-
1
-
-
0027255483
-
Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases
-
Carter CW, Jr (1993) Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases. Annu Rev Biochem 62(1):715-748.
-
(1993)
Annu Rev Biochem
, vol.62
, Issue.1
, pp. 715-748
-
-
Carter, C.W.1
-
2
-
-
0035937134
-
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1
-
Ko YG, et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J Biol Chem 276(8):6030-6036.
-
(2001)
J Biol Chem
, vol.276
, Issue.8
, pp. 6030-6036
-
-
Ko, Y.G.1
-
3
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han JM, et al. (2012) Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149(2):410-424.
-
(2012)
Cell
, vol.149
, Issue.2
, pp. 410-424
-
-
Han, J.M.1
-
4
-
-
84902659423
-
tRNA synthetase counteracts c-Myc to develop functional vasculature
-
Shi Y, et al. (2014) tRNA synthetase counteracts c-Myc to develop functional vasculature. eLife 3:e02349.
-
(2014)
eLife
, vol.3
-
-
Shi, Y.1
-
5
-
-
31744448271
-
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
-
Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202.
-
(2006)
Nat Genet
, vol.38
, Issue.2
, pp. 197-202
-
-
Jordanova, A.1
-
6
-
-
84925503952
-
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
-
Sajish M, Schimmel P (2015) A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature 519(7543):370-373.
-
(2015)
Nature
, vol.519
, Issue.7543
, pp. 370-373
-
-
Sajish, M.1
Schimmel, P.2
-
7
-
-
84922329343
-
Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage
-
Wei N, et al. (2014) Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Mol Cell 56(2):323-332.
-
(2014)
Mol Cell
, vol.56
, Issue.2
, pp. 323-332
-
-
Wei, N.1
-
8
-
-
84863357487
-
tRNA-controlled nuclear import of a human tRNA synthetase
-
Fu G, Xu T, Shi Y, Wei N, Yang XL (2012) tRNA-controlled nuclear import of a human tRNA synthetase. J Biol Chem 287(12):9330-9334.
-
(2012)
J Biol Chem
, vol.287
, Issue.12
, pp. 9330-9334
-
-
Fu, G.1
Xu, T.2
Shi, Y.3
Wei, N.4
Yang, X.L.5
-
9
-
-
84904872156
-
The growing landscape of lysine acetylation links metabolism and cell signalling
-
Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M (2014) The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol 15(8):536-550.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, Issue.8
, pp. 536-550
-
-
Choudhary, C.1
Weinert, B.T.2
Nishida, Y.3
Verdin, E.4
Mann, M.5
-
10
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S, et al. (2010) Regulation of cellular metabolism by protein lysine acetylation. Science 327(5968):1000-1004.
-
(2010)
Science
, vol.327
, Issue.5968
, pp. 1000-1004
-
-
Zhao, S.1
-
11
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim SC, et al. (2006) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 23(4):607-618.
-
(2006)
Mol Cell
, vol.23
, Issue.4
, pp. 607-618
-
-
Kim, S.C.1
-
12
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325(5942):834-840.
-
(2009)
Science
, vol.325
, Issue.5942
, pp. 834-840
-
-
Choudhary, C.1
-
13
-
-
83255186739
-
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
-
Peng L, et al. (2011) SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol 31(23):4720-4734.
-
(2011)
Mol Cell Biol
, vol.31
, Issue.23
, pp. 4720-4734
-
-
Peng, L.1
-
14
-
-
84904052542
-
Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase
-
Xu Y, et al. (2014) Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Res 74(13):3630-3642.
-
(2014)
Cancer Res
, vol.74
, Issue.13
, pp. 3630-3642
-
-
Xu, Y.1
-
15
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
Wang C, et al. (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol 8(9):1025-1031.
-
(2006)
Nat Cell Biol
, vol.8
, Issue.9
, pp. 1025-1031
-
-
Wang, C.1
-
16
-
-
67651210858
-
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
-
Rajamohan SB, et al. (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol 29(15):4116-4129.
