Greater organ involution in highly proliferative tissues associated with the early onset and acceleration of ageing in humans

Experimental Gerontology

Volumn 55, Issue , 2014, Pages 80-91

  Richardson, Richard B ^a   Allan, David S ^b   Le, Yevgeniya ^a  

^a ATOMIC ENERGY OF CANADA LIMITED   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Accelerated ageing; Cell death; Evolution; Human; Proliferation

Indexed keywords

ADIPOSE TISSUE; AGING; APOPTOSIS; ARTICLE; ATROPHY; CELL AGING; CELL DEATH; CELL METABOLISM; CELL PROLIFERATION; EVOLUTIONARY ADAPTATION; HUMAN; INVOLUTION; NEOPLASM; NONHUMAN; ORGAN INVOLUTION; ORGAN SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENESCENCE; PATHOLOGY; PHYSIOLOGY; PREMATURE AGING;

AGING; AGING, PREMATURE; APOPTOSIS; CELL AGING; CELL PROLIFERATION; HUMANS; ORGAN SIZE;

EID: 84899139699     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.03.015     Document Type: Article

References (147)

1. Allsopp R.C., Chang E., Kashefi-Aazam M., Rogaev E.I., Piatyszek M.A., Shay J.W., Harley C.B. Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res. 1995, 220:194-200.
2. Almeida M., Han L., Martin-Millan M., Plotkin L.I., Stewart S.A., Roberson P.K., Kousteni S., O'Brien C.A., Bellido T., Parfitt A.M., Weinstein R.S., Jilka R.L., Manolagas S.C. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J. Biol. Chem. 2007, 282:27285-27297.
3. Amir W., Micha B., Ariel H., Liat L.G., Jehoshua D., Adrian S. Predicting factors for endometrial thickness during treatment with assisted reproductive technology. Fertil. Steril. 2007, 87:799-804.
4. Andreasen E., Ottesen J. Studies on the lymphocyte production. Investigations on the nucleic acid turnover in the lymphoid organs. Acta Physiol. Scand. 1945, 10:258-270.
5. Austad S.N. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana). J. Zool. (Lond.) 1993, 229:695-708.
6. Bai B., Vanhoutte P.M., Wang Y. Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5. Trends Cardiovasc. Med. 2014, 24:81-84.
7. Bain B.J., Clark D.M., Wilkins B. Bone Marrow Pathology 2010, Wiley-Blackwell, Chichester, UK; Hoboken, NJ.
8. Baserga R., Wiebel F. The cell cycle of mammalian cells. Int. Rev. Exp. Pathol. 1969, 7:1-30.
9. Batisse D., Bazin R., Baldeweck T., Querleux B., Leveque J.L. Influence of age on the wrinkling capacities of skin. Skin Res. Technol. 2002, 8:148-154.
10. Bean R.B. Composite study of weight of vital organs in man. Am. J. Phys. Anthropol. 1926, 9:293-319.
11. Bergmann O., Bhardwaj R.D., Bernard S., Zdunek S., Barnabe-Heider F., Walsh S., Zupicich J., Alkass K., Buchholz B.A., Druid H., Jovinge S., Frisen J. Evidence for cardiomyocyte renewal in humans. Science 2009, 324:98-102.
12. Bertalanffy F.D. Tritiated thymidine versus colchicine technique in the study of cell population cytodynamics. Lab. Invest. 1964, 13:871-886.
13. Bertalanffy F.D., Nagy K.P. Mitotic activity and renewal rate of the epithelial cells of human duodenum. Acta Anat. (Basel) 1961, 45:362-370.
14. Bhardwaj R.D., Curtis M.A., Spalding K.L., Buchholz B.A., Fink D., Bjork-Eriksson T., Nordborg C., Gage F.H., Druid H., Eriksson P.S., Frisen J. Neocortical neurogenesis in humans is restricted to development. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12564-12568.
15. Blenkinsopp W.K. Proliferation of respiratory tract epithelium in the rat. Exp. Cell Res. 1967, 46:144-154.
16. Boehm A.M., Khalturin K., Anton-Erxleben F., Hemmrich G., Klostermeier U.C., Lopez-Quintero J.A., Oberg H.H., Puchert M., Rosenstiel P., Wittlieb J., Bosch T.C. FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:19697-19702.
