Gcn5 Modulates the Cellular Response to Oxidative Stress and Histone Deacetylase Inhibition

Journal of Cellular Biochemistry

Volumn 116, Issue 9, 2015, Pages 1982-1992

  Gaupel, Ann Christin ^a   Begley, Thomas J ^a,b   Tenniswood, Martin ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b SUNY POLYTECHNIC INSTITUTE   (United States)

Author keywords

GCN5; HISTONE ACETYL TRANSFERASE; HISTONE DEACETYLASE; MAMMALIAN; OXIDATIVE STRESS; YEAST

Indexed keywords

CG 1521; HISTONE ACETYLTRANSFERASE GCN5; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MB 3; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SAGA; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VORINOSTAT; 7-PHENYL-2,4,6-HEPTATRIENOYLHYDROXAMIC ACID; GCN5 PROTEIN, S CEREVISIAE; HISTONE ACETYLTRANSFERASE; HYDROXAMIC ACID; P300-CBP-ASSOCIATED FACTOR; SACCHAROMYCES CEREVISIAE PROTEIN; SAGA COMPLEX, S CEREVISIAE; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DELETION MUTANT; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME INHIBITION; GCN5 GENE; GENE; GENE EXPRESSION PROFILING; GENE INTERACTION; HUMAN; HUMAN CELL; METABOLISM; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; CELL DEATH; DRUG EFFECTS; GENE DELETION; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; HT 29 CELL LINE; SACCHAROMYCES CEREVISIAE;

CELL DEATH; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENE LIBRARY; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITORS; HT29 CELLS; HUMANS; HYDROXAMIC ACIDS; OXIDATIVE STRESS; P300-CBP TRANSCRIPTION FACTORS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION; TRANS-ACTIVATORS;

EID: 84937501592     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25153     Document Type: Article

References (36)

1. Begley TJ, Rosenbach AS, Ideker T, Samson LD,. 2004. Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Mol Cell 16: 117-125.
2. Butler LM, Zhou X, Xu W-S, Scher HI, Rifkind RA, Marks PA Richon,. 2002. The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci USA 99: 11700-11705.
3. Chatterjee N, Wang WL, Conklin T, Chittur S, Tenniswood M,. 2013. Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells. Cancer Biol Ther 14: 658-671.
4. Cherry JM, Hong EL, Amundsen C, Balakrishnan R, Binkley G, Chan ET, Christie KR, Costazo MC, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hitz BC, Karra K, Krieger CJ, Miyasato SR, Nash RS, Park J, Skrzypek MS, Simison M, Weng S, Wong ED,. 2011. Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res 40: D700-D705.
5. Coleman ST, Fang TK, Rovinsky SA, Turano FJ, Moye-Rowley WS,. 2001. Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276: 244-250.
6. Dekker FJ, Haisma HJ,. 2009. Histone acetyl transferases as emerging drug targets. Drug Discov Today 14: 942-948.
7. Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP,. 2013. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol 23: 1638-1648.
8. Eberharter AA, Sterner DE, Schieltz D, Hassan A, Yates JR, Berger SL, Workman JL,. 1999. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol 19: 6621-6631.
9. Eisen MB, Spellman PT, Brown PO, Botstein D,. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95: 14863-14868.
10. Garcerá A, Barreto L, Piedrafita L, Tamarit J, Herrero E,. 2006. Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1 -Cys thiol transferases. Biochem J 398: 187-196.
11. Gaupel AC, Begley T, Tenniswood M,. 2014. High throughput screening identifies modulators of histone deacetylase inhibitors. BMC Genomics 15: 528.
12. Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL,. 1997. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11: 1640-1650.
13. Hoke SMT, Guzzo J, Andrews B, Brandl CJ,. 2008. Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes. BMC Genetics 9: 46.
14. Huisinga KL, Pugh BF,. 2004. A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae. Mol Cell 13: 573-585.
15. Kikuchi H, Takami Y, Nakayama T,. 2005. GCN5: A supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes. Gene 347: 83-97.
16. Kikuchi H, Kuribayashi F, Takami Y, Imajoh-Ohmi S, Nakayama T,. 2011a. GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk. Biochem Biophys Res Commun 405: 657-661.
17. Kikuchi H, Kuribayashi F, Kiwaki N, Takami Y, Nakayama T,. 2011b. GCN5 regulates the superoxide-generating system in leukocytes via controlling gp91-phox gene expression. J Immunol 186: 3015-3022.
18. Lee JH, Choy ML, Ngo L, Foster SS, Marks PA,. 2010a. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci USA 107: 14639-14644.
19. Lee JH, Jeong EG, Choi MC, Kim SH, Park JH, Song SH, Park J, Bang YJ, Kim TY,. 2010b. Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells. Mol Cells 30: 107-112.
20. Lee YJ, Kim KJ, Kang HY, Kim H-R, Maeng PJ,. 2012. Involvement of GDH3-encoded NADP+- dependent glutamate dehydrogenase in yeast cell resistance to stress-induced apoptosis in stationary phase cells. J Biol Chem 287: 44221-44233.
21. Livak KJ, Schmittgen TD,. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
22. Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC,. 2009. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch Toxicol 83: 121-129.
23. Mallory MJ, Law MJ, Sterner DE, Berger SL, Strich R,. 2012. Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p. Mol Biol Cell 23: 1609-1617.
24. Mann BS, Johnson JR, Cohen MH, Justice R, Pazdur R,. 2007. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 12: 1247-1252.
25. Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB,. 2006. PCAF modulates PTEN activity. J Biol Chem 281: 26562-26568.
26. Outten CE, Falk RL, Culotta VC,. 2005. Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Biochem J 388: 93-101.
27. Parmigiani RB, Xu WS, Venta-Perez G, Erdjument- Bromage H, Yaneva M, Tempst P, Marks PA,. 2008. HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A 105: 9633-9638.
28. Portanova P, Russo T, Pellerito O, Calvaruso G, Giuliano M, Vento R, Tesoriere G,. 2008. The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. Int J Oncol 33: 325-331.
29. Qiu T, Zhou L, Zhu W, Wang T, Wang J, Shu Y, Liu P,. 2013. Effects of treatment with histone deacetylase inhibitors in solid tumors: A review based on 30 clinical trials. Future Oncol 9: 255-269.
30. Rozen S, Skaletsky H,. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
31. Slingerland M, Guchelaar HJ, Gelderblom H,. 2014. Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors. Anticancer Drugs 25: 140-149.
32. Ungerstedt JS, Sowa Y, Xu W-S, Shao Y, Dokmanovic M, Perez G, Ngo L, Holmgren A, Jiang X, Marks PA,. 2005. Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. Proc Natl Acad Sci USA 102: 673-678.
33. VanderMolen KM, McCulloch W, Pearce CJ, Oberlies NH,. 2011. Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): A natural product recently approved for cutaneous T-cell lymphoma. J Antibiotics 64: 525-531.
34. West AC, Johnstone RW,. 2014. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest 124: 30-39.
35. Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY,. 2000. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nature Genet 26: 229-232.
36. Yamauchi T, Yamauchi J, Kuwata T, Tamura T, Yamashita T, Bae N, Westphal H, Ozato K, Nakatani Y,. 2000. Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF- B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci USA 97: 11303-11306.