메뉴 건너뛰기




Volumn 66, Issue 1, 2017, Pages 193-205

Metformin suppresses diabetes-accelerated atherosclerosis via the inhibition of Drp1-mediated mitochondrial fission

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN I; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; SUPEROXIDE; APOLIPOPROTEIN E; DNM1L PROTEIN, MOUSE; DYNAMIN; REACTIVE OXYGEN METABOLITE;

EID: 85007302876     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db16-0915     Document Type: Article
Times cited : (279)

References (52)
  • 1
    • 85027926284 scopus 로고    scopus 로고
    • Oxidative stress as a mechanism of added sugar-induced cardiovascular disease
    • Prasad K, Dhar I. Oxidative stress as a mechanism of added sugar-induced cardiovascular disease. Int J Angiol 2014;23:217-226
    • (2014) Int J Angiol , vol.23 , pp. 217-226
    • Prasad, K.1    Dhar, I.2
  • 2
    • 84906222930 scopus 로고    scopus 로고
    • Redox regulation of endothelial cell fate
    • Song P, Zou MH. Redox regulation of endothelial cell fate. Cell Mol Life Sci 2014;71:3219-3239
    • (2014) Cell Mol Life Sci , vol.71 , pp. 3219-3239
    • Song, P.1    Zou, M.H.2
  • 3
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-820
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 4
    • 34247895799 scopus 로고    scopus 로고
    • Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions
    • Zhang H, Luo Y, Zhang W, et al. Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. Am J Pathol 2007;170:1108-1120
    • (2007) Am J Pathol , vol.170 , pp. 1108-1120
    • Zhang, H.1    Luo, Y.2    Zhang, W.3
  • 5
    • 84856752588 scopus 로고    scopus 로고
    • The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/-mice
    • Mercer JR, Yu E, Figg N, et al. The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/-mice. Free Radic Biol Med 2012;52:841-849
    • (2012) Free Radic Biol Med , vol.52 , pp. 841-849
    • Mercer, J.R.1    Yu, E.2    Figg, N.3
  • 6
    • 78649413837 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in cell life and death
    • Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010;11:872-884
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 872-884
    • Westermann, B.1
  • 7
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 2006;103:2653-2658
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 8
    • 84863011641 scopus 로고    scopus 로고
    • Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle
    • Jheng HF, Tsai PJ, Guo SM, et al. Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol 2012;32:309-319
    • (2012) Mol Cell Biol , vol.32 , pp. 309-319
    • Jheng, H.F.1    Tsai, P.J.2    Guo, S.M.3
  • 9
    • 79961021186 scopus 로고    scopus 로고
    • Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
    • Shenouda SM, Widlansky ME, Chen K, et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011;124:444-453
    • (2011) Circulation , vol.124 , pp. 444-453
    • Shenouda, S.M.1    Widlansky, M.E.2    Chen, K.3
  • 10
    • 80055118346 scopus 로고    scopus 로고
    • Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells
    • Lugus JJ, Ngoh GA, Bachschmid MM, Walsh K. Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells. J Mol Cell Cardiol 2011;51:885-893
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 885-893
    • Lugus, J.J.1    Ngoh, G.A.2    Bachschmid, M.M.3    Walsh, K.4
  • 11
    • 84863023552 scopus 로고    scopus 로고
    • Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
    • Wang W, Wang Y, Long J, et al. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 2012;15:186-200
    • (2012) Cell Metab , vol.15 , pp. 186-200
    • Wang, W.1    Wang, Y.2    Long, J.3
  • 12
    • 84923602928 scopus 로고    scopus 로고
    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
    • Westermeier F, Navarro-Marquez M, López-Crisosto C, et al. Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy. Biochim Biophys Acta 2015;1853:1113-1118
    • (2015) Biochim Biophys Acta , vol.1853 , pp. 1113-1118
    • Westermeier, F.1    Navarro-Marquez, M.2    López-Crisosto, C.3
  • 13
    • 84930462727 scopus 로고    scopus 로고
    • Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease
    • Zhan M, Usman IM, Sun L, Kanwar YS. Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease. J Am Soc Nephrol 2015;26:1304-1321
    • (2015) J Am Soc Nephrol , vol.26 , pp. 1304-1321
    • Zhan, M.1    Usman, I.M.2    Sun, L.3    Kanwar, Y.S.4
  • 14
