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Volumn 24, Issue 1, 2017, Pages

PPARs modulate cardiac metabolism and mitochondrial function in diabetes

Author keywords

Cardiomyopathy; Diabetes mellitus; Metabolism; Mitochondria; Peroxisome proliferator activated receptors

Indexed keywords

FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; GLUCOSE;

EID: 85008668630     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-016-0309-5     Document Type: Review
Times cited : (86)

References (75)
  • 1
    • 82955247909 scopus 로고    scopus 로고
    • IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • 22079683
    • Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94:311-21.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3    Shaw, J.4
  • 2
    • 84906791265 scopus 로고    scopus 로고
    • Certain dietary patterns are beneficial for the metabolic syndrome: Reviewing the evidence
    • 1:CAS:528:DC%2BC2cXht1WjsrrK 25150114
    • Calton EK, James AP, Pannu PK, Soares MJ. Certain dietary patterns are beneficial for the metabolic syndrome: reviewing the evidence. Nutr Res. 2014;34:559-68.
    • (2014) Nutr Res , vol.34 , pp. 559-568
    • Calton, E.K.1    James, A.P.2    Pannu, P.K.3    Soares, M.J.4
  • 3
    • 45249117733 scopus 로고    scopus 로고
    • Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: Observations from the Dallas Heart Study
    • 18537096
    • Chen K, Lindsey JB, Khera A, Lemos JAD, Ayers CR, Goyal A, et al. Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study. Diab Vasc Dis Res. 2008;5:96-101.
    • (2008) Diab Vasc Dis Res , vol.5 , pp. 96-101
    • Chen, K.1    Lindsey, J.B.2    Khera, A.3    Lemos, J.A.D.4    Ayers, C.R.5    Goyal, A.6
  • 4
    • 77954605168 scopus 로고    scopus 로고
    • Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease - Do we need to screen our patients?
    • 20368207
    • Roberts AW, Clark AL, Witte KK. Review article: left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease - do we need to screen our patients? Diab Vasc Dis Res. 2009;6:153-63.
    • (2009) Diab Vasc Dis Res , vol.6 , pp. 153-163
    • Roberts, A.W.1    Clark, A.L.2    Witte, K.K.3
  • 5
    • 75149129609 scopus 로고    scopus 로고
    • Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study
    • 1:CAS:528:DC%2BC3cXos1Whuw%3D%3D 19844184 3005764
    • de Simone G, Devereux RB, Chinali M, Lee ET, Galloway JM, Barac A, et al. Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study. J Hypertens. 2010;28:353-60.
    • (2010) J Hypertens , vol.28 , pp. 353-360
    • De Simone, G.1    Devereux, R.B.2    Chinali, M.3    Lee, E.T.4    Galloway, J.M.5    Barac, A.6
  • 6
    • 84861601268 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Myth or reality?
    • 22633296
    • Ernande L, Derumeaux G. Diabetic cardiomyopathy: myth or reality? Arch Cardiovasc Dis. 2012;105:218-25.
    • (2012) Arch Cardiovasc Dis , vol.105 , pp. 218-225
    • Ernande, L.1    Derumeaux, G.2
  • 7
    • 84925374055 scopus 로고    scopus 로고
    • Potential of Vitamin D in treating diabetic cardiomyopathy
    • 1:CAS:528:DC%2BC2MXktlSrtr4%3D 25770692
    • Lee TW, Lee TI, Chang CJ, Lien GS, Kao YH, Chao TF, et al. Potential of vitamin D in treating diabetic cardiomyopathy. Nutr Res. 2015;35:269-79.
    • (2015) Nutr Res , vol.35 , pp. 269-279
    • Lee, T.W.1    Lee, T.I.2    Chang, C.J.3    Lien, G.S.4    Kao, Y.H.5    Chao, T.F.6
  • 8
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • 1:CAS:528:DC%2BD3MXitF2ktr0%3D 11282301
    • Barger PM, Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med. 2000;10:238-45.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 9
    • 30544453439 scopus 로고    scopus 로고
    • Molecular aspects of atherogenesis: New insights and unsolved questions
    • 1:CAS:528:DC%2BD28XivVSjs7g%3D 16328782
    • Puddu GM, Cravero E, Arnone G, Muscari A, Puddu P. Molecular aspects of atherogenesis: new insights and unsolved questions. J Biomed Sci. 2005;12:839-53.
