Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Science

Volumn 347, Issue 6219, 2015, Pages 273-277

  Flynn, Rachel Litman ^a,b   Cox, Kelli E ^b   Jeitany, Maya ^c   Wakimoto, Hiroaki ^d   Bryll, Alysia R ^b   Ganem, Neil J ^b   Bersani, Francesca ^a,d   Pineda, Jose R ^c   Suvà, Mario L ^a,d   Benes, Cyril H ^a   Haber, Daniel A ^a,d   Boussin, Francois D ^c   Zou, Lee ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ANTINEOPLASTIC AGENT; ATR PROTEIN; ATR PROTEIN INHIBITOR; ATRX PROTEIN; CELL EXTRACT; CHAPERONE; DNA; GEMCITABINE; HISTONE H2AX; NUCLEOPROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN SERINE THREONINE KINASE INHIBITOR; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TELOMERASE; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; UNTRANSLATED RNA; 3-AMINO-6-(4-(METHYLSULFONYL)PHENYL)-N-PHENYLPYRAZINE-2-CARBOXAMIDE; ATM PROTEIN; ATR PROTEIN, HUMAN; ATRX PROTEIN, HUMAN; DNA HELICASE; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; PYRAZINE DERIVATIVE; REPLICATION FACTOR A; RPA1 PROTEIN, HUMAN; SULFONE; TERF2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

AMINO ACID; CANCER; ENZYME ACTIVITY; GERM CELL; MORTALITY; PROTEIN; RNA;

ALTERNATIVE LENGTHENING OF TELOMERE; ARTICLE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA REPLICATION; DRUG HYPERSENSITIVITY; DRUG SENSITIVITY; FEMALE; GENE LOSS; GENE REPLICATION; GENETIC ASSOCIATION; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; MITOSIS; OSTEOSARCOMA; OSTEOSARCOMA CELL LINE; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SISTER CHROMATID EXCHANGE; TELOMERE HOMEOSTASIS; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CYCLE; DRUG EFFECTS; GENE SILENCING; GENETICS; GLIOMA; HOMOLOGOUS RECOMBINATION; METABOLISM; TELOMERE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL CYCLE; CELL LINE, TUMOR; DNA HELICASES; GENE KNOCKDOWN TECHNIQUES; GLIOMA; HELA CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; NUCLEAR PROTEINS; OSTEOSARCOMA; PYRAZINES; REPLICATION PROTEIN A; RNA, UNTRANSLATED; SULFONES; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS; TELOMERIC REPEAT BINDING PROTEIN 2; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84922480767     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1257216     Document Type: Article

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