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Volumn 67, Issue , 2017, Pages 23-28

Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art

Author keywords

Cancer; Immune system; Microenvironment; microRNAs; Tumor derived exosomes

Indexed keywords

GENOMIC DNA; MESSENGER RNA; MICRORNA; TUMOR PROTEIN;

EID: 85008323150     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2016.12.004     Document Type: Review
Times cited : (60)

References (65)
  • 1
    • 0020565476 scopus 로고
    • Isolation of plasma membrane fragments from cultured murine melanoma cells
    • Taylor, D.D., Chou, I.N., Black, P.H., Isolation of plasma membrane fragments from cultured murine melanoma cells. Biochem. Biophys. Res. Commun. 113 (1983), 470–476.
    • (1983) Biochem. Biophys. Res. Commun. , vol.113 , pp. 470-476
    • Taylor, D.D.1    Chou, I.N.2    Black, P.H.3
  • 2
    • 0023921439 scopus 로고
    • Characterization of plasma membrane shedding from murine melanoma cells
    • Taylor, D.D., Taylor, C.G., Jiang, C.G., Black, P.H., Characterization of plasma membrane shedding from murine melanoma cells. Int. J. Cancer 41 (1988), 629–635.
    • (1988) Int. J. Cancer , vol.41 , pp. 629-635
    • Taylor, D.D.1    Taylor, C.G.2    Jiang, C.G.3    Black, P.H.4
  • 3
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • Taylor, D.D., Gercel-Taylor, C., Lyons, K.S., Stanson, J., Whiteside, T.L., T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin. Cancer Res. 9 (2003), 5113–5119.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gercel-Taylor, C.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 4
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone, R.M., Adam, M., Hammond, J.R., Orr, L., Turbide, C., Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262 (1987), 9412–9420.
    • (1987) J. Biol. Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 5
    • 79958048581 scopus 로고    scopus 로고
    • Body fluid derived exosomes as a novel template for clinical diagnostics
    • Keller, S., Ridinger, J., Rupp, A.-K., Janssen, J.W.G., Altevogt, P., Body fluid derived exosomes as a novel template for clinical diagnostics. J. Transl. Med., 9, 2011, 86, 10.1186/1479-5876-9-86.
    • (2011) J. Transl. Med. , vol.9 , pp. 86
    • Keller, S.1    Ridinger, J.2    Rupp, A.-K.3    Janssen, J.W.G.4    Altevogt, P.5
  • 6
    • 58849151841 scopus 로고    scopus 로고
    • Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen
    • Poliakov, A., Spilman, M., Dokland, T., Amling, C.L., Mobley, J.A., Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen. Prostate 69 (2009), 159–167, 10.1002/pros.20860.
    • (2009) Prostate , vol.69 , pp. 159-167
    • Poliakov, A.1    Spilman, M.2    Dokland, T.3    Amling, C.L.4    Mobley, J.A.5
  • 7
    • 82455184277 scopus 로고    scopus 로고
    • Quantitative nano-structural and single molecule force spectroscopy bio-molecular analysis of human saliva derived exosomes
    • Sharma, S., Gillespie, B.M., Palanisamy, V., Gimzewski, J.K., Quantitative nano-structural and single molecule force spectroscopy bio-molecular analysis of human saliva derived exosomes. Langmuir 27 (2011), 14394–14400, 10.1021/la2038763.
    • (2011) Langmuir , vol.27 , pp. 14394-14400
    • Sharma, S.1    Gillespie, B.M.2    Palanisamy, V.3    Gimzewski, J.K.4
  • 8
    • 33845618038 scopus 로고    scopus 로고
    • Association of citrullinated proteins with synovial exosomes
    • Skriner, K., Adolph, K., Jungblut, P.R., Burmester, G.R., Association of citrullinated proteins with synovial exosomes. Arthritis Rheum. 54 (2006), 3809–3814, 10.1002/art..22276.
    • (2006) Arthritis Rheum. , vol.54 , pp. 3809-3814
    • Skriner, K.1    Adolph, K.2    Jungblut, P.R.3    Burmester, G.R.4
  • 9
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: shedding the confusion between extracellular vesicles
    • Cocucci, E., Meldolesi, J., Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 25 (2015), 364–372, 10.1016/j.tcb.2015.01.004.
    • (2015) Trends Cell Biol. , vol.25 , pp. 364-372
    • Cocucci, E.1    Meldolesi, J.2
  • 10
    • 33947185874 scopus 로고    scopus 로고
    • Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles
    • Wieckowski, E., Whiteside, T.L., Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles. Immunol. Res. 36 (2006), 247–254, 10.1385/IR:36:1:247.
    • (2006) Immunol. Res. , vol.36 , pp. 247-254
    • Wieckowski, E.1    Whiteside, T.L.2
  • 11
    • 84941260399 scopus 로고    scopus 로고
