ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

Cell Reports

Volumn 17, Issue 4, 2016, Pages 1037-1052

  Zhao, Steven ^a,b   Torres, AnnMarie ^a,b   Henry, Ryan A ^d   Trefely, Sophie ^a,b,c   Wallace, Martina ^e   Lee, Joyce V ^a,b   Carrer, Alessandro ^a,b   Sengupta, Arjun ^a   Campbell, Sydney L ^a,b   Kuo, Yin Ming ^d   Frey, Alexander J ^c   Meurs, Noah ^e   Viola, John M ^a,b   Blair, Ian A ^a   Weljie, Aalim M ^a   Metallo, Christian M ^e   Snyder, Nathaniel W ^c   Andrews, Andrew J ^d   Wellen, Kathryn E ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DREXEL UNIVERSITY   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

acetate; acetyl CoA; acetylation; ACLY; ACSS2; adipose tissue; fatty acid synthesis; metabolic flexibility; metabolism

Indexed keywords

ACETIC ACID; ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE SHORT CHAIN FAMILY MEMBER 2; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; FATTY ACID; GLUCOSE; HISTONE; LONG CHAIN FATTY ACID COENZYME A LIGASE; MALONYL COENZYME A; UNCLASSIFIED DRUG; ACETATE COENZYME A LIGASE; ACETIC ACID DERIVATIVE; ACSS2 PROTEIN, MOUSE; LIPID;

ACLY GENE; ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME DEFICIENCY; ENZYME REGULATION; FATTY ACID ANALYSIS; FATTY ACID SYNTHESIS; GENE DELETION; HISTONE ACETYLATION; IN VIVO STUDY; LIPID STORAGE; LIPOGENESIS; MALE; METABOLIC PARAMETERS; METABOLIC SWITCH; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ACETYLATION; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; LIPID METABOLISM; METABOLISM;

ACETATE-COA LIGASE; ACETATES; ACETYL COENZYME A; ACETYLATION; ADIPOCYTES; ANIMALS; ATP CITRATE (PRO-S)-LYASE; CELL PROLIFERATION; CELL SURVIVAL; FIBROBLASTS; GENE DELETION; GLUCOSE; HISTONES; LIPID METABOLISM; LIPIDS; MALE; MICE; UP-REGULATION;

EID: 84994840428     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.069     Document Type: Article

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