oncol (2013) 3:178. doi:10.3389/fonc.2013.00178
2. Smirnova A, Gamba R, Khoriauli L, Vitelli V, Nergadze SG, Giulotto E. TERRA expression levels do not correlate with telomere length and radiation sensitivity in human cancer cell lines. Front Oncol (2013) 3:115. doi:10.3389/fonc.2013.00115
3. Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science (2007) 318:798-801. doi:10.1126/science.1147182
4. Nergadze SG, Farnung BO, Wischnewski H, Khoriauli L, Vitelli V, Chawla R, et al. CpG-island promoters drive transcription of human telomeres. RNA (2009) 15:2186-94. doi:10.1261/rna.1748309
5. Farnung BO, Giulotto E, Azzalin CM. Promoting transcription of chromosome ends. Transcription (2010) 1:140-3. doi:10.4161/trns.1.3.13191
6. Deng Z, Norseenm J, Wiedmer A, Riethman H, Lieberman PM. TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell (2009) 35:403-13. doi:10.1016/j.molcel.2009.06.025
7. López de Silanes I, Stagno d'Alcontres M, Blasco MA. TERRA transcripts are bound by a complex array of RNA-binding proteins. Nat Commun (2010) 1:33.
8. Redon S, Zemp I, Lingner J. A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res (2013) Epub ahead of print. doi:10.1093/nar/gkt695
9. Scheibe M, Arnoult N, Kappei D, Buchholz F, Decottignies A, Butter F, et al. Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators. Genome Res (2013) Epub ahead of print. doi:10.1101/gr.151878.112
10. Xu Y, Kaminaga K, Komiyama M. G-quadruplex formation by human telomeric repeats-containing RNA in Na+ solution. J Am Chem Soc (2008) 130:11179-84. doi:10.1021/ja8031532
11. Biffi G, Tannahill D, Balasubramanian S. An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2. J Am Chem Soc (2012) 134:11974-76. doi:10.1021/ja305734x
12. Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res (2010) 38:5797-806. doi:10.1093/nar/gkq296
13. Farnung BO, Brun CM, Arora R, Lorenzi LE, Azzalin CM. Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One (2012) 7(4):e35714. doi:10.1371/journal.pone.0035714
14. Arnoult N, Van Beneden A, Decottignies A. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1a. Nat Struct Mol Biol (2012) 19:948-56. doi:10.1038/nsmb.2364
15. Deng Z, Wang Z, Stong N, Plasschaert R, Moczan A, Chen H-S, et al. A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection. EMBO J (2012) 31:4165-78. doi:10.1038/emboj.2012.266
16. Riethman H, Ambrosini A, Castaneda C, Finklestein J, Hu X-L, Mudunuri U, et al. Mapping and initial analysis of human subtelomeric sequence assemblies. Genome Res (2004) 14:18-28. doi:10.1101/gr.1245004
17. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet (2003) 33:203-7. doi:10.1038/ng1084