17. Boyd E. Normal variability in weight of the adult human liver and spleen. Arch. Pathol. 1933, 16:350-372.
18. Boyd N.F., Martin L.J., Bronskill M., Yaffe M.J., Duric N., Minkin S. Breast tissue composition and susceptibility to breast cancer. J. Natl. Cancer Inst. 2010, 102:1224-1237.
19. Branchet M.C., Boisnic S., Frances C., Robert A.M. Skin thickness changes in normal aging skin. Gerontology 1990, 36:28-35.
20. Brault M.E., Autexier C. Telomeric recombination induced by dysfunctional telomeres. Mol. Biol. Cell 2011, 22:179-188.
21. Bree R.T., Stenson-Cox C., Grealy M., Byrnes L., Gorman A.M., Samali A. Cellular longevity: role of apoptosis and replicative senescence. Biogerontology 2002, 3:195-206.
22. Bridge D., Theofiles A.G., Holler R.L., Marcinkevicius E., Steele R.E., Martinez D.E. FoxO and stress responses in the cnidarian Hydra vulgaris. PLoS One 2010, 5:e11686.
23. Burns J.M., Johnson D.K., Watts A., Swerdlow R.H., Brooks W.M. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch. Neurol. 2010, 67:428-433.
24. Cameron I.L. Cell renewal in the organs and tissues of the nongrowing adult mouse. Tex. Rep. Biol. Med. 1970, 28:203-248.
25. Campisi J., Kim S.H., Lim C.S., Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp. Gerontol. 2001, 36:1619-1637.
26. Cherif H., Tarry J.L., Ozanne S.E., Hales C.N. Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res. 2003, 31:1576-1583.
27. Chung H.Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A.Y., Carter C., Yu B.P., Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 2009, 8:18-30.
28. Coclet J., Foureau F., Ketelbant P., Galand P., Dumont J.E. Cell population kinetics in dog and human adult thyroid. Clin. Endocrinol. (Oxf.) 1989, 31:655-665.
29. Cohen H.L., Tice H.M., Mandel F.S. Ovarian volumes measured by US: bigger than we think. Radiology 1990, 177:189-192.
30. Cole J.W., McKalen A. Observations of cell renewal in human rectal mucosa in vivo with thymidine-H3. Gastroenterology 1961, 41:122-125.
31. Dekaban A.S., Sadowsky D. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann. Neurol. 1978, 4:345-356.
32. Dettenborn L., Tietze A., Kirschbaum C., Stalder T. The assessment of cortisol in human hair: associations with sociodemographic variables and potential confounders. Stress 2012, 15:578-588.
33. Eisenberg D.T., Hayes M.G., Kuzawa C.W. Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:10251-10256.
34. El-Bastawissi A.Y., White E., Mandelson M.T., Taplin S.H. Reproductive and hormonal factors associated with mammographic breast density by age (United States). Cancer Causes Control 2000, 11:955-963.
35. Flachsbart F., Caliebe A., Kleindorp R., Blanche H., von Eller-Eberstein H., Nikolaus S., Schreiber S., Nebel A. Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2700-2705.
36. Gambichler T., Matip R., Moussa G., Altmeyer P., Hoffmann K. In vivo data of epidermal thickness evaluated by optical coherence tomography: effects of age, gender, skin type, and anatomic site. J. Dermatol. Sci. 2006, 44:145-152.
37. Garcia-Cao I., Garcia-Cao M., Martin-Caballero J., Criado L.M., Klatt P., Flores J.M., Weill J.C., Blasco M.A., Serrano M. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 2002, 21:6225-6235.
38. Gavrilov L.A., Gavrilova N.S. Biodemography of exceptional longevity: early-life and mid-life predictors of human longevity. Biodemography Soc. Biol. 2012, 58:14-39.
39. Gavrilova N.S., Gavrilov L.A. Search for predictors of exceptional human longevity: using computerized genealogies and internet resources for human longevity studies. N. Am. Actuarial J. 2007, 11:49-67.
40. Ghartimagar D., Naik R., Gupta A., Ghosh A. Histopathology of prostatic lesions - an autopsy study of 100 cases. Internet J. Forensic Sci. 2012, 5.
41. Gilmore J.R., Martin W.J. The weight of the parathyroid glands. J. Pathol. Bacteriol. 1937, 44:431-462.
42. Guillaume F., Otto S.P. Gene functional trade-offs and the evolution of pleiotropy. Genetics 2012, 192:1389-1409.
43. Gurbuz B., Yalti S., Yildirim G. Endometrial thickness and uterine size in postmenopausal women. Int. J. Gynaecol. Obstet. 2004, 84:268-270.