    • Information transfer by exosomes: a new frontier in hematologic malignancies
    • Boyiadzis, M., Whiteside, T.L., Information transfer by exosomes: a new frontier in hematologic malignancies. Blood Rev. 29 (2015), 281–290, 10.1016/j.blre.2015.01.004.
    • (2015) Blood Rev. , vol.29 , pp. 281-290
    • Boyiadzis, M.1    Whiteside, T.L.2
  • 12
    • 84873153440 scopus 로고    scopus 로고
    • Exosomes and communication between tumours and the immune system: are all exosomes equal?
    • Bobrie, A., Thery, C., Exosomes and communication between tumours and the immune system: are all exosomes equal?. Biochem Soc. Trans. 41 (2013), 263–267, 10.1042/BST20120245.
    • (2013) Biochem Soc. Trans. , vol.41 , pp. 263-267
    • Bobrie, A.1    Thery, C.2
  • 13
    • 84926252110 scopus 로고    scopus 로고
    • Exosomes in immunity and cancer–friends or foes?
    • Gabrielsson, S., Scheynius, A., Exosomes in immunity and cancer–friends or foes?. Semin. Cancer Biol. 28 (2014), 1–2, 10.1016/j.semcancer.2014.06.007.
    • (2014) Semin. Cancer Biol. , vol.28 , pp. 1-2
    • Gabrielsson, S.1    Scheynius, A.2
  • 14
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • Robbins, P.D., Morelli, A.E., Regulation of immune responses by extracellular vesicles. Nat. Rev. Immunol. 14 (2014), 195–208, 10.1038/nri3622.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 15
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim, J.W., Wieckowski, E., Taylor, D.D., Reichert, T.E., Watkins, S., Whiteside, T.L., Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin. Cancer Res. 11 (2005), 1010–1020.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 16
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo, G., Stoorvogel, W., Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200 (2013), 373–383, 10.1083/jcb.201211138.
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 17
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J.J., Lotvall, J.O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9 (2007), 654–659, 10.1038/ncb1596.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 18
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics biogenesis mechanism, and function
    • Bartel, D.P., MicroRNAs: genomics biogenesis mechanism, and function. Cell 116 (2004), 281–297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 19
    • 84891818318 scopus 로고    scopus 로고
    • miRBase: annotating high confidence microRNAs using deep sequencing data
    • Epub 2013 Nov 25. (n.d.)
    • Kozomara, A., Griffiths-Jones, S., miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42:Jan (Database issue) (2014), D68–D73, 10.1093/nar/gkt1181 Epub 2013 Nov 25. (n.d.).
    • (2014) Nucleic Acids Res. , vol.42 , Issue.Jan (Database issue) , pp. D68-D73
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 20
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Jan 14(n.d.)
    • Lewis, B.P., Burge, C.B., Bartel, D.P., Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:1 (2005), 15–20 Jan 14(n.d.).
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 21
    • 34547441263 scopus 로고    scopus 로고
    • Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
    • Lytle, J.R., Yario, T.A., Steitz, J.A., Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR. Proc. Natl. Acad. Sci. U. S. A. 104:23 (2007), 9667–9672.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.23 , pp. 9667-9672
    • Lytle, J.R.1    Yario, T.A.2    Steitz, J.A.3
  • 22
    • 54449097149 scopus 로고    scopus 로고
    • A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence
    • Forman, J.J., Legesse-Miller, A., Coller, H.A., A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc. Natl. Acad. Sci. U. S. A. 105:39 (2008), 14879–14884, 10.1073/pnas.0803230105.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , Issue.39 , pp. 14879-14884
    • Forman, J.J.1    Legesse-Miller, A.2    Coller, H.A.3
  • 23
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros, V., The functions of animal microRNAs. Nature 431:7006 (2004), 350–355.
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 24
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: microRNAs can up-regulate translation
    • Vasudevan, S., Tong, Y., Steitz, J.A., Switching from repression to activation: microRNAs can up-regulate translation. Science 318:5858 (2007), 1931–1934.
    • (2007) Science , vol.318 , Issue.5858 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 29
