-
1
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
Spalding, K. L. et al. Dynamics of fat cell turnover in humans. Nature 453, 783–787 (2008).
-
(2008)
Nature
, vol.453
, pp. 783-787
-
-
Spalding, K.L.1
-
2
-
-
44449113934
-
Cell turnover and adult tissue homeostasis: From humans to planarians
-
Pellettieri, J. & Sanchez Alvarado, A. Cell turnover and adult tissue homeostasis: from humans to planarians. Annu. Rev. Genet. 41, 83–105 (2007).
-
(2007)
Annu. Rev. Genet.
, vol.41
, pp. 83-105
-
-
Pellettieri, J.1
Sanchez Alvarado, A.2
-
3
-
-
84899139699
-
Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans
-
Richardson, R. B., Allan, D. S. & Le, Y. Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans. Exp. Gerontol. 55, 80–91 (2014).
-
(2014)
Exp. Gerontol.
, vol.55
, pp. 80-91
-
-
Richardson, R.B.1
Allan, D.S.2
Le, Y.3
-
4
-
-
22144497124
-
Retrospective birth dating of cells in humans
-
Spalding, K. L., Bhardwaj, R. D., Buchholz, B. A., Druid, H. & Frisen, J. Retrospective birth dating of cells in humans. Cell 122, 133–143 (2005).
-
(2005)
Cell
, vol.122
, pp. 133-143
-
-
Spalding, K.L.1
Bhardwaj, R.D.2
Buchholz, B.A.3
Druid, H.4
Frisen, J.5
-
5
-
-
84931571363
-
Dynamics of cell generation and turnover in the human heart
-
Bergmann, O. et al. Dynamics of cell generation and turnover in the human heart. Cell 161, 1566–1575 (2015).
-
(2015)
Cell
, vol.161
, pp. 1566-1575
-
-
Bergmann, O.1
-
6
-
-
84901670239
-
The age and genomic integrity of neurons after cortical stroke in humans
-
Huttner, H. B. et al. The age and genomic integrity of neurons after cortical stroke in humans. Nat. Neurosci. 17, 801–803 (2014).
-
(2014)
Nat. Neurosci.
, vol.17
, pp. 801-803
-
-
Huttner, H.B.1
-
7
-
-
84875023255
-
Lifespan of neurons is uncoupled from organismal lifespan
-
Magrassi, L., Leto, K. & Rossi, F. Lifespan of neurons is uncoupled from organismal lifespan. Proc. Natl Acad. Sci. USA 110, 4374–4379 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 4374-4379
-
-
Magrassi, L.1
Leto, K.2
Rossi, F.3
-
8
-
-
0015254063
-
Epidermal ‘turnover time’--a re-examination
-
Halprin, K. M. Epidermal ‘turnover time’--a re-examination. Br. J. Dermatol. 86, 14–19 (1972).
-
(1972)
Br. J. Dermatol.
, vol.86
, pp. 14-19
-
-
Halprin, K.M.1
-
9
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98–102 (2009).
-
(2009)
Science
, vol.324
, pp. 98-102
-
-
Bergmann, O.1
-
10
-
-
0033566742
-
Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1
-
Fahy, R. J., Doseff, A. I. & Wewers, M. D. Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1. J. Immunol. 163, 1755–1762 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 1755-1762
-
-
Fahy, R.J.1
Doseff, A.I.2
Wewers, M.D.3
-
11
-
-
0025788133
-
Differential regulation of human monocyte programmed cell death (Apoptosis) by chemotactic factors and pro-inflammatory cytokines
-
Mangan, D. F. & Wahl, S. M. Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. J. Immunol. 147, 3408–3412 (1991).
-
(1991)
J. Immunol.
, vol.147
, pp. 3408-3412
-
-
Mangan, D.F.1
Wahl, S.M.2
-
12
-
-
0024806067
-
Cell population kinetics in dog and human adult thyroid
-
Coclet, J., Foureau, F., Ketelbant, P., Galand, P. & Dumont, J. E. Cell population kinetics in dog and human adult thyroid. Clin. Endocrinol. (Oxf) 31, 655–665 (1989).
-
(1989)
Clin. Endocrinol. (Oxf)
, vol.31
, pp. 655-665
-
-
Coclet, J.1
Foureau, F.2
Ketelbant, P.3
Galand, P.4
Dumont, J.E.5
-
13
-
-
0000568625
-
Renewal of cell populations
-
Leblond, C. P. & Walker, B. E. Renewal of cell populations. Physiol. Rev. 36, 255–276 (1956).
-
(1956)
Physiol. Rev.