    • 84901015809 scopus 로고    scopus 로고
    • Mitochondrial dynamics in peripheral neuropathies
    • Sajic M. Mitochondrial dynamics in peripheral neuropathies. Antioxid Redox Signal 2014;21:601-620
    • (2014) Antioxid Redox Signal , vol.21 , pp. 601-620
    • Sajic, M.1
  • 15
    • 84891350009 scopus 로고    scopus 로고
    • C-peptide activates AMPKa and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
    • Bhatt MP, Lim YC, Kim YM, Ha KS. C-peptide activates AMPKa and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes 2013;62:3851-3862
    • (2013) Diabetes , vol.62 , pp. 3851-3862
    • Bhatt, M.P.1    Lim, Y.C.2    Kim, Y.M.3    Ha, K.S.4
  • 16
    • 84874357500 scopus 로고    scopus 로고
    • Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
    • Hong J, Zhang Y, Lai S, et al.; SPREAD-DIMCAD Investigators. Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care 2013;36:1304-1311
    • (2013) Diabetes Care , vol.36 , pp. 1304-1311
    • Hong, J.1    Zhang, Y.2    Lai, S.3
  • 17
    • 2342446628 scopus 로고    scopus 로고
    • Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes
    • Matsumoto K, Sera Y, Abe Y, Tominaga T, Yeki Y, Miyake S. Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes. Diabetes Res Clin Pract 2004;64:225-228
    • (2004) Diabetes Res Clin Pract , vol.64 , pp. 225-228
    • Matsumoto, K.1    Sera, Y.2    Abe, Y.3    Tominaga, T.4    Yeki, Y.5    Miyake, S.6
  • 18
    • 84871267241 scopus 로고    scopus 로고
    • Primary preventive effect of metformin upon atherosclerosis in patients with type 2 diabetes mellitus
    • Zhang XY, Du JL, Jia YJ, et al. [Primary preventive effect of metformin upon atherosclerosis in patients with type 2 diabetes mellitus]. Zhonghua Yi Xue Za Zhi 2009;89:2134-2137
    • (2009) Zhonghua Yi Xue Za Zhi , vol.89 , pp. 2134-2137
    • Zhang, X.Y.1    Du, J.L.2    Jia, Y.J.3
  • 19
    • 84974851800 scopus 로고    scopus 로고
    • Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice
    • Li A, Zhang S, Li J, Liu K, Huang F, Liu B. Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice. Mol Cell Endocrinol 2016;434:36-47
    • (2016) Mol Cell Endocrinol , vol.434 , pp. 36-47
    • Li, A.1    Zhang, S.2    Li, J.3    Liu, K.4    Huang, F.5    Liu, B.6
  • 20
    • 84955242874 scopus 로고    scopus 로고
    • Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction
    • Li J, Wang Y, Wang Y, et al. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. J Mol Cell Cardiol 2015;86:62-74
    • (2015) J Mol Cell Cardiol , vol.86 , pp. 62-74
    • Li, J.1    Wang, Y.2    Wang, Y.3
  • 21
    • 84884735588 scopus 로고    scopus 로고
    • AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1
    • Wikstrom JD, Israeli T, Bachar-Wikstrom E, et al. AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1. Mol Endocrinol 2013;27:1706-1723
    • (2013) Mol Endocrinol , vol.27 , pp. 1706-1723
    • Wikstrom, J.D.1    Israeli, T.2    Bachar-Wikstrom, E.3
  • 22
    • 84961291233 scopus 로고    scopus 로고
    • Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury
    • Morigi M, Perico L, Rota C, et al. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. J Clin Invest 2015;125:715-726
    • (2015) J Clin Invest , vol.125 , pp. 715-726
    • Morigi, M.1    Perico, L.2    Rota, C.3
  • 23
    • 84903127192 scopus 로고    scopus 로고
    • Dietary supplementation with fish oil alters the expression levels of proteins governing mitochondrial dynamics and prevents high-fat diet-induced endothelial dysfunction
    • Sun R, Wang X, Liu Y, Xia M. Dietary supplementation with fish oil alters the expression levels of proteins governing mitochondrial dynamics and prevents high-fat diet-induced endothelial dysfunction. Br J Nutr 2014;112:145-153
    • (2014) Br J Nutr , vol.112 , pp. 145-153
    • Sun, R.1    Wang, X.2    Liu, Y.3    Xia, M.4
  • 24
    • 4444270915 scopus 로고    scopus 로고
    • Dysregulation of HSG triggers vascular proliferative disorders
    • Chen KH, Guo X, Ma D, et al. Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol 2004;6:872-883
    • (2004) Nat Cell Biol , vol.6 , pp. 872-883
    • Chen, K.H.1    Guo, X.2    Ma, D.3
  • 25
    • 77950989801 scopus 로고    scopus 로고
    • AMPKalpha2 deletion causes aberrant expression and activation of NAD (P) H oxidase and consequent endothelial dysfunction in vivo: Role of 26S proteasomes