    • (2005) J Biomed Sci , vol.12 , pp. 839-853
    • Puddu, G.M.1    Cravero, E.2    Arnone, G.3    Muscari, A.4    Puddu, P.5
  • 10
    • 77954481762 scopus 로고    scopus 로고
    • Oxidative stress and inflammation modulate peroxisome proliferator-activated receptors with regional discrepancy in diabetic heart
    • 1:CAS:528:DC%2BC3cXhtVKis73N 20561028
    • Lee TI, Kao YH, Chen YC, Pan NH, Chen YJ. Oxidative stress and inflammation modulate peroxisome proliferator-activated receptors with regional discrepancy in diabetic heart. Eur J Clin Invest. 2010;40:692-9.
    • (2010) Eur J Clin Invest , vol.40 , pp. 692-699
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Pan, N.H.4    Chen, Y.J.5
  • 11
    • 84856610250 scopus 로고    scopus 로고
    • Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes
    • 1:CAS:528:DC%2BC3MXntlSjsbY%3D
    • Lee TI, Kao YH, Chen YC, Pan NH, Lin YK, Chen YJ. Cardiac peroxisome-proliferator-activated receptor expression in hypertension co-existing with diabetes. Clin Sci (Lond). 2011;121:305-12.
    • (2011) Clin Sci (Lond) , vol.121 , pp. 305-312
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Pan, N.H.4    Lin, Y.K.5    Chen, Y.J.6
  • 12
    • 84878493642 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy
    • 1:CAS:528:DC%2BC3sXhvFSqur4%3D 23369225
    • Lee TI, Kao YH, Chen YC, Huang JH, Hsiao FC, Chen YJ. Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy. Diabetes Res Clin Pract. 2013;100:330-9.
    • (2013) Diabetes Res Clin Pract , vol.100 , pp. 330-339
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Huang, J.H.4    Hsiao, F.C.5    Chen, Y.J.6
  • 13
    • 84906318851 scopus 로고    scopus 로고
    • Cardiac metabolism, inflammation, and peroxisome proliferator-activated receptors modulated by 1,25-dihydroxyvitamin D3 in diabetic rats
    • 25062566
    • Lee TI, Kao YH, Chen YC, Tsai WC, Chung CC, Chen YJ. Cardiac metabolism, inflammation, and peroxisome proliferator-activated receptors modulated by 1,25-dihydroxyvitamin D3 in diabetic rats. Int J Cardiol. 2014;176:151-7.
    • (2014) Int J Cardiol , vol.176 , pp. 151-157
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Tsai, W.C.4    Chung, C.C.5    Chen, Y.J.6
  • 14
    • 84982852235 scopus 로고    scopus 로고
    • HDAC inhibition modulates cardiac PPARs and fatty acid metabolism in diabetic cardiomyopathy
    • Article ID: 5938740
    • Lee TI, Kao YH, Tsai WC, Chung CC, Chen YC, Chen YJ. HDAC inhibition modulates cardiac PPARs and fatty acid metabolism in diabetic cardiomyopathy. PPAR Res. 2016;2016:Article ID: 5938740.
    • (2016) PPAR Res; 2016
    • Lee, T.I.1    Kao, Y.H.2    Tsai, W.C.3    Chung, C.C.4    Chen, Y.C.5    Chen, Y.J.6
  • 15
    • 11144346132 scopus 로고    scopus 로고
    • Mouse models of mitochondrial dysfunction and heart failure
    • 1:CAS:528:DC%2BD2cXhtFGgs7jN 15623424
    • Russell LK, Finck BN, Kelly DP. Mouse models of mitochondrial dysfunction and heart failure. J Mol Cell Cardiol. 2005;38:81-91.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 81-91
    • Russell, L.K.1    Finck, B.N.2    Kelly, D.P.3
  • 16
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - An engine out of fuel
    • 17360992
    • Neubauer S. The failing heart - an engine Out of fuel. N Engl J Med. 2007;356:1140-51.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 17
    • 34547590901 scopus 로고    scopus 로고
    • Metabolic mechanisms in heart failure
    • 1:CAS:528:DC%2BD2sXnslKksLs%3D 17646594
    • Ashrafian H, Frenneaux MP, Opie LH. Metabolic mechanisms in heart failure. Circulation. 2007;116:434-48.
