-
1
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D., Yu Y., Israelsen W.J., Jiang J.K., Boxer M.B., Hong B.S., Tempel W., Dimov S., Shen M., Jha A., et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 2012, 8:839-847.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Shen, M.9
Jha, A.10
-
2
-
-
0025884038
-
An invitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate
-
Ashizawa K., McPhie P., Lin K.H., Cheng S.Y. An invitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate. Biochemistry 1991, 30:7105-7111.
-
(1991)
Biochemistry
, vol.30
, pp. 7105-7111
-
-
Ashizawa, K.1
McPhie, P.2
Lin, K.H.3
Cheng, S.Y.4
-
3
-
-
0026053273
-
Invitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential
-
Barbosa M.S., Vass W.C., Lowy D.R., Schiller J.T. Invitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J.Virol. 1991, 65:292-298.
-
(1991)
J.Virol.
, vol.65
, pp. 292-298
-
-
Barbosa, M.S.1
Vass, W.C.2
Lowy, D.R.3
Schiller, J.T.4
-
4
-
-
0345549485
-
Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300
-
Bernat A., Avvakumov N., Mymryk J.S., Banks L. Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300. Oncogene 2003, 22:7871-7881.
-
(2003)
Oncogene
, vol.22
, pp. 7871-7881
-
-
Bernat, A.1
Avvakumov, N.2
Mymryk, J.S.3
Banks, L.4
-
5
-
-
0034687726
-
Determinants of allosteric activation of yeast pyruvate kinase and identification of novel effectors using computational screening
-
Bond C.J., Jurica M.S., Mesecar A., Stoddard B.L. Determinants of allosteric activation of yeast pyruvate kinase and identification of novel effectors using computational screening. Biochemistry 2000, 39:15333-15343.
-
(2000)
Biochemistry
, vol.39
, pp. 15333-15343
-
-
Bond, C.J.1
Jurica, M.S.2
Mesecar, A.3
Stoddard, B.L.4
-
6
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
Olsen, J.V.7
Mann, M.8
-
7
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., Fleming M.D., Schreiber S.L., Cantley L.C. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
8
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk H.R., Vander Heiden M.G., Wu N., Asara J.M., Cantley L.C. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
9
-
-
75149150660
-
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
-
David C.J., Chen M., Assanah M., Canoll P., Manley J.L. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 2010, 463:364-368.
-
(2010)
Nature
, vol.463
, pp. 364-368
-
-
David, C.J.1
Chen, M.2
Assanah, M.3
Canoll, P.4
Manley, J.L.5
-
10
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
Dombrauckas J.D., Santarsiero B.D., Mesecar A.D. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005, 44:9417-9429.
-
(2005)
Biochemistry
, vol.44
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santarsiero, B.D.2
Mesecar, A.D.3
-
11
-
-
84862776933
-
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
-
Gao X., Wang H., Yang J.J., Liu X., Liu Z.R. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol. Cell 2012, 45:598-609.
-
(2012)
Mol. Cell
, vol.45
, pp. 598-609
-
-
Gao, X.1
Wang, H.2
Yang, J.J.3
Liu, X.4
Liu, Z.R.5
-
12
-
-
0026609366
-
The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells
-
Halbert C.L., Demers G.W., Galloway D.A. The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J.Virol. 1992, 66:2125-2134.
-
(1992)
J.Virol.
, vol.66
, pp. 2125-2134
-
-
Halbert, C.L.1
Demers, G.W.2
Galloway, D.A.3
-
13
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi T., Kang S., Vander Heiden M.G., Chung T.W., Elf S., Lythgoe K., Dong S., Lonial S., Wang X., Chen G.Z., et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci. Signal. 2009, 2:ra73.
-
(2009)
Sci. Signal.
, vol.2
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
-
14
-
-
0032520197
-
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
-
Jurica M.S., Mesecar A., Heath P.J., Shi W., Nowak T., Stoddard B.L. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure 1998, 6:195-210.
-
(1998)
Structure
, vol.6
, pp. 195-210
-
-
Jurica, M.S.1
Mesecar, A.2
Heath, P.J.3
Shi, W.4
Nowak, T.5
Stoddard, B.L.6
-
15
-
-
0012288533
-
Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase
-
Kato H., Fukuda T., Parkison C., McPhie P., Cheng S.Y. Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase. Proc. Natl. Acad. Sci. USA 1989, 86:7861-7865.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7861-7865
-
-
Kato, H.1
Fukuda, T.2
Parkison, C.3
McPhie, P.4
Cheng, S.Y.5
-
16
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 2006, 23:607-618.
