Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Kopeikina, Katherine J ^a,b,g   Wegmann, Susanne ^b,c   Pitstick, Rose ^d   Carlson, George A ^d   Bacskai, Brian J ^b,c   Betensky, Rebecca A ^e   Hyman, Bradley T ^b,c   Spires Jones, Tara L ^b,c,f  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM; TAU PROTEIN; CALCIUM BINDING PROTEIN; YELLOW CAMELEON;

ADENO ASSOCIATED VIRUS; AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; CELL LOSS; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; DENDRITIC SPINE; DISEASE ASSOCIATION; DISEASE SEVERITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMAGE ANALYSIS; IN VIVO STUDY; MENTAL HEALTH; MOUSE; MULTIPHOTON MICROSCOPY; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; SYNAPSE; TAUOPATHY; ANIMAL; DISEASE MODEL; HOMEOSTASIS; HUMAN; METABOLISM; MOLECULAR IMAGING;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; HOMEOSTASIS; HUMANS; MICE; MOLECULAR IMAGING; SYNAPSES; TAU PROTEINS; TAUOPATHIES;

EID: 84894235216     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080834     Document Type: Article

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