    • (2007) Circulation , vol.116 , pp. 434-448
    • Ashrafian, H.1    Frenneaux, M.P.2    Opie, L.H.3
  • 18
    • 0034749276 scopus 로고    scopus 로고
    • Mitochondrial pathology in cardiac failure
    • 1:CAS:528:DC%2BD3cXovFGqsb4%3D 11121792
    • Marin-Garcia J, Goldenthal MJ, Moe GW. Mitochondrial pathology in cardiac failure. Cardiovasc Res. 2001;49:17-26.
    • (2001) Cardiovasc Res , vol.49 , pp. 17-26
    • Marin-Garcia, J.1    Goldenthal, M.J.2    Moe, G.W.3
  • 19
    • 33749321945 scopus 로고    scopus 로고
    • Role of changes in cardiac metabolism in development of diabetic cardiomyopathy
    • 1:CAS:528:DC%2BD28XhtFegtrjO 16751293
    • An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2006;291:H1489-506.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. H1489-H1506
    • An, D.1    Rodrigues, B.2
  • 20
    • 38949135755 scopus 로고    scopus 로고
    • Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
    • 1:CAS:528:DC%2BD1cXksVCqsQ%3D%3D
    • Bugger H, Abel ED. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond). 2008;114:195-210.
    • (2008) Clin Sci (Lond) , vol.114 , pp. 195-210
    • Bugger, H.1    Abel, E.D.2
  • 21
    • 84890315467 scopus 로고
    • Mitochondrial dysfunction in diabetic cardiomyopathy
    • Duncan JG. Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta. 1813;2011:1351-9.
    • (1813) Biochim Biophys Acta , vol.2011 , pp. 1351-1359
    • Duncan, J.G.1
  • 22
    • 0036143320 scopus 로고    scopus 로고
    • The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus
    • 1:CAS:528:DC%2BD38XjtlarsQ%3D%3D 11781357 150824
    • Finck BN, Lehman JJ, Leone TC, Welch MJ, Bennett MJ, Kovacs A, et al. The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest. 2002;109:121-30.
    • (2002) J Clin Invest , vol.109 , pp. 121-130
    • Finck, B.N.1    Lehman, J.J.2    Leone, T.C.3    Welch, M.J.4    Bennett, M.J.5    Kovacs, A.6
  • 23
    • 84892952980 scopus 로고    scopus 로고
    • Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase
    • 1:CAS:528:DC%2BC2cXltFKhtrc%3D 24334638
    • Teshima Y, Takahashi N, Nishio S, Saito S, Kondo H, Fukui A, et al. Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase. Circ J. 2014;78:300-6.
    • (2014) Circ J , vol.78 , pp. 300-306
    • Teshima, Y.1    Takahashi, N.2    Nishio, S.3    Saito, S.4    Kondo, H.5    Fukui, A.6
  • 24
    • 0030856714 scopus 로고    scopus 로고
    • Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
    • 1:CAS:528:DyaK2sXmsFanurc%3D 9305864
    • Gudz TI, Tserng KY, Hoppel CL. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem. 1997;272:24154-8.
    • (1997) J Biol Chem , vol.272 , pp. 24154-24158
    • Gudz, T.I.1    Tserng, K.Y.2    Hoppel, C.L.3
  • 25
    • 84930665631 scopus 로고    scopus 로고
    • The mitochondria in diabetic heart failure: From pathogenesis to therapeutic promise
    • 1:CAS:528:DC%2BC2MXovV2hsbY%3D 25761843 4449623
    • Schilling JD. The mitochondria in diabetic heart failure: from pathogenesis to therapeutic promise. Antioxid Redox Signal. 2015;22:1515-26.
    • (2015) Antioxid Redox Signal , vol.22 , pp. 1515-1526
    • Schilling, J.D.1
  • 26
    • 84870372928 scopus 로고    scopus 로고
    • UCP3 regulates cardiac efficiency and mitochondrial coupling in high Fat-Fed mice but Not in leptin-deficient mice
    • 1:CAS:528:DC%2BC38XhvVaht7%2FJ 22912419 3501860
    • Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, et al. UCP3 regulates cardiac efficiency and mitochondrial coupling in high Fat-Fed mice but Not in leptin-deficient mice. Diabetes. 2012;61:3260-9.
    • (2012) Diabetes , vol.61 , pp. 3260-3269
    • Boudina, S.1    Han, Y.H.2    Pei, S.3    Tidwell, T.J.4    Henrie, B.5    Tuinei, J.6
  • 27
    • 42049090126 scopus 로고    scopus 로고
    • Mitochondria: The Hub of cellular Ca2+ signaling
    • 1:CAS:528:DC%2BD1cXmtFKls7s%3D
    • Szabadkai G, Duchen MR. Mitochondria: the Hub of cellular Ca2+ signaling. Physiology (Bethesda). 2008;23:84-94.