44. Gurven M., Kaplan H. Hunter-gatherer longevity: cross-cultural examination. Popul. Dev. Rev. 2007, 33:321-365.
45. Haber H.P., Stern M. Intestinal ultrasonography in children and young adults: bowel wall thickness is age dependent. J. Ultrasound Med. 2000, 19:315-321.
46. Halprin K.M. Epidermal "turnover time"-a re-examination. Br. J. Dermatol. 1972, 86:14-19.
47. Hamilton W.D. The moulding of senescence by natural selection. J. Theor. Biol. 1966, 12:12-45.
48. Handelsman D.J., Staraj S. Testicular size: the effects of aging, malnutrition, and illness. J. Androl. 1985, 6:144-151.
49. Hanna C., Bicknell D.S., O'Brien J.E. Cell turnover in the adult human eye. Arch. Ophthalmol. 1961, 65:695-698.
50. Harper C., Mina L. A comparison of Australian Caucasian and aboriginal brain weights. Clin. Exp. Neurol. 1981, 18:44-51.
51. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
52. He Q., Heshka S., Albu J., Boxt L., Krasnow N., Elia M., Gallagher D. Smaller organ mass with greater age, except for heart. J. Appl. Physiol. 2009, 106:1780-1784.
53. Heller C.G., Clermont Y. Spermatogenesis in man: an estimate of its duration. Science 1963, 140:184-186.
54. Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013, 14:R115.
55. ICRP Report of the Task Group on Reference Man. Oxford; International Commission on Radiological Protection Publication 23 1975, Pergamon Press, New York.
56. Ilyenko I., Lyaskivska O., Bazyka D. Analysis of relative telomere length and apoptosis in humans exposed to ionising radiation. Exp. Oncol. 2011, 33:235-238.
57. Ishii A., Nakamura K., Kishimoto H., Honma N., Aida J., Sawabe M., Arai T., Fujiwara M., Takeuchi F., Kato M., Oshimura M., Izumiyama N., Takubo K. Telomere shortening with aging in the human pancreas. Exp. Gerontol. 2006, 41:882-886.
58. Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
59. Jiang H., Ju Z., Rudolph K.L. Telomere shortening and ageing. Z. Gerontol. Geriatr. 2007, 40:314-324.
60. Johnstone R.A., Cant M.A. The evolution of menopause in cetaceans and humans: the role of demography. Proc. Biol. Sci. 2010, 277:3765-3771.
61. Kajstura J., Gurusamy N., Ogorek B., Goichberg P., Clavo-Rondon C., Hosoda T., D'Amario D., Bardelli S., Beltrami A.P., Cesselli D., Bussani R., del Monte F., Quaini F., Rota M., Beltrami C.A., Buchholz B.A., Leri A., Anversa P. Myocyte turnover in the aging human heart. Circ. Res. 2010, 107:1374-1386.
62. Kinouchi R., Matsuzaki T., Iwasa T., Gereltsetseg G., Nakazawa H., Kunimi K., Kuwahara A., Yasui T., Irahara M. Prepubertal exposure to glucocorticoid delays puberty independent of the hypothalamic Kiss1-GnRH system in female rats. Int. J. Dev. Neurosci. 2012, 30:596-601.
63. Kirkwood T.B. Evolution of ageing. Nature 1977, 270:301-304.
64. Kraus C., Pavard S., Promislow D.E. The size-life span trade-off decomposed: why large dogs die young. Am. Nat. 2013, 181:492-505.
65. Krems C., Luhrmann P.M., Strassburg A., Hartmann B., Neuhauser-Berthold M. Lower resting metabolic rate in the elderly may not be entirely due to changes in body composition. Eur. J. Clin. Nutr. 2005, 59:255-262.
66. Krogman W.M. Growth of Man 1941, W. Junk, Den Haag.
67. Krumbhaar E.B., Lippincott S.W. The postmortem weight of the "normal" human spleen at different ages. Am. J. Med. Sci. 1939, 197:344-358.
68. Kyle U.G., Genton L., Hans D., Karsegard L., Slosman D.O., Pichard C. Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94years. Eur. J. Clin. Nutr. 2001, 55:663-672.
69. Leblond C.P. Classification of cell populations on the basis of their proliferative behavior. Natl. Cancer Inst. Monogr. 1964, 14:119-150.