    • 85008952417 scopus 로고    scopus 로고
    • Tumor-associated macrophages, multi-tasking cells in the cancer landscape, Cancer Res
    • Marelli, G., Allavena, P., Erreni, M., Tumor-associated macrophages, multi-tasking cells in the cancer landscape, Cancer Res. Front 1 (2015), 149–161, 10.17980/2015.149.
    • (2015) Front , vol.1 , pp. 149-161
    • Marelli, G.1    Allavena, P.2    Erreni, M.3
  • 30
    • 84904654557 scopus 로고    scopus 로고
    • Tumor-associated macrophages contribute to tumor progression in ovarian cancer
    • Colvin, E.K., Tumor-associated macrophages contribute to tumor progression in ovarian cancer. Front. Oncol., 4, 2014, 137, 10.3389/fonc.2014.00137.
    • (2014) Front. Oncol. , vol.4 , pp. 137
    • Colvin, E.K.1
  • 34
    • 84883887202 scopus 로고    scopus 로고
    • Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization
    • Jang, J.-Y., Lee, J.-K., Jeon, Y.-K., Kim, C.-W., Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. BMC Cancer, 13, 2013, 421, 10.1186/1471-2407-13-421.
    • (2013) BMC Cancer , vol.13 , pp. 421
    • Jang, J.-Y.1    Lee, J.-K.2    Jeon, Y.-K.3    Kim, C.-W.4
  • 38
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov, R., Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1 (2001), 135–145, 10.1038/35100529.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 39
  • 40
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich, D., Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 4 (2004), 941–952, 10.1038/nri1498.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 41
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine, T., Gabrilovich, D.I., Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 32 (2011), 19–25, 10.1016/j.it.2010.10.002.
    • (2011) Trends Immunol. , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 42
    • 77952042113 scopus 로고    scopus 로고
    • Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    • Liu, Y., Xiang, X., Zhuang, X., Zhang, S., Liu, C., Cheng, Z., Michalek, S., Grizzle, W., Zhang, H.-G., Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells. Am. J. Pathol. 176 (2010), 2490–2499, 10.2353/ajpath.2010.090777.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2490-2499
    • Liu, Y.1    Xiang, X.2    Zhuang, X.3    Zhang, S.4    Liu, C.5    Cheng, Z.6    Michalek, S.7    Grizzle, W.8    Zhang, H.-G.9
  • 44
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes
    • Valenti, R., Huber, V., Filipazzi, P., Pilla, L., Sovena, G., Villa, A., Corbelli, A., Fais, S., Parmiani, G., Rivoltini, L., Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res. 66 (2006), 9290–9298, 10.1158/0008-5472.CAN-06-1819.
    • (2006) Cancer Res. , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6    Corbelli, A.7    Fais, S.8    Parmiani, G.9    Rivoltini, L.10
  • 45
    • 34248200155 scopus 로고    scopus 로고
    • MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma
    • Szafranska, A.E., Davison, T.S., John, J., Cannon, T., Sipos, B., Maghnouj, A., Labourier, E., Hahn, S.A., MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 26 (2007), 4442–4452, 10.1038/sj.onc.1210228.
    • (2007) Oncogene , vol.26 , pp. 4442-4452
    • Szafranska, A.E.1    Davison, T.S.2    John, J.3    Cannon, T.4    Sipos, B.5    Maghnouj, A.6    Labourier, E.7    Hahn, S.A.8
  • 46
    • 73449134501 scopus 로고    scopus 로고
    • Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    • Greither, T., Grochola, L.F., Udelnow, A., Lautenschlager, C., Wurl, P., Taubert, H., Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int. J. Cancer 126 (2010), 73–80, 10.1002/ijc.24687.
    • (2010) Int. J. Cancer , vol.126 , pp. 73-80
    • Greither, T.1    Grochola, L.F.2    Udelnow, A.3    Lautenschlager, C.4    Wurl, P.5    Taubert, H.6
  • 47
    • 84908312386 scopus 로고    scopus 로고
    • Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203
    • Zhou, M., Chen, J., Zhou, L., Chen, W., Ding, G., Cao, L., Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203. Cell. Immunol. 292 (2014), 65–69, 10.1016/j.cellimm.2014.09.004.
    • (2014) Cell. Immunol. , vol.292 , pp. 65-69
    • Zhou, M.1    Chen, J.2    Zhou, L.3    Chen, W.4    Ding, G.5    Cao, L.6
  • 48
    • 84945157600 scopus 로고    scopus 로고
    • Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p
    • Ding, G., Zhou, L., Qian, Y., Fu, M., Chen, J., Chen, J., Xiang, J., Wu, Z., Jiang, G., Cao, L., Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p. Oncotarget 6 (2015), 29877–29888, 10.18632/oncotarget.4924.
