Enantioselective α-trifluoromethylation of aldehydes via photoredox organocatalysis

Journal of the American Chemical Society

Volumn 131, Issue 31, 2009, Pages 10875-10877

  Nagib, David A ^a   Scott, Mark E ^a   MacMillan, David W C ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; CHEMICAL EQUATIONS; ENANTIOSELECTIVE; HIGH EFFICIENCY; ORGANOCATALYSIS; ORGANOCATALYTIC; PERFLUOROALKYLATION; TRIFLUOROMETHYL; TRIFLUOROMETHYLATION;

CATALYSIS; ENANTIOSELECTIVITY; IRIDIUM; PHOTOCATALYSIS; REACTION KINETICS;

ALDEHYDES;

ALDEHYDE DERIVATIVE; ALPHA PERFLUOROALKYL ALDEHYDE; ALPHA TRIFLUOROMETHYL ALDEHYDE; HALIDE; IMIDAZOLIDINE DERIVATIVE; IRIDIUM; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYST; CHEMICAL STRUCTURE; CHIRAL CHROMATOGRAPHY; ENANTIOSELECTIVITY; METHYLATION; OXIDATION REDUCTION REACTION; PHOTOCATALYSIS;

ALDEHYDES; CATALYSIS; CHLOROFLUOROCARBONS, METHANE; METHYLATION; OXIDATION-REDUCTION; PHOTOCHEMICAL PROCESSES; STEREOISOMERISM;

EID: 68249144236     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9053338     Document Type: Article

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46. 19F NMR yield); however facile postreaction racemization is observed.
47. 2 and MeOH to afford β-trifluoromethyl alcohols in high yield and enantioselectivity.