, vol.36
, pp. 255-276
-
-
Leblond, C.P.1
Walker, B.E.2
-
14
-
-
84940004351
-
Genetics, lifestyle and longevity: Lessons from centenarians
-
Govindaraju, D., Atzmon, G. & Barzilai, N. Genetics, lifestyle and longevity: Lessons from centenarians. Appl. Transl. Genomics 4, 23–32 (2015).
-
(2015)
Appl. Transl. Genomics
, vol.4
, pp. 23-32
-
-
Govindaraju, D.1
Atzmon, G.2
Barzilai, N.3
-
15
-
-
84922541951
-
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes
-
Fang, X. et al. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 8, 1354–1364 (2014).
-
(2014)
Cell Rep
, vol.8
, pp. 1354-1364
-
-
Fang, X.1
-
16
-
-
84927910038
-
Gene expression defines natural changes in mammalian lifespan
-
Fushan, A. A. et al. Gene expression defines natural changes in mammalian lifespan. Aging Cell 14, 352–365 (2015).
-
(2015)
Aging Cell
, vol.14
, pp. 352-365
-
-
Fushan, A.A.1
-
17
-
-
84920269464
-
Proteomics. Tissue-based map of the human proteome
-
Uhlen, M. et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015).
-
(2015)
Science
, vol.347
, pp. 1260419
-
-
Uhlen, M.1
-
18
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57–74 (2012).
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
19
-
-
84897406127
-
A promoter-level mammalian expression atlas
-
Fantom Consortium. A promoter-level mammalian expression atlas. Nature 507, 462–470 (2014).
-
(2014)
Nature
, vol.507
, pp. 462-470
-
-
-
20
-
-
84929015296
-
Human genomics. The human transcriptome across tissues and individuals
-
Mele, M. et al. Human genomics. The human transcriptome across tissues and individuals. Science 348, 660–665 (2015).
-
(2015)
Science
, vol.348
, pp. 660-665
-
-
Mele, M.1
-
21
-
-
84923072107
-
The statistical geometry of transcriptome divergence in cell-type evolution and cancer
-
Liang, C., Consortium, F., Forrest, A. R. & Wagner, G. P. The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nat. Commun. 6, 6066 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6066
-
-
Liang, C.1
Consortium, F.2
Forrest, A.R.3
Wagner, G.P.4
-
22
-
-
84924548492
-
Cell-type phylogenetics and the origin of endometrial stromal cells
-
Kin, K., Nnamani, M. C., Lynch, V. J., Michaelides, E. & Wagner, G. P. Cell-type phylogenetics and the origin of endometrial stromal cells. Cell Rep. 10, 1398–1409 (2015).
-
(2015)
Cell Rep
, vol.10
, pp. 1398-1409
-
-
Kin, K.1
Nnamani, M.C.2
Lynch, V.J.3
Michaelides, E.4
Wagner, G.P.5
-
23
-
-
84923345330
-
An integrative analysis of TFBS-clustered regions reveals new transcriptional regulation models on the accessible chromatin landscape
-
Chen, H. et al. An integrative analysis of TFBS-clustered regions reveals new transcriptional regulation models on the accessible chromatin landscape. Sci. Rep. 5, 8465 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 8465
-
-
Chen, H.1
-
24
-
-
84882766972
-
Developmental fate and cellular maturity encoded in human regulatory DNA landscapes
-
Stergachis, A. B. et al. Developmental fate and cellular maturity encoded in human regulatory DNA landscapes. Cell 154, 888–903 (2013).
-
(2013)
Cell
, vol.154
, pp. 888-903
-
-
Stergachis, A.B.1
-
25
-
-
84923362619
-
Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes
-
Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes. Nature 518, 317–330 (2015).
-
(2015)
Nature
, vol.518
, pp. 317-330
-
-
-
26
-
-
0034036980
-
Anaplerosis of the citric acid cycle: Role in energy metabolism of heart and skeletal muscle
-
Gibala, M. J., Young, M. E. & Taegtmeyer, H. Anaplerosis of the citric acid cycle: role in energy metabolism of heart and skeletal muscle. Acta Physiol. Scand. 168, 657–665 (2000).
-
(2000)
Acta Physiol. Scand.
, vol.168
, pp. 657-665
-
-
Gibala, M.J.1
Young, M.E.2
Taegtmeyer, H.3
-
27
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. Elegans
-
Herndon, L. A. et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808–814 (2002).
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.A.1
-
28
-
-
84894491283
-
Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity
-
Dong, C., Bach, S. V., Haynes, K. A. & Hegde, A. N. Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity. J. Neurosci. 34, 3171–3182 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 3171-3182
-
-
Dong, C.1
Bach, S.V.2
Haynes, K.A.3
Hegde, A.N.4
-
29
-
-
84880085087
-
Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism
-
Stout, G. J. et al. Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism. Mol. Syst. Biol. 9, 679 (2013).