    • (2008) Physiology (Bethesda) , vol.23 , pp. 84-94
    • Szabadkai, G.1    Duchen, M.R.2
  • 28
    • 0037338493 scopus 로고    scopus 로고
    • Store-operated Ca (2+) entry: Dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane
    • 1:CAS:528:DC%2BD3sXivFSrt7w%3D 12576497 2342659
    • Parekh AB. Store-operated Ca (2+) entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane. J Physiol. 2003;547:333-48.
    • (2003) J Physiol , vol.547 , pp. 333-348
    • Parekh, A.B.1
  • 29
    • 76249124669 scopus 로고    scopus 로고
    • The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis
    • 20003216 2800844
    • Puddu P, Puddu GM, Cravero E, De Pascalis S, Muscari A. The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci. 2009;16:112.
    • (2009) J Biomed Sci , vol.16 , pp. 112
    • Puddu, P.1    Puddu, G.M.2    Cravero, E.3    De Pascalis, S.4    Muscari, A.5
  • 31
    • 77955435653 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes
    • 1:CAS:528:DC%2BC3cXhtVOhu7jL 20543078 2930393
    • Dabkowski ER, Baseler WA, Williamson CL, Powell M, Razunguzwa TT, Frisbee JC, et al. Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes. Am J Physiol Heart Circ Physiol. 2010;299:H529-H40.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H529-H540
    • Dabkowski, E.R.1    Baseler, W.A.2    Williamson, C.L.3    Powell, M.4    Razunguzwa, T.T.5    Frisbee, J.C.6
  • 32
    • 84862776790 scopus 로고    scopus 로고
    • A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy
    • 1:CAS:528:DC%2BC38XitVGnt7g%3D 22322947
    • Zhang X, Chen C. A new insight of mechanisms, diagnosis and treatment of diabetic cardiomyopathy. Endocrine. 2012;41:398-409.
    • (2012) Endocrine , vol.41 , pp. 398-409
    • Zhang, X.1    Chen, C.2
  • 33
    • 84878282881 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Pathophysiological mechanisms and cardiac dysfuntion
    • 1:CAS:528:DC%2BC2cXhs1Ort7nK 23174745
    • Goyal B, Mehta A. Diabetic cardiomyopathy: Pathophysiological mechanisms and cardiac dysfuntion. Hum Exp Toxicol. 2013;32:571-90.
    • (2013) Hum Exp Toxicol , vol.32 , pp. 571-590
    • Goyal, B.1    Mehta, A.2
  • 34
    • 84862272469 scopus 로고    scopus 로고
    • Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
    • 1:CAS:528:DC%2BC38XhslOiu7jK 22713251 3472273
    • Li CJ, Lv L, Li H, Yu DM. Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid. Cardiovasc Diabetol. 2012;11:73.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 73
    • Li, C.J.1    Lv, L.2    Li, H.3    Yu, D.M.4
  • 35
    • 0038488294 scopus 로고    scopus 로고
    • Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus
    • 1:CAS:528:DC%2BD3sXotFaht74%3D 12875772
    • Diamant M, Lamb HJ, Groeneveld Y, Endert EL, Smit JW, Bax JJ, et al. Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol. 2003;42:328-35.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 328-335
    • Diamant, M.1    Lamb, H.J.2    Groeneveld, Y.3    Endert, E.L.4    Smit, J.W.5    Bax, J.J.6
  • 36
    • 70350445742 scopus 로고    scopus 로고
    • Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart
    • 1:CAS:528:DC%2BD1MXhsFOmtbvF 19892241 2800130
    • Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol. 2009;54:1891-8.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1891-1898
    • Anderson, E.J.1    Kypson, A.P.2    Rodriguez, E.3    Anderson, C.A.4    Lehr, E.J.5    Neufer, P.D.6
  • 37
    • 84906070274 scopus 로고    scopus 로고
    • Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients
    • 1:CAS:528:DC%2BC2cXhtlKksL%2FM 24928681
    • Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, et al. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. Circulation. 2014;130:554-64.
    • (2014) Circulation , vol.130 , pp. 554-564
    • Montaigne, D.1    Marechal, X.2    Coisne, A.3    Debry, N.4    Modine, T.5    Fayad, G.6
  • 38
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • 1:CAS:528:DyaK3MXhsl2gs7g%3D 2129546
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990;347:645-50.