-
(2009)
Mol Cell Biol
, vol.29
, Issue.15
, pp. 4116-4129
-
-
Rajamohan, S.B.1
-
17
-
-
84863618431
-
Acetylation-dependent regulation of Skp2 function
-
Inuzuka H, et al. (2012) Acetylation-dependent regulation of Skp2 function. Cell 150(1):179-193.
-
(2012)
Cell
, vol.150
, Issue.1
, pp. 179-193
-
-
Inuzuka, H.1
-
18
-
-
84887206685
-
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization
-
Lv L, et al. (2013) Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell 52(3):340-352.
-
(2013)
Mol Cell
, vol.52
, Issue.3
, pp. 340-352
-
-
Lv, L.1
-
19
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang W, et al. (2011) Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell 43(1):33-44.
-
(2011)
Mol Cell
, vol.43
, Issue.1
, pp. 33-44
-
-
Jiang, W.1
-
20
-
-
15244355745
-
Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme
-
Avalos JL, Bever KM, Wolberger C (2005) Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 17(6):855-868.
-
(2005)
Mol Cell
, vol.17
, Issue.6
, pp. 855-868
-
-
Avalos, J.L.1
Bever, K.M.2
Wolberger, C.3
-
21
-
-
40849135481
-
The Sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne JC, Denu JM (2008) The Sirtuin family: Therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12(1):11-17.
-
(2008)
Curr Opin Chem Biol
, vol.12
, Issue.1
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
22
-
-
34548772930
-
Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation
-
Kim MY, et al. (2007) Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation. Mol Cell Biol 27(18):6506-6519.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.18
, pp. 6506-6519
-
-
Kim, M.Y.1
-
23
-
-
84863794131
-
The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3
-
Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ (2012) The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3. Cell Cycle 11(13):2458-2466.
-
(2012)
Cell Cycle
, vol.11
, Issue.13
, pp. 2458-2466
-
-
Love, I.M.1
Sekaric, P.2
Shi, D.3
Grossman, S.R.4
Androphy, E.J.5
-
24
-
-
37349025432
-
FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
-
Bakker WJ, Harris IS, Mak TW (2007) FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell 28(6):941-953.
-
(2007)
Mol Cell
, vol.28
, Issue.6
, pp. 941-953
-
-
Bakker, W.J.1
Harris, I.S.2
Mak, T.W.3
-
25
-
-
84937501592
-
Gcn5 modulates the cellular response to oxidative stress and histone deacetylase inhibition
-
Gaupel AC, Begley TJ, Tenniswood M (2015) Gcn5 modulates the cellular response to oxidative stress and histone deacetylase inhibition. J Cell Biochem 116(9):1982-1992.
-
(2015)
J Cell Biochem
, vol.116
, Issue.9
, pp. 1982-1992
-
-
Gaupel, A.C.1
Begley, T.J.2
Tenniswood, M.3
-
26
-
-
77956180402
-
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
-
Caito S, et al. (2010) SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J 24(9):3145-3159.
-
(2010)
FASEB J
, vol.24
, Issue.9
, pp. 3145-3159
-
-
Caito, S.1
-
27
-
-
33847035824
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
-
Abdelmohsen K, et al. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 25(4):543-557.
-
(2007)
Mol Cell
, vol.25
, Issue.4
, pp. 543-557
-
-
Abdelmohsen, K.1
-
28
-
-
84905905141
-
An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells
-
González F, et al. (2014) An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells. Cell Stem Cell 15(2):215-226.
-
(2014)
Cell Stem Cell
, vol.15
, Issue.2
, pp. 215-226
-
-
González, F.1
-
29
-
-
84875729307
-
A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity
-
Cestari I, Stuart K (2013) A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity. J Biomol Screen 18(4):490-497.
-
(2013)
J Biomol Screen
, vol.18
, Issue.4
, pp. 490-497
-
-
Cestari, I.1
Stuart, K.2
-
30
-
-
0034604716
-
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
-
Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK (2000) The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem 275(31):23899-23903.
-
(2000)
J Biol Chem
, vol.275
, Issue.31
, pp. 23899-23903
-
-
Bhattacharyya, A.1
Ear, U.S.2
Koller, B.H.3
Weichselbaum, R.R.4
Bishop, D.K.5
-
31
-
-
33645003172
-
BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
-
Deng CX (2006) BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 34(5):1416-1426.
