-
1
-
-
84955254841
-
A next generation multiscale view of inborn errors of metabolism
-
Argmann CA, Houten SM, Zhu J, Schadt EE. A next generation multiscale view of inborn errors of metabolism. Cell Metab 2016; 23:13-26.
-
(2016)
Cell Metab
, vol.23
, pp. 13-26
-
-
Argmann, C.A.1
Houten, S.M.2
Zhu, J.3
Schadt, E.E.4
-
2
-
-
84934284791
-
The convergence of systems and reductionist approaches in complex trait analysis
-
Williams EG, Auwerx J. The convergence of systems and reductionist approaches in complex trait analysis. Cell 2015; 162:23-32.
-
(2015)
Cell
, vol.162
, pp. 23-32
-
-
Williams, E.G.1
Auwerx, J.2
-
3
-
-
77956331627
-
Integrating common and rare genetic variation in diverse human populations
-
International HapMap. Altshuler DM, Gibbs RA, Peltonen L, et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010; 467:52-58.
-
(2010)
Nature
, vol.467
, pp. 52-58
-
-
Altshuler, D.M.1
Gibbs, R.A.2
Peltonen, L.3
-
4
-
-
84982253941
-
Exome Aggregation Consortium. Analysis of protein-coding genetic variation in 60 706 humans
-
Lek M, Karczewski KJ, Minikel EV, et al., Exome Aggregation Consortium. Analysis of protein-coding genetic variation in 60 706 humans. Nature 2016; 536:285-291.
-
(2016)
Nature
, vol.536
, pp. 285-291
-
-
Lek, M.1
Karczewski, K.J.2
Minikel, E.V.3
-
5
-
-
84978128486
-
The genetic architecture of type 2 diabetes
-
Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic architecture of type 2 diabetes. Nature 2016; 536:41-47.
-
(2016)
Nature
, vol.536
, pp. 41-47
-
-
Fuchsberger, C.1
Flannick, J.2
Teslovich, T.M.3
-
6
-
-
0141705880
-
One hundred years of mouse genetics: An intellectual history. II. The molecular revolution (1981-2002)
-
Paigen K. One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002). Genetics 2003; 163:1227-1235.
-
(2003)
Genetics
, vol.163
, pp. 1227-1235
-
-
Paigen, K.1
-
7
-
-
84957555626
-
Joint mouse-human phenome-wide association to test gene function and disease risk
-
Wang X, Pandey AK, Mulligan MK, et al. Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun 2016; 7:10464.
-
(2016)
Nat Commun
, vol.7
, pp. 10464
-
-
Wang, X.1
Pandey, A.K.2
Mulligan, M.K.3
-
9
-
-
84989204804
-
High-throughput discovery of novel developmental phenotypes
-
Dickinson ME, Flenniken AM, Ji X, et al. High-throughput discovery of novel developmental phenotypes. Nature 2016; 537:508-514.
-
(2016)
Nature
, vol.537
, pp. 508-514
-
-
Dickinson, M.E.1
Flenniken, A.M.2
Ji, X.3
-
10
-
-
84940571939
-
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
-
Hrabe de Angelis M, Nicholson G, Selloum M, et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet 2015; 47:969-978.
-
(2015)
Nat Genet
, vol.47
, pp. 969-978
-
-
Hrabe De Angelis, M.1
Nicholson, G.2
Selloum, M.3
-
11
-
-
84880562927
-
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes
-
White JK, Gerdin AK, Karp NA, et al. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell 2013; 154:452-464.
-
(2013)
Cell
, vol.154
, pp. 452-464
-
-
White, J.K.1
Gerdin, A.K.2
Karp, N.A.3
-
12
-
-
0000736325
-
Obese, a new mutation in the house mouse
-
Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 1950; 41:317-318.
-
(1950)
J Hered
, vol.41
, pp. 317-318
-
-
Ingalls, A.M.1
Dickie, M.M.2
Snell, G.D.3
-
14
-
-
0016289615
-
Hyperinsulinemia in preweaning diabetes (db) mice
-
Coleman DL, Hummel KP. Hyperinsulinemia in preweaning diabetes (db) mice. Diabetologia 1974; 10:607-610.
