TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells

Experimental Neurology

Volumn 271, Issue , 2015, Pages 112-121

  Wang, Mei Xia ^a,b   Cheng, Xiao Yu ^a,b   Jin, Mengmeng ^a,b   Cao, Yu Lan ^a,b   Yang, Ya Ping ^a,c   Wang, Jian Da ^a,b   Li, Qian ^b   Wang, Fen ^b   Hu, Li Fang ^b   Liu, Chun Feng ^a,b,c  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c Beijing Key Laboratory for Parkinson's Disease   (China)

Author keywords

Autophagy; Dopaminergic cells; Lysosome acidification; TNF; Synuclein

Indexed keywords

2 (4 AMINO 1 ISOPROPYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 3 YL) 1H INDOL 5 OL; ALPHA SYNUCLEIN; CELL PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LC3 PROTEIN; LC3II PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; CHOLECYSTOKININ OCTAPEPTIDE; INDOLE DERIVATIVE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PURINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ACIDIFICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOACCUMULATION; BIOGENESIS; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; FEMALE; INVESTIGATIVE PROCEDURES; LYSOSOME; MESENCEPHALON; NERVE CELL; NERVE CELL DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARKINSON DISEASE; PC12 CELL LINE; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; RFP GFP TANDEM FLUORESCENT LC3; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CYTOLOGY; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CELL SURVIVAL; CELLS, CULTURED; DOPAMINERGIC NEURONS; EMBRYO, MAMMALIAN; FEMALE; HYDROGEN-ION CONCENTRATION; INDOLES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOMES; MESENCEPHALON; PC12 CELLS; PREGNANCY; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SINCALIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930637229     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.05.008     Document Type: Article

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