-
(2006)
Nucleic Acids Res
, vol.34
, Issue.5
, pp. 1416-1426
-
-
Deng, C.X.1
-
32
-
-
0035099044
-
BRCA2 is required for homology-directed repair of chromosomal breaks
-
Moynahan ME, Pierce AJ, Jasin M (2001) BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 7(2):263-72.
-
(2001)
Mol Cell
, vol.7
, Issue.2
, pp. 263-272
-
-
Moynahan, M.E.1
Pierce, A.J.2
Jasin, M.3
-
33
-
-
77956260966
-
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization
-
Qiang L, Banks AS, Accili D (2010) Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem 285(35):27396-27401.
-
(2010)
J Biol Chem
, vol.285
, Issue.35
, pp. 27396-27401
-
-
Qiang, L.1
Banks, A.S.2
Accili, D.3
-
34
-
-
62449178216
-
The critical role of the class III histone deacetylase SIRT1 in cancer
-
Liu T, Liu PY, Marshall GM (2009) The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res 69(5):1702-1705.
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 1702-1705
-
-
Liu, T.1
Liu, P.Y.2
Marshall, G.M.3
-
35
-
-
34249669270
-
Sirt1 regulates aging and resistance to oxidative stress in the heart
-
Alcendor RR, et al. (2007) Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100(10):1512-1521.
-
(2007)
Circ Res
, vol.100
, Issue.10
, pp. 1512-1521
-
-
Alcendor, R.R.1
-
36
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks AS, et al. (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8(4):333-341.
-
(2008)
Cell Metab
, vol.8
, Issue.4
, pp. 333-341
-
-
Banks, A.S.1
-
37
-
-
41549136422
-
Paths of convergence: Sirtuins in aging and neurodegeneration
-
Gan L, Mucke L (2008) Paths of convergence: Sirtuins in aging and neurodegeneration. Neuron 58(1):10-14.
-
(2008)
Neuron
, vol.58
, Issue.1
, pp. 10-14
-
-
Gan, L.1
Mucke, L.2
-
38
-
-
84875109253
-
Crosstalk between oxidative stress and SIRT1: Impact on the aging process
-
Salminen A, Kaarniranta K, Kauppinen A (2013) Crosstalk between oxidative stress and SIRT1: Impact on the aging process. Int J Mol Sci 14(2):3834-3859.
-
(2013)
Int J Mol Sci
, vol.14
, Issue.2
, pp. 3834-3859
-
-
Salminen, A.1
Kaarniranta, K.2
Kauppinen, A.3
-
39
-
-
84865731753
-
The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease
-
Bai P, Cantó C (2012) The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab 16(3):290-295.
-
(2012)
Cell Metab
, vol.16
, Issue.3
, pp. 290-295
-
-
Bai, P.1
Cantó, C.2
-
40
-
-
45549102566
-
Regulation of SIRT1 protein levels by nutrient availability
-
Kanfi Y, et al. (2008) Regulation of SIRT1 protein levels by nutrient availability. FEBS Lett 582(16):2417-2423.
-
(2008)
FEBS Lett
, vol.582
, Issue.16
, pp. 2417-2423
-
-
Kanfi, Y.1
-
41
-
-
66449115592
-
LysRS serves as a key signaling molecule in the immune response by regulating gene expression
-
Yannay-Cohen N, et al. (2009) LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol Cell 34(5):603-611.
-
(2009)
Mol Cell
, vol.34
, Issue.5
, pp. 603-611
-
-
Yannay-Cohen, N.1
-
42
-
-
84861337799
-
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
-
Sajish M, et al. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat Chem Biol 8(6):547-554.
-
(2012)
Nat Chem Biol
, vol.8
, Issue.6
, pp. 547-554
-
-
Sajish, M.1
-
43
-
-
84945899837
-
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase
-
He W, et al. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 526(7575):710-714.
-
(2015)
Nature
, vol.526
, Issue.7575
, pp. 710-714
-
-
He, W.1
|