Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury

Basic Research in Cardiology

Volumn 111, Issue 2, 2016, Pages

  Reforgiato, M R ^a   Milano, G ^b,c   Fabrias G ^d   Casas, J ^d   Gasco, P ^e   Paroni, R ^a   Samaja, M ^a   Ghidoni, R ^a   Caretti, A ^a   Signorelli, Paola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c CENTRO CARDIOLOGICO MONZINO   (Italy)

^d INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^e NANOVECTOR S R L   (Italy)

Author keywords

Ceramide; Infarct; Inflammation; Myocardium; Oxidative stress; Postconditioning; Reperfusion

Indexed keywords

CERAMIDE; HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; SERINE PALMITOYLTRANSFERASE; THERMOZYMOCIDIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; MONOUNSATURATED FATTY ACID; NFE2L2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; DOWN REGULATION; DRUG EFFECT; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; HEART PROTECTION; INFLAMMATION; ISCHEMIC POSTCONDITIONING; LIPOGENESIS; MALE; MOUSE; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CARDIAC MUSCLE; DRUG EFFECTS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PRECLINICAL STUDY; PROCEDURES;

ANIMALS; CERAMIDES; DRUG EVALUATION, PRECLINICAL; FATTY ACIDS, MONOUNSATURATED; HEME OXYGENASE-1; ISCHEMIC POSTCONDITIONING; MALE; MICE, INBRED C57BL; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 85007174580     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0533-x     Document Type: Article

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