    • Wang S, Zhang M, Liang B, et al. AMPKalpha2 deletion causes aberrant expression and activation of NAD (P) H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res 2010;106:1117-1128
    • (2010) Circ Res , vol.106 , pp. 1117-1128
    • Wang, S.1    Zhang, M.2    Liang, B.3
  • 26
    • 77149134285 scopus 로고    scopus 로고
    • Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo
    • Dong Y, Zhang M, Liang B, et al. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 2010;121:792-803
    • (2010) Circulation , vol.121 , pp. 792-803
    • Dong, Y.1    Zhang, M.2    Liang, B.3
  • 27
    • 84894056145 scopus 로고    scopus 로고
    • Activation of NAD (P) H oxidase by tryptophanderived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo
    • Wang Q, Zhang M, Ding Y, et al. Activation of NAD (P) H oxidase by tryptophanderived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo. Circ Res 2014;114:480-492
    • (2014) Circ Res , vol.114 , pp. 480-492
    • Wang, Q.1    Zhang, M.2    Ding, Y.3
  • 28
    • 68049129864 scopus 로고    scopus 로고
    • In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I
    • Wang S, Xu J, Song P, Viollet B, Zou MH. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes 2009;58:1893-1901
    • (2009) Diabetes , vol.58 , pp. 1893-1901
    • Wang, S.1    Xu, J.2    Song, P.3    Viollet, B.4    Zou, M.H.5
  • 29
    • 84898059358 scopus 로고    scopus 로고
    • Endothelial cell-specific liver kinase B1 deletion causes endothelial dysfunction and hypertension in mice in vivo
    • Zhang W, Wang Q, Wu Y, et al. Endothelial cell-specific liver kinase B1 deletion causes endothelial dysfunction and hypertension in mice in vivo. Circulation 2014;129:1428-1439
    • (2014) Circulation , vol.129 , pp. 1428-1439
    • Zhang, W.1    Wang, Q.2    Wu, Y.3
  • 30
    • 84923264186 scopus 로고    scopus 로고
    • Hypochlorous acid via peroxynitrite activates protein kinase Cu and insulin resistance in adipocytes
    • Zhou J, Wang Q, Ding Y, Zou MH. Hypochlorous acid via peroxynitrite activates protein kinase Cu and insulin resistance in adipocytes. J Mol Endocrinol 2015;54:25-37
    • (2015) J Mol Endocrinol , vol.54 , pp. 25-37
    • Zhou, J.1    Wang, Q.2    Ding, Y.3    Zou, M.H.4
  • 31
    • 84959228554 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation
    • Torres G, Morales PE, García-Miguel M, et al. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem Pharmacol 2016;104:52-61
    • (2016) Biochem Pharmacol , vol.104 , pp. 52-61
    • Torres, G.1    Morales, P.E.2    García-Miguel, M.3
  • 32
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • Xie Z, Lau K, Eby B, et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 2011;60:1770-1778
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1    Lau, K.2    Eby, B.3
  • 33
    • 84949118251 scopus 로고    scopus 로고
    • Hypertension and insulin resistance: Implications of mitochondrial dysfunction
    • Manucha W, Ritchie B, Ferder L. Hypertension and insulin resistance: implications of mitochondrial dysfunction. Curr Hypertens Rep 2015;17:504
    • (2015) Curr Hypertens Rep , vol.17 , pp. 504
    • Manucha, W.1    Ritchie, B.2    Ferder, L.3
  • 34
    • 49849084827 scopus 로고    scopus 로고
    • Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities
    • Thomas SR, Witting PK, Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2008;10:1713-1765
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1713-1765
    • Thomas, S.R.1    Witting, P.K.2    Drummond, G.R.3
  • 36
    • 34247598856 scopus 로고    scopus 로고
    • Endothelial mitochondria: Contributing to vascular function and disease
    • Davidson SM, Duchen MR. Endothelial mitochondria: contributing to vascular function and disease. Circ Res 2007;100:1128-1141
    • (2007) Circ Res , vol.100 , pp. 1128-1141
    • Davidson, S.M.1    Duchen, M.R.2
  • 37
    • 78650869947 scopus 로고    scopus 로고
    • Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis
    • Devarajan A, Bourquard N, Hama S, et al. Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxid Redox Signal 2011;14:341-351
    • (2011) Antioxid Redox Signal , vol.14 , pp. 341-351
    • Devarajan, A.1    Bourquard, N.2    Hama, S.3
  • 38
    • 33644749330 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
    • Kukidome D, Nishikawa T, Sonoda K, et al. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 2006;55:120-127
    • (2006) Diabetes , vol.55 , pp. 120-127
    • Kukidome, D.1    Nishikawa, T.2    Sonoda, K.3
  • 39
