Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism

Intensive Care Medicine

Volumn 31, Issue 5, 2005, Pages 709-717

  Yang, Runkuan ^a   Harada, Tomoyuki ^a   Li, Jinyou ^a   Uchiyama, Takashi ^a   Han, Yusheng ^a   Englert, Joshua A ^a   Fink, Mitchell P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bile; Extracellular signal related kinase; Gut mucosal barrier; Intestinal epithelial barrier; Obstructive jaundice; Tight junction proteins

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OCCLUDIN; PROTEIN ZO1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; BILE; BILE DUCT LIGATION; COMMON BILE DUCT; CONTROLLED STUDY; FOLLOW UP; ILEUM MUCOSA; INTESTINE CELL; INTESTINE EPITHELIUM; MALE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; BILE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; INTESTINAL MUCOSA; JAUNDICE, OBSTRUCTIVE; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS;

EID: 18844365431     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2601-9     Document Type: Article

References (48)

1. Pitt HA, Cameron JL, Postier RG, Gadacz TR (1981) Factors affecting mortality in biliary tract surgery. Am J Surg 141:66-72
2. Armstrong CP, Dixon JM, Taylor TV, Davies GC (1984) Surgical experience of deeply jaundiced patients with bile duct obstruction. Br J Surg 71:234-238
3. Povoski SP, Karpeh MS Jr, Conlon KC, Blumgart LH, Brennan MF (1999) Preoperative biliary drainage: impact on intraoperative bile cultures and infectious morbidity and mortality after pancreaticoduodenectomy. J Gastrointest Surg 3:496-505
4. Welsh FKS, Ramsden CW, MacLennan K, Sheridan MB, Barclay RG, Guillou PJ, Reynolds JV (1998) Increased intestinal permeability and altered mucosal immunity in cholestatic jaundice. Ann Surg 227:205-212
5. Parks RW, Halliday MI, McCrory DC, Erwin P, Smye M, Diamond T, Rowlands BJ (2003) Host immune responses and intestinal permeability in patients with jaundice. Br J Surg 90:239-245
6. Parks RW, Clements WD, Smye MG, Pope C, Rowlands BJ, Diamond T (1996) Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage. Br J Surg 83:1345-1349
7. Deitch EA, Sittig K, Li M, Berg R, Specian RD (1990) Obstructive jaundice promotes bacterial translocation from the gut. Am J Surg 159:79-84
8. Sileri P, Morini S, Sica GS, Schena S, Rastellini C, Gaspari AL, Benedetti E, Cicalese L (2002) Bacterial translocation and intestinal morphological findings in jaundiced rats. Dig Dis Sci 47:929-934
9. Ding JW, Andersson R, Soltesz V, Willen R, Bengmark S (1993) The role of bile bile acids in bacterial translocation in obstructive jaundice in rats. Eur Surg Res 25:11-19
10. Erbil Y, Berber E, Ozarmagan S, Seven R, Eminoglu L, Calis A, Olgac V, Gurler N (1999) The effects of sodium deoxycholate, lactulose glutamine on bacterial translocation in common bile duct ligated rats. Hepatogastroenterology 46:2791-2795
11. Ogata Y, Nishi M, Nakayama H, Kuwahara T, Ohnishi Y, Tashiro S (2003) Role of bile in intestinal barrier function its inhibitory effect on bacterial translocation in obstructive jaundice in rats. J Surg Res 115:18-23
12. Aldemir M, Geyik MF, Kokoglu OF, Buyukbayram H, Hosoglu S, Yagmur Y (2003) Effects of ursodeoxycholic acid, glutamine polyclonal immunoglobulins on bacterial translocation in common bile duct ligated rats. ANZ J Surg 73:722-726
13. Kamiya S, Nagino M, Kanazawa H, Komatsu S, Mayumi T, Takagi K, Asahara T, Nomoto K, Tanaka R, Nimura Y (2004) The value of bile replacement during external biliary drainage: an analysis of intestinal permeability, integrity, microflora. Ann Surg 239:510-517
14. Stevenson BR (1999) Understanding tight junction clinical physiology at the molecular level. J Clin Invest 104:3-4
15. Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003) Tight junction proteins. Prog Biophys Mol Biol 81:1-44
16. Anderson JM Van Itallie CM (1995) Tight junctions the molecular basis for regulation of paracellular permeability. Am J Physiol 269:G467-G475
17. Gumbiner BM (1993) Breaking through the tight junction barrier. J Cell Biol 123:1631-1633
18. Balda MS Matter K (2000) Transmembrane proteins of tight junctions. Semin Cell Dev Biol 11:281-289
19. Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM (1998) The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin the actin cytoskeleton. J Biol Chem 273:29745-29753
20. Mitic LL Anderson JM (1998) Molecular architecture of tight junctions. Annu Rev Physiol 60:121-142
21. Gonzalez-Mariscal L, Betanzos A, Avila-Flores A (2000) MAGUK proteins: structure role in the tight junction. Semin Cell Dev Biol 11:315-324