-
(1974)
Diabetologia
, vol.10
, pp. 607-610
-
-
Coleman, D.L.1
Hummel, K.P.2
-
15
-
-
0015792424
-
Effects of parabiosis of obese with diabetes and normal mice
-
Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9:294-298.
-
(1973)
Diabetologia
, vol.9
, pp. 294-298
-
-
Coleman, D.L.1
-
16
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
-
17
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83:1263-1271.
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
18
-
-
84874241199
-
Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states
-
El Ouaamari A, Kawamori D, Dirice E, et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 2013; 3:401-410.
-
(2013)
Cell Rep
, vol.3
, pp. 401-410
-
-
El Ouaamari, A.1
Kawamori, D.2
Dirice, E.3
-
19
-
-
84955237184
-
SerpinB1 promotes pancreatic b cell proliferation
-
El Ouaamari A, Dirice E, Gedeon N, et al. SerpinB1 promotes pancreatic b cell proliferation. Cell Metab 2016; 23:194-205.
-
(2016)
Cell Metab
, vol.23
, pp. 194-205
-
-
El Ouaamari, A.1
Dirice, E.2
Gedeon, N.3
-
20
-
-
84966605886
-
Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk
-
Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab 2016; 23:770-784.
-
(2016)
Cell Metab
, vol.23
, pp. 770-784
-
-
Stern, J.H.1
Rutkowski, J.M.2
Scherer, P.E.3
-
21
-
-
22944434929
-
Serum retinol binding protein 4 con-tributes to insulin resistance in obesity and type 2 diabetes
-
Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 con-tributes to insulin resistance in obesity and type 2 diabetes. Nature 2005; 436:356-362.
-
(2005)
Nature
, vol.436
, pp. 356-362
-
-
Yang, Q.1
Graham, T.E.2
Mody, N.3
-
22
-
-
79959893524
-
Human resistin: Found in translation from mouse to man
-
Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab 2011; 22:259-265.
-
(2011)
Trends Endocrinol Metab
, vol.22
, pp. 259-265
-
-
Schwartz, D.R.1
Lazar, M.A.2
-
23
-
-
0028112970
-
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
-
Lu D, Willard D, Patel IR, et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 1994; 371:799-802.
-
(1994)
Nature
, vol.371
, pp. 799-802
-
-
Lu, D.1
Willard, D.2
Patel, I.R.3
-
24
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40:768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
-
25
-
-
80055076208
-
Positional cloning of a type 2 diabetes quantitative trait locus; Tomosyn-2, a negative regulator of insulin secretion
-
Bhatnagar S, Oler AT, Rabaglia ME, et al. Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet 2011; 7:e1002323.
-
(2011)
PLoS Genet
, vol.7
, pp. e1002323
-
-
Bhatnagar, S.1
Oler, A.T.2
Rabaglia, M.E.3
-
26
-
-
84907482353
-
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed beta cells
-
Kebede MA, Oler AT, Gregg T, et al. SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed beta cells. J Clin Invest 2014; 124:4240-4256.
-
(2014)
J Clin Invest
, vol.124
, pp. 4240-4256
-
-
Kebede, M.A.1
Oler, A.T.2
Gregg, T.3
-
27
-
-
84943542650
-
Identification of four mouse diabetes candidate genes altering beta-cell proliferation
-
Kluth O, Matzke D, Kamitz A, et al. Identification of four mouse diabetes candidate genes altering beta-cell proliferation. PLoS Genet 2015; 11:e1005506.
-
(2015)
PLoS Genet
, vol.11
, pp. e1005506
-
-
Kluth, O.1
Matzke, D.2
Kamitz, A.3
-
28
-
-
68249127301
-
Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL
-
Scherneck S, Nestler M, Vogel H, et al. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genet 2009; 5:e1000541.
-
(2009)
PLoS Genet
, vol.5
, pp. e1000541
-
-
Scherneck, S.1
Nestler, M.2
Vogel, H.3
-
29
-
-
0031087023
-
Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval
-
Darvasi A. Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan interval. Mamm Genome 1997; 8:163-167.
-
(1997)
Mamm Genome
, vol.8
, pp. 163-167
-
-
Darvasi, A.1
-
30
-
-
84931836526
-
Contrasting genetic architectures in different mouse reference populations used for studying complex traits
-
Buchner DA, Nadeau JH. Contrasting genetic architectures in different mouse reference populations used for studying complex traits. Genome Res 2015; 25:775-791.