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 679
-
-
Stout, G.J.1
-
30
-
-
33750044901
-
Ribosome biogenesis and cell growth: MTOR coordinates transcription by all three classes of nuclear RNA polymerases
-
Mayer, C. & Grummt, I. Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 25, 6384–6391 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 6384-6391
-
-
Mayer, C.1
Grummt, I.2
-
31
-
-
0029898203
-
Accelerated neuronal differentiation induced by p53 suppression
-
Ferreira, A. & Kosik, K. S. Accelerated neuronal differentiation induced by p53 suppression. J. Cell Sci. 109, 1509–1516 (1996).
-
(1996)
J. Cell Sci.
, vol.109
, pp. 1509-1516
-
-
Ferreira, A.1
Kosik, K.S.2
-
32
-
-
33748203042
-
A comment on phylogenetic correction
-
Rohlf, F. J. A comment on phylogenetic correction. Evolution 60, 1509–1515 (2006).
-
(2006)
Evolution
, vol.60
, pp. 1509-1515
-
-
Rohlf, F.J.1
-
33
-
-
0033984235
-
The Ki-67 protein: From the known and the unknown
-
Scholzen, T. & Gerdes, J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 182, 311–322 (2000).
-
(2000)
J. Cell. Physiol.
, vol.182
, pp. 311-322
-
-
Scholzen, T.1
Gerdes, J.2
-
34
-
-
67650517544
-
Ki67 cytoplasmic expression: Observations in normal tissue from heart atrial appendages of healthy rats
-
Ciulla, M. M. et al. Ki67 cytoplasmic expression: observations in normal tissue from heart atrial appendages of healthy rats. Cell Cycle 8, 2125 (2009).
-
(2009)
Cell Cycle
, vol.8
, pp. 2125
-
-
Ciulla, M.M.1
-
35
-
-
84902315945
-
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability
-
Yata, K. et al. BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability. Cell Rep. 7, 1547–1559 (2014).
-
(2014)
Cell Rep
, vol.7
, pp. 1547-1559
-
-
Yata, K.1
-
36
-
-
15844373362
-
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
-
Esashi, F. et al. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434, 598–604 (2005).
-
(2005)
Nature
, vol.434
, pp. 598-604
-
-
Esashi, F.1
-
37
-
-
78649326442
-
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination
-
O'Donnell, L. et al. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol. Cell 40, 619–631 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 619-631
-
-
O'donnell, L.1
-
38
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi, J. & d'AddadiFagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729–740 (2007).
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'addadifagagna, F.2
-
39
-
-
84948953210
-
Mitochondrial dysfunction and longevity in animals: Untangling the knot
-
Wang, Y. & Hekimi, S. Mitochondrial dysfunction and longevity in animals: Untangling the knot. Science 350, 1204–1207 (2015).
-
(2015)
Science
, vol.350
, pp. 1204-1207
-
-
Wang, Y.1
Hekimi, S.2
-
40
-
-
10744224439
-
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
-
Mootha, V. K. et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115, 629–640 (2003).
-
(2003)
Cell
, vol.115
, pp. 629-640
-
-
Mootha, V.K.1
-
41
-
-
84892915705
-
The free radical theory of aging is dead. Long live the damage theory!
-
Gladyshev, V. N. The free radical theory of aging is dead. Long live the damage theory!. Antioxid. Redox Signal. 20, 727–731 (2014).
-
(2014)
Antioxid. Redox Signal.
, vol.20
, pp. 727-731
-
-
Gladyshev, V.N.1
-
42
-
-
84878864199
-
The hallmarks of aging
-
Lopez-Otin, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
Lopez-Otin, C.1
Blasco, M.A.2
Partridge, L.3
Serrano, M.4
Kroemer, G.5
-
43
-
-
84880509894
-
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
-
Mercken, E. M. et al. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 12, 645–651 (2013).
-
(2013)
Aging Cell
, vol.12
, pp. 645-651
-
-
Mercken, E.M.1
-
44
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
van Heemst, D. et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40, 11–15 (2005).
-
(2005)
Exp. Gerontol.
, vol.40
, pp. 11-15
-
-
van Heemst, D.1
-
45
-
-
38048999665
-
Two faces of p53: Aging and tumor suppression
-
Rodier, F., Campisi, J. & Bhaumik, D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 35, 7475–7484 (2007).
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 7475-7484
-
-
Rodier, F.1
Campisi, J.2
Bhaumik, D.3
-
46
-
-
77956108683
-
Trade-offs between cancer and other diseases: Do they exist and influence longevity?
-
Ukraintseva, S. V. et al. Trade-offs between cancer and other diseases: do they exist and influence longevity? Rejuvenation Res. 13, 387–396 (2010).