22. Yang R, Gallo DJ, Baust JJ, Uchiyama T, Watkins SK, Delude RL, Fink MP (2002) Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 283:G212-G22
23. Han X, Fink MP, Yang R, Delude RL (2004) Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock 21:261-270
24. Han X, Fink MP, Delude RL (2003) Proinflammatory cytokines cause NO·-dependent independent changes in expression localization of tight junction proteins in intestinal epithelial cells. Shock 19:229-237
25. Bemelmans MH, Gouma DJ, Greve JW, Buurman WA (1992) Cytokines tumor necrosis factor interleukin-6 in experimental biliary obstruction in mice. Hepatology 15:1132-1136
26. Tu B, Gong JP, Feng HY, Wu CX, Shi YY, Li XH, Peng Y, Liu CA, Li SW (2003) Role of NF-kB in multiple organ dysfunction during acute obstructive cholangitis. World J Gastroenterol 9:179-183
27. Guo X, Rao JN, Liu L, Zou TT, Turner DJ, Bass BL, Wang JY (2004) Regulation of adherens junctions epithelial paracellular permeability: a novel function for polyamines. Am J Physiol Cell Physiol 285:C1174-C1187
28. Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Musu MP, Di Pierro MR, Drago S, Congia M, Fasano A (2003) Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 52:218-223
29. Xu DZ, Lu Q, Deitch EA (2002) Nitric oxide directly impairs intestinal barrier function. Shock 17:139-145
30. Sappington PL, Yang R, Yang H, Tracey KJ, Delude RL, Fink MP (2002) HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers impairs intestinal barrier function in mice. Gastroenterology 123:790-802
31. Le Bacquer O, Laboisse C, Darmaun D (2003) Glutamine preserves protein synthesis paracellular permeability in Caco-2 cells submitted to "luminal fasting." Am J Physiol Gastrointest Liver Physiol 285:G128-G136
32. Banan A, Fields JZ, Talmage DA, Zhang L, Keshavarzian A (2002) PKC-zeta is required in EGF protection of microtubules intestinal barrier integrity against oxidant injury. Am J Physiol Gastrointest Liver Physiol 282:G794-G808
33. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P (2003) Bile acid regulation of C/EBPbeta, CREB, c-Jun function, via the extracellular signal-regulated kinase c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23:3052-3066
34. Haussinger D, Kurz AK, Wettstein M, Graf D, Vom Dahl S, Schliess F (2003) Involvement of integrins Src in tauroursodeoxycholate-induced swelling-induced choleresis. Gastroenterology 124:1476-1487
35. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632
36. Assimakopoulos SF, Scopa CD, Charonis A, Spiliopoulou I, Georgiou C, Nikolopoulou V, Vagianos CE (2004) Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: beneficial effect of bombesin neurotensin. J Am Coll Surg 198:748-757
37. Yang R, Gallo DJ, Baust JJ, Watkins SK, Delude RL, Fink MP (2002) Effect of hemorrhagic shock on gut barrier function expression of stress-related genes in normal gnotobiotic mice. Am J Physiol Regul Integr Comp Physiol 283:R1263-R1274
38. Yang R, Han X, Uchiyama T, Watkins SK, Yaguchi A, Delude RL, Fink MP (2003) IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock resuscitation in mice. Am J Physiol Gastrointest Liver Physiol 285:G621-G629
39. Wang Q, Fang CH, Hasselgren PO (2001) Intestinal permeability is reduced IL-10 levels are increased in septic IL-6 knockout mice. Am J Physiol 281:R1013-R1023
40. Li Z, Tanaka M, Kataoka H, Nakamura R, Sanjar R, Shinmura K, Sugimura H (2003) EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase p53-independence. J Cancer Res Clin Oncol 129:703-708
41. Qiao D, Stratagouleas ED, Martinez JD (2001) Activation role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. Carcinogenesis 22:35-41
42. Dieckgraefe BK, Weems DM, Santoro SA, Alpers DH (1997) ERK p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction. Biochem Biophys Res Commun 233:389-394
43. Goke M, Kanai M, Lynch-Devaney K, Podolsky DK (1998) Rapid mitogen-activated protein kinase activation by transforming growth factor alpha in wounded rat intestinal epithelial cells. Gastroenterology 114:697-705
44. Bhattacharya S, Ray RM, Johnson LR (2004) Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2. Am J Physiol Gastrointest Liver Physiol 286:G479-G490
45. 2-mediated permeability: role of MAPK occludin. Am J Physiol Cell Physiol 279:C21-C30
46. Pedram A, Razandi M, Levin ER (2002) Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. J Biol Chem 277:44385-44398
47. Wachtel M, Frei K, Ehler E, Bauer C, Gassmann M, Gloor SM (2002) Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure. Biochem J 367:873-879
48. Kinugasa T, Salaguchi T, Gu X, Reinecker HC (2000) Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118:1001-1011