Prediction and mechanism elucidation of analyte retention on phospholipid stationary phases (IAM-HPLC) by in silico calculated physico-chemical descriptors

European Journal of Pharmaceutical Sciences

Volumn 99, Issue , 2017, Pages 173-184

  Russo, Giacomo ^a   Grumetto, Lucia ^a   Barbato, Francesco ^a   Vistoli, Giulio ^b   Pedretti, Alessandro ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Biochromatography; IAM HPLC; Immobilized artificial membrane; Prediction of phospholipid affinity; Quantitative structure property relationship models

Indexed keywords

1 NAPHTHYLAMINE; 1,2 DICHLOROETHANE; 1,3 DICHLOROBENZENE; 2 BUTANOL; 3 CHLOROPHENOL; 4 NITROANILINE; ACEBUTOLOL; ACETONITRILE; ACETOPHENONE; ACETYLSALICYLIC ACID; ACRIDINE; ALPRAZOLAM; ALPRENOLOL; AMINOPHENAZONE; AMITRIPTYLINE; AMLODIPINE; AMOXICILLIN; ANILINE; ANISOLE; ATENOLOL; BENZENE; BENZYL ALCOHOL; BENZYLAMINE; HEXANOL; NITROBENZENE; OCTANOL; PENTANOL; PHENETHYLAMINE; PHOSPHOLIPID; UNINDEXED DRUG; ARTIFICIAL MEMBRANE; PHOSPHATIDYLCHOLINE; WATER;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COMPUTER MODEL; COMPUTER PREDICTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIPOPHILICITY; MEASUREMENT ACCURACY; MEMBRANE STRUCTURE; MOLECULAR INTERACTION; MOLECULAR SIZE; PHASE PARTITIONING; PHYSICAL CHEMISTRY; PHYSICAL PHASE; PKA; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE PROPERTY RELATION; RETENTION TIME; STATIC ELECTRICITY; SURFACE AREA; ARTIFICIAL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; COMPUTER SIMULATION; PH; PROCEDURES;

1-OCTANOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANES, ARTIFICIAL; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; STATIC ELECTRICITY; WATER;

EID: 85007409390     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2016.11.026     Document Type: Article

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