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 39
    • 57649198440 scopus 로고    scopus 로고
    • Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors
    • 19067734
    • Lee TI, Kao YH, Chen YC, Chen YJ. Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors. Eur J Clin Invest. 2009;39:23-30.
    • (2009) Eur J Clin Invest , vol.39 , pp. 23-30
    • Lee, T.I.1    Kao, Y.H.2    Chen, Y.C.3    Chen, Y.J.4
  • 40
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • 1:CAS:528:DC%2BD3sXhtF2gtbw%3D 12552126 298755
    • Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, et al. A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A. 2003;100:1226-31.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6
  • 41
    • 14844295029 scopus 로고    scopus 로고
    • The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart
    • 1:CAS:528:DC%2BD2cXmsVShsLc%3D 15192440
    • Finck BN. The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart. Curr Opin Clin Nutr Metab Care. 2004;7:391-6.
    • (2004) Curr Opin Clin Nutr Metab Care , vol.7 , pp. 391-396
    • Finck, B.N.1
  • 42
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • 1:CAS:528:DC%2BD2cXptVOgsbo%3D 15475963
    • Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004;10:1245-50.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5    He, N.6
  • 43
    • 0037459358 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism
    • 1:CAS:528:DC%2BD3sXitVSjsbg%3D 12600885
    • Gilde AJ, van der Lee KA, Willemsen PH, Chinetti G, van der Leij FR, van der Vusse GJ, et al. Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. Circ Res. 2003;92:518-24.
    • (2003) Circ Res , vol.92 , pp. 518-524
    • Gilde, A.J.1    Van Der Lee, K.A.2    Willemsen, P.H.3    Chinetti, G.4    Van Der Leij, F.R.5    Van Der Vusse, G.J.6
  • 44
    • 0345735302 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    • 1:CAS:528:DC%2BD3sXpvVWmt7k%3D 14684157
    • Cheng L, Ding G, Qin Q, Xiao Y, Woods D, Chen YE, et al. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun. 2004;313:277-86.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 277-286
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Xiao, Y.4    Woods, D.5    Chen, Y.E.6
  • 45
    • 4644231528 scopus 로고    scopus 로고
    • Nuclear receptor signaling and cardiac energetics
    • 1:CAS:528:DC%2BD2cXntlyjur4%3D 15375023
    • Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95:568-78.
    • (2004) Circ Res , vol.95 , pp. 568-578
    • Huss, J.M.1    Kelly, D.P.2
  • 46
    • 36849068108 scopus 로고    scopus 로고
    • Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart
    • 1:CAS:528:DC%2BD2sXhsValsLzM 18037994 2082147
    • Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, et al. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007;117:3930-9.
    • (2007) J Clin Invest , vol.117 , pp. 3930-3939
    • Burkart, E.M.1    Sambandam, N.2    Han, X.3    Gross, R.W.4    Courtois, M.5    Gierasch, C.M.6
  • 47
    • 34948910262 scopus 로고    scopus 로고
    • Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice
    • 1:CAS:528:DC%2BD2sXhtFCnt73P 17823655 1964508
    • Son NH, Park TS, Yamashita H, Yokoyama M, Huggins LA, Okajima K, et al. Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J Clin Invest. 2007;117:2791-801.
    • (2007) J Clin Invest , vol.117 , pp. 2791-2801
    • Son, N.H.1    Park, T.S.2    Yamashita, H.3    Yokoyama, M.4    Huggins, L.A.5    Okajima, K.6
  • 48
    • 44649151707 scopus 로고    scopus 로고
    • The PPAR trio: Regulators of myocardial energy metabolism in health and disease
    • 1:CAS:528:DC%2BD1cXmvVOnu7w%3D 18462747
    • Madrazo JA, Kelly DP. The PPAR trio: regulators of myocardial energy metabolism in health and disease. J Mol Cell Cardiol. 2008;44:968-75.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 968-975
    • Madrazo, J.A.1    Kelly, D.P.2
  • 49
    • 84913553521 scopus 로고
    • H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation
    • Kuznetsov AV, Javadov S, Sickinger S, Frotschnig S, Grimm M. H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochim Biophys Acta. 1853;2015:276-84.
    • (1853) Biochim Biophys Acta , vol.2015 , pp. 276-284
    • Kuznetsov, A.V.1    Javadov, S.2    Sickinger, S.3    Frotschnig, S.4    Grimm, M.5
  • 50
    • 33847110733 scopus 로고    scopus 로고
    • Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway
    • 1:CAS:528:DC%2BD2sXhsF2ktLY%3D 17261654 4322937
    • Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway. Circulation. 2007;115:909-17.
