Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale

Chem

Volumn 1, Issue 3, 2016, Pages 456-472

  Beatty, Joel W ^a   Douglas, James J ^b   Miller, Richard ^b   McAtee, Rory C ^a   Cole, Kevin P ^b   Stephenson, Corey R J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

SDG3: Good health and well being

Indexed keywords

EID: 85008264082     PISSN: 24519294     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chempr.2016.08.002     Document Type: Article

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96. 96 See the Supplemental Information for full details of the reactor design.
97. 97 Pumps were temporarily stopped for <1 min while the feed bottles were refilled.
98. 98 We appreciate that direct trifluoromethylations to form pyrrole 25 have been reported; however, it remains unclear whether those processes could be operated at a kilogram scale. SeeBaar, M., Blechert, S., Graphitic carbon nitride polymer as a recyclable photoredox catalyst for fluoroalkylation of arenes. Chem. Eur. J. 21 (2015), 526–530.
99. 99 We use 24 hr to define a day, but it should be appreciated that in many cases, other restrictions may prevent full 24 hr operation on a large (e.g., plant) manufacturing scale.
100. 83.