-
(2015)
Genome Res
, vol.25
, pp. 775-791
-
-
Buchner, D.A.1
Nadeau, J.H.2
-
31
-
-
0015864927
-
The influence of genetic background on the expression of the obese (Ob) gene in the mouse
-
Coleman DL, Hummel KP. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 1973; 9:287-293.
-
(1973)
Diabetologia
, vol.9
, pp. 287-293
-
-
Coleman, D.L.1
Hummel, K.P.2
-
32
-
-
0035287508
-
Modifier genes in mice and humans
-
Nadeau JH. Modifier genes in mice and humans. Nat Rev Genet 2001; 2:165-174.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 165-174
-
-
Nadeau, J.H.1
-
33
-
-
43149125186
-
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
-
Keller MP, Choi Y, Wang P, et al. A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome research 2008; 18:706-716.
-
(2008)
Genome Research
, vol.18
, pp. 706-716
-
-
Keller, M.P.1
Choi, Y.2
Wang, P.3
-
34
-
-
58149396842
-
Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
-
Shao H, Burrage LC, Sinasac DS, et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci USA 2008; 105:19910-19914.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19910-19914
-
-
Shao, H.1
Burrage, L.C.2
Sinasac, D.S.3
-
35
-
-
84897139220
-
Transgenerational epigenetic inheritance: Myths and mechanisms
-
Heard E, Martienssen RA. Transgenerational epigenetic inheritance: myths and mechanisms. Cell 2014; 157:95-109.
-
(2014)
Cell
, vol.157
, pp. 95-109
-
-
Heard, E.1
Martienssen, R.A.2
-
36
-
-
84964959956
-
Intergenerational Transfer of Epigenetic Information in Sperm
-
Rando OJ. Intergenerational Transfer of Epigenetic Information in Sperm. Cold Spring Harb Perspect Med 2016; 6:6.
-
(2016)
Cold Spring Harb Perspect Med
, vol.6
, pp. 6
-
-
Rando, O.J.1
-
37
-
-
84948164212
-
The genetics of epigenetic inheritance: Modes, molecules, and mechanisms
-
Schaefer S, Nadeau JH. The genetics of epigenetic inheritance: modes, molecules, and mechanisms. Q Rev Biol 2015; 90:381-415.
-
(2015)
Q Rev Biol
, vol.90
, pp. 381-415
-
-
Schaefer, S.1
Nadeau, J.H.2
-
38
-
-
84978902230
-
Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
-
Cropley JE, Eaton SA, Aiken A, et al. Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity. Mol Metab 2016; 5:699-708.
-
(2016)
Mol Metab
, vol.5
, pp. 699-708
-
-
Cropley, J.E.1
Eaton, S.A.2
Aiken, A.3
-
39
-
-
84959083268
-
High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring
-
de Castro Barbosa T, Ingerslev LR, Alm PS, et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab 2016; 5:184-197.
-
(2016)
Mol Metab
, vol.5
, pp. 184-197
-
-
De Castro Barbosa, T.1
Ingerslev, L.R.2
Alm, P.S.3
-
40
-
-
84950157428
-
RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders
-
Grandjean V, Fourre S, De Abreu DA, et al. RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders. Sci Rep 2015; 5:18193.
-
(2015)
Sci Rep
, vol.5
, pp. 18193
-
-
Grandjean, V.1
Fourre, S.2
De Abreu, D.A.3
-
41
-
-
84961226127
-
Epigenetic germline inheritance of diet-induced obesity and insulin resistance
-
Huypens P, Sass S, Wu M, et al. Epigenetic germline inheritance of diet-induced obesity and insulin resistance. Nat Genet 2016; 48:497-499.
-
(2016)
Nat Genet
, vol.48
, pp. 497-499
-
-
Huypens, P.1
Sass, S.2
Wu, M.3
-
42
-
-
63249089823
-
Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice
-
Jimenez-Chillaron JC, Isganaitis E, Charalambous M, et al. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes 2009; 58:460-468.