    • (2015) Oncotarget , vol.6 , pp. 29877-29888
    • Ding, G.1    Zhou, L.2    Qian, Y.3    Fu, M.4    Chen, J.5    Chen, J.6    Xiang, J.7    Wu, Z.8    Jiang, G.9    Cao, L.10
  • 49
    • 84969749839 scopus 로고    scopus 로고
    • Increasing the immune activity of exosomes: the effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer
    • Que, L., Lin, Ri-sheng, Ding, Cheng, Wu, Guo-pin, Cao, Zheng-rong, Increasing the immune activity of exosomes: the effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer. J. Zhejiang Univ. B 17 (2016), 352–360, 10.1631/jzus.B1500305.
    • (2016) J. Zhejiang Univ. B , vol.17 , pp. 352-360
    • Que, L.1    Lin, R.-S.2    Ding, C.3    Wu, G.-P.4    Cao, Z.-R.5
  • 50
    • 84906933853 scopus 로고    scopus 로고
    • Natural killer T cells: drivers or passengers in preventing human disease?
    • Berzins, S.P., Ritchie, D.S., Natural killer T cells: drivers or passengers in preventing human disease?. Nat. Rev. Immunol. 14 (2014), 640–646, 10.1038/nri3725.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 640-646
    • Berzins, S.P.1    Ritchie, D.S.2
  • 52
    • 84866361046 scopus 로고    scopus 로고
    • Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells
    • Noman, M.Z., Buart, S., Romero, P., Ketari, S., Janji, B., Mari, B., Mami-Chouaib, F., Chouaib, S., Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells. Cancer Res. 72 (2012), 4629–4641, 10.1158/0008-5472.CAN-12-1383.
    • (2012) Cancer Res. , vol.72 , pp. 4629-4641
    • Noman, M.Z.1    Buart, S.2    Romero, P.3    Ketari, S.4    Janji, B.5    Mari, B.6    Mami-Chouaib, F.7    Chouaib, S.8
  • 54
    • 84918517100 scopus 로고    scopus 로고
    • Activation of glioma cells generates immune tolerant NKT cells
    • Tang, B., Wu, W., Wei, X., Li, Y., Ren, G., Fan, W., Activation of glioma cells generates immune tolerant NKT cells. J. Biol. Chem. 289 (2014), 34595–34600, 10.1074/jbc.M114.614503.
    • (2014) J. Biol. Chem. , vol.289 , pp. 34595-34600
    • Tang, B.1    Wu, W.2    Wei, X.3    Li, Y.4    Ren, G.5    Fan, W.6
  • 55
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S., Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22 (2004), 531–562, 10.1146/annurev.immunol.21.120601.141122.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 56
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi, S., Yamaguchi, T., Nomura, T., Ono, M., Regulatory T cells and immune tolerance. Cell 133 (2008), 775–787, 10.1016/j.cell.2008.05.009.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 58
    • 51049108540 scopus 로고    scopus 로고
    • Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
    • Quezada, S.A., Peggs, K.S., Simpson, T.R., Shen, Y., Littman, D.R., Allison, J.P., Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J. Exp. Med. 205 (2008), 2125–2138, 10.1084/jem.20080099.
    • (2008) J. Exp. Med. , vol.205 , pp. 2125-2138
    • Quezada, S.A.1    Peggs, K.S.2    Simpson, T.R.3    Shen, Y.4    Littman, D.R.5    Allison, J.P.6
  • 59
    • 70449723156 scopus 로고    scopus 로고
    • Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
    • Zhou, Q., Bucher, C., Munger, M.E., Highfill, S.L., Tolar, J., Munn, D.H., Levine, B.L., Riddle, M., June, C.H., Vallera, D.A., Weigel, B.J., Blazar, B.R., Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood 114 (2009), 3793–3802, 10.1182/blood-2009-03-208181.
    • (2009) Blood , vol.114 , pp. 3793-3802
    • Zhou, Q.1    Bucher, C.2    Munger, M.E.3    Highfill, S.L.4    Tolar, J.5    Munn, D.H.6    Levine, B.L.7    Riddle, M.8    June, C.H.9    Vallera, D.A.10    Weigel, B.J.11    Blazar, B.R.12
  • 62
    • 84906851359 scopus 로고    scopus 로고
    • Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression
    • Xie, J., Liu, M., Li, Y., Nie, Y., Mi, Q., Zhao, S., Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression. Cell. Mol. Immunol. 11 (2014), 495–502, 10.1038/cmi.2014.30.
    • (2014) Cell. Mol. Immunol. , vol.11 , pp. 495-502
    • Xie, J.1    Liu, M.2    Li, Y.3    Nie, Y.4    Mi, Q.5    Zhao, S.6
  • 65
    • 70349091451 scopus 로고    scopus 로고
    • Tricks tumors use to escape from immune control
    • Whiteside, T.L., Tricks tumors use to escape from immune control. Oral Oncol. 45 (2009), e119–e123, 10.1016/j.oraloncology.2009.03.006.
    • (2009) Oral Oncol. , vol.45 , pp. e119-e123
    • Whiteside, T.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.