70. Leblond C.P., Walker B.E. Renewal of cell populations. Physiol. Rev. 1956, 36:255-276.
71. Lee R.C., Wang Z., Heo M., Ross R., Janssen I., Heymsfield S.B. Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. Am. J. Clin. Nutr. 2000, 72:796-803.
72. Li T., Sun L., Miller N., Nicklee T., Woo J., Hulse-Smith L., Tsao M.S., Khokha R., Martin L., Boyd N. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol. Biomarkers Prev. 2005, 14:343-349.
73. Lin J., Kroenke C.H., Epel E., Kenna H.A., Wolkowitz O.M., Blackburn E., Rasgon N.L. Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline. Brain Res. 2011, 1379:224-231.
74. Lipkin M. Cell replication in the gastrointestinal tract of man. Gastroenterology 1965, 48:616-624.
75. Lok E., Scott F.W., Mongeau R., Nera E.A., Malcolm S., Clayson D.B. Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse. Cancer Lett. 1990, 51:67-73.
76. MacDonald R.A. "Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch. Intern. Med. 1961, 107:335-343.
77. MacDonald W.C., Trier J.S., Everett N.B. Cell proliferation and migration in the stomach, duodenum, and rectum of man: radioautographic studies. Gastroenterology 1964, 46:405-417.
78. MacNulty D.R., Smith D.W., Vucetich J.A., Mech L.D., Stahler D.R., Packer C. Predatory senescence in ageing wolves. Ecol. Lett. 2009, 12:1347-1356.
79. 3H-thymidine autoradiographic investigation. Gastroenterol. Jpn. 1990, 25:514.
80. Magdon-Maksymowicz M.S., Maksymowicz A.Z. Numerical solution of the Penna model of biological aging with age-modified mutation rate. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 2009, 79:061919.
81. Marchal J., Dal-Pan A., Epelbaum J., Blanc S., Mueller S., Wittig Kieffer M., Metzger F., Aujard F. Calorie restriction and resveratrol supplementation prevent age-related DNA and RNA oxidative damage in a non-human primate. Exp. Gerontol. 2013, 48:992-1000.
82. Marcus R.L., Addison O., Kidde J.P., Dibble L.E., Lastayo P.C. Skeletal muscle fat infiltration: impact of age, inactivity, and exercise. J. Nutr. Health Aging 2010, 14:362-366.
83. Mariani E., Meneghetti A., Formentini I., Neri S., Cattini L., Ravaglia G., Forti P., Facchini A. Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing. Exp. Gerontol. 2003, 38:653-659.
84. Martola E.L., Baum J.L. Central and peripheral corneal thickness. A clinical study. Arch. Ophthalmol. 1968, 79:28-30.
85. Matsumura T., Zerrudo Z., Hayflick L. Senescent human diploid cells in culture: survival, DNA synthesis and morphology. J. Gerontol. 1979, 34:328-334.
86. Medawar P. An Unsolved Problem in Biology 1952, HK Lewis, London.
87. Medh R.D., Thompson E.B. Hormonal regulation of physiological cell turnover and apoptosis. Cell Tissue Res. 2000, 301:101-124.
88. Mendenhall A.R., Wu D., Park S.K., Cypser J.R., Tedesco P.M., Link C.D., Phillips P.C., Johnson T.E. Genetic dissection of late-life fertility in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66:842-854.
89. Meyer J.S. Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Effects of menstrual phase, age, and oral contraceptive hormones. Hum. Pathol. 1977, 8:67-81.
90. Milanese T.R., Hartmann L.C., Sellers T.A., Frost M.H., Vierkant R.A., Maloney S.D., Pankratz V.S., Degnim A.C., Vachon C.M., Reynolds C.A., Thompson R.A., Melton L.J., Goode E.L., Visscher D.W. Age-related lobular involution and risk of breast cancer. J. Natl. Cancer Inst. 2006, 98:1600-1607.
91. Misell L.M., Hwang E.S., Au A., Esserman L., Hellerstein M.K. Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans. Breast Cancer Res. Treat. 2005, 89:257-264.
92. Mochizuki Y., Mowafy R., Pasternack B. Weights of human thyroids in New York City. Health Phys. 1963, 9:1299-1301.
93. Musicco M., Adorni F., Di Santo S., Prinelli F., Pettenati C., Caltagirone C., Palmer K., Russo A. Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study. Neurology 2013, 81:322-328.
