메뉴 건너뛰기




Volumn 32, Issue 21, 2013, Pages 2861-2871

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

Author keywords

DNA replication stress; R loops; telomere instability; TERRA; THO

Indexed keywords

EXONUCLEASE; LONG UNTRANSLATED RNA; PROTEIN; PROTEIN THO; PROTEIN THP2; RIBONUCLEASE H; RNA; TELOMERE BINDING PROTEIN; TELOMERIC REPEAT CONTAINING RNA; UNCLASSIFIED DRUG;

EID: 84887053583     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.217     Document Type: Article
Times cited : (117)

References (46)
  • 2
    • 33751237066 scopus 로고    scopus 로고
    • The S. Cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes
    • DOI 10.1101/gad.1478906
    • Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, Zakian VA (2006) The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev 20: 3104-3116 (Pubitemid 44790626)
    • (2006) Genes and Development , vol.20 , Issue.22 , pp. 3104-3116
    • Azvolinsky, A.1    Dunaway, S.2    Torres, J.Z.3    Bessler, J.B.4    Zakian, V.A.5
  • 3
    • 37349043972 scopus 로고    scopus 로고
    • Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
    • DOI 10.1126/science.1147182
    • Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318: 798-801 (Pubitemid 351411771)
    • (2007) Science , vol.318 , Issue.5851 , pp. 798-801
    • Azzalin, C.M.1    Reichenbach, P.2    Khoriauli, L.3    Giulotto, E.4    Lingner, J.5
  • 4
    • 84859042868 scopus 로고    scopus 로고
    • Preventing replication stress to maintain genome stability: Resolving conflicts between replication and transcription
    • Bermejo R, Lai MS, Foiani M (2012) Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription. Mol Cell 45: 710-718
    • (2012) Mol Cell , vol.45 , pp. 710-718
    • Bermejo, R.1    Lai, M.S.2    Foiani, M.3
  • 5
    • 0022516464 scopus 로고
    • Characterization of monoclonal antibody to DNA · RNA and its application to immunodetection of hybrids
    • DOI 10.1016/0022-1759(86)90040-2
    • Boguslawski SJ, Smith DE, Michalak MA, Mickelson KE, Yehle CO, Patterson WL, Carrico RJ (1986) Characterization of monoclonal antibody to DNA.RNA and its application to immunodetection of hybrids. J Immunol Methods 89: 123-130 (Pubitemid 16079589)
    • (1986) Journal of Immunological Methods , vol.89 , Issue.1 , pp. 123-130
    • Boguslawski, S.J.1    Smith, D.E.2    Michalak, M.A.3
  • 6
    • 65549148649 scopus 로고    scopus 로고
    • A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32regulates DNA replication in mammalian cells
    • Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB (2009) A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32regulates DNA replication in mammalian cells. J Biol Chem 284: 5807-5818
    • (2009) J Biol Chem , vol.284 , pp. 5807-5818
    • Casteel, D.E.1    Zhuang, S.2    Zeng, Y.3    Perrino, F.W.4    Boss, G.R.5    Goulian, M.6    Pilz, R.B.7
  • 7
    • 80053615725 scopus 로고    scopus 로고
    • Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
    • Chawla R, Redon S, Raftopoulou C, Wischnewski H, Gagos S, Azzalin CM (2011) Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication. EMBO J 30: 4047-4058
    • (2011) EMBO J , vol.30 , pp. 4047-4058
    • Chawla, R.1    Redon, S.2    Raftopoulou, C.3    Wischnewski, H.4    Gagos, S.5    Azzalin, C.M.6
  • 8
    • 10344256183 scopus 로고    scopus 로고
    • Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
    • DOI 10.1126/science.1103619
    • Crabbe L, Verdun RE, Haggblom CI, Karlseder J (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306: 1951-1953 (Pubitemid 39627862)
    • (2004) Science , vol.306 , Issue.5703 , pp. 1951-1953
    • Crabbe, L.1    Verdun, R.E.2    Haggblom, C.I.3    Karlseder, J.4
  • 9
    • 0034803110 scopus 로고    scopus 로고
    • RNase H1 of Saccharomyces cerevisiae: Methods and nomenclature
    • DOI 10.1016/S0076-6879(01)41166-9