-
(2009)
Diabetes
, vol.58
, pp. 460-468
-
-
Jimenez-Chillaron, J.C.1
Isganaitis, E.2
Charalambous, M.3
-
43
-
-
84893470415
-
Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals
-
Wei Y, Yang CR, Wei YP, et al. Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc Natl Acad Sci USA 2014; 111:1873-1878.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 1873-1878
-
-
Wei, Y.1
Yang, C.R.2
Wei, Y.P.3
-
44
-
-
78650446334
-
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
-
Carone BR, Fauquier L, Habib N, et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 2010; 143:1084-1096.
-
(2010)
Cell
, vol.143
, pp. 1084-1096
-
-
Carone, B.R.1
Fauquier, L.2
Habib, N.3
-
45
-
-
85003682297
-
Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues
-
Krautkramer KA, Kreznar JH, Romano KA, et al. Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues. Mol Cell 2016; 64:982-992.
-
(2016)
Mol Cell
, vol.64
, pp. 982-992
-
-
Krautkramer, K.A.1
Kreznar, J.H.2
Romano, K.A.3
-
46
-
-
77957887124
-
Ancestral paternal geno-type controls body weight and food intake for multiple generations
-
Yazbek SN, Spiezio SH, Nadeau JH, Buchner DA. Ancestral paternal geno-type controls body weight and food intake for multiple generations. Hum Mol Genet 2010; 19:4134-4144.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 4134-4144
-
-
Yazbek, S.N.1
Spiezio, S.H.2
Nadeau, J.H.3
Buchner, D.A.4
-
47
-
-
84978081339
-
Human gut microbes impact host serum metabolome and insulin sensitivity
-
Pedersen HK, Gudmundsdottir V, Nielsen HB, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 2016; 535:376-381.
-
(2016)
Nature
, vol.535
, pp. 376-381
-
-
Pedersen, H.K.1
Gudmundsdottir, V.2
Nielsen, H.B.3
-
48
-
-
84860390533
-
Programming of host metabolism by the gut microbiota
-
Backhed F. Programming of host metabolism by the gut microbiota. Ann Nutr Metab 2011; 58 (Suppl 2):44-52.
-
(2011)
Ann Nutr Metab
, vol.58
, pp. 44-52
-
-
Backhed, F.1
-
49
-
-
78449296237
-
Individuality in gut microbiota com-position is a complex polygenic trait shaped by multiple environmental and host genetic factors
-
Benson AK, Kelly SA, Legge R, et al. Individuality in gut microbiota com-position is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci USA 2010; 107:18933-18938.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18933-18938
-
-
Benson, A.K.1
Kelly, S.A.2
Legge, R.3
-
50
-
-
85002680324
-
Antibiotic effects on gut microbiota and metabolism are host dependent
-
Fujisaka S, Ussar S, Clish C, et al. Antibiotic effects on gut microbiota and metabolism are host dependent. J Clin Invest 2016; 126:4430-4443.
-
(2016)
J Clin Invest
, vol.126
, pp. 4430-4443
-
-
Fujisaka, S.1
Ussar, S.2
Clish, C.3
-
51
-
-
84862491799
-
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits
-
McKnite AM, Perez-Munoz ME, Lu L, et al. Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 2012; 7:e39191.
-
(2012)
PLoS One
, vol.7
, pp. e39191
-
-
McKnite, A.M.1
Perez-Munoz, M.E.2
Lu, L.3
-
52
-
-
84991056627
-
Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome
-
Ussar S, Fujisaka S, Kahn CR. Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome. Mol Metab 2016; 5:795-803.
-
(2016)
Mol Metab
, vol.5
, pp. 795-803
-
-
Ussar, S.1
Fujisaka, S.2
Kahn, C.R.3
-
53
-
-
85018193359
-
Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome
-
Ussar S, Griffin NW, Bezy O, et al. Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome. Cell Metab 2015; 22:516-530.
-
(2015)
Cell Metab
, vol.22
, pp. 516-530
-
-
Ussar, S.1
Griffin, N.W.2
Bezy, O.3
-
54
-
-
14644441018
-
The collaborative cross, a community resource for the genetic analysis of complex traits
-
Churchill GA, Airey DC, Allayee H, et al. The collaborative cross, a community resource for the genetic analysis of complex traits. Nature genetics 2004; 36:1133-1137.