-
(2010)
Rejuvenation Res
, vol.13
, pp. 387-396
-
-
Ukraintseva, S.V.1
-
47
-
-
27844596799
-
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
-
Bauer, J. H., Poon, P. C., Glatt-Deeley, H., Abrams, J. M. & Helfand, S. L. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15, 2063–2068 (2005).
-
(2005)
Curr. Biol.
, vol.15
, pp. 2063-2068
-
-
Bauer, J.H.1
Poon, P.C.2
Glatt-Deeley, H.3
Abrams, J.M.4
Helfand, S.L.5
-
48
-
-
77950024020
-
Dominant-negative Dmp53 extends life span through the dTOR pathway in D. Melanogaster
-
Bauer, J. H., Chang, C., Bae, G., Morris, S. N. & Helfand, S. L. Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster. Mech. Ageing Dev. 131, 193–201 (2010).
-
(2010)
Mech. Ageing Dev.
, vol.131
, pp. 193-201
-
-
Bauer, J.H.1
Chang, C.2
Bae, G.3
Morris, S.N.4
Helfand, S.L.5
-
49
-
-
84946035099
-
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans
-
Abegglen, L. M. et al. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. JAMA 314, 1850–1860 (2015).
-
(2015)
JAMA
, vol.314
, pp. 1850-1860
-
-
Abegglen, L.M.1
-
50
-
-
4344663507
-
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
-
Ashur-Fabian, O. et al. Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc. Natl Acad. Sci. USA 101, 12236–12241 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 12236-12241
-
-
Ashur-Fabian, O.1
-
51
-
-
84901937260
-
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
-
Fang, X. et al. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nat. Commun. 5, 3966 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 3966
-
-
Fang, X.1
-
52
-
-
85051969408
-
Defining molecular basis for longevity traits in natural yeast isolates
-
Kaya, A. et al. Defining molecular basis for longevity traits in natural yeast isolates. npj Aging Mech. Dis. 1, 15001 (2015).
-
(2015)
Npj Aging Mech. Dis.
, vol.1
, pp. 15001
-
-
Kaya, A.1
-
53
-
-
0242380209
-
The osteocyte
-
Knothe Tate, M. L., Adamson, J. R., Tami, A. E. & Bauer, T. W. The osteocyte. Int. J. Biochem. Cell Biol. 36, 1–8 (2004).
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 1-8
-
-
Knothe Tate, M.L.1
Adamson, J.R.2
Tami, A.E.3
Bauer, T.W.4
-
54
-
-
84882455458
-
Single-cell sequencing-based technologies will revolutionize whole-organism science
-
Shapiro, E., Biezuner, T. & Linnarsson, S. Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat. Rev. Genet. 14, 618–630 (2013).
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 618-630
-
-
Shapiro, E.1
Biezuner, T.2
Linnarsson, S.3
-
55
-
-
84929001104
-
Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
-
GTEx Consortium
-
GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648–660 (2015).
-
(2015)
Science
, vol.348
, pp. 648-660
-
-
-
56
-
-
84908441328
-
Obesity accelerates epigenetic aging of human liver
-
Horvath, S. et al. Obesity accelerates epigenetic aging of human liver. Proc. Natl Acad. Sci. USA 111, 15538–15543 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 15538-15543
-
-
Horvath, S.1
-
57
-
-
84886111619
-
DNA methylation age of human tissues and cell types
-
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).
-
(2013)
Genome Biol
, vol.14
, pp. R115
-
-
Horvath, S.1
-
58
-
-
84883415285
-
Identification of long-lived proteins reveals exceptional stability of essential cellular structures
-
Toyama, B. H. et al. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell 154, 971–982 (2013).
-
(2013)
Cell
, vol.154
, pp. 971-982
-
-
Toyama, B.H.1
-
59
-
-
84857649763
-
Extremely long-lived nuclear pore proteins in the rat brain
-
Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R. 3rd & Hetzer, M. W. Extremely long-lived nuclear pore proteins in the rat brain. Science 335, 942 (2012).
-
(2012)
Science
, vol.335
, pp. 942
-
-
Savas, J.N.1
Toyama, B.H.2
Xu, T.3
Yates, J.R.4
Hetzer, M.W.5
-
60
-
-
19344372220
-
A neutral model of transcriptome evolution
-
Khaitovich, P. et al. A neutral model of transcriptome evolution. PLoS Biol. 2, E132 (2004).
-
(2004)
Plos Biol
, vol.2
, pp. E132
-
-
Khaitovich, P.1
-
61
-
-
84929011938
-
Lifespan of mice and primates correlates with immunoproteasome expression
-
Pickering, A. M., Lehr, M. & Miller, R. A. Lifespan of mice and primates correlates with immunoproteasome expression. J. Clin. Invest. 125, 2059–2068 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2059-2068
-
-
Pickering, A.M.1
Lehr, M.2
Miller, R.A.3
|