A practical flow reactor for continuous organic photochemistry

Journal of Organic Chemistry

Volumn 70, Issue 19, 2005, Pages 7558-7564

  Hook, Benjamin D A ^a   Dohle, Wolfgang ^a   Hirst, Paul R ^a   Pickworth, Mark ^a   Berry, Malcolm B ^b   Booker Milburn, Kevin I ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OPTIMIZATION; ORGANIC POLYMERS; ORGANIC SOLVENTS;

FLOW REACTOR; IMMERSION WELL EQUIPMENT; ORGANIC PHOTOCHEMISTRY; SOLVENT-RESISTANCE FLUOROPOLYMER;

PHOTOCHEMICAL REACTIONS;

1 HEXYNE; 3,4 DIMETHYL 1 PENT 4 ENYLPYRROLE 2,5 DIONE; ALKENE; ALKYNE; AZEPINE DERIVATIVE; CYCLOBUTENE; FLUOROPOLYMER; MALEIMIDE; POLYMER; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BATCH REACTOR; CYCLOADDITION; FLOW REACTOR; IMMERSION; IRRADIATION; PHOTOCHEMISTRY; REACTION ANALYSIS; REACTOR; ULTRAVIOLET RADIATION;

EID: 24944575233     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050705p     Document Type: Article

References (18)

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2. (b) CRC Handbook of Organic Photochemistry and Photobiology; Horspool, W. M., Lenci, F., Eds.; CRC Press: Boca Raton, 2004.
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8. Recently, Griesbeck et al. have developed a novel falling film reactor based on the use of a high-power XeCl excimer lamp which is a monochromatic UV source at 308 nm. These authors have shown that this technology can deliver 50-200 g of photoproduct from various established photochemical reactions: Griesbeck, A. G.; Bondock, S.; Maptue, N.; Oelgemöller, M. Photochem. Photobiol Sci. 2003, 2, 450-451.
9. Feehs, R. H. US Pat. 3,554,887, 1971.
10. For the use of PTFE and FEP tubing to construct postcolumn photochemical detectors for HPLC analysis, see: (a) Schölten, A. H. M. T.; Welling, P. L. M.; Brinkman, U. A. Th.; Frei, R. W. J. Chromatogr. A 1980, 199, 239-248.
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14. For example, the intermolecular [2 + 2] photocycloaddition of tetrahydrophthalic anhydride with alkynols: Booker-Milburn, K. I.; Cowell, J. K.; Delgado Jimenez, F.; Sharpe, A.; White, A. J. Tetrahedron 1999, 55, 5875-5888.
15. (a) Booker-Milburn, K. I.; Anson, E. A.; Clissold, C.; Costin, N. J.; Dainty, R. F.; Murray, M.; Patel, D.; Sharpe, A. Eur. J. Org. Chem. 2001, 1473-1482.
16. (b) Booker-Milburn, K. I.; Hirst, P.; Charmant, J. P. H.; Taylor, L. H. J. Angew. Chem., Int. Ed. 2003, 42, 1642-1644.
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18. All commercially acquired immersion well apparatus, lamps, and power supplies were purchased from Photochemical Reactors Ltd. (U.K.), www.photochemicalreactors.com. Custom Pyrex and Vycor immersion well apparatus was constructed by Mr. Duncan Tarling (University of Bristol); FEP tubing was purchased from Adtech Polymer Engineering Ltd. (U.K.), www.adtech.co.uk. Vycor was purchased from Corning, www.corning.com.