CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

Nature

Volumn 526, Issue 7575, 2015, Pages 710-714

  He, Weiwei ^a   Bai, Ge ^b   Zhou, Huihao ^a   Wei, Na ^a   White, Nicholas M ^b   Lauer, Janelle ^c   Liu, Huaqing ^d   Shi, Yi ^a   Dumitru, Calin Dan ^a   Lettieri, Karen ^b   Shubayev, Veronica ^d   Jordanova, Albena ^e   Guergueltcheva, Velina ^f   Griffin, Patrick R ^c   Burgess, Robert W ^g   Pfaff, Samuel L ^b   Yang, Xiang Lei ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d University of California at San Diego   (United States)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^g JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE TRANSFER RNA LIGASE; NEUROPILIN 1; VASCULOTROPIN; LIGAND; PROTEIN BINDING; VASCULOTROPIN A;

CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; HERITABILITY; LIGAND; MUTATION; NERVOUS SYSTEM DISORDER; NEUROLOGY; PROTEIN; RNA; RODENT;

ARTICLE; BINDING AFFINITY; CELL SURVIVAL; ENZYME CONFORMATION; GENE MUTATION; HEREDITARY MOTOR SENSORY NEUROPATHY; MOTONEURON; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ANIMAL; AXON; BINDING COMPETITION; CELL LINE; CHARCOT-MARIE-TOOTH DISEASE; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; MALE; METABOLISM; MOLECULAR MODEL; MOTOR PERFORMANCE; MOUSE; MUTATION; PATHOLOGY; PROTEIN MULTIMERIZATION;

MUS;

ANIMALS; AXONS; BINDING, COMPETITIVE; CELL LINE; CELL SURVIVAL; CHARCOT-MARIE-TOOTH DISEASE; FEMALE; GLYCINE-TRNA LIGASE; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOTOR NEURONS; MOTOR SKILLS; MUTATION; NEUROPILIN-1; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84945899837     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15510     Document Type: Article

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