    • 58149473706 scopus 로고    scopus 로고
    • TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis
    • Fujisawa K, Nishikawa T, Kukidome D, et al. TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis. Biochem Biophys Res Commun 2009;379:43-48
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 43-48
    • Fujisawa, K.1    Nishikawa, T.2    Kukidome, D.3
  • 40
    • 84937768865 scopus 로고    scopus 로고
    • Metformin beyond diabetes: Pleiotropic benefits of metformin in attenuation of atherosclerosis
    • Forouzandeh F, Salazar G, Patrushev N, et al. Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. J Am Heart Assoc 2014;3:e001202
    • (2014) J Am Heart Assoc , vol.3 , pp. e001202
    • Forouzandeh, F.1    Salazar, G.2    Patrushev, N.3
  • 41
    • 84930762844 scopus 로고    scopus 로고
    • Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: Potential role in atherosclerosis
    • Vasamsetti SB, Karnewar S, Kanugula AK, Raj AT, Kumar JM, Kotamraju S. Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis. Diabetes 2015;64:2028-2041
    • (2015) Diabetes , vol.64 , pp. 2028-2041
    • Vasamsetti, S.B.1    Karnewar, S.2    Kanugula, A.K.3    Raj, A.T.4    Kumar, J.M.5    Kotamraju, S.6
  • 42
    • 84941055870 scopus 로고    scopus 로고
    • Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia
    • Zhang L, Ji L, Tang X, et al. Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia. Ren Fail 2015;37:903-910
    • (2015) Ren Fail , vol.37 , pp. 903-910
    • Zhang, L.1    Ji, L.2    Tang, X.3
  • 43
    • 84940700273 scopus 로고    scopus 로고
    • Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model
    • Huang S, Wang Y, Gan X, et al. Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model. Diabetes 2015;64:1728-1742
    • (2015) Diabetes , vol.64 , pp. 1728-1742
    • Huang, S.1    Wang, Y.2    Gan, X.3
  • 44
    • 59649130026 scopus 로고    scopus 로고
    • Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis
    • Men X, Wang H, Li M, et al. Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis. Int J Biochem Cell Biol 2009;41:879-890
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 879-890
    • Men, X.1    Wang, H.2    Li, M.3
  • 45
    • 21544469973 scopus 로고    scopus 로고
    • Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    • Schulz E, Anter E, Zou MH, Keaney JF Jr. Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation 2005;111:3473-3480
    • (2005) Circulation , vol.111 , pp. 3473-3480
    • Schulz, E.1    Anter, E.2    Zou, M.H.3    Keaney, J.F.4
  • 46
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006;55:496-505
    • (2006) Diabetes , vol.55 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.H.4
  • 47
    • 61949165795 scopus 로고    scopus 로고
    • AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
    • Chen Z, Peng IC, Sun W, et al. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res 2009;104:496-505
    • (2009) Circ Res , vol.104 , pp. 496-505
    • Chen, Z.1    Peng, I.C.2    Sun, W.3
  • 48
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011;331:456-461
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3
  • 49
    • 1842334456 scopus 로고    scopus 로고
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-1197
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
  • 50
    • 84954318420 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
    • Toyama EQ, Herzig S, Courchet J, et al. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 2016;351:275-281
    • (2016) Science , vol.351 , pp. 275-281
    • Toyama, E.Q.1    Herzig, S.2    Courchet, J.3
  • 51
    • 84877270825 scopus 로고    scopus 로고
    • NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis
    • Gray SP, Di Marco E, Okabe J, et al. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation 2013;127:1888-1902
    • (2013) Circulation , vol.127 , pp. 1888-1902
    • Gray, S.P.1    Di Marco, E.2    Okabe, J.3
  • 52
    • 84946856610 scopus 로고    scopus 로고
    • Direct endothelial nitric oxide synthase activation provides atheroprotection in diabetes-accelerated atherosclerosis
    • Sharma A, Sellers S, Stefanovic N, et al. Direct endothelial nitric oxide synthase activation provides atheroprotection in diabetes-accelerated atherosclerosis. Diabetes 2015;64:3937-3950
    • (2015) Diabetes , vol.64 , pp. 3937-3950
    • Sharma, A.1    Sellers, S.2    Stefanovic, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.