-
(2004)
Nature Genetics
, vol.36
, pp. 1133-1137
-
-
Churchill, G.A.1
Airey, D.C.2
Allayee, H.3
-
55
-
-
85015685222
-
Glucose tolerance female-specific QTL mapped in collaborative cross mice
-
Abu-Toamih Atamni HJ, Ziner Y, Mott R, et al. Glucose tolerance female-specific QTL mapped in collaborative cross mice. Mamm Genome 2016.
-
(2016)
Mamm Genome
-
-
Abu-Toamih Atamni, H.J.1
Ziner, Y.2
Mott, R.3
-
56
-
-
84978792860
-
Mapping liver fat female-dependent quantitative trait loci in collaborative cross mice
-
Atamni HJ, Botzman M, Mott R, et al. Mapping liver fat female-dependent quantitative trait loci in collaborative cross mice. Mamm Genome 2016; 27:565-573.
-
(2016)
Mamm Genome
, vol.27
, pp. 565-573
-
-
Atamni, H.J.1
Botzman, M.2
Mott, R.3
-
57
-
-
84997521962
-
Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains
-
Nachshon A, Abu-Toamih Atamni HJ, Steuerman Y, et al. Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross mouse strains. Front Genet 2016; 7:172.
-
(2016)
Front Genet
, vol.7
, pp. 172
-
-
Nachshon, A.1
Abu-Toamih Atamni, H.J.2
Steuerman, Y.3
-
58
-
-
85008506997
-
Diversity outbred mice at 21: Maintaining allelic variation in the face of selection
-
Chesler EJ, Gatti DM, Morgan AP, et al. Diversity outbred mice at 21: maintaining allelic variation in the face of selection. G3 (Bethesda) 2016; 6:3893-3902.
-
(2016)
G3 (Bethesda)
, vol.6
, pp. 3893-3902
-
-
Chesler, E.J.1
Gatti, D.M.2
Morgan, A.P.3
-
59
-
-
84975717746
-
Defining the consequences of genetic variation on a proteome-wide scale
-
Chick JM, Munger SC, Simecek P, et al. Defining the consequences of genetic variation on a proteome-wide scale. Nature 2016; 534:500-505.
-
(2016)
Nature
, vol.534
, pp. 500-505
-
-
Chick, J.M.1
Munger, S.C.2
Simecek, P.3
-
60
-
-
84866420982
-
Systems genetics of metabolism: The use of the BXD murine reference panel for multiscalar integration of traits
-
Andreux PA, Williams EG, Koutnikova H, et al. Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell 2012; 150:1287-1299.
-
(2012)
Cell
, vol.150
, pp. 1287-1299
-
-
Andreux, P.A.1
Williams, E.G.2
Koutnikova, H.3
-
61
-
-
84975156981
-
Systems proteomics of liver mitochondria function
-
Williams EG, Wu Y, Jha P, et al. Systems proteomics of liver mitochondria function. Science 2016; 352:aad0189.
-
(2016)
Science
, vol.352
, pp. aad0189
-
-
Williams, E.G.1
Wu, Y.2
Jha, P.3
-
62
-
-
84908077262
-
Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population
-
Wu Y, Williams EG, Dubuis S, et al. Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell 2014; 158:1415-1430.
-
(2014)
Cell
, vol.158
, pp. 1415-1430
-
-
Wu, Y.1
Williams, E.G.2
Dubuis, S.3
-
63
-
-
84971554688
-
The hybrid mouse diversity panel: A resource for systems genetics analyses of metabolic and cardiovascular traits
-
Lusis AJ, Seldin MM, Allayee H, et al. The hybrid mouse diversity panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res 2016; 57:925-942.
-
(2016)
J Lipid Res
, vol.57
, pp. 925-942
-
-
Lusis, A.J.1
Seldin, M.M.2
Allayee, H.3
-
64
-
-
84953295344
-
Genetic architecture of atherosclerosis in mice: A systems genetics analysis of common inbred strains
-
Bennett BJ, Davis RC, Civelek M, et al. Genetic architecture of atherosclerosis in mice: a systems genetics analysis of common inbred strains. PLoS Genet 2015; 11:e1005711.
-
(2015)
PLoS Genet
, vol.11
, pp. e1005711
-
-
Bennett, B.J.1
Davis, R.C.2
Civelek, M.3
-
65
-
-
84872156123
-
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
-
Parks BW, Nam E, Org E, et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab 2013; 17:141-152.