    • (2007) Circulation , vol.115 , pp. 909-917
    • Duncan, J.G.1    Fong, J.L.2    Medeiros, D.M.3    Finck, B.N.4    Kelly, D.P.5
  • 51
    • 76649123086 scopus 로고    scopus 로고
    • Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators
    • 1:CAS:528:DC%2BC3cXlvFajsA%3D%3D 20065164 2825753
    • Duncan JG, Bharadwaj KG, Fong JL, Mitra R, Sambandam N, Courtois MR, et al. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation. 2010;121:426-35.
    • (2010) Circulation , vol.121 , pp. 426-435
    • Duncan, J.G.1    Bharadwaj, K.G.2    Fong, J.L.3    Mitra, R.4    Sambandam, N.5    Courtois, M.R.6
  • 52
    • 0034698051 scopus 로고    scopus 로고
    • Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
    • 1:CAS:528:DC%2BD3cXlt1ehu7g%3D 10801788
    • Watanabe K, Fujii H, Takahashi T, Kodama M, Aizawa Y, Ohta Y, et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem. 2000;275:22293-9.
    • (2000) J Biol Chem , vol.275 , pp. 22293-22299
    • Watanabe, K.1    Fujii, H.2    Takahashi, T.3    Kodama, M.4    Aizawa, Y.5    Ohta, Y.6
  • 53
    • 0035024343 scopus 로고    scopus 로고
    • A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle
    • 1:CAS:528:DC%2BD3MXjtVajsro%3D 11158930
    • Minnich A, Tian N, Byan L, Bilder G. A potent PPARα agonist stimulates mitochondrial fatty acid β-oxidation in liver and skeletal muscle. Am J Physiol Endocrinol Metab. 2001;280:E270-E9.
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , pp. E270-E279
    • Minnich, A.1    Tian, N.2    Byan, L.3    Bilder, G.4
  • 54
    • 0036686288 scopus 로고    scopus 로고
    • Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle
    • 1:CAS:528:DC%2BD38XmslCqt7o%3D 12176671
    • Furuhashi M, Ura N, Murakami H, Hyakukoku M, Yamaguchi K, Higashiura K, et al. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. J Endocrinol. 2002;174:321-9.
    • (2002) J Endocrinol , vol.174 , pp. 321-329
    • Furuhashi, M.1    Ura, N.2    Murakami, H.3    Hyakukoku, M.4    Yamaguchi, K.5    Higashiura, K.6
  • 55
    • 33846465014 scopus 로고    scopus 로고
    • Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate
    • 17245174 1876998
    • Cree MG, Zwetsloot JJ, Herndon DN, Qian T, Morio B, Fram R, et al. Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg. 2007;245:214-21.
    • (2007) Ann Surg , vol.245 , pp. 214-221
    • Cree, M.G.1    Zwetsloot, J.J.2    Herndon, D.N.3    Qian, T.4    Morio, B.5    Fram, R.6
  • 56
    • 84949555128 scopus 로고    scopus 로고
    • Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential
    • 1:CAS:528:DC%2BC2MXitVGrsLfL 26659390
    • Hong M, Song KD, Lee HK, Yi S, Lee YS, Heo TH, et al. Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential. In Vitro Cell Dev Biol Anim. 2016;52:349-55.
    • (2016) Vitro Cell Dev Biol Anim , vol.52 , pp. 349-355
    • Hong, M.1    Song, K.D.2    Lee, H.K.3    Yi, S.4    Lee, Y.S.5    Heo, T.H.6
  • 57
    • 84878923597 scopus 로고    scopus 로고
    • Gemfibrozil pretreatment resulted in a sexually dimorphic outcome in the Rat models of global cerebral ischemia-reperfusion via modulation of mitochondrial Pro-survival and apoptotic cell death factors as well as MAPKs
    • 1:CAS:528:DC%2BC3sXptVOns78%3D 23288702
    • Mohagheghi F, Ahmadiani A, Rahmani B, Moradi F, Romond N, Khalaj L. Gemfibrozil pretreatment resulted in a sexually dimorphic outcome in the Rat models of global cerebral ischemia-reperfusion via modulation of mitochondrial Pro-survival and apoptotic cell death factors as well as MAPKs. J Mol Neurosci. 2013;50:379-93.
