메뉴 건너뛰기




Volumn 111, Issue 9, 2014, Pages 3377-3382

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

Author keywords

[No Author keywords available]

Indexed keywords

LONG UNTRANSLATED RNA; MESSENGER RNA; MUTANT PROTEIN; PROTEIN THO; RIBONUCLEASE H; TELOMERASE; TELOMERE ASSOCIATED NONCODING TELOMERE REPEAT CONTAINING RNA; UNCLASSIFIED DRUG;

EID: 84895807392     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307415111     Document Type: Article
Times cited : (102)

References (47)
  • 1
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer MS, Gottschling DE (1994) TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266(5184):404-409.
    • (1994) Science , vol.266 , Issue.5184 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 2
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57(4):633-643.
    • (1989) Cell , vol.57 , Issue.4 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 3
    • 0027266758 scopus 로고
    • An alternative pathway for yeast telomere maintenance rescues est1-senescence
    • Lundblad V, Blackburn EH (1993) An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell 73(2):347-360.
    • (1993) Cell , vol.73 , Issue.2 , pp. 347-360
    • Lundblad, V.1    Blackburn, E.H.2
  • 4
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-1412.
    • (1996) Genetics , vol.144 , Issue.4 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 5
    • 0029746495 scopus 로고    scopus 로고
    • Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
    • McEachern MJ, Blackburn EH (1996) Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev 10(14):1822-1834.
    • (1996) Genes Dev , vol.10 , Issue.14 , pp. 1822-1834
    • McEachern, M.J.1    Blackburn, E.H.2
  • 6
    • 0032959506 scopus 로고    scopus 로고
    • RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
    • Le S, Moore JK, Haber JE, Greider CW (1999) RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152(1): 143-152.
    • (1999) Genetics , vol.152 , Issue.1 , pp. 143-152
    • Le, S.1    Moore, J.K.2    Haber, J.E.3    Greider, C.W.4
  • 7
    • 0033513079 scopus 로고    scopus 로고
    • Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
    • Teng S-C, Zakian VA (1999) Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol 19(12): 8083-8093.
    • (1999) Mol Cell Biol , vol.19 , Issue.12 , pp. 8083-8093
    • Teng, S.-C.1    Zakian, V.A.2
  • 8
    • 0035131699 scopus 로고    scopus 로고
    • Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
    • Chen Q, Ijpma A, Greider CW (2001) Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events. Mol Cell Biol 21(5):1819-1827.
    • (2001) Mol Cell Biol , vol.21 , Issue.5 , pp. 1819-1827
    • Chen, Q.1    Ijpma, A.2    Greider, C.W.3
  • 9
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Models, mechanisms and implications
    • Cesare AJ, Reddel RR (2010) Alternative lengthening of telomeres: Models, mechanisms and implications. Nat Rev Genet 11(5):319-330.
    • (2010) Nat Rev Genet , vol.11 , Issue.5 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2
  • 10
    • 0033636907 scopus 로고    scopus 로고
    • Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
    • Teng S-C, Chang J, McCowan B, Zakian VA (2000) Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol Cell 6(4):947-952.
    • (2000) Mol Cell , vol.6 , Issue.4 , pp. 947-952
    • Teng, S.-C.1    Chang, J.2    McCowan, B.3    Zakian, V.A.4
  • 11
    • 37349043972 scopus 로고    scopus 로고
    • Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
    • Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318(5851):798-801.
    • (2007) Science , vol.318 , Issue.5851 , pp. 798-801
    • Azzalin, C.M.1    Reichenbach, P.2    Khoriauli, L.3    Giulotto, E.4    Lingner, J.5
  • 12
    • 55949106494 scopus 로고    scopus 로고
    • The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