    • Crouch RJ, Arudchandran A, Cerritelli SM (2001) RNase H1 of Saccharomyces cerevisiae: methods and nomenclature. Methods Enzymol 341: 395-413 (Pubitemid 32928540)
    • (2001) Methods in Enzymology , vol.341 , pp. 395-413
    • Crouch, R.J.1    Arudchandran, A.2    Cerritelli, S.M.3
  • 10
    • 77954841539 scopus 로고    scopus 로고
    • Loss of Topoisomerase i leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
    • El Hage A, French SL, Beyer AL, Tollervey D (2010) Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev 24: 1546-1558
    • (2010) Genes Dev , vol.24 , pp. 1546-1558
    • El Hage, A.1    French, S.L.2    Beyer, A.L.3    Tollervey, D.4
  • 11
    • 0034662244 scopus 로고    scopus 로고
    • Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres
    • Forstemann K, Hoss M, Lingner J (2000) Telomerase-dependent repeat divergence at the 30 ends of yeast telomeres. Nucleic Acids Res 28: 2690-2694 (Pubitemid 30488012)
    • (2000) Nucleic Acids Research , vol.28 , Issue.14 , pp. 2690-2694
    • Forstemann, K.1    Hoss, M.2    Lingner, J.3
  • 12
    • 84859087611 scopus 로고    scopus 로고
    • R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
    • Ginno PA, Lott PL, Christensen HC, Korf I, Chedin F (2012) R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol Cell 45: 814-825
    • (2012) Mol Cell , vol.45 , pp. 814-825
    • Ginno, P.A.1    Lott, P.L.2    Christensen, H.C.3    Korf, I.4    Chedin, F.5
  • 13
    • 70349335582 scopus 로고    scopus 로고
    • The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
    • Gomez-Gonzalez B, Felipe-Abrio I, Aguilera A (2009) The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol 29: 5203-5213
    • (2009) Mol Cell Biol , vol.29 , pp. 5203-5213
    • Gomez-Gonzalez, B.1    Felipe-Abrio, I.2    Aguilera, A.3
  • 15
    • 2442564703 scopus 로고    scopus 로고
    • Pol12, the B subunit of DNA polymerase α, functions in both telomere capping and length regulation
    • DOI 10.1101/gad.300004
    • Grossi S, Puglisi A, Dmitriev PV, Lopes M, Shore D (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18: 992-1006 (Pubitemid 38620240)
    • (2004) Genes and Development , vol.18 , Issue.9 , pp. 992-1006
    • Grossi, S.1    Puglisi, A.2    Dmitriev, P.V.3    Lopes, M.4    Shore, D.5
  • 16
    • 84861198042 scopus 로고    scopus 로고
    • CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion
    • Gu P, Min JN, Wang Y, Huang C, Peng T, Chai W, Chang S (2012) CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J 31: 2309-2321
    • (2012) EMBO J , vol.31 , pp. 2309-2321
    • Gu, P.1    Min, J.N.2    Wang, Y.3    Huang, C.4    Peng, T.5    Chai, W.6    Chang, S.7
  • 18
    • 84870599782 scopus 로고    scopus 로고
    • Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in
    • Huang C, Dai X, Chai W (2012) Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Res 22: 1681-1695
    • (2012) Cell Res , vol.22 , pp. 1681-1695
    • Huang, C.1    Dai, X.2    Chai, W.3
  • 19
    • 0141819093 scopus 로고    scopus 로고
    • Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
    • DOI 10.1016/j.molcel.2003.08.010
    • Huertas P, Aguilera A (2003) Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol Cell 12: 711-721 (Pubitemid 37222491)
    • (2003) Molecular Cell , vol.12 , Issue.3 , pp. 711-721
    • Huertas, P.1    Aguilera, A.2
  • 20
    • 79957983472 scopus 로고    scopus 로고
    • Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast
    • Iglesias N, Redon S, Pfeiffer V, Dees M, Lingner J, Luke B (2011) Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep 12: 587-593
    • (2011) EMBO Rep , vol.12 , pp. 587-593
    • Iglesias, N.1    Redon, S.2    Pfeiffer, V.3    Dees, M.4    Lingner, J.5    Luke, B.6
  • 21
    • 0020529962 scopus 로고
    • Transformation of intact yeast cells treated with alkali cations
    • Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168 (Pubitemid 13119852)
    • (1983) Journal of Bacteriology , vol.153 , Issue.1 , pp. 163-168
    • Ito, H.1    Fukuda, Y.2    Murata, K.3    Kimura, A.4
  • 22
    • 0036606186 scopus 로고    scopus 로고
    • Saccharomyces Rrm3p, a 5′ to 3′ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA
    • DOI 10.1101/gad.982902
    • Ivessa AS, Zhou JQ, Schulz VP, Monson EK, Zakian VA (2002) Saccharomyces Rrm3p, a 50 to 30 DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes Dev 16: 1383-1396 (Pubitemid 34615091)
    • (2002) Genes and Development , vol.16 , Issue.11 , pp. 1383-1396
    • Ivessa, A.S.1    Zhou, J.-Q.2    Schulz, V.P.3    Monson, E.K.4    Zakian, V.A.5
  • 23
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
    • Longtine MS, McKenzie 3rd A, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953-961 (Pubitemid 28328001)
    • (1998) Yeast , vol.14 , Issue.10 , pp. 953-961
    • Longtine, M.S.1    McKenzie III, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8
  • 24
    • 55949106494 scopus 로고    scopus 로고
    • The Rat1p 50 to 30 exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
    • Luke B, Panza A, Redon S, Iglesias N, Li Z, Lingner J (2008) The Rat1p 50 to 30 exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell 32: 465-477
    • (2008) Mol Cell , vol.32 , pp. 465-477
    • Luke, B.1    Panza, A.2    Redon, S.3    Iglesias, N.4    Li, Z.5    Lingner, J.6
  • 25
    • 1942518292 scopus 로고    scopus 로고
    • Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions
    • DOI 10.1128/MCB.24.9.4019-4031.2004
    • Makovets S, Herskowitz I, Blackburn EH (2004) Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol 24: 4019-4031 (Pubitemid 38496178)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.9 , pp. 4019-4031
    • Makovets, S.1    Herskowitz, I.2    Blackburn, E.H.3
  • 26
    • 33645747064 scopus 로고    scopus 로고
    • Semi-conservative DNA replication through telomeres requires Taz1
    • Miller KM, Rog O, Cooper JP (2006) Semi-conservative DNA replication through telomeres requires Taz1. Nature 440: 824-828
    • (2006) Nature , vol.440 , pp. 824-828
    • Miller, K.M.1    Rog, O.2    Cooper, J.P.3
  • 28
    • 79957556530 scopus 로고    scopus 로고
    • DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase
    • Paeschke K, Capra JA, Zakian VA (2011) DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Cell 145: 678-691
    • (2011) Cell , vol.145 , pp. 678-691
    • Paeschke, K.1    Capra, J.A.2    Zakian, V.A.3
  • 29
    • 84860594537 scopus 로고    scopus 로고
    • A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae
    • Paschini M, Toro TB, Lubin JW, Braunstein-Ballew B, Morris DK, Lundblad V (2012) A naturally thermolabile activity compromises genetic analysis of telomere function in Saccharomyces cerevisiae. Genetics 191: 79-93
    • (2012) Genetics , vol.191 , pp. 79-93
    • Paschini, M.1    Toro, T.B.2    Lubin, J.W.3    Braunstein-Ballew, B.4    Morris, D.K.5    Lundblad, V.6
  • 30
    • 84864041566 scopus 로고    scopus 로고
    • TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends
    • Pfeiffer V, Lingner J (2012) TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends. PLoS Genet 8: e1002747
    • (2012) PLoS Genet , vol.8
    • Pfeiffer, V.1    Lingner, J.2
  • 31
    • 0034661246 scopus 로고    scopus 로고
    • The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase α and the telomerase-associated Est1 protein
    • Qi H, Zakian VA (2000) The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein. Genes Dev 14: 1777-1788 (Pubitemid 30602996)
    • (2000) Genes and Development , vol.14 , Issue.14 , pp. 1777-1788
    • Qi, H.1    Zakian, V.A.2
  • 32
    • 77957243987 scopus 로고    scopus 로고
    • The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