    • (2013) J Mol Neurosci , vol.50 , pp. 379-393
    • Mohagheghi, F.1    Ahmadiani, A.2    Rahmani, B.3    Moradi, F.4    Romond, N.5    Khalaj, L.6
  • 58
    • 84863522631 scopus 로고    scopus 로고
    • PPARα-dependent induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
    • 1:CAS:528:DC%2BC38XpvVegurs%3D 22318764 3378765
    • Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ. PPARα-dependent induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology. 2012;56:281-90.
    • (2012) Hepatology , vol.56 , pp. 281-290
    • Patterson, A.D.1    Shah, Y.M.2    Matsubara, T.3    Krausz, K.W.4    Gonzalez, F.J.5
  • 59
    • 4644298829 scopus 로고    scopus 로고
    • Fenofibrate impairs Rat mitochondrial function by inhibition of respiratory complex i
    • 1:CAS:528:DC%2BD2cXosVKrtrw%3D 15166256
    • Brunmair B, Lest A, Staniek K, Gras F, Scharf N, Roden M, et al. Fenofibrate impairs Rat mitochondrial function by inhibition of respiratory complex I. J Pharmacol Exp Ther. 2004;311:109-14.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 109-114
    • Brunmair, B.1    Lest, A.2    Staniek, K.3    Gras, F.4    Scharf, N.5    Roden, M.6
  • 60
    • 0033057924 scopus 로고    scopus 로고
    • The effect of peroxisome proliferators on mitochondrial bioenergetics
    • 1:CAS:528:DyaK1MXjt12rt7c%3D 10330687
    • Zhou S, Wallace KB. The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicol Sci. 1999;48:82-9.
    • (1999) Toxicol Sci , vol.48 , pp. 82-89
    • Zhou, S.1    Wallace, K.B.2
  • 61
    • 73349120247 scopus 로고    scopus 로고
    • Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function
    • 1:CAS:528:DC%2BD1MXhtlCqurvO 19360380
    • Zungu M, Young ME, Stanley WC, Essop MF. Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function. Mol Cell Biochem. 2009;330:55-62.
    • (2009) Mol Cell Biochem , vol.330 , pp. 55-62
    • Zungu, M.1    Young, M.E.2    Stanley, W.C.3    Essop, M.F.4
  • 62
    • 84899473698 scopus 로고    scopus 로고
    • The formation of brown adipose tissue induced by transgenic over-expression of PPARgamma2
    • 1:CAS:528:DC%2BC2cXltFCksb8%3D 24642257
    • Zhou Y, Yang J, Huang J, Li T, Xu D, Zuo B, et al. The formation of brown adipose tissue induced by transgenic over-expression of PPARgamma2. Biochem Biophys Res Commun. 2014;446:959-64.
    • (2014) Biochem Biophys Res Commun , vol.446 , pp. 959-964
    • Zhou, Y.1    Yang, J.2    Huang, J.3    Li, T.4    Xu, D.5    Zuo, B.6
  • 63
    • 36649035297 scopus 로고    scopus 로고
    • Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage
    • 1:CAS:528:DC%2BD2sXhtFGrtLfP 17678635
    • Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, et al. Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res. 2007;76:269-79.
    • (2007) Cardiovasc Res , vol.76 , pp. 269-279
    • Ding, G.1    Fu, M.2    Qin, Q.3    Lewis, W.4    Kim, H.W.5    Fukai, T.6
  • 64
    • 84876684394 scopus 로고    scopus 로고
    • Rosiglitazone induces arrhythmogenesis in diabetic hypertensive rats with calcium handling alteration
    • 21917327
    • Lee TI, Chen YC, Kao YH, Hsiao FC, Lin YK, Chen YJ. Rosiglitazone induces arrhythmogenesis in diabetic hypertensive rats with calcium handling alteration. Int J Cardiol. 2013;165:299-307.
    • (2013) Int J Cardiol , vol.165 , pp. 299-307
    • Lee, T.I.1    Chen, Y.C.2    Kao, Y.H.3    Hsiao, F.C.4    Lin, Y.K.5    Chen, Y.J.6
  • 65
    • 81255178486 scopus 로고    scopus 로고
    • Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone
    • 22098677 3230127
    • Håkansson J, Eliasson B, Smith U, Enerbäck S. Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone. Diabetol Metab Syndr. 2011;3:32.