-
(2013)
Cell Metab
, vol.17
, pp. 141-152
-
-
Parks, B.W.1
Nam, E.2
Org, E.3
-
66
-
-
84922879234
-
Genetic architecture of insulin resistance in the mouse
-
Parks BW, Sallam T, Mehrabian M, et al. Genetic architecture of insulin resistance in the mouse. Cell Metab 2015; 21:334-346.
-
(2015)
Cell Metab
, vol.21
, pp. 334-346
-
-
Parks, B.W.1
Sallam, T.2
Mehrabian, M.3
-
67
-
-
84937046632
-
The genetic architecture of NAFLD among inbred strains of mice
-
Hui ST, Parks BW, Org E, et al. The genetic architecture of NAFLD among inbred strains of mice. Elife 2015; 4:e05607.
-
(2015)
Elife
, vol.4
, pp. e05607
-
-
Hui, S.T.1
Parks, B.W.2
Org, E.3
-
68
-
-
11144355685
-
Genetic dissection of complex traits with chromosome substitution strains of mice
-
Singer JB, Hill AE, Burrage LC, et al. Genetic dissection of complex traits with chromosome substitution strains of mice. Science 2004; 304:445-448.
-
(2004)
Science
, vol.304
, pp. 445-448
-
-
Singer, J.B.1
Hill, A.E.2
Burrage, L.C.3
-
69
-
-
84957851709
-
Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome
-
Sinasac DS, Riordan JD, Spiezio SH, et al. Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome. Int J Obes (Lond) 2016; 40:346-355.
-
(2016)
Int J Obes (Lond)
, vol.40
, pp. 346-355
-
-
Sinasac, D.S.1
Riordan, J.D.2
Spiezio, S.H.3
-
71
-
-
33645088824
-
Nicotinamide nucleotide transhy-drogenase: A key role in insulin secretion
-
Freeman H, Shimomura K, Horner E, et al. Nicotinamide nucleotide transhy-drogenase: a key role in insulin secretion. Cell Metab 2006; 3:35-45.
-
(2006)
Cell Metab
, vol.3
, pp. 35-45
-
-
Freeman, H.1
Shimomura, K.2
Horner, E.3
-
72
-
-
33747032052
-
Deletion of nicotinamide nucleotide transhydrogenase: A new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice
-
Freeman HC, Hugill A, Dear NT, et al. Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes 2006; 55:2153-2156.
-
(2006)
Diabetes
, vol.55
, pp. 2153-2156
-
-
Freeman, H.C.1
Hugill, A.2
Dear, N.T.3
-
73
-
-
0141446037
-
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis
-
Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem 2003; 278:33609-33612.
-
(2003)
J Biol Chem
, vol.278
, pp. 33609-33612
-
-
Minokoshi, Y.1
Kahn, C.R.2
Kahn, B.B.3
-
74
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002; 8:1376-1382.
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
75
-
-
34249651956
-
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Konner AC, Janoschek R, Plum L, et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007; 5:438-449.
-
(2007)
Cell Metab
, vol.5
, pp. 438-449
-
-
Konner, A.C.1
Janoschek, R.2
Plum, L.3
-
76
-
-
18344374382
-
Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
-
Hidaka S, Yoshimatsu H, Kondou S, et al. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J 2002; 16:509-518.
-
(2002)
FASEB J
, vol.16
, pp. 509-518
-
-
Hidaka, S.1
Yoshimatsu, H.2
Kondou, S.3
-
77
-
-
84973667684
-
Acetate mediates a microbiome-brain-b-cell axis to promote metabolic syndrome
-
Perry RJ, Peng L, Barry NA, et al. Acetate mediates a microbiome-brain-b-cell axis to promote metabolic syndrome. Nature 2016; 534:213-217.
-
(2016)
Nature
, vol.534
, pp. 213-217
-
-
Perry, R.J.1
Peng, L.2
Barry, N.A.3
-
78
-
-
79952048799
-
Genetics. Systems genetics
-
Nadeau JH, Dudley AM. Genetics. Systems genetics. Science 2011; 331:1015-1016.
-
(2011)
Science
, vol.331
, pp. 1015-1016
-
-
Nadeau, J.H.1
Dudley, A.M.2
|