Capillary electrochromatography as a new tool to assess drug affinity for membrane phospholipids

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 5, 2011, Pages 893-899

  Barbato, Francesco ^a   Grumetto, Lucia ^a   Carpentiero, Carmen ^a   Rocco, Anna ^b   Fanali, Salvatore ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

Author keywords

Biomembranes; IAM capillary electrochromatography; IAM HPLC; Lipophilicity; Phospholipids

Indexed keywords

ATENOLOL; BENZENE; BUFFER; CAFFEINE; DIPHENHYDRAMINE; EPHEDRINE; KETAMINE; MEMBRANE PHOSPHOLIPID; NICOTINAMIDE; OXAZEPAM; PHENYLPROPANOLAMINE; RANITIDINE; TEMAZEPAM; THEOBROMINE; THIOPENTAL; TOLUENE; TRAMADOL; VERAPAMIL;

ARTICLE; ARTIFICIAL MEMBRANE; CAPILLARY ELECTROCHROMATOGRAPHY; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG RETENTION; ELECTROPHORETIC MOBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID ANALYSIS; LIPOPHILICITY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PH; PRIORITY JOURNAL;

BIOLOGICAL TRANSPORT; CAPILLARY ELECTROCHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78751702124     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.037     Document Type: Article

References (21)

1. Leo A.J., Hansch C., Elkins D. Partition coefficients and their use. Chem. Rev. 1971, 71:525-616.
2. Taillardat-Bertschinger A., Carrupt P-A., Barbato F., Testa B. Immobilized artificial membrane HPLC in drug research. J. Med. Chem. 2003, 46:655-665.
3. Barbato F. The use of immobilised artificial membrane (IAM) chromatography for determination of lipophilicity. Curr. Comput.-Aided Drug Des. 2006, 2:341-352.
4. Amato M., Barbato F., Morrica P., Quaglia F., La Rotonda M.I. Interactions between amines and phospholipids: a chromatographic study on immobilized artificial membrane (IAM) stationary phases at various pH values. Helv. Chim. Acta 2000, 83:2836-2847.
5. Barbato F., La Rotonda M.I., Quaglia F. Chromatographic indices determined on an immobilized artificial membrane (IAM) column as descriptors of lipophilic and polar interactions of 4-phenyldihydropyridine calcium-channel blockers with biomembranes. Eur. J. Med. Chem. 1996, 31:311-318.
6. Barbato F., La Rotonda M.I., Quaglia F. Chromatographic indexes on Immobilized Artificial Membranes for local anesthetics: relationships with activity data on closed sodium channels. Pharm. Res. 1997, 14:1699-1705.
7. Barbato F., di Martino G., Grumetto L., La Rotonda M.I. Prediction of drug-membrane interactions by IAM-HPLC: effects of different phospholipid stationary phases on the partition of bases. Eur. J. Pharm. Sci. 2004, 22:261-269.
8. Barbato F., di Martino G., Grumetto L., La Rotonda M.I. Can protonated beta-blockers interact with biomembranes stronger than neutral isolipophilic compounds? A chromatographic study on three different phospholipids stationary phases (IAM-HPLC). Eur. J. Pharm. Sci. 2005, 25:379-386.
9. Quaglia M.G., Barbato F., Fanali S., Santucci E., Donati E., Carafa M., Marianecci C. Direct determination by capillary electrophoresis of cardiovascular drugs, previously included in liposomes. J. Pharm. Biomed. Anal. 2005, 37:73-79.
10. Quaglia M.G., Fanali S., Barbato F., Donati E. Micellar electrokinetic chromatography for determination of drug partition in phospholipids. Farmaco 2005, 60:77-83.
11. Fanali S., Catarcini P., Blaschke G., Chankvetadze B. Enantioseparation by capillary electrocromatography. Electrophoresis 2001, 22:3131-3151.
12. Eeltink S., Rozing G.P., Kok W.Th. Recent applications in capillary electrochromatography. Electrophoresis 2003, 24:3935-3961.
13. Rathore A.S., Horvath C. Chromatographic and electrophoretic migration parameters in capillary electrochromatography. Electrophoresis 2002, 23:1211-1216.
14. Braumann Th., Weber G., Grimme L.H. Quantitative structure-activity relationships for herbicides. Reversed-phase liquid chromatographic retention parameters, logkw, versus liquid-liquid partition coefficients as a model of the hydrophobicity of phenylureas, S-triazines and phenoxycarbonic acid derivatives. J. Chromatogr. 1983, 261:329-343.
15. Barbato F., Caliendo G., La Rotonda M.I., Morrica P., Silipo C., Vittoria A. Relationships between octanol-water partition data, chromatographic indices and their dependance on pH in a set of beta adrenoceptor blocking agents. Farmaco 1990, 45:647-663.
16. Barbato F., La Rotonda M.I., Quaglia F. Interactions of nonsteroidal antiinflammatory drugs with phospholipids: comparison between octanol/buffer coefficients and chromatographic indexes on immobilized artificial membranes. J. Pharm. Sci. 1997, 86:225-229.
17. Fanali S., Catarcini P., Presutti C., Stancanelii R., Quaglia M.G. Use of short end injection capillary packed with a glycopeptide antibiotic stationary phase in electrochromatography and capillary liquid chromatography for the enantiomeric separation of hydroxy acids. J. Chromatogr. A 2003, 990:143-151.
18. Aturki Z., D'Orazio G., Fanali S. Rapid assay of vitamin E in vegetable oils by reversed-phase capillary electrochromatography. Electrophoresis 2005, 26:798-803.
19. Barbato F., Cirocco V., Grumetto L., La Rotonda M.I. Comparison between Immobilized Artificial Membrane (IAM) HPLC data and lipophilicity in n-octanol for quinolone antibacterial agents. Eur. J. Pharm. Sci. 2007, 31:288-297.
20. Avdeef A. Physicochemical profiling (solubility, permeability and charge state). Curr. Top. Med. Chem. 2001, 1:277-351.
21. Vrakas D., Giaginis C., Tsantili-Kakoulidou A. Electrostatic interactions and ionization effect in immobilized artificial membrane retention. A comparative study with octanol-water partitioning. J. Chromatogr. A 2008, 1187:67-78.