94. Nakayama D., Magami Y., Azuma T., Inokuchi H., Furukawa M., Ohyashiki J., Yoshimoto T., Mizuguchi J., Moriyasu F., Kawai K., Hattori T. Turnover of acinar and islet cells in the pancreas of monosodium glutamate-treated obese mice. Obes. Res. 2003, 11:87-94.
95. Nolan L.A., Lunness H.R., Lightman S.L., Levy A. The effects of age and spontaneous adenoma formation on trophic activity in the rat pituitary gland: a comparison with trophic activity in the human pituitary and in human pituitary adenomas. J. Neuroendocrinol. 1999, 11:393-401.
96. Ogawa T., Kitagawa M., Hirokawa K. Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mech. Ageing Dev. 2000, 117:57-68.
97. Ogiu N., Nakamura Y., Ijiri I., Hiraiwa K., Ogiu T. A statistical analysis of the internal organ weights of normal Japanese people. Health Phys. 1997, 72:368-383.
98. Olivetti G., Melissari M., Capasso J.M., Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ. Res. 1991, 68:1560-1568.
99. Panossian L.A., Porter V.R., Valenzuela H.F., Zhu X., Reback E., Masterman D., Cummings J.L., Effros R.B. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging 2003, 24:77-84.
100. Pike M.C., Spicer D.V., Dahmoush L., Press M.F. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol. Rev. 1993, 15:17-35.
101. Pollack M., Phaneuf S., Dirks A., Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann. N. Y. Acad. Sci. 2002, 959:93-107.
102. Popovic M. Modeling age- and sex-related changes in lead metabolism: a physiological approach. Medical Physics and Applied Radiation Science 2006, McMaster University, Hamilton, Ontario.
103. Porter R.K., Brand M.D. Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate. Nature 1993, 362:628-630.
104. Potten C.S., Watson R.J., Williams G.T., Tickle S., Roberts S.A., Harris M., Howell A. The effect of age and menstrual cycle upon proliferative activity of the normal human breast. Br. J. Cancer 1988, 58:163-170.
105. Pradhan B.K., Chandra K. Morphogenesis of nodular hyperplasia-prostate. J. Urol. 1975, 113:210-213.
106. Rawlins E.L., Hogan B.L. Ciliated epithelial cell lifespan in the mouse trachea and lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L231-L234.
107. Renault V., Thornell L.E., Eriksson P.O., Butler-Browne G., Mouly V. Regenerative potential of human skeletal muscle during aging. Aging Cell 2002, 1:132-139.
108. Richardson R.B. Ionizing radiation and aging: rejuvenating an old idea. Aging (Albany NY) 2009, 1:887-902.
109. Richardson R.B. Promotional etiology for common childhood acute lymphoblastic leukemia: the infective lymphoid recovery hypothesis. Leuk. Res. 2011, 35:1425-1431.
110. Richardson R.B. Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults. Int. J. Radiat. Biol. 2011, 87:343-359.
111. Richardson R.B. p53 mutations associated with aging-related rise in cancer incidence rates. Cell Cycle 2013, 12:2468-2478.
112. Richardson R.B., Dubeau J. Monte Carlo determination of age-dependent steady-state dose to red bone marrow and bone from C-14 exposure. Radiat. Prot. Dosim. 2003, 103:5-18.
113. Richart R.M. A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix. Am. J. Obstet. Gynecol. 1963, 86:925-930.
114. Russo J., Calaf G., Roi L., Russo I.H. Influence of age and gland topography on cell kinetics of normal human breast tissue. J. Natl. Cancer Inst. 1987, 78:413-418.
115. Sabin R.J., Anderson R.M. Cellular senescence - its role in cancer and the response to ionizing radiation. Genome Integr. 2011, 2:7.
116. Saisho Y., Butler A.E., Meier J.J., Monchamp T., Allen-Auerbach M., Rizza R.A., Butler P.C. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin. Anat. 2007, 20:933-942.
117. Salthouse T.A. When does age-related cognitive decline begin?. Neurobiol. Aging 2009, 30:507-514.
118. Sanchez R., Morales M., Cardozo J. Weight of the normal brain of the Venezuelan adult according to sex and age. Invest. Clin. 1997, 38:83-93.
119. Sasaki T., Maier B., Bartke A., Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 2006, 5:413-422.
120. Schaffler A., Muller-Ladner U., Scholmerich J., Buchler C. Role of adipose tissue as an inflammatory organ in human diseases. Endocr. Rev. 2006, 27:449-467.