-
(2006)
Mol. Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
Cheng, T.7
Kho, Y.8
Xiao, H.9
Xiao, L.10
-
17
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W., Hu H., Chang R., Zhong J., Knabel M., O'Meally R., Cole R.N., Pandey A., Semenza G.L. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011, 145:732-744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
18
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L., Li D., Zhao D., Lin R., Chu Y., Zhang H., Zha Z., Liu Y., Li Z., Xu Y., et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol. Cell 2011, 42:719-730.
-
(2011)
Mol. Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
-
19
-
-
79958103961
-
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
-
Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int. J. Biochem. Cell Biol. 2011, 43:969-980.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 969-980
-
-
Mazurek, S.1
-
20
-
-
0035909527
-
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7
-
Mazurek S., Zwerschke W., Jansen-Dürr P., Eigenbrodt E. Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7. Oncogene 2001, 20:6891-6898.
-
(2001)
Oncogene
, vol.20
, pp. 6891-6898
-
-
Mazurek, S.1
Zwerschke, W.2
Jansen-Dürr, P.3
Eigenbrodt, E.4
-
21
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
Mazurek S., Boschek C.B., Hugo F., Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin. Cancer Biol. 2005, 15:300-308.
-
(2005)
Semin. Cancer Biol.
, vol.15
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
22
-
-
0022930036
-
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
-
Noguchi T., Inoue H., Tanaka T. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J.Biol. Chem. 1986, 261:13807-13812.
-
(1986)
J.Biol. Chem.
, vol.261
, pp. 13807-13812
-
-
Noguchi, T.1
Inoue, H.2
Tanaka, T.3
-
23
-
-
0023656468
-
The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters
-
Noguchi T., Yamada K., Inoue H., Matsuda T., Tanaka T. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J.Biol. Chem. 1987, 262:14366-14371.
-
(1987)
J.Biol. Chem.
, vol.262
, pp. 14366-14371
-
-
Noguchi, T.1
Yamada, K.2
Inoue, H.3
Matsuda, T.4
Tanaka, T.5
-
24
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden M.G., Locasale J.W., Swanson K.D., Sharfi H., Heffron G.J., Amador-Noguez D., Christofk H.R., Wagner G., Rabinowitz J.D., Asara J.M., Cantley L.C. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010, 329:1492-1499.
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
Cantley, L.C.11
-
25
-
-
0029303509
-
[Alteration of isozyme gene expression during cell differentiation and oncogenesis]
-
Yamada K., Noguchi T. [Alteration of isozyme gene expression during cell differentiation and oncogenesis]. Nippon Rinsho 1995, 53:1112-1118.
-
(1995)
Nippon Rinsho
, vol.53
, pp. 1112-1118
-
-
Yamada, K.1
Noguchi, T.2
-
26
-
-
82555170271
-
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
-
Yang W., Xia Y., Ji H., Zheng Y., Liang J., Huang W., Gao X., Aldape K., Lu Z. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 2011, 480:118-122.
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
27
-
-
84865266173
-
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis
-
Yang W., Xia Y., Hawke D., Li X., Liang J., Xing D., Aldape K., Hunter T., Alfred Yung W.K., Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 2012, 150:685-696.
-
(2012)
Cell
, vol.150
, pp. 685-696
-
-
Yang, W.1
Xia, Y.2
Hawke, D.3
Li, X.4
Liang, J.5
Xing, D.6
Aldape, K.7
Hunter, T.8
Alfred Yung, W.K.9
Lu, Z.10
-
28
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L., Zeng Y., Li H., et al. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327:1000-1004.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Jiang, W.3
Yu, W.4
Lin, Y.5
Zhang, T.6
Yao, J.7
Zhou, L.8
Zeng, Y.9
Li, H.10
-
29
-
-
0033573795
-
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein
-
Zwerschke W., Mazurek S., Massimi P., Banks L., Eigenbrodt E., Jansen-Dürr P. Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA 1999, 96:1291-1296.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1291-1296
-
-
Zwerschke, W.1
Mazurek, S.2
Massimi, P.3
Banks, L.4
Eigenbrodt, E.5
Jansen-Dürr, P.6
|