Advances in therapeutic Fc engineering - modulation of IgG-associated effector functions and serum half-life

Frontiers in Immunology

Volumn 7, Issue DEC, 2016, Pages

  Saxena, Abhishek ^a   Wu, Donghui ^a  

^a SHANGHAITECH UNIVERSITY   (China)

Author keywords

ADCC; ADCP; Aglycosylated antibody; Antibody Fc region; Cancer therapy; CDC; FcRn; Serum half life

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ANTIGEN BINDING; APOPTOSIS; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; CELL MEDIATED CYTOTOXICITY; CELL PHAGOCYTOSIS; CLINICAL EVALUATION; CLINICAL TRIAL (TOPIC); COMPLEMENT DEPENDENT CYTOTOXICITY; DEGRADATION; DNA FLANKING REGION; GENE MUTATION; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LUPUS ERYTHEMATOSUS; MELANOMA; MODULATION; MODULATION TRANSFER FUNCTION; PLASMA HALF LIFE; RAJI CELL LINE; REVIEW; TUMOR GROWTH;

EID: 85009348215     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2016.00580     Document Type: Review

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