Inhibition of autophagic degradation process contributes to claudin-2 expression increase and epithelial tight junction dysfunction in TNF-α treated cell monolayers

International Journal of Molecular Sciences

Volumn 18, Issue 1, 2017, Pages

  Zhang, Cong ^a   Yan, Junkai ^b   Xiao, Yongtao ^b   Shen, Yujie ^a   Wang, Jiazheng ^a   Ge, Wensong ^a   Chen, Yingwei ^a,b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Institute for Pediatric Research   (China)

Author keywords

Autophagy; Barrier function; Claudin 2; Inflammatory; TNF

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; ADENOVIRUS VECTOR; CLAUDIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; SEQUESTOSOME 1; TUMOR NECROSIS FACTOR; 3-METHYLADENINE; ADENINE; BAFILOMYCIN A1; INDOLE DERIVATIVE; MACROLIDE; MAP1LC3B PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PURINE DERIVATIVE; SQSTM1 PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; LYSOSOME; MONOLAYER CULTURE; PH; PROTEIN EXPRESSION; TIGHT JUNCTION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CACO-2 CELL LINE; CELL LINE; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM; RAT;

ADENINE; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CACO-2 CELLS; CELL LINE; CLAUDIN-2; EPITHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INDOLES; LYSOSOMES; MACROLIDES; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; PURINES; RATS; SEQUESTOSOME-1 PROTEIN; TIGHT JUNCTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85009895031     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18010157     Document Type: Article

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