    • (2011) Diabetol Metab Syndr , vol.3 , pp. 32
    • Håkansson, J.1    Eliasson, B.2    Smith, U.3    Enerbäck, S.4
  • 66
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • 1:CAS:528:DC%2BD2MXktVCksL8%3D 15855325
    • Bogacka I, Xie H, Bray GA, Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes. 2005;54:1392-9.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4
  • 67
    • 81955162873 scopus 로고    scopus 로고
    • PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease
    • 1:CAS:528:DC%2BC3MXhsFGqsLnI 21907283
    • Chiang MC, Chern Y, Huang RN. PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease. Neurobiol Dis. 2012;45:322-8.
    • (2012) Neurobiol Dis , vol.45 , pp. 322-328
    • Chiang, M.C.1    Chern, Y.2    Huang, R.N.3
  • 68
    • 0037199943 scopus 로고    scopus 로고
    • Thiazolidinedione activation of peroxisome proliferator-activated receptor γ Can enhance mitochondrial potential and promote cell survival
    • 1:CAS:528:DC%2BD38XmslOqtLs%3D 12082115
    • Wang YL, Frauwirth KA, Rangwala SM, Lazar MA, Thompson CB. Thiazolidinedione activation of peroxisome proliferator-activated receptor γ Can enhance mitochondrial potential and promote cell survival. J Biol Chem. 2002;277:31781-8.
    • (2002) J Biol Chem , vol.277 , pp. 31781-31788
    • Wang, Y.L.1    Frauwirth, K.A.2    Rangwala, S.M.3    Lazar, M.A.4    Thompson, C.B.5
  • 69
    • 84932102477 scopus 로고    scopus 로고
    • Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: An in vitro model in mitochondria
    • 1:CAS:528:DC%2BC2MXjs1yjtb8%3D 25727309
    • Hu D, Wu CQ, Li ZJ, Liu Y, Fan X, Wang QJ, et al. Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: an in vitro model in mitochondria. Toxicol Appl Pharmacol. 2015;284:134-41.
    • (2015) Toxicol Appl Pharmacol , vol.284 , pp. 134-141
    • Hu, D.1    Wu, C.Q.2    Li, Z.J.3    Liu, Y.4    Fan, X.5    Wang, Q.J.6
  • 70
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
    • 1:CAS:528:DC%2BD2cXivFyqsbs%3D 15047621
    • Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes. 2004;53:1052-9.
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1    Staniek, K.2    Gras, F.3    Scharf, N.4    Althaym, A.5    Clara, R.6
  • 71
    • 20444497357 scopus 로고    scopus 로고
    • Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?
    • 1:CAS:528:DC%2BD2MXlt1Skt74%3D 15925327
    • Feinstein DL, Spagnolo A, Akar C, Weinberg G, Murphy P, Gavrilyuk V, et al. Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key? Biochem Pharmacol. 2005;70:177-88.
    • (2005) Biochem Pharmacol , vol.70 , pp. 177-188
    • Feinstein, D.L.1    Spagnolo, A.2    Akar, C.3    Weinberg, G.4    Murphy, P.5    Gavrilyuk, V.6
  • 72
    • 84889795928 scopus 로고    scopus 로고
    • Insulin sensitizers in 2013: New insights for the development of novel therapeutic agents to treat metabolic diseases
    • 1:CAS:528:DC%2BC3sXhvVyqsLnK 24073940
    • Colca JR, Tanis SP, McDonald WG, Kletzien RF. Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseases. Expert Opin Investig Drugs. 2014;23:1-7.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1-7
    • Colca, J.R.1    Tanis, S.P.2    McDonald, W.G.3    Kletzien, R.F.4
  • 74
    • 84877771544 scopus 로고    scopus 로고
    • Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) - Relationship to newly identified mitochondrial pyruvate carrier proteins
    • 1:CAS:528:DC%2BC3sXosVKhsbw%3D 23690925 3655167
    • Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, et al. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT) - relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One. 2013;8:e61551.
    • (2013) PLoS One , vol.8 , pp. e61551
    • Colca, J.R.1    McDonald, W.G.2    Cavey, G.S.3    Cole, S.L.4    Holewa, D.D.5    Brightwell-Conrad, A.S.6
  • 75
    • 34248359155 scopus 로고    scopus 로고
    • MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity
    • 1:CAS:528:DC%2BD2sXkt1emsb4%3D 17376863 1838440
    • Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007;104:5318-23.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5318-5323
    • Wiley, S.E.1    Murphy, A.N.2    Ross, S.A.3    Van Der Geer, P.4    Dixon, J.E.5


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