Polar interactions drug/phospholipids estimated by IAM-HPLC vs cultured cell line passage data: Their relationships and comparison of their effectiveness in predicting drug human intestinal absorption

International Journal of Pharmaceutics

Volumn 500, Issue 1-2, 2016, Pages 275-290

  Grumetto, Lucia ^a   Russo, Giacomo ^a   Barbato, Francesco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Caco 2; IAM HPLC; Intestinal absorption; Lipophilicity; MDCK; Oral bioavailability; Transcellular passage

Indexed keywords

ACEBUTOLOL; ACETYLSALICYLIC ACID; ACICLOVIR; ADRENALIN; ALPRENOLOL; AMINOPHENAZONE; AMOXICILLIN; ATENOLOL; BETAXOLOL; CAFFEINE; CARBAMAZEPINE; CEFALEXIN; CHLORAMPHENICOL; CHLORPROMAZINE; CIMETIDINE; CLONIDINE; DESIPRAMINE; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; DILTIAZEM; DIPHENHYDRAMINE; DOMPERIDONE; DRUG; FLUMEQUINE; OCTANOL; PARACETAMOL; PHENAZONE; PHOSPHOLIPID; UNINDEXED DRUG;

ARTICLE; ARTIFICIAL MEMBRANE; CACO 2 CELL LINE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMICAL INTERACTION; CONTROLLED STUDY; CULTURED CELL LINE PASSAGE; DIFFUSION; DRUG ABSORPTION; DRUG PENETRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMOBILIZED ARTIFICIAL MEMBRANE; IN VIVO STUDY; INTESTINE ABSORPTION; LIPOPHILICITY; PKA; POLAR INTERACTION; PRIORITY JOURNAL; SMALL INTESTINE ABSORPTION; STATIC ELECTRICITY; TRANSCYTOSIS; ANIMAL; CACO-2 CELL LINE; CHEMISTRY; DOG; MDCK CELL LINE; METABOLISM;

1-OCTANOL; ANIMALS; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; INTESTINAL ABSORPTION; MADIN DARBY CANINE KIDNEY CELLS; PHARMACEUTICAL PREPARATIONS; PHOSPHOLIPIDS;

EID: 84971571993     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.01.019     Document Type: Article

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