    • Redon S, Reichenbach P, Lingner J (2010) The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 38: 5797-5806
    • (2010) Nucleic Acids Res , vol.38 , pp. 5797-5806
    • Redon, S.1    Reichenbach, P.2    Lingner, J.3
  • 33
    • 77955664901 scopus 로고    scopus 로고
    • The interface between transcription and mRNP export: From THO to THSC/TREX-2
    • Rondon AG, Jimeno S, Aguilera A (2010) The interface between transcription and mRNP export: from THO to THSC/TREX-2. Biochim Biophys Acta 1799: 533-538
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 533-538
    • Rondon, A.G.1    Jimeno, S.2    Aguilera, A.3
  • 35
    • 38849111756 scopus 로고    scopus 로고
    • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    • DOI 10.1038/ncb1685, PII NCB1685
    • Schoeftner S, Blasco MA (2008) Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 10: 228-236 (Pubitemid 351194053)
    • (2008) Nature Cell Biology , vol.10 , Issue.2 , pp. 228-236
    • Schoeftner, S.1    Blasco, M.A.2
  • 36
    • 84860456242 scopus 로고    scopus 로고
    • Removal of shelterin reveals the telomere end-protection problem
    • Sfeir A, De Lange T (2012) Removal of shelterin reveals the telomere end-protection problem. Science 336: 593-597
    • (2012) Science , vol.336 , pp. 593-597
    • Sfeir, A.1    De Lange, T.2
  • 38
    • 79959345878 scopus 로고    scopus 로고
    • Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    • Skourti-Stathaki K, Proudfoot NJ, Gromak N (2011) Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Mol Cell 42: 794-805
    • (2011) Mol Cell , vol.42 , pp. 794-805
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2    Gromak, N.3
  • 39
  • 42
    • 2042534735 scopus 로고    scopus 로고
    • Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states
    • DOI 10.1016/S0092-8674(04)00334-4, PII S0092867404003344
    • Teixeira MT, Arneric M, Sperisen P, Lingner J (2004) Telomere length homeostasis is achieved via a switch between telomeraseextendible and-nonextendible states. Cell 117: 323-335 (Pubitemid 38534539)
    • (2004) Cell , vol.117 , Issue.3 , pp. 323-335
    • Teixeira, M.T.1    Arneric, M.2    Sperisen, P.3    Lingner, J.4
  • 43
    • 84860854071 scopus 로고    scopus 로고
    • RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
    • Vannier JB, Pavicic-Kaltenbrunner V, Petalcorin MI, Ding H, Boulton SJ (2012) RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell 149: 795-806
    • (2012) Cell , vol.149 , pp. 795-806
    • Vannier, J.B.1    Pavicic-Kaltenbrunner, V.2    Petalcorin, M.I.3    Ding, H.4    Boulton, S.J.5
  • 44
    • 84255177502 scopus 로고    scopus 로고
    • RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability
    • Wahba L, Amon JD, Koshland D, Vuica-Ross M (2011) RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability. Mol Cell 44: 978-988
    • (2011) Mol Cell , vol.44 , pp. 978-988
    • Wahba, L.1    Amon, J.D.2    Koshland, D.3    Vuica-Ross, M.4
  • 45
    • 84863622662 scopus 로고    scopus 로고
    • Telomeric 30 overhangs derive from resection by Exo1 and Apollo and Fill-In by POT1b-associated CST
    • Wu P, Takai H, De Lange T (2012) Telomeric 30 overhangs derive from resection by Exo1 and Apollo and Fill-In by POT1b-associated CST. Cell 150: 39-52
    • (2012) Cell , vol.150 , pp. 39-52
    • Wu, P.1    Takai, H.2    De Lange, T.3
  • 46
    • 0036889334 scopus 로고    scopus 로고
    • Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p
    • DOI 10.1128/MCB.22.23.8241-8253.2002
    • Zenklusen D, Vinciguerra P, Wyss JC, Stutz F (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22: 8241-8253 (Pubitemid 35304057)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.23 , pp. 8241-8253
    • Zenklusen, D.1    Vinciguerra, P.2    Wyss, J.-C.3    Stutz, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.