    • Luke B, et al. (2008) The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell 32(4):465-477.
    • (2008) Mol Cell , vol.32 , Issue.4 , pp. 465-477
    • Luke, B.1
  • 13
    • 38849111756 scopus 로고    scopus 로고
    • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    • Schoeftner S, Blasco MA (2008) Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 10(2):228-236.
    • (2008) Nat Cell Biol , vol.10 , Issue.2 , pp. 228-236
    • Schoeftner, S.1    Blasco, M.A.2
  • 15
    • 84864041566 scopus 로고    scopus 로고
    • TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends
    • Pfeiffer V, Lingner J (2012) TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends. PLoS Genet 8(6):e1002747.
    • (2012) PLoS Genet , vol.8 , Issue.6
    • Pfeiffer, V.1    Lingner, J.2
  • 16
    • 68949198783 scopus 로고    scopus 로고
    • TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres
    • Deng Z, Norseen J, Wiedmer A, Riethman H, Lieberman PM (2009) TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell 35(4):403-413.
    • (2009) Mol Cell , vol.35 , Issue.4 , pp. 403-413
    • Deng, Z.1    Norseen, J.2    Wiedmer, A.3    Riethman, H.4    Lieberman, P.M.5
  • 17
    • 84863461725 scopus 로고    scopus 로고
    • Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
    • Maicher A, Kastner L, Dees M, Luke B (2012) Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res 40(14):6649-6659.
    • (2012) Nucleic Acids Res , vol.40 , Issue.14 , pp. 6649-6659
    • Maicher, A.1    Kastner, L.2    Dees, M.3    Luke, B.4
  • 18
    • 0034329461 scopus 로고    scopus 로고
    • A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
    • Chávez S, et al. (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-5834.
    • (2000) EMBO J , vol.19 , Issue.21 , pp. 5824-5834
    • Chávez, S.1
  • 19
    • 0037118052 scopus 로고    scopus 로고
    • TREX is a conserved complex coupling transcription with messenger RNA export
    • Strässer K, et al. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-308.
    • (2002) Nature , vol.417 , Issue.6886 , pp. 304-308
    • Strässer, K.1
  • 20
    • 0141819093 scopus 로고    scopus 로고
    • Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
    • Huertas P, Aguilera A (2003) Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol Cell 12(3):711-721.
    • (2003) Mol Cell , vol.12 , Issue.3 , pp. 711-721
    • Huertas, P.1    Aguilera, A.2
  • 21
    • 70349335582 scopus 로고    scopus 로고
    • The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
    • Gómez-González B, Felipe-Abrio I, Aguilera A (2009) The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol 29(19): 5203-5213.
    • (2009) Mol Cell Biol , vol.29 , Issue.19 , pp. 5203-5213
    • Gómez-González, B.1    Felipe-Abrio, I.2    Aguilera, A.3
  • 22
    • 84860338675 scopus 로고    scopus 로고
    • R loops: From transcription byproducts to threats to genome stability
    • Aguilera A, García-Muse T (2012) R loops: From transcription byproducts to threats to genome stability. Mol Cell 46(2):115-124.
    • (2012) Mol Cell , vol.46 , Issue.2 , pp. 115-124
    • Aguilera, A.1    García-Muse, T.2
  • 23
    • 84856253456 scopus 로고    scopus 로고
    • R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants
    • Stirling PC, et al. (2012) R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. Genes Dev 26(2):163-175.
    • (2012) Genes Dev , vol.26 , Issue.2 , pp. 163-175
    • Stirling, P.C.1
  • 24
    • 84863346524 scopus 로고    scopus 로고
    • Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p
    • Yu T-Y, Wang C-Y, Lin J-J (2012) Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p. PLoS ONE 7(3):e33498.
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Yu, T.-Y.1    Wang, C.-Y.2    Lin, J.-J.3
  • 25
    • 79957983472 scopus 로고    scopus 로고
    • Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast
    • Iglesias N, et al. (2011) Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep 12(6):587-593.
    • (2011) EMBO Rep , vol.12 , Issue.6 , pp. 587-593
    • Iglesias, N.1
  • 26
    • 0037178788 scopus 로고    scopus 로고
    • Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
    • Boube M, Joulia L, Cribbs DL, Bourbon HM (2002) Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110(2): 143-151.
    • (2002) Cell , vol.110 , Issue.2 , pp. 143-151
    • Boube, M.1    Joulia, L.2    Cribbs, D.L.3    Bourbon, H.M.4
  • 27
    • 26444507919 scopus 로고    scopus 로고
    • Targets of the Gal4 transcription activator in functional transcription complexes
    • Reeves WM, Hahn S (2005) Targets of the Gal4 transcription activator in functional transcription complexes. Mol Cell Biol 25(20):9092-9102.
    • (2005) Mol Cell Biol , vol.25 , Issue.20 , pp. 9092-9102
    • Reeves, W.M.1    Hahn, S.2
  • 28
    • 0028890189 scopus 로고
    • Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation
    • Santos-Rosa H, Aguilera A (1995) Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation. Genetics 139(1):57-66.
    • (1995) Genetics , vol.139 , Issue.1 , pp. 57-66
    • Santos-Rosa, H.1    Aguilera, A.2
  • 29
    • 0034932941 scopus 로고    scopus 로고
    • High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability
    • Fan H-Y, Merker RJ, Klein HL (2001) High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability. Mol Cell Biol 21(16):5459-5470.
    • (2001) Mol Cell Biol , vol.21 , Issue.16 , pp. 5459-5470
    • Fan, H.-Y.1    Merker, R.J.2    Klein, H.L.3
  • 30
    • 0036645687 scopus 로고    scopus 로고
    • The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability
    • Jimeno S, Rondón AG, Luna R, Aguilera A (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-3535.
    • (2002) EMBO J , vol.21 , Issue.13 , pp. 3526-3535
    • Jimeno, S.1    Rondón, A.G.2    Luna, R.3    Aguilera, A.4
  • 31
    • 0037123367 scopus 로고    scopus 로고
    • DEAD-box RNA helicase Sub2 is required for expression of lacZ fusions in Saccharomyces cerevisiae and is a dosage-dependent suppressor of RLR1 (THO2)
    • West RW, Jr., Milgrom E (2002) DEAD-box RNA helicase Sub2 is required for expression of lacZ fusions in Saccharomyces cerevisiae and is a dosage-dependent suppressor of RLR1 (THO2). Gene 288(1-2):19-27.
    • (2002) Gene , vol.288 , Issue.1-2 , pp. 19-27
    • West Jr., R.W.1    Milgrom, E.2
  • 32
    • 0035180388 scopus 로고    scopus 로고
    • Multiple roles for the yeast SUB2/yUAP56 gene in splicing
    • Libri D, Graziani N, Saguez C, Boulay J (2001) Multiple roles for the yeast SUB2/yUAP56 gene in splicing. Genes Dev 15(1):36-41.
    • (2001) Genes Dev , vol.15 , Issue.1 , pp. 36-41
    • Libri, D.1    Graziani, N.2    Saguez, C.3    Boulay, J.4
  • 33
    • 0035975969 scopus 로고    scopus 로고
    • The DECD box putative ATPase Sub2p is an early mRNA export factor
    • Jensen TH, Boulay J, Rosbash M, Libri D (2001) The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol 11(21):1711-1715.
    • (2001) Curr Biol , vol.11 , Issue.21 , pp. 1711-1715
    • Jensen, T.H.1    Boulay, J.2    Rosbash, M.3    Libri, D.4
  • 34
    • 0035846109 scopus 로고    scopus 로고
    • Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p
    • Strässer K, Hurt E (2001) Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature 413(6856):648-652.
    • (2001) Nature , vol.413 , Issue.6856 , pp. 648-652
    • Strässer, K.1    Hurt, E.2
  • 35
    • 0036889334 scopus 로고    scopus 로고
    • Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p
    • Zenklusen D, Vinciguerra P, Wyss JC, Stutz F (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22(23):8241-8253.
    • (2002) Mol Cell Biol , vol.22 , Issue.23 , pp. 8241-8253
    • Zenklusen, D.1    Vinciguerra, P.2    Wyss, J.C.3    Stutz, F.4
  • 36
    • 0035177309 scopus 로고    scopus 로고
    • Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase
    • Kistler AL, Guthrie C (2001) Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev 15(1): 42-49.
    • (2001) Genes Dev , vol.15 , Issue.1 , pp. 42-49
    • Kistler, A.L.1    Guthrie, C.2
  • 37
    • 21644439656 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes
    • Lahue E, Heckathorn J, Meyer Z, Smith J, Wolfe C (2005) The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes. Yeast 22(7):537-551.
    • (2005) Yeast , vol.22 , Issue.7 , pp. 537-551
    • Lahue, E.1    Heckathorn, J.2    Meyer, Z.3    Smith, J.4    Wolfe, C.5
  • 38
    • 0025222442 scopus 로고
    • RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
    • Conrad MN, Wright JH, Wolf AJ, Zakian VA (1990) RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability. Cell 63(4):739-750.
    • (1990) Cell , vol.63 , Issue.4 , pp. 739-750
    • Conrad, M.N.1    Wright, J.H.2    Wolf, A.J.3    Zakian, V.A.4
  • 39
    • 77957243987 scopus 로고    scopus 로고
    • The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
    • Redon S, Reichenbach P, Lingner J (2010) The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 38(17):5797-5806.
    • (2010) Nucleic Acids Res , vol.38 , Issue.17 , pp. 5797-5806
    • Redon, S.1    Reichenbach, P.2    Lingner, J.3
  • 40
    • 0027988467 scopus 로고
    • Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability
    • Sandell LL, Gottschling DE, Zakian VA (1994) Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proc Natl Acad Sci USA 91(25):12061-12065.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.25 , pp. 12061-12065
    • Sandell, L.L.1    Gottschling, D.E.2    Zakian, V.A.3
  • 41
    • 56549114545 scopus 로고    scopus 로고
    • RNA-dependent recruitment of the origin recognition complex
    • Norseen J, et al. (2008) RNA-dependent recruitment of the origin recognition complex. EMBO J 27(22):3024-3035.
    • (2008) EMBO J , vol.27 , Issue.22 , pp. 3024-3035
    • Norseen, J.1
  • 42
    • 57349185689 scopus 로고    scopus 로고
    • The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability
    • González-Aguilera C, et al. (2008) The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell 19(10):4310-4318.
    • (2008) Mol Biol Cell , vol.19 , Issue.10 , pp. 4310-4318
    • González-Aguilera, C.1
  • 43
    • 60349120914 scopus 로고    scopus 로고
    • Long non-coding RNAs: Insights into functions
    • Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: Insights into functions. Nat Rev Genet 10(3):155-159.
    • (2009) Nat Rev Genet , vol.10 , Issue.3 , pp. 155-159
    • Mercer, T.R.1    Dinger, M.E.2    Mattick, J.S.3
  • 44
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley CB (2008) Telomerase and cancer therapeutics. Nat Rev Cancer 8(3):167-179.
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 167-179
    • Harley, C.B.1
  • 45
    • 37549012958 scopus 로고    scopus 로고
    • The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein
    • Hsieh YC, et al. (2007) The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein. Biochem J 408(3):387-393.
    • (2007) Biochem J , vol.408 , Issue.3 , pp. 387-393
    • Hsieh, Y.C.1
  • 46
    • 84885429957 scopus 로고    scopus 로고
    • Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
    • Balk B, et al. (2013) Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol 20(10):1199-1205.
    • (2013) Nat Struct Mol Biol , vol.20 , Issue.10 , pp. 1199-1205
    • Balk, B.1
  • 47
    • 84887053583 scopus 로고    scopus 로고
    • The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening
    • Pfeiffer V, Crittin J, Grolimund L, Lingner J (2013) The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J 32(21):2861-2871.
    • (2013) EMBO J , vol.32 , Issue.21 , pp. 2861-2871
    • Pfeiffer, V.1    Crittin, J.2    Grolimund, L.3    Lingner, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.