121. Shorter R.G., Moertel C.G., Titus J.L., Reitemeier R.J. Cell kinetics in the jejunum and rectum of man. Am. J. Dig. Dis. 1964, 9:760-763.
122. Sieglova Z., Zilovcova S., Cermak J., Rihova H., Brezinova D., Dvorakova R., Markova M., Maaloufova J., Sajdova J., Brezinova J., Zemanova Z., Michalova K. Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis?. Leuk. Res. 2004, 28:1013-1021.
123. Sosnik H. Studies on the participation of tunica albuginea and rete testis (TA and RT) in the quantitative structure of human testis. Gegenbaurs Morphol. Jahrb. 1985, 131:347-356.
124. Spalding K.L., Bhardwaj R.D., Buchholz B.A., Druid H., Frisén J. Retrospective birth dating of cells in humans. Cell 2005, 122:133-143.
125. Spalding K.L., Arner E., Westermark P.O., Bernard S., Buchholz B.A., Bergmann O., Blomqvist L., Hoffstedt J., Naslund E., Britton T., Concha H., Hassan M., Ryden M., Frisen J., Arner P. Dynamics of fat cell turnover in humans. Nature 2008, 453:783-787.
126. Steinmann G.G., Klaus B., Muller-Hermelink H.K. The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand. J. Immunol. 1985, 22:563-575.
127. 2H2O). Am. J. Physiol. Endocrinol. Metab. 2004, 286:E577-E588.
128. Strehler B.L., Mildvan A.S. General theory of mortality and aging. Science 1960, 132:14-21.
129. Swyer G.I. Post-natal growth changes in the human prostate. J. Anat. 1944, 78:130-145.
130. Tanaka G. Reference Japanese. Anatomical Data 1992, vol. 1. National Institute of Radiological Sciences, Chiba, Japan.
131. Tiemann-Boege I., Navidi W., Grewal R., Cohn D., Eskenazi B., Wyrobek A.J., Arnheim N. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:14952-14957.
132. Törnblom N. Contribution to the discussion on the etiology of prostatic hypertrophy in man. I. The weight of prostate and seminal vesicles in men of different ages. Acta Med. Scand. 1946, 123(S170):1-5.
133. Tsubouchi S., Kano E., Suzuki H. Demonstration of expanding cell populations in mouse pancreatic acini and islets. Anat. Rec. 1987, 218:111-115.
134. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee Park S., Thompson T., Karsenty G., Bradley A., Donehower L.A. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002, 415:45-53.
135. Verma S., Tachtatzis P., Penrhyn-Lowe S., Scarpini C., Jurk D., Von Zglinicki T., Coleman N., Alexander G.J. Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver. Hepatology 2012, 56:1510-1520.
136. von Zglinicki T., Saretzki G., Ladhoff J., d'Adda di Fagagna F., Jackson S.P. Human cell senescence as a DNA damage response. Mech. Ageing Dev. 2005, 126:111-117.
137. Vorobtsova I., Semenov A., Timofeyeva N., Kanayeva A., Zvereva I. An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionising radiation. Mech. Ageing Dev. 2001, 122:1373-1382.
138. Wang Q., Palnitkar S., Parfitt A.M. Parathyroid cell proliferation in the rat: effect of age and of phosphate administration and recovery. Endocrinology 1996, 137:4558-4562.
139. Weismann A. Essays upon Heredity and Kindred Biological Problems 1889, Clarendon Press, Oxford.
140. Westendorp R.G., Kirkwood T.B. Human longevity at the cost of reproductive success. Nature 1998, 396:743-746.
141. Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957, 11:398-411.
142. Womack H.C. The relationship between human body weight, subcutaneous fat, heart weight, and epicardial fat. Hum. Biol. 1983, 55:667-676.
143. Wright W.E., Shay J.W. The two-stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 1992, 27:383-389.
144. Youm J.K., Park K., Uchida Y., Chan A., Mauro T.M., Holleran W.M., Elias P.M. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen. 2013, 21:715-722.
145. Zajicek G., Oren R., Weinreb M. The streaming liver. Liver 1985, 5:293-300.
146. Zhao R., Xuan Y., Li X., Xi R. Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila. Aging Cell 2008, 7:344-354.
147. Zhou S., Greenberger J.S., Epperly M.W., Goff J.P., Adler C., Leboff M.S., Glowacki J. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 2008, 7:335-343.