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Volumn 74, Issue 4, 2001, Pages 288-294
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Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FcγRIII
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BIOGEN
(United States)
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Author keywords
Fc RIII; Glycosylation engineering; GnTIII; Immunoglobulin; Production Chinese hamster ovary (CHO) cell line
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Indexed keywords
ANTIBODIES;
BIOASSAY;
ENZYMES;
GROWTH KINETICS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
POLYSACCHARIDES;
GENE ENCODING;
CLONING;
ASPARAGINE LINKED OLIGOSACCHARIDE;
CD20 ANTIGEN;
FC RECEPTOR;
IMMUNOGLOBULIN G1;
MONOCLONAL ANTIBODY;
MONOCLONAL ANTIBODY CD20;
N ACETYLGLUCOSAMINE;
N ACETYLGLUCOSAMINYLTRANSFERASE;
RITUXIMAB;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY;
ARTICLE;
CHO CELL;
CONTROLLED STUDY;
ENZYME LINKED IMMUNOSORBENT ASSAY;
GLYCOLYSIS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
IMMUNOGLOBULIN PRODUCTION;
MOLECULAR CLONING;
NONHUMAN;
POLYMERASE CHAIN REACTION;
PROTEIN EXPRESSION;
RECEPTOR AFFINITY;
ANIMALS;
ANTIBODIES, MONOCLONAL;
ANTIBODY-DEPENDENT CELL CYTOTOXICITY;
ANTIGENS, CD20;
CARBOHYDRATE SEQUENCE;
CELL DIVISION;
CHO CELLS;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CLONING, MOLECULAR;
CRICETINAE;
ENZYME-LINKED IMMUNOSORBENT ASSAY;
GENETIC ENGINEERING;
GLYCOSYLATION;
IMMUNOGLOBULIN G;
MOLECULAR SEQUENCE DATA;
N-ACETYLGLUCOSAMINYLTRANSFERASES;
RATS;
RECEPTORS, IGG;
RECOMBINANT PROTEINS;
RNA, MESSENGER;
CRICETINAE;
CRICETULUS GRISEUS;
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EID: 0035921175
PISSN: 00063592
EISSN: None
Source Type: Journal
DOI: 10.1002/bit.1119 Document Type: Article |
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Times cited : (293)
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References (15)
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