Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux

Journal of Biological Chemistry

Volumn 288, Issue 43, 2013, Pages 31363-31369

  Fan, Jing ^a   Kamphorst, Jurre J ^a   Rabinowitz, Joshua D ^a,b   Shlomi, Tomer ^a,c  

^a PRINCETON UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ISOCITRATE DEHYDROGENASE; ISOTOPE EXCHANGE; ISOTOPE TRACERS; KETOGLUTARATE; LARGE AMOUNTS; LIPID BIOSYNTHESIS; QUANTITATIVE FLUX; REVERSE FLUXES;

AMINO ACIDS; BIOCHEMISTRY; CARBOXYLATION; ISOTOPES; MAMMALS;

FATTY ACIDS;

ACETYL COENZYME A; GLUTAMINE; ISOCITRATE DEHYDROGENASE;

ARTICLE; CANCER CELL; CELL HYPOXIA; CONTROLLED STUDY; ELECTRON TRANSPORT; FATTY ACID SYNTHESIS; HYPOXIA; ISOTOPE LABELING; MITOCHONDRIAL ENERGY TRANSFER; PRIORITY JOURNAL;

CANCER; HYPOXIA; ISOTOPIC TRACERS; METABOLISM; MITOCHONDRIAL METABOLISM;

ACETYL COENZYME A; CELL HYPOXIA; CELL LINE, TUMOR; FATTY ACIDS; GLUTAMINE; HUMANS; ISOCITRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; OXIDATION-REDUCTION;

EID: 84886642779     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.502740     Document Type: Article

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