SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

Journal of Clinical Investigation

Volumn 124, Issue 10, 2014, Pages 4240-4256

  Kebede, Melkam A ^a   Oler, Angie T ^a   Gregg, Trillian ^a   Balloon, Allison J ^a   Johnson, Adam ^b   Mitok, Kelly ^a   Rabaglia, Mary ^a   Schueler, Kathryn ^a   Stapleton, Donald ^a   Thorstenson, Candice ^a   Wrighton, Lindsay ^a   Floyd, Brendan J ^a   Richards, Oliver ^a   Raines, Summer ^a   Eliceiri, Kevin ^a   Seidah, Nabil G ^c   Rhodes, Christopher ^d   Keller, Mark P ^a   Coon, Joshua L ^a,b   Audhya, Anjon ^b   Attie, Alan D ^a   more..

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; PALMITIC ACID; PROINSULIN; PROTEIN; SORCS 1 PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; SORCS1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE DELETION; GENE MUTATION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; GOLGI COMPLEX; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LONG TERM EXPOSURE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLIC STRESS; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SECRETORY GRANULE; ANIMAL; CHEMISTRY; CYTOLOGY; GENETICS; GENOTYPE; KNOCKOUT MOUSE; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SECRETORY VESICLE;

ANIMALS; DIABETES MELLITUS; GENE DELETION; GENOTYPE; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PALMITIC ACID; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; SECRETORY VESICLES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84907482353